Aerobic Exercise Improves Postprandial Inflammatory and Hemostatic Markers After a High-Fat Meal: A Randomized Cross-Over Study

2020 ◽  
Author(s):  
Bruno Costa Teixeira ◽  
Renata L. Krüger ◽  
Juliano Boufleur Farinha ◽  
Francesco P Boeno ◽  
Rodrigo Cauduro Oliveira Macedo ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Exercise Intensity ◽  
Inflammatory Markers ◽  
Factor Vii ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial State ◽  
Anti Inflammatory ◽  
Fat Meal

Exercise intensity modulates postprandial lipemia. It is still unknown, however, its effect on hemostatic and pro- and anti-inflammatory markers in the postprandial state. Eleven young males perform a 2-day trial on different conditions: (i) REST: rest for 45 min; (ii) MIE: moderate-intensity exercise; and (iii) HIE: heavy-intensity exercise. Experimental conditions were performed in the evening. On the following morning, blood samples were taken in the fasted state (0 h) and at 1, 3, and 5 h after the consumption of a high-fat meal (HFM). Interleukin-10 (IL-10) levels were higher in the HIE vs. MIE trial at 0 and 1 h (p < 0.033) and IL-10 iAUC was greater in the MIE (p = 0.027) and HIE (p = 0.045) vs. REST. Lower levels of anti-coagulation factor VII (FVII) were observed at 1 h in the MIE condition vs. REST (p = 0.043). In comparison with REST, MIE improved hemostatic (FVII) and anti-inflammatory markers (IL-10 iAUC) whereas HIE enhanced IL-10 in the postprandial state. Regardless of the exercise intensity, aerobic exercise mitigates the deleterious consequences of an HFM. Novelty Bullets: • Prior aerobic exercise at moderate-intensity attenuates next day’s postprandial FVII and IL-10 levels whereas exercise performed at heavy-intensity increases IL-10 levels. • Moderate-intensity exercise may be more beneficial to improve hemostatic (FVII) and anti-inflammatory (IL-10) responses while heavy-intensity exercise may improve anti-inflammatory (IL-10) levels only.

scholarly journals Is the effect of prior exercise on postprandial lipaemia the same for a moderate-fat meal as it is for a high-fat meal?

2010 ◽  
Vol 105 (4) ◽  
pp. 506-516 ◽  
Author(s):  
Nicholas M. Hurren ◽  
Frank F. Eves ◽  
Andrew K. Blannin
Keyword(s):  
Test Meal ◽  
Venous Blood ◽  
Exercise Bout ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Lipaemia ◽  
Fasted State ◽  
Prior Exercise ◽  
Fat Meal

Moderate-intensity exercise can lower the TAG response to a high-fat meal; however, the British diet is moderate in fat, and no study to date has compared the effect of such exercise on responses to high-fat and moderate-fat meals. The present work investigated the effect of brisk walking performed 13 h before intake of both high-fat and moderate-fat meals on postprandial plasma TAG concentrations. Eight inactive, overweight men completed four separate 2 d trials, i.e. rest (Con) or a 90-min treadmill walk (Ex) on the evening of day 1, followed by the ingestion of a moderate-fat (Mod) or high-fat (High) meal on the morning of day 2. High-fat meals contained 66 % of total energy as fat, while the percentage was 35 % for moderate-fat meals; both the meals were, however, isoenergetic. On day 2, venous blood was sampled in the fasted state, 30 and 60 min after ingesting the test meal and then hourly until 6 h post-meal. Exercise reduced plasma TAG concentrations significantly (P < 0·001), with no exercise × meal interaction (P = 0·459). Walking reduced the total TAG response to a high-fat meal by 29 % (relative to High Con); the same bout of exercise performed before ingesting a moderate-fat meal lowered total TAG by 26 % (compared with Mod Con). The ability of a single moderate-intensity aerobic exercise bout to lower postprandial TAG concentrations is just as great, in percentage terms, when the test meal ingested is of a moderate rather than a high fat content.

High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

2012 ◽  
Vol 123 (5) ◽  
pp. 313-321 ◽  
Author(s):  
Brendan Gabriel ◽  
Aivaras Ratkevicius ◽  
Patrick Gray ◽  
Michael P. Frenneaux ◽  
Stuart R. Gray
Keyword(s):  
Oxidative Stress ◽  
Adhesion Molecule ◽  
High Intensity ◽  
Intermittent Exercise ◽  
Protein Carbonyls ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Markers Of Oxidative Stress ◽  
Fat Meal

Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

scholarly journals Exercise Intensity and Postprandial Lipemia (La intensidad del ejercicio y la lipemia postprandial)

Retos ◽  
2015 ◽  
pp. 206-212
Author(s):  
Laurel A. Littlefield ◽  
Peter W. Grandjean
Keyword(s):  
Cardiovascular Disease ◽  
Aerobic Exercise ◽  
Exercise Intensity ◽  
Postprandial Lipemia ◽  
High Fat ◽  
Post Exercise ◽  
Increased Risk ◽  
Síndrome Metabólico ◽  
Fat Meal

Exaggerated postprandial lipemia has been observed in metabolic and cardiovascular diseases and is associated with increased risk for cardiovascular disease (CVD). Prior aerobic exercise reduces the triglyceride response to a high-fat meal. The purpose of this review is to examine the factors contributing to metabolic dyslipidemia and to review available evidence supporting the role of aerobic exercise in reducing postprandial lipemia. The contribution of exercise intensity and excess-post exercise oxygen consumption (EPOC) to changes in postprandial lipemia is examined.Key words. lipemia, Metabolic Syndrome, exercise, EPOC.Resumen. La exagerada lipemia postprandial exagerada ha sido observada en enfermedades metabólicas y cardiovasculares, y está asociada a un mayor riesgo de enfermedad cardiovascular (ECV). Se ha encontrado que el ejercicio aeróbico previo reduce la respuesta de los triglicéridos a una comida rica en grasas. El propósito de esta revisión es examinar los factores que contribuyen a la dislipidemia metabólica y revisar la evidencia disponible que respalda el papel del ejercicio aeróbico en la reducción de la lipemia postprandial. Se examina la contribución de la intensidad del ejercicio y el exceso de consumo de oxígeno post-ejercicio (EPOC) en los cambios en la lipemia postprandial.Palabras claves. lipemia, Síndrome Metabólico, ejercicio, EPOC

scholarly journals Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

2016 ◽  
Vol 41 (12) ◽  
pp. 1278-1284 ◽  
Author(s):  
Renata Lopes Krüger ◽  
Bruno Costa Teixeira ◽  
Juliano Boufleur Farinha ◽  
Rodrigo Cauduro Oliveira Macedo ◽  
Francesco Pinto Boeno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Acute Exercise ◽  
Postprandial Lipemia ◽  
Moderate Intensity ◽  
Thiobarbituric Acid Reactive Substance ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Period ◽  
Fat Meal

The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.

scholarly journals Acute moderate-intensity exercise increases total antioxidant capacity and anti-inflammatory responses in competitive cyclists: The role of adiponectin

2021 ◽  
Vol 19 ◽  
pp. 205873922199889
Author(s):  
Tadeja Jakus ◽  
Mihaela Jurdana ◽  
Lovro Žiberna ◽  
Zala J Pražnikar
Keyword(s):  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Inflammatory Markers ◽  
Inflammatory Responses ◽  
The Body ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Total Antioxidant ◽  
Competitive Cyclists ◽  
Anti Inflammatory

High-intensity exercise can elicit acute changes in the biochemical and physiological processes in the body of an athlete, including increased oxidative stress and inflammation. The purpose of this study was to explore the effect of acute moderate-intensity exercise on total antioxidant capacity (TAC) and serum levels of anti-inflammatory adiponectin (APN), and inflammatory markers in competitive cyclists. Ten male cyclists (age 15–26 years, body mass index 19.4–24.7 kg/m2) participated in this study. Each subject performed the maximal oxygen uptake test (VO2peak) and completed a 10-min cycling exercise at a workload of 50% of the peak of VO2peak. Blood samples were collected on three different occasions: after an overnight fasting and at the exercise workloads of 50% and 100% VO2peak. We measured APN, TAC, inflammatory markers as well as assessed nutrient and energy intake for each participant. Baseline concentration of serum APN (10.92 µg/mL) significantly increased at 50% and at 100% VO2peak. In addition, TAC also increased after acute exercise (0.079 vs 0.093 nmol/µL). The concentration of APN at 50% VO2peak positively correlated with the CRP ( r = 0.640, p = 0.046) and negatively correlated with TNF-α ( r = −0.696, p = 0.025). This test showed that short (10 min) and medium-intensity (50% VO2peak) exercise activity in trained athletes evoked beneficial antioxidant and anti-inflammatory responses. Importantly, this response correlates with the increase in APN levels thereby showing that highly trained individuals have beneficial responses originating from adipose tissue. Our observations show that a short training at moderate activity can be an important preservative strategy during the recovery training period.

scholarly journals 30 Minutes of Acute Moderate-Intensity Exercise Prior to a High Fat Meal Does not Attenuate Postprandial Triglycerides in Postmenopausal Women

2019 ◽  
Vol 8 (1) ◽  
pp. 72-78
Author(s):  
Nathaniel Glen Bodell ◽  
Trevor Gillum
Keyword(s):  
Heart Rate ◽  
Postmenopausal Women ◽  
Blood Lipids ◽  
Moderate Intensity ◽  
Lipid Levels ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Post Feeding ◽  
Postprandial Triglycerides ◽  
Fat Meal

There is an increased instance of circulating triglycerides among older adults which could lead to atherosclerosis; therefore, we sought to determine if 30 minutes of moderate-intensity exercise, prior to a high fat meal, attenuates postprandial triglycerides (PPT) in postmenopausal women. Five postmenopausal women (59.8 years), participated in an exercise trial consisting of 30 minutes of moderate-intensity exercise 60% heart rate reserve (HRR), heart rate, blood pressure, and blood lipids collected. Following exercise participants ingested a high-fat meal (62 grams CHO, and 57 grams fat) and rested for four hours. Lipid levels were collected at 1, 2, 3, and 4 hours post-feeding. The control trial did not exercise and were given the high fat meal followed by rest. A randomized cross-over design was utilized, in which all subjects participated in the control and exercise trial. There was no difference in PPT between the control and exercise trials. PPT increased from pre-exercise in both trials (p<0.05) (pre-feeding 88.4±26.7 con. 93.6±36.8 ex., 1hr 141±51.7 con. 139±65.4 ex., 2hrs 195±32.7 con. 166±82.4 ex., 3hrs 203±52.2 con. 185±78.1 ex., 4hrs 179±22.4 con. 193±50.5 ex). Glucose values were similar between trials; peaking post-feeding followed by a gradual return to baseline in both trials (p<0.05) (prefeeding 86±5.5 con. 84.6±5.8 ex., 1hr 117±11.3 con. 125±23.5 ex., 2hrs 104±4.1 con., 113±16.7 ex., 3hrs 97.4±6.3 con., 88.6±11.6 ex., 4hrs 87.6±6.7 con., 81.2±9 ex). 30 minutes of moderate-intensity exercise does not attenuate PPT in postmenopausal women.

scholarly journals Moderate physical activity improves inflammatory markers (IL-6 and TNF Alpha) and diabetic profile in prediabetic population

2021 ◽  
Vol 11 (2) ◽  
pp. 131-144
Author(s):  
Zubia Shah ◽  
Abdul Waheed Mughal ◽  
Sherbaz Khan ◽  
Saman Tauqir ◽  
Inayat Shah
Keyword(s):  
Aerobic Exercise ◽  
Inflammatory Cytokines ◽  
Inflammatory Markers ◽  
Demographic Data ◽  
Local Population ◽  
Moderate Intensity ◽  
Moderate Physical Activity ◽  
Moderate Intensity Exercise ◽  
Positive Effects ◽  
Tnf Α

Purpose: Prediabetes is a health condition that precedes type 2 diabetes. Globally prevalence of prediabetes is on the rise and approximately 37% of local population are suffering from it. Apart from many other factors, inflammatory markers especially IL-6 and TNF-α play a significant part in development of prediabetes to diabetes. How exercise affects the inflammatory cytokines is elucidated and not completely understood. Methods: A non commercial experimental trail including a total of 48 participants, (36 males and 12 females) with mean age 30.7 ± 7.80 years was carried out after ethical approval and written informed consent. Demographic data, Body plethysmography, exercise parameters, diabetic and inflammatory markers were determined at pre- and post-interventional stage. The exact intensity of exercise capable of eliciting the required heart rate was determined and each participant was asked to perform moderate intensity exercise (45 minutes including warm up and cool down) for 5 days a week for 12 weeks. Results: Twelve weeks of moderate intensity aerobic exercise at (55% to 65% of PMHR) had significant positive effects on body composition including BMI (<0.001), weight (<0.001), diabetic parameters (FBS (0.02), HbA1c (0.001)) and inflammatory parameters (IL-6 (0.018), and TNF-α (0.02)). The effects were identical for males and females with mild differences. Conclusion:Moderate intensity exercise significantly decreases the levels of circulating inflammatory cytokines. Moderate intensity aerobic exercise is easy to incorporate in lifestyle of prediabetic population and can be used as one of the effective strategies for prevention of development of diabetes.

scholarly journals Does Moderate Intensity Exercise Attenuate the Postprandial Lipemic and Airway Inflammatory Response to a High-Fat Meal?

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Stephanie P. Kurti ◽  
Sara K. Rosenkranz ◽  
Morton Levitt ◽  
Brooke J. Cull ◽  
Colby S. Teeman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Response ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Period ◽  
Acute Bout ◽  
Fat Meal

We investigated whether an acute bout of moderate intensity exercise in the postprandial period attenuates the triglyceride and airway inflammatory response to a high-fat meal (HFM) compared to remaining inactive in the postprandial period. Seventeen (11 M/6 F) physically active (≥150 min/week of moderate-vigorous physical activity (MVPA)) subjects were randomly assigned to an exercise (EX; 60%VO2peak) or sedentary (CON) condition after a HFM (10 kcal/kg, 63% fat). Blood analytes and airway inflammation via exhaled nitric oxide (eNO) were measured at baseline, and 2 and 4 hours after HFM. Airway inflammation was assessed with induced sputum and cell differentials at baseline and 4 hours after HFM. Triglycerides doubled in the postprandial period (~113 ± 18%,P<0.05), but the increase did not differ between EX and CON. Percentage of neutrophils was increased 4 hours after HFM (~17%), but the increase did not differ between EX and CON. Exhaled nitric oxide changed nonlinearly from baseline to 2 and 4 hours after HFM(P<0.05, η2=0.36). Our findings suggest that, in active individuals, an acute bout of moderate intensity exercise does not attenuate the triglyceride or airway inflammatory response to a high-fat meal.

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