Experiences with alluvial foundations for earth dams in the Prairie provinces

1979 ◽  
Vol 16 (2) ◽  
pp. 255-271 ◽  
Author(s):  
N. Peters ◽  
K. N. Lamb
Keyword(s):  
Rational Design ◽  
Preliminary Design ◽  
Empirical Relationships ◽  
Design Concepts ◽  
Theoretical Design ◽  
Pore Pressures ◽  
Wide Range ◽  
Thick Layers ◽  
Limited Testing ◽  
Prairie Provinces

The foundations for numerous dams in proglacial and interglacial valleys in the Prairie provinces consist of soft alluvial soils. The deposits are up to 60 m deep, and contain thick layers of clay interspersed with lenses and layers of silt, sand, and gravel.This paper describes the damsite investigation and laboratory testing required, the design methods and construction procedures used, and the foundation performance observed during and after construction. A number of empirical relationships between index tests and physical properties of the soils, which provide useful guidelines for preliminary design, are presented.The design approach has gradually evolved from an empirical design with limited testing to a more rational design based on detailed investigations and thorough instrumentation. Increased reliance is placed on observational apparatus to monitor movements and pore pressures to confirm design assumptions as construction proceeds. The theoretical design is always checked with former designs of dams that have performed satisfactorily.Safe economical dams have been constructed in spite of large deformations and high pore pressures. Two case histories illustrate the wide range in dam design for alluvial foundations. The first shows an older design cross section with modifications required to ensure a stable dam, and the second describes a recently constructed dam that incorporates many of the latest design concepts.

scholarly journals Fluorescent thermal shift-based method for detection of NF-κB binding to double-stranded DNA

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Peter D. Leitner ◽  
Ilja Vietor ◽  
Lukas A. Huber ◽  
Taras Valovka
Keyword(s):  
Dna Binding ◽  
Rational Design ◽  
Dissociation Constants ◽  
Inflammatory Diseases ◽  
Dimethyl Fumarate ◽  
Bioinformatic Analysis ◽  
Quantitative Detection ◽  
Regulatory Sequences ◽  
Wide Range ◽  
Inhibitory Drug

AbstractThe nuclear factor kappa B (NF-κB) family of dimeric transcription factors regulates a wide range of genes by binding to their specific DNA regulatory sequences. NF-κB is an important therapeutic target linked to a number of cancers as well as autoimmune and inflammatory diseases. Therefore, effective high-throughput methods for the detection of NF-κB DNA binding are essential for studying its transcriptional activity and for inhibitory drug screening. We describe here a novel fluorescence-based assay for quantitative detection of κB consensus double-stranded (ds) DNA binding by measuring the thermal stability of the NF-κB proteins. Specifically, DNA binding proficient NF-κB probes, consisting of the N-terminal p65/RelA (aa 1–306) and p50 (aa 1–367) regions, were designed using bioinformatic analysis of protein hydrophobicity, folding and sequence similarities. By measuring the SYPRO Orange fluorescence during thermal denaturation of the probes, we detected and quantified a shift in the melting temperatures (ΔTm) of p65/RelA and p50 produced by the dsDNA binding. The increase in Tm was proportional to the concentration of dsDNA with apparent dissociation constants (KD) of 2.228 × 10–6 M and 0.794 × 10–6 M, respectively. The use of withaferin A (WFA), dimethyl fumarate (DMF) and p-xyleneselenocyanate (p-XSC) verified the suitability of this assay for measuring dose-dependent antagonistic effects on DNA binding. In addition, the assay can be used to analyse the direct binding of inhibitors and their effects on structural stability of the protein probe. This may facilitate the identification and rational design of new drug candidates interfering with NF-κB functions.

Using CFD to Enhance the Preliminary Design of High-Pressure Steam Turbines

2013 ◽  
Author(s):  
Juri Bellucci ◽  
Federica Sazzini ◽  
Filippo Rubechini ◽  
Andrea Arnone ◽  
Lorenzo Arcangeli ◽  
...  
Keyword(s):  
High Pressure ◽  
Steam Turbine ◽  
Design Tool ◽  
Tip Clearance ◽  
Large Set ◽  
Preliminary Design ◽  
Steam Turbines ◽  
High Pressure Steam ◽  
Wide Range ◽  
Pressure Steam

This paper focuses on the use of the CFD for improving a steam turbine preliminary design tool. Three-dimensional RANS analyses were carried out in order to independently investigate the effects of profile, secondary flow and tip clearance losses, on the efficiency of two high-pressure steam turbine stages. The parametric study included geometrical features such as stagger angle, aspect ratio and radius ratio, and was conducted for a wide range of flow coefficients to cover the whole operating envelope. The results are reported in terms of stage performance curves, enthalpy loss coefficients and span-wise distribution of the blade-to-blade exit angles. A detailed discussion of these results is provided in order to highlight the different aerodynamic behavior of the two geometries. Once the analysis was concluded, the tuning of a preliminary steam turbine design tool was carried out, based on a correlative approach. Due to the lack of a large set of experimental data, the information obtained from the post-processing of the CFD computations were applied to update the current correlations, in order to improve the accuracy of the efficiency evaluation for both stages. Finally, the predictions of the tuned preliminary design tool were compared with the results of the CFD computations, in terms of stage efficiency, in a broad range of flow coefficients and in different real machine layouts.

scholarly journals Empirical Correlation between Inelastic and Elastic Spectral Displacement Demands

2016 ◽  
Vol 32 (3) ◽  
pp. 1419-1448 ◽  
Author(s):  
Peter J. Stafford ◽  
Timothy J. Sullivan ◽  
Domenico Pennucci
Keyword(s):  
Seismic Hazard ◽  
Hazard Assessment ◽  
Spectral Response ◽  
Seismic Hazard Assessment ◽  
Assessment Process ◽  
Earthquake Intensity ◽  
Empirical Relationships ◽  
Wide Range ◽  
Performance Based Seismic Design ◽  
Displacement Demand

Inelastic spectral displacement demand is arguably one of the most effective, simplified means of relating earthquake intensity to building damage. However, seismic hazard assessment is typically conducted using empirical ground-motion prediction equations (GMPEs) that only provide indications of elastic spectral response quantities, which an engineer subsequently relates to inelastic demands using empirical relationships such as the equal-displacement rule. An alternative approach is to utilize relationships for the inelastic spectral displacement demand directly within the seismic hazard assessment process. Such empirical relationships are developed in this work, as a function of magnitude, distance, building period, and yield strength coefficient, for four different hysteretic models that are representative of a wide range of possible structural typologies found in practice. The new relationships are likely to be particularly useful for performance-based seismic design and assessment.

Automation and Management of Design Process of the Main Drive for an Innovative Fruits and Vegetables Washer

2021 ◽  
Vol 27 (1) ◽  
pp. 9-17
Author(s):  
V. P. Bui ◽  
◽  
S. S. Gavruishin ◽  
V. B. Phung ◽  
H. M. Dang ◽  
...  
Keyword(s):  
Design Process ◽  
Rational Design ◽  
Fruits And Vegetables ◽  
Rational Solution ◽  
Quality Criteria ◽  
Pareto Optimal ◽  
Optimal Domain ◽  
Wide Range ◽  
A New Technique ◽  
New Generation

A new technique is described, used by the authors to automate the design process of the main drive of a new generation machine intended for industrial washing of fruits and vegetables. To solve the problem of multi-criteria design, the original approach is proposed that uses interconnected mathematical models describing the dynamic behavior, strength reliability and functional characteristics of the machine in a unified information space. The generalized mathematical model includes 12 controlled parameters, 16 functional constraints, and 3 quality criteria. A genetic algorithm was used to find the space of Pareto-optimal solutions. The situational approach was used to select the final rational solution from a set of solutions belonging to the Pareto-optimal domain. The rational design of option the washer found using the proposed approach is compared with the existing ones. The proposed design methodology can be recommended for the design of a wide range of similar mechanical structures.

A Reduced-Order Model for the Preliminary Design of Small-Scale Radial Inflow Turbines

2021 ◽  
Author(s):  
Marco Manfredi ◽  
Marco Alberio ◽  
Marco Astolfi ◽  
Andrea Spinelli
Keyword(s):  
Heat Recovery ◽  
Internal Combustion Engines ◽  
Reduced Order Model ◽  
Pollutant Emissions ◽  
Small Scale ◽  
Preliminary Design ◽  
Order Model ◽  
Reduced Order ◽  
Wide Range ◽  
Loss Models

Abstract Power production from waste heat recovery represents an attractive and viable solution to contribute to the reduction of pollutant emissions generated by industrial plants and automotive sector. For transport applications, a promising technology can be identified in bottoming mini-organic Rankine cycles (ORCs), devoted to heat recovery from internal combustion engines (ICE). While commercial ORCs exploiting turbo-expanders in the power range of hundreds kW to several MW are a mature technology, well-established design guidelines are not yet available for turbines targeting small power outputs (below 50 kW). The present work develops a reduced-order model for the preliminary design of mini-ORC radial inflow turbines (RITs) for high-pressure ratio applications, suitable to be integrated in a comprehensive cycle optimization. An exhaustive review of existing loss models, whose development pattern is retraced up to the original approaches, is proposed. This investigation is finalized in a loss models effectiveness analysis performed by testing several correlations over six existing geometries. These test case turbines, operating with different fluids and covering a wide range of target expansion ratio, size, and gross power output, are then employed to carry out the validation procedure, whose results prove the robustness and prediction capability of the proposed reduced-order model.

scholarly journals Gelation Impairs Phase Separation and Small Molecule Migration in Polymer Mixtures

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1576
Author(s):  
Biswaroop Mukherjee ◽  
Buddhapriya Chakrabarti
Keyword(s):  
Phase Separation ◽  
Rational Design ◽  
Surface Segregation ◽  
Multiscale Methods ◽  
Coarse Grained ◽  
Polymer Gel ◽  
Polymer Mixtures ◽  
Separation Processes ◽  
Surface Migration ◽  
Wide Range

Surface segregation of the low molecular weight component of a polymeric mixture is a ubiquitous phenomenon that leads to degradation of industrial formulations. We report a simultaneous phase separation and surface migration phenomena in oligomer–polymer ( O P ) and oligomer–gel ( O G ) systems following a temperature quench that induces demixing of components. We compute equilibrium and time varying migrant (oligomer) density profiles and wetting layer thickness in these systems using coarse grained molecular dynamics (CGMD) and mesoscale hydrodynamics (MH) simulations. Such multiscale methods quantitatively describe the phenomena over a wide range of length and time scales. We show that surface migration in gel–oligomer systems is significantly reduced on account of network elasticity. Furthermore, the phase separation processes are significantly slowed in gels leading to the modification of the well known Lifshitz–Slyozov–Wagner (LSW) law ℓ ( τ ) ∼ τ 1 / 3 . Our work allows for rational design of polymer/gel–oligomer mixtures with predictable surface segregation characteristics that can be compared against experiments.

scholarly journals The relationship between aerosol and cloud drop number concentrations in a global aerosol microphysics model

2009 ◽  
Vol 9 (1) ◽  
pp. 3207-3241 ◽  
Author(s):  
K. J. Pringle ◽  
K. S. Carslaw ◽  
D. V. Spracklen ◽  
G. M. Mann ◽  
M. P. Chipperfield
Keyword(s):  
Size Distribution ◽  
Cloud Droplet ◽  
Global Scale ◽  
Rate Of Change ◽  
The Arctic ◽  
Aerosol Size Distribution ◽  
Percentage Error ◽  
Empirical Relationships ◽  
Wide Range ◽  
Global Mean

Abstract. Empirical relationships that link cloud droplet number (CDN) to aerosol number or mass are commonly used to calculate global fields of CDN for climate forcing assessments. In this work we use a sectional global model of sulfate and sea-salt aerosol coupled to a mechanistic aerosol activation scheme to explore the limitations of this approach. We find that a given aerosol number concentration produces a wide range of CDN concentrations due to variations in the shape of the aerosol size distribution. On a global scale, the dependence of CDN on the size distribution results in regional biases in predicted CDN (for a given aerosol number). Empirical relationships between aerosol number and CDN are often derived from regional data but applied to the entire globe. In an analogous process, we derive regional "correlation-relations" between aerosol number and CDN and apply these regional relations to calculations of CDN on the global scale. The global mean percentage error in CDN caused by using regionally derived CDN-aerosol relations is 20 to 26%, which is about half the global mean percentage change in CDN caused by doubling the updraft velocity. However, the error is as much as 25–75% in the Southern Ocean, the Arctic and regions of persistent stratocumulus when an aerosol-CDN correlation relation from the North Atlantic is used. These regions produce much higher CDN concentrations (for a given aerosol number) than predicted by the globally uniform empirical relations. CDN-aerosol number relations from different regions also show very different sensitivity to changing aerosol. The magnitude of the rate of change of CDN with particle number, a measure of the aerosol efficacy, varies by a factor 4. CDN in cloud processed regions of persistent stratocumulus is particularly sensitive to changing aerosol number. It is therefore likely that the indirect effect will be underestimated in these important regions.

Standard Outfit Package Units in the LPD 17 Ship Design: A Production Impact Study

1995 ◽  
Vol 11 (04) ◽  
pp. 252-263
Author(s):  
Walter L. Christensen ◽  
Philip C. Koenig
Keyword(s):  
Production Scheduling ◽  
Ship Design ◽  
Design Stage ◽  
Traditional Practices ◽  
Preliminary Design ◽  
Wide Range ◽  
Preliminary Design Stage ◽  
And Performance ◽  
Assessment Problems ◽  
Material Ordering

Standard outfit package units for reverse osmosis plants, fire pumps, steering gear, and sanitary spaces were proposed for the LPD 17 amphibious transport dock ship design. The ship was in the preliminary design stage, and it was necessary to determine how this shift to outfit modularity would affect the ship procurement program. Because the use of package units would not have a significant impact on the overall characteristics and performance of the ship, the focus of the investigation was on material ordering and production scheduling. The analysis took account of zone-area-stage outfitting methods and also more traditional practices. With either approach, it was found that the package units did not present any schedule or procurement problems This particular study was focused on a very specific issue, but the approach is applicable to a wide range of production impact assessment problems.

A Thorough Insight into Theoretical and Practical Developments in MultiAgent Systems

2020 ◽  
pp. 83-111
Author(s):  
Dimple Juneja ◽  
Aarti Singh ◽  
Rashmi Singh ◽  
Saurabh Mukherjee
Keyword(s):  
Multiagent Systems ◽  
Real World ◽  
Research Community ◽  
Theoretical Design ◽  
Wide Range ◽  
Universal Applicability ◽  
Insight Into ◽  
Real World Problems

Multiagent systems have been a fascination for research community and are often seen as an intelligent solution to many complex real world problems. Researchers have been active in the domain since last three decades and many developments pertaining to theoretical design and practical developments of multiagent systems are worth appreciating. The growth in MAS is multidirectional ranging from conceptual ideas to practical implementations and from the wide range of applications; it appears that multiagent systems are proving to be universal. The paper presents a concise survey of developments in MAS highlighting the important contributions in the field and also questions the universal applicability of agents.

scholarly journals Excited state dynamics for visible-light sensitization of a photochromic benzil-subsituted phenoxyl-imidazolyl radical

2019 ◽  
Vol 15 ◽  
pp. 2369-2379
Author(s):  
Yoichi Kobayashi ◽  
Yukie Mamiya ◽  
Katsuya Mutoh ◽  
Hikaru Sotome ◽  
Masafumi Koga ◽  
...  
Keyword(s):  
Visible Light ◽  
Rational Design ◽  
Materials Science ◽  
Transient Absorption ◽  
Life Sciences ◽  
Transient Absorption Spectroscopy ◽  
Back Reaction ◽  
Switching Speed ◽  
Wide Range ◽  
Potential Applications

Visible-light sensitized photoswitches have been paid particular attention in the fields of life sciences and materials science because long-wavelength light reduces photodegradation, transmits deep inside of matters, and achieves the selective excitation in condensed systems. Among various photoswitch molecules, the phenoxyl-imidazolyl radical complex (PIC) is a recently developed thermally reversible photochromic molecule whose thermal back reaction can be tuned from tens of nanoseconds to tens of seconds by rational design of the molecular structure. While the wide range of tunability of the switching speed of PIC opened up various potential applications, no photosensitivity to visible light limits its applications. In this study, we synthesized a visible-light sensitized PIC derivative conjugated with a benzil unit. Femtosecond transient absorption spectroscopy revealed that the benzil unit acts as a singlet photosensitizer for PIC by the Dexter-type energy transfer. Visible-light sensitized photochromic reactions of PIC are important for expanding the versatility of potential applications to life sciences and materials science.

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