Core-Shell Structured Theranotics

Nano LIFE ◽  
2021 ◽  
pp. 2141004
Author(s):  
Qingwen Guan ◽  
Min Wang

Cancer threatens the life and well-being of human beings. Millions of newly diagnosed cancer cases and a large number of deaths caused by cancer are reported each year in the world. Early detection and effective treatment are key to reduce cancer mortality, which can be potentially realized by using “theranostics”. Theranostics are a group of hybrid nanoparticles that perform in cancer patients to provide both diagnostic and therapeutic functions through a single nano-sized structure. In particular, core-shell structured theranostics have shown unique physicochemical properties, allowing them to facilitate molecular/cell targeting, bio-imaging, and drug delivery functions. This review, therefore, aims to present and discuss the recent development of research on core-shell structured theranostics. Specifically, it focuses on core-shell structured theranostics made of metals, silica and polymers. Different aspects, such as synthesis and structure, of core-shell structured theranostics are discussed in this review. This review helps readers to have a good understanding of the design and fabrication of core-shell structured theranostics.

2018 ◽  
Vol 7 ◽  
Author(s):  
Christine Peta

In 2016, the World Health Organization, through the Global Cooperation on Assistive Technology Initiative, issued the Priority Assistive Products List which is meant to be a guide to member states of the 50 assistive products needed for a basic health care and/or social welfare system; it is also a model from which nations can develop their national priority assistive products lists. The aim of this opinion paper is to share my views about the Priority Assistive Products List on the grounds that it makes no distinct mention of sexual assistive devices, yet research has indicated that sexuality is an area of great concern for persons with disabilities. In any case, sexuality forms a core part of being human, and it impacts on both the physical and mental well-being of all human beings. I conclude in part that, in its present format, the list perpetuates the myth that persons with disabilities are asexual beings who are innocent of sexual thoughts, feelings and experiences. The list also propagates the stereotype that sexuality is a sacred, private, bedroom matter that should be kept out of the public domain, to the detriment of the health and well-being of persons with disabilities.


Author(s):  
Christopher Janaway

It is sometimes assumed that Schopenhauer regards existence as meaningless, and it seems that pessimism should be associated with meaninglessness. However, Schopenhauer insists that there must a “moral meaning” to the world because human beings have a metaphysical need: we must see the world as pointing to a higher purpose beyond itself. Schopenhauer rejects theism and any optimistic higher purpose, but regards Christianity, which he views as pessimistic, as correctly identifying the higher purpose: negation of the will, which will bring “salvation.” There is, however, a difficulty in construing this meaning as “moral.” Schopenhauer regards morality as a case of willing the well-being of others, but also as a step toward will-lessness, so there is a question whether the “meaning” is coherently characterized. Nietzsche’s analysis of Schopenhauer seems correct: after abandoning any theistic or optimistic meaning, Schopenhauer raises the question whether existence has any meaning at all, but his positive answer retains the commitment to self-negation that he found in Christianity.


2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Naachimuthu K. P.

The five natural elements (earth, water, fire, air, and sky), the sun and the moon, plants, trees, birds, and animals, came into existence much ahead of the human beings. In fact, man, as a part of nature, was the last creation in the universe. Though, we (human beings) have been created with the superlative degree of intellect, there is so much that can be learnt from nature, traditions of wisdom from the world teach us that a divine essence flows through all creations. Together with nature, man can co-create groundbreaking ideas that would help create wealth and well-being, for nature offers solutions for inclusive growth and sustainable development. Food scarcity is the major issue concerning the developing countries these days, one out of every 8 person in the world goes to bed without food (FAO, 2012). Of the several hundred million hungry people in the world, 98 percent are in developing countries. There were several things done to alleviate this problem, but the consequences of those actions are even more costly. Usage of heavy machines, pesticides and chemical fertilizers in the soil created a lasting impact causing imbalance in ecosystem, degradation of soil, soil erosion and land degradation. Natural farming is an ancient form of agriculture which follows the principles of nature to develop systems for raising crops, and livestock that are self-sustaining. The present paper attempts to explicate the sustainable nature of natural farming, as against the quick fix solution agriculture of using fertilizers, and chemicals. This holistic learning outlook also tries to bring out the role of farm animals (and remain of farm animals, and farm produces), microorganisms in the soil, in creating food abundance, concerns about food loss and food wastage and its global impact.


Profanações ◽  
2018 ◽  
Vol 5 (1) ◽  
pp. 45
Author(s):  
Sandro Luiz Bazzanella ◽  
Danielly Borguezan

O presente artigo é resultado da análise do filme “O Capital” (Le Capitale), lançado em 4 de outubro de 2013 (1h53min). Direção: Costa-Gavras. Elenco: Gad Elmaleh, Gabriel Byrne, Natacha Régnier; Gêneros: Drama, Suspense. Nacionalidade: França. A referida obra cinematográfica coloca em debate a financeirização do mundo, das relações sociais e individuais em que a sociedade contemporânea esta envolvida. O crédito que substituiu no imaginário individual e social a ideia de dinheiro, mas que preserva a sua condição “essencial” como aquilo que desperta reações, paixões, desejos mobilizando forças vitais, determinando as expectativas de vida, de futuro dos seres humanos e sociedades, apresenta-se na forma de transcendência. Assim, na condição de transcendência exige culto, sacrifico e, sobretudo crença incondicional em suas condições de efetivação de suas promessas de uma economia da salvação. A financeirização dos espaços e tempos vitais nas quais se movem sociedades e indivíduos demarca o recrudescimento da ação política realizada entre homens com o fim de potencialização do espaço público como lócus por excelência do bem viver, da busca da felicidade. O dogma da financeirização afirma diuturnamente que a felicidade pode ser comprada e, usufruída individualmente basta ter crédito, ter fé no futuro.AbstractThis article is the result of the analysis of the film "The Capital" (Le Capitale), released on October 4, 2013 (1h53min). Direction: Costa-Gavras. Cast: Gad Elmaleh, Gabriel Byrne, Natacha Régnier; Genres: Drama, Thriller. Nationality: France. The aforementioned cinematographic work challenges the financialization of the world, of the social and individual relations in which contemporary society is involved. The credit that replaced the idea of money in the individual and social imaginary, but which preserves its "essential" condition as that which awakens reactions, passions, desires mobilizing vital forces, determining the expectations of life, the future of human beings and societies, Presents itself in the form of transcendence. Thus, in the condition of transcendence requires worship, sacrifice and, above all, unconditional belief in its conditions of realization of its promises of an economy of salvation. The financialisation of spaces and vital times in which societies and individuals move, marks the intensification of the political action carried out among men with the aim of enhancing the public space as the locus par excellence of well-being and the pursuit of happiness. The dogma of financialization affirms day after day that happiness can be bought and, enjoyed individually, it is enough to have credit, to have faith in the future.


2017 ◽  
Vol 5 (4) ◽  
pp. 246-249
Author(s):  
Jatin Bishoyi

For Bhagavad-Gita, both individual and society as a whole is dependent on three principal conditions for their existence such as Niskama karma, Svadharma and Loksamgrah.  Loksamgrah is used in a very comprehensive connotation as it not only looks at the collective well-being of this world but the universe as a whole. It is because in Loksamgrah the word ‘Loko’ does not mean only people of this world but all the beings of satyaloka, pitruloka, devaloka, bhurloka and other loka. In Gitarahasya Tilak points out, “The word ‘Loksamgrah’ has been used in the Bhagavad-Gita to mean the maintenance, not only of human beings, but that the human and all others spheres, such as of the Gods etc. should be maintained, and that they should become mutually beneficial”. True to say the recommendation of Loksamgrah on our public life have triggered concerns that public services, ranging from physical world to metaphysical world could become more imperative but in fact, it only would have minimal impact on public life i.e. it only attempts to minimize distress and problems both at individual and society levels. As a whole it could only attempt to inculcate the values of public service and integrity attitude. Radhakrishnan points out that, “Loksamgrah stands for the unity of the world, the interconnectedness of society.  If the world is not to sink into a condition of physical misery and moral degradation, if the common life is to be decent and dignified, religious ethics must control social action”.


1989 ◽  
Vol 6 (2) ◽  
pp. 354-357
Author(s):  
IIIT - USA

The Eastern Mediterranean Regional Office of the World Health Organization,the Islamic Organization for Medical Sciences, and the Royal Academyfor Islamic Civilization Research (the Aal Al-Bayt Foundation) jointly sponsoreda seminar on “Islamic Lifestyles and their Impact on Health and theGeneral Development of Mankind” in order to put this Islamic heritage inthe service of all human beings.The idea of.holding this Seminar was first conceived by the EasternMediterranean Regional Office of the World Health Organization becauseof its profound conviction that:1. Health constitutes the physical, psychological, and social wellbeingof the individual.2. Particular lifestyles have a major impact on the health ofthe individual and the society at large.3. Islam views the concept of well-being as a pre-requisite of‘Aqidah (creed) and Shari’ah which the Muslims fully appliedand implemented in their Golden Age -thus, providingliving proof of its success in real life.The first task undertaken by the participants involved the exhaustive listingand description of Islamic lifestyles in all spheres, and, the determiningof their Islamic roots on the basis of evidence from the Qur’an and Hadith.The second task focused on exploring the benefits to be acquired and theharms to be avoided through the adoption of these Islamic lifestyles by theindividual, the family, the society, and all human beings especially in thespheres of mental and physical health, and the well-being of social and humanrelationships. The third task involved devising plans of action for utilizingand applying all or part of the knowledge gained about Islamic lifestylesin order to demonstrate their beneficial influence as a means of reforminglife and setting mankind on the straight path.The Seminar participants also formed a smaller committee to exatninethe results of its research and deliberations so as to prepare, as soon as possible ...


2013 ◽  
Vol 9 (4) ◽  
pp. 474-491 ◽  
Author(s):  
Bivash Mandal ◽  
Himanshu Bhattacharjee ◽  
Nivesh Mittal ◽  
Hongkee Sah ◽  
Pavan Balabathula ◽  
...  

Author(s):  
Zeynep Aca

COVID-19 appeared in Wuhan, China's Hubei Province in December 2019, and human beings have faced a global crisis resulting from spreading the virus across the world, leading the World Health Organization (WHO) to declare a pandemic on March 11, 2020. Social work has become one of the fields that the pandemic has disproportionately damaged the most with its severe consequences in every respect. In this context, the study aims to reveal the impacts of the pandemic on social work comprehensively. These impacts are discussed under four topics: increasing inequalities (economic, healthcare, access to services, digital divide, and education), changing services due to lockdowns, social well-being (impacts of economic changes, unpaid labor, and lockdowns and social isolation on social well-being), and ethical dilemmas.


Author(s):  
Maria Inés López-Ibor ◽  
Julia Picazo Zappino

Anxiety is an ambiguous word, it is used to describe a feeling, a clinical symptom, but it is also a disorder or a group of disorders (anxiety disorder). Anxiety is related to our intimate relationship with ceasing to exist, with nothingness, with the limits of human beings. The problem of anxiety is intimately related to hope, because there is no human or psychological situation worse than despair. To know the meaning of anguish and anxiety helps to know mankind. From a phenomenological perspective, vital anxiety is a vital feeling, with the same characteristics as other vital feelings such as those of well-being, discomfort, or vertigo. They are feelings that express our way of “being in the world”. In this chapter, the concepts of anxiety and phenomenology of vital anxiety will be reviewed, as well as the point when a normal feeling turns into a pathological one, because the transition between a vital or mood feeling is of psychopathological interest and it is important to understand mood and anxiety disorders.


2018 ◽  
Vol 16 (2) ◽  
pp. 135-146
Author(s):  
Mohammad Ghozali ◽  
Tryas Titi Sari

The philosophy of Economics Sharia or Islamic real economics have appeared since the existence of the religion of Islam, i.e. Since the days of the Prophet. His goal was to bring humans to the world and the hereafter fallah and putting human beings as the Caliph was given a treasure by God to take advantage of what is on Earth with his best. A Socialist or a capitalist system is not able to answer the problem humans with leaves many problems of life, with evidence that the system is not able to give welfare to humanity as a whole even just for some particular people only. This factor becomes one evidence that economy more Islamic have the right concept and can provide overall well-being to mankind. It can be seen from the deployment of Islamic economic system since the days of the Prophet, which has provided a good impact to the society that existed at the time. And when the system is taken down to the next generation, in fact it can be applied with good and provide solutions for existing problems. Thus Islamic economic philosophy is holding an important role in the development of the economy of humans for the sake of reaching fallah is expected.


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