Characterization of Effector–Target Interactions in Necrotrophic Pathosystems Reveals Trends and Variation in Host Manipulation

2021 ◽  
Vol 59 (1) ◽  
Author(s):  
Timothy L. Friesen ◽  
Justin D. Faris
Keyword(s):  
Current Model ◽  
Annual Review ◽  
Publication Date ◽  
Zymoseptoria Tritici ◽  
Effective Response ◽  
Pyrenophora Tritici Repentis ◽  
Effector Triggered Immunity ◽  
Parastagonospora Nodorum ◽  
Made In

Great strides have been made in defining the details of the plant defense response involving biotrophic fungal and bacterial pathogens. The groundwork for the current model was laid by H.H. Flor and others who defined the gene-for-gene hypothesis, which is now known to involve effector-triggered immunity (ETI). PAMP-triggered immunity (PTI) is also a highly effective response to most pathogens because of the recognition of common pathogen molecules by pattern recognition receptors. In this article, we consider the three pathogens that make up the foliar disease complex of wheat, Zymoseptoria tritici, Pyrenophora tritici-repentis, and Parastagonospora nodorum, to review the means by which necrotrophic pathogens circumvent, or outright hijack, the ETI and PTI pathways to cause disease. Expected final online publication date for the Annual Review of Phytopathology, Volume 59 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Learning Through Processing: Toward an Integrated Approach to Early Word Learning

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Stephan C. Meylan ◽  
Elika Bergelson
Keyword(s):  
Word Learning ◽  
Empirical Work ◽  
Integrated Approach ◽  
Linguistic Knowledge ◽  
Annual Review ◽  
Publication Date ◽  
Learning Mechanisms ◽  
Lexical Knowledge ◽  
Novel Word Learning

Children's linguistic knowledge and the learning mechanisms by which they acquire it grow substantially in infancy and toddlerhood, yet theories of word learning largely fail to incorporate these shifts. Moreover, researchers’ often-siloed focus on either familiar word recognition or novel word learning limits the critical consideration of how these two relate. As a step toward a mechanistic theory of language acquisition, we present a framework of “learning through processing” and relate it to the prevailing methods used to assess children's early knowledge of words. Incorporating recent empirical work, we posit a specific, testable timeline of qualitative changes in the learning process in this interval. We conclude with several challenges and avenues for building a comprehensive theory of early word learning: better characterization of the input, reconciling results across approaches, and treating lexical knowledge in the nascent grammar with sufficient sophistication to ensure generalizability across languages and development. Expected final online publication date for the Annual Review of Linguistics, Volume 8 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Perspective on Data Science

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Roger D. Peng ◽  
Hilary S. Parker
Keyword(s):  
Iterative Process ◽  
Data Science ◽  
Annual Review ◽  
Publication Date ◽  
Broad Definition ◽  
The Core ◽  
Fields Of Study ◽  
Points Of Interest ◽  
New Knowledge

The field of data science currently enjoys a broad definition that includes a wide array of activities which borrow from many other established fields of study. Having such a vague characterization of a field in the early stages might be natural, but over time maintaining such a broad definition becomes unwieldy and impedes progress. In particular, the teaching of data science is hampered by the seeming need to cover many different points of interest. Data scientists must ultimately identify the core of the field by determining what makes the field unique and what it means to develop new knowledge in data science. In this review we attempt to distill some core ideas from data science by focusing on the iterative process of data analysis and develop some generalizations from past experience. Generalizations of this nature could form the basis of a theory of data science and would serve to unify and scale the teaching of data science to large audiences. Expected final online publication date for the Annual Review of Statistics, Volume 9 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Plant-Based Proteins: The Good, Bad, and Ugly

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
William R. Aimutis
Keyword(s):  
Agricultural Production ◽  
Future Generations ◽  
Annual Review ◽  
Food Science ◽  
Publication Date ◽  
The Past ◽  
Per Capita ◽  
Consumption Enjoyment ◽  
Global Population ◽  
Made In

Our global population is growing at a pace to exceed 10 billion people by the year 2050. This growth will place pressure on the agricultural production of food to feed the hungry masses. One category that will be strained is protein. Per capita protein consumption is rising in virtually every country for both nutritional reasons and consumption enjoyment. The United Nations estimates protein demand will double by 2050, and this will result in a critical overall protein shortage if drastic changes are not made in the years preceding these changes. Therefore, the world is in the midst of identifying technological breakthroughs to make protein more readily available and sustainable for future generations. One protein sourcing category that has grown in the past decade is plant-based proteins, which seem to fit criteria established by discerning consumers, including healthy, sustainable, ethical, and relatively inexpensive. Although demand for plant-based protein continues to increase, these proteins are challenging to utilize in novel food formulations. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 13 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

New Approaches for the Prevention and Treatment of Cardiovascular Disease: Focus on Lipoproteins and Inflammation

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Aliza Hussain ◽  
Christie M. Ballantyne
Keyword(s):  
Cardiovascular Disease ◽  
Statin Therapy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Annual Review ◽  
Publication Date ◽  
Atherosclerotic Cardiovascular Disease ◽  
Substantial Progress ◽  
Ascvd Risk ◽  
Made In

Although numerous trials have convincingly shown benefits of statin therapy in both primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD), most showed relative risk reductions of 25–40%, and thus many individuals continue to have ASCVD events despite statin therapy. Substantial progress has been made in developing therapies that address the residual risk for ASCVD despite statin therapy. In this review, we summarize progress of currently available therapies along with therapies under development that further reduce low-density lipoprotein cholesterol and apolipoprotein B–containing lipoproteins, reduce lipoprotein(a), reduce ASCVD events in patients with high triglycerides, and directly target inflammation to reduce ASCVD risk. Expected final online publication date for the Annual Review of Medicine, Volume 72 is January 27, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Philanthrocapitalism and the Separation of Powers

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Linsey McGoey
Keyword(s):  
Separation Of Powers ◽  
Public Welfare ◽  
Annual Review ◽  
Publication Date ◽  
New Paradigm ◽  
Checks And Balances ◽  
Public Benefits ◽  
Legal Traditions ◽  
Private Profit ◽  
Made In

This article discusses the rise of an approach to philanthropic giving known as philanthrocapitalism. I relate it to a new paradigm in management theory that has claimed that private profit making naturally aligns with improved public welfare. I show how growing belief in the inherent “compatibility” of corporate missions and public benefits has led to new laws and contributed to major shifts in how giving practices are structured and legitimated. The original point made in this article is that the philanthrocapitalist turn is more than simply an organizational change in the structure of different philanthropic institutions. Rather, the belief that profit-making and public welfare are naturally aligned also has significant, undertheorized implications for different principles in European-American legal traditions. The ascendancy of the philanthrocapitalist approach represents a subtle but profound displacement of belief in the need for democratic checks and balances on the use of public funds for private enrichment. Expected final online publication date for the Annual Review of Law and Social Science, Volume 17 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Double and Charge-Transfer Excitations in Time-Dependent Density Functional Theory

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Neepa T. Maitra
Keyword(s):  
Density Functional Theory ◽  
Charge Transfer ◽  
Density Functional ◽  
System Size ◽  
Time Dependent ◽  
Annual Review ◽  
Publication Date ◽  
Functional Theory ◽  
Dependent Density ◽  
Made In

Time-dependent density functional theory has emerged as a method of choice for calculations of spectra and response properties in physics, chemistry, and biology, with its system-size scaling enabling computations on systems much larger than otherwise possible. While increasingly complex and interesting systems have been successfully tackled with relatively simple functional approximations, there has also been increasing awareness that these functionals tend to fail for certain classes of approximations. Here I review the fundamental challenges the approximate functionals have in describing double excitations and charge-transfer excitations, which are two of the most common impediments for the theory to be applied in a black-box way. At the same time, I describe the progress made in recent decades in developing functional approximations that give useful predictions for these excitations. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 73 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Regulation of the Plant Cell Cycle in Response to Hormones and the Environment

2021 ◽  
Vol 72 (1) ◽  
Author(s):  
Akie Shimotohno ◽  
Shiori S. Aki ◽  
Naoki Takahashi ◽  
Masaaki Umeda
Keyword(s):  
Cell Cycle ◽  
Plant Cell ◽  
Cell Cycle Progression ◽  
Current Model ◽  
Annual Review ◽  
Publication Date ◽  
Cell Cycle Regulators ◽  
Environmental Signals ◽  
Plant Cell Cycle ◽  
Internal And External Factors

Developmental and environmental signals converge on cell cycle machinery to achieve proper and flexible organogenesis under changing environments. Studies on the plant cell cycle began 30 years ago, and accumulated research has revealed many links between internal and external factors and the cell cycle. In this review, we focus on how phytohormones and environmental signals regulate the cell cycle to enable plants to cope with a fluctuating environment. After introducing key cell cycle regulators, we first discuss how phytohormones and their synergy are important for regulating cell cycle progression and how environmental factors positively and negatively affect cell division. We then focus on the well-studied example of stress-induced G2 arrest and view the current model from an evolutionary perspective. Finally, we discuss the mechanisms controlling the transition from the mitotic cycle to the endocycle, which greatly contributes to cell enlargement and resultant organ growth in plants. Expected final online publication date for the Annual Review of Plant Biology, Volume 72 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Causative Microbes in Host-Microbiome Interactions

2021 ◽  
Vol 75 (1) ◽  
Author(s):  
Graham J. Britton ◽  
Jeremiah J. Faith
Keyword(s):  
Immune System ◽  
Human Microbiome ◽  
Individual Species ◽  
Annual Review ◽  
Publication Date ◽  
Sequencing Technology ◽  
Specific Effects ◽  
Therapeutic Benefits ◽  
Experimental Approaches

Despite identification of numerous associations between microbiomes and diseases, the complexity of the human microbiome has hindered identification of individual species and strains that are causative in host phenotype or disease. Uncovering causative microbes is vital to fully understand disease processes and to harness the potential therapeutic benefits of microbiota manipulation. Developments in sequencing technology, animal models, and bacterial culturing have facilitated the discovery of specific microbes that impact the host and are beginning to advance the characterization of host-microbiome interaction mechanisms. We summarize the historical and contemporary experimental approaches taken to uncover microbes from the microbiota that affect host biology and describe examples of commensals that have specific effects on the immune system, inflammation, and metabolism. There is still much to learn, and we lay out challenges faced by the field and suggest potential remedies for common pitfalls encountered in the hunt for causative commensal microbes. Expected final online publication date for the Annual Review of Microbiology, Volume 75 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Salicylic Acid: Biosynthesis and Signaling

2021 ◽  
Vol 72 (1) ◽  
Author(s):  
Yujun Peng ◽  
Jianfei Yang ◽  
Xin Li ◽  
Yuelin Zhang
Keyword(s):  
Salicylic Acid ◽  
Systemic Acquired Resistance ◽  
Current Knowledge ◽  
Plant Immunity ◽  
Acquired Resistance ◽  
Annual Review ◽  
Publication Date ◽  
Basal Defense ◽  
Made In ◽  
Key Questions

Salicylic acid (SA) is an essential plant defense hormone that promotes immunity against biotrophic and semibiotrophic pathogens. It plays crucial roles in basal defense and the amplification of local immune responses, as well as the establishment of systemic acquired resistance. During the past three decades, immense progress has been made in understanding the biosynthesis, homeostasis, perception, and functions of SA. This review summarizes the current knowledge regarding SA in plant immunity and other biological processes. We highlight recent breakthroughs that substantially advanced our understanding of how SA is biosynthesized from isochorismate, how it is perceived, and how SA receptors regulate different aspects of plant immunity. Some key questions in SA biosynthesis and signaling, such as how SA is produced via another intermediate benzoic acid and how SA affects the activities of its receptors in the transcriptional regulation of defense genes, remain to be addressed. Expected final online publication date for the Annual Review of Plant Biology, Volume 72 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Plea Bargaining, Conviction Without Trial, and the Global Administratization of Criminal Convictions

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Máximo Langer
Keyword(s):  
Online Publication ◽  
Plea Bargaining ◽  
Annual Review ◽  
Publication Date ◽  
National Data ◽  
Criminal Convictions ◽  
The World ◽  
Made In ◽  
Cross National

This article documents the diffusion of plea bargaining and other mechanisms to reach criminal convictions without a trial and argues that their spread implies what this article terms an administratization of criminal convictions in many corners of the world. Criminal convictions have been administratized in two ways: ( a) Trial-avoiding mechanisms have given a larger role to nonjudicial, administrative officials in the determination of who gets convicted and for which crimes, and ( b) these decisions are made in proceedings that do not include a trial with its attached defendants’ rights. The article also proposes a way this phenomenon could be quantitatively measured by articulating the rate of administratization of criminal convictions, a metric to allow for comparison among different jurisdictions. The article then presents cross-national data from 26 jurisdictions on their rate of administratization of criminal convictions and different hypotheses that may help explain variation across jurisdictions on this rate. Expected final online publication date for the Annual Review of Criminology, Volume 4 is January 13, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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