Temperature regulation in mice during withdrawal from ethanol dependence

1994 ◽  
Vol 267 (4) ◽  
pp. R929-R934 ◽  
Author(s):  
L. I. Crawshaw ◽  
C. S. O'Connor ◽  
J. C. Crabbe ◽  
D. L. Hayteas
Keyword(s):  
Temperature Regulation ◽  
Thermal Gradient ◽  
Ethanol Vapor ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Preferred Temperature ◽  
Ethanol Dependence ◽  
Hypermetabolic State ◽  
The Difference ◽  
Increased Activity

Temperature regulation during withdrawal from ethanol dependence was studied in mice. Dependence was induced utilizing ethanol vapor inhalation combined with injections of pyrazole, an alcohol dehydrogenase inhibitor. One control group received vehicle (0.9% NaCl); another received pyrazole (68.1 mg/kg) in vehicle. During withdrawal, mice were placed in a thermal gradient, with core temperature (Tc) and preferred temperature (Tpref) continuously recorded for 26 h. During the period of maximal withdrawal severity (4-10 h after removal from ethanol vapor), the withdrawal group was more active than controls. Withdrawal group Tc [36.4 +/- 0.1 (SE) degrees C] was similar to that of NaCl (36.2 +/- 0.1 degrees C) and pyrazole (36.3 +/- 0.2 degrees C) controls. Withdrawal group Tpref (30.5 +/- 0.5 degrees C) was significantly lower than either NaCl (33.5 +/- 0.3 degrees C) or pyrazole (32.9 +/- 0.5 degrees C) controls. Analysis of covariance with activity as covariate indicated that the difference between Tc and Tpref was greater for the withdrawal group and was due to more than increased activity. Mice withdrawing at constant temperature (29.5 degrees C) did not show Tc different from that of controls. These results support the conclusion that regulated body temperature is not altered during withdrawal. We propose that the lower Tpref of withdrawing mice represents a means of dissipating excess heat that is partly generated by the hypermetabolic state accompanying withdrawal from ethanol dependence.

scholarly journals Explaining Lord's Paradox in Introductory Statistical Theory Courses

2018 ◽  
Vol 7 (4) ◽  
pp. 1
Author(s):  
Steven B. Kim
Keyword(s):  
Statistical Theory ◽  
Treatment Group ◽  
Random Variables ◽  
T Test ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Clear Understanding ◽  
Ancova Model ◽  
The Difference ◽  
Two Parameters

When two groups are compared in a pre-post study, two different conclusions can be drawn between the two-sample t-test and the analysis of covariance (ANCOVA). It is known as Lord's Paradox, and it occurs because the parameter in the two-sample t-test and the parameter of interest in the ANCOVA model are not the same quantity. The difference between the two parameters can be explained by the covariance of linearly combined random variables which is an important topic in introductory statistical theory courses. Lord's paradox is frequently observed in practice, and it is very important for students (future researchers) to have clear understanding of the paradox. The objective of this article is to explain Lord's Paradox using the covariance of linearly combined random variables. The paradox is explained using three scenarios in the context of educational research. The first scenario is when the average baseline (pre-score) is greater in the treatment group than the control group, the second scenario is when the average baseline is lower in the treatment group than the control group, and the third scenario is when the average baseline is same between the two groups by randomization. This article is written at the level of introductory statistical theory courses for undergraduate and graduate statistics students to help understanding the difference between the parameter of interest in the two-sample t-test and the parameter of interest in the ANCOVA model.

Pengaruh Strategi Pembelajaran What’s My Line terhadap Kesadaran Metakognitif Siswa

2019 ◽  
Vol 20 (1) ◽  
pp. 1
Author(s):  
Eka Fitriana Hamsyah
Keyword(s):  
Learning Strategy ◽  
Hypothesis Test ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Colloid System ◽  
Cognitive Awareness ◽  
The Difference ◽  
Subject Material

ABSTRAK Penelitian ini bertujuan untuk mengetahui perbedaan kesadaran metakognitif yang diajar dengan strategi What’s My Line ber-LKS induktif dengan strategi konvensional ber-LKS induktif siswa kelas XI IPA MAN Malakaji Gowa pada materi pokok sistem koloid. Jenis penelitian ini adalah eksperimen semu dengan menggunakan pretest- posttest control grup design. Populasi penelitian adalah seluruh siswa kelas XI MAN Malakaji Gowa yang terdiri dari 4 kelas. Sampel penelitian sebanyak 2 kelas yaitu kelas XI IPA 1 dan XI IPA 2 yang dipilih secara acak. Pengujian hipotesis dianalisis dengan menggunakan Analisis Of Covariance (Anacova) dengan bantuan SPSS For Windows 16,0. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan kesadaran metakognitif siswa yang diajar dengan strategi What’s My Line ber-LKS induktif dengan strategi konvensional ber-LKS induktif pada materi pokok sistem koloid dengan signifikansi 0,15. Kata kunci: Strategi Pembelajaran, Kesadaran Metakognitif ABSTRACT The study aimed at examining the difference of meta-cognitive who were taught by using What’s My Line of LKS Inductive strategy and the conventional of LKS Inductive strategy of grade XI IPA students at MAN Malakaji Gowa on Colloid system subject material. This study was a quasi-experiment research which employed pretest-posttest control group design. The population of the study was all grade XI students at MAN Malakaji consisted of 4 classes. Sample were selected randomly and obtained 2 classes, namely grade XI IPA 1 and XI IPA 2. The hypothesis test was analyzed using analysis of covariance (Anacova) supported by SPSS for windows 16.0 program. The result of the study revealed that (1) there was not difference of meta-cognitive awareness of student who were taught by using What’s My Line of LKS Inductive strategy and the conventional of LKS Inductive strategy on Colloid system subject material with the level of significant 0,15. Keywords: learning strategy, meta-cognitive awareness

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

2020 ◽  
Vol 63 (4) ◽  
pp. 1018-1032
Author(s):  
Chia-Hsin Wu ◽  
Roger W. Chan
Keyword(s):  
Acoustic Analysis ◽  
Vocal Tract ◽  
Exercise Program ◽  
Analysis Of Covariance ◽  
Elderly Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Positive Effects ◽  
Aging Voice ◽  
Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

The Effects of a Caffeine Placebo and Experimenter Expectation on Blood Pressure, Heart Rate, Well-Being, and Cognitive Performance

2001 ◽  
Vol 6 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Harald Walach ◽  
Stefan Schmidt ◽  
Yvonne-Michelle Bihr ◽  
Susanne Wiesch
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cognitive Task ◽  
Well Being ◽  
Control Group ◽  
Double Blind ◽  
Main Effect ◽  
The Difference ◽  
Being There ◽  
To Receive

We studied the effect of experimenter expectations and different instructions in a balanced placebo design. 157 subjects were randomized into a 2 × 4 factorial design. Two experimenters were led to expect placebos either to produce physiological effects or not (pro- vs. antiplacebo). All subjects except a control group received a caffeine placebo. They were either made to expect coffee, no coffee, or were in a double-blind condition. Dependent measures were blood pressure, heart rate, well-being, and a cognitive task. There was one main effect on the instruction factor (p = 0.03) with the group “told no caffeine” reporting significantly better well-being. There was one main effect on the experimenter factor with subjects instructed by experimenter “proplacebo” having higher systolic blood pressure (p = 0.008). There was one interaction with subjects instructed by experimenter “proplacebo” to receive coffee doing worse in the cognitive task than the rest. Subjects instructed by experimenter “antiplacebo” were significantly less likely to believe the experimental instruction, and that mostly if they had been instructed to receive coffee. Contrary to the literature we could not show an effect of instruction, but there was an effect of experimenters. It is likely, however, that these experimenter effects were not due to experimental manipulations, but to the difference in personalities.

Peritoneal Fluid and Plasma Fibrinolytic Activity in Women with Pelvic Inflammatory Disease

1992 ◽  
Vol 68 (02) ◽  
pp. 102-105 ◽  
Author(s):  
P J Dörr ◽  
E J P Brommer ◽  
G Dooijewaard ◽  
H M Vemer
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Peritoneal Fluid ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Adhesion Formation ◽  
High Rate ◽  
Control Group ◽  
The Difference ◽  
Fibrinolytic Parameters

SummaryPrevious studies have shown that the fibrinolytic activity of peritoneum is depressed in local inflammation. We measured fibrinolytic parameters in peritoneal fluid and in plasma of 10 women with pelvic inflammatory disease (PID). Nine women, in whom laparoscopy for sterilisation was performed, served as a control group.In the peritoneal fluid of women with PID, PAI-Ag, t-PA-Ag and u-PA-Ag were many times higher than in the control group. In contrast to the antigens which may be present in inert complexes, the potentially active compounds, measured as t-PA activity and plasmin-activable scu-PA, were not significantly different in the two groups, and in none of the samples was the active enzyme tcu-PA detectable. Nevertheless, the mean peritoneal fluid TDP and FbDP concentrations were about twenty times higher in the PID group than in the control group. In plasma of PID patients, none of the parameters except u-PA-Ag differed from those in the control group. The difference between control and patient plasma u-PA-Ag was statistically significant, but too small to attach any relevance to the observation.Our data suggest that, in contrast to the classical concept of decreased fibrinolytic activity as a cause of adhesion formation, intraperitoneal fibrinolysis is enhanced in peritoneal inflammation through stimulation of the local production of t-PA and u-PA. Despite concomitant production of PAI, fibrinolysis occurs at a high rate, resulting in high levels of fibrin degradation products. Since this activated fibrinolysis does not meet the demand, therapeutic enhancement should be considered to prevent adhesions.

Changes in Platelet Aggregability after Ovariectomy

1979 ◽  
Vol 42 (04) ◽  
pp. 1332-1339 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Takeshi Motomiya ◽  
Minoru Sonoda ◽  
Noboru Miyagawa
Keyword(s):  
Platelet Count ◽  
Platelet Activation ◽  
Ovarian Hormones ◽  
Control Group ◽  
Platelet Aggregability ◽  
Appearance Rate ◽  
Before And After ◽  
The Difference ◽  
Induced Aggregation ◽  
Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

PENGARUH TERAPI TERTAWA TERHADAP PENURUNAN TEKANAN DARAH LANSIA DI UPT PANTI WREDHA BUDHI DHARMA YOGYAKARTA

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Niken Setyaningrum ◽  
Andri Setyorini ◽  
Fachruddin Tri Fitrianta
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
The Elderly ◽  
Control Group ◽  
Group Comparison ◽  
Control Blood Pressure ◽  
Men And Women ◽  
Treatment Of Hypertension ◽  
Before And After ◽  
The Difference

ABSTRACTBackground: Hypertension is one of the most common diseases, because this disease is suffered byboth men and women, as well as adults and young people. Treatment of hypertension does not onlyrely on medications from the doctor or regulate diet alone, but it is also important to make our bodyalways relaxed. Laughter can help to control blood pressure by reducing endocrine stress andcreating a relaxed condition to deal with relaxation.Objective: The general objective of the study was to determine the effect of laughter therapy ondecreasing elderly blood pressure in UPT Panti Wredha Budhi Dharma Yogyakarta.Methods: The design used in this study is a pre-experimental design study with one group pre-posttestresearch design where there is no control group (comparison). The population in this study wereelderly aged over> 60 years at 55 UPT Panti Wredha Budhi Dharma Yogyakarta. The method oftaking in this study uses total sampling. The sample in this study were 55 elderly. Data analysis wasused to determine the difference in blood pressure before and after laughing therapy with a ratio datascale that was using Pairs T-TestResult: There is an effect of laughing therapy on blood pressure in the elderly at UPT Panti WredhaBudhi Dharma Yogyakarta marked with a significant value of 0.000 (P <0.05)

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

The effectiveness of positive training on happiness, aggression and hope in adolescents with leukemia in Ahvaz

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Marzieh . Shamkhani ◽  
Ali . Khalafi
Keyword(s):  
Sampling Method ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Positive Attitudes ◽  
Measurement Tools ◽  
Post Test ◽  
Aggression Questionnaire ◽  
Experimental Group ◽  
Period Measurement

The purpose of this study was to determine the effectiveness of positive learning on happiness, Aggression and hope for adolescents with leukemia in Ahvaz. The sample consisted of 30 people who were selected by available sampling method. 15 subjects in the experimental group and 15 in the control group were randomly assigned. The experimental design was a pre-test-post-test type with control group and follow-up period. Measurement tools included Oxford Happiness Inventory (Argyle, 1989); Ahwaz's Aggression Questionnaire (Zahedifar, Najarian, and Shokrkon, 2000); Hope Scale (Schneider, 1991). To run, at first, the pre-test was taken from both groups. Then, the experimental group was trained in 14 sessions of 90 minutes, and after each group, they were subjected to post-test. And one month later, the follow-up process was completed. Data analysis was performed using multivariate covariance analysis (MANCOVA) and one-way analysis of covariance (ANCOVA). The results showed that positive attitudes toward happiness, aggressiveness and hopefulness of adolescents with leukemia in Ahvaz were effective.

PENGARUH PEMBELAJARAN INOVATIF TERHADAP HASIL BELAJAR BAHASA INGGRIS SISWA KELAS VIIIB1 SMP NEGERI 2 GEROKGAK DENGAN PENGENDALIAN KECERDASAN LINGUISTIK

2019 ◽  
Vol 1 (1) ◽  
pp. 108-114
Author(s):  
I Made Wirta
Keyword(s):  
Sampling Technique ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Learning Approaches ◽  
Control Group Design ◽  
Post Test ◽  
Quasi Experimental ◽  
Innovative Learning ◽  
Inferential Analysis ◽  
English Students

The main objective of the present study is to investigate the effect of implementing innovative learning approaches upon English students’ achievement. The study was quasi experimental study using the post-test only control group design involving 35 students altogether selected using census sampling technique. The instrument which is used to gather data in the study was test. There were two tests used to gather intended data. They were linguistic test and student achievement test. The obtained data were analyzed statistically using descriptive and inferential analysis. The analysis of covariance was conducted to test the hypotheses.

Sign in / Sign up

Export Citation Format

Share Document