The love of a lifetime: 5-HT in the cardiovascular system

2009 ◽  
Vol 296 (2) ◽  
pp. R252-R256 ◽  
Author(s):  
Stephanie W. Watts
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Essential Amino Acid ◽  
Vascular Tone ◽  
Physiological Function ◽  
The Body ◽  
Gastrointestinal Function ◽  
Elevated Blood ◽  
Amino Acid Tryptophan ◽  
Induced Changes

Serotonin [5-hydroxytryptamine (5-HT)] is an amine made from the essential amino acid tryptophan. 5-HT serves numerous functions in the body, including mood, satiety, and gastrointestinal function. Less understood is the role 5-HT plays in the cardiovascular system, although 5-HT receptors have been localized to every important cardiovascular organ and 5-HT-induced changes in physiological function attributed to activation of these receptors. This manuscript relates a few scientific stories that test the idea that 5-HT is important to the control of normal vascular tone, more so in the hypertensive condition. Currently, our laboratory is faced with two different lines of experimentation from which one could draw vastly different conclusions as to the ability of 5-HT to modify endogenous vascular tone and blood pressure. Studies point to 5-HT being important in maintaining high blood pressure, but other studies solidly support the ability of 5-HT to reduce elevated blood pressure. This work underscores that our knowledge of the functions of 5-HT in the cardiovascular system is significantly incomplete. As such, this field is an exciting one in which to be, because there are superb questions to be asked.

Modelling of autonomic regulation in cardiovascular system based on baroreflex mechanism and overwhelming controller

2017 ◽  
Vol 231 (4) ◽  
pp. 299-311 ◽  
Author(s):  
Kartik Sharma ◽  
Tarun Kumar Bera
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Cardiovascular System ◽  
Transfer Functions ◽  
Systolic Pressure ◽  
Bond Graph ◽  
Autonomic Regulation ◽  
The Body ◽  
Autonomic Nervous

The control of cardiovascular system by autonomic nervous system using model-based analysis is very useful to predict blood flow and blood pressure at different locations of human body. The regulation of cardiovascular system by autonomic nervous system is a very complex mechanism, so, an experimental-based model analysis may prove very helpful in studying and analysing its working properly. In this article, a very basic model of cardiovascular system is presented with blood pressure dynamics studied throughout the body. A new bond graph model of the autonomic nervous system embedded with baroreflex system is also presented. Autonomic regulation of ventricular contractility is represented by means of transfer functions. The results in terms of maximum ventricular elastance ([Formula: see text]) and end systolic pressure are shown for two experiments. Another alternative modelling approach to represent the function of nervous system action in blood pressure regulation in terms of an overwhelming controller has been proposed. This controller overwhelms the system properties and therefore helps in managing the unmodelled parts or properties of a system and makes it impeccable for controlling complex systems. All the results and simulations are obtained using Symbols Shakti® software (Bond graph software).

scholarly journals Comparative characteristics of changes in central hemodynamics during early recovery after different exercise regimes

2021 ◽  
Vol 27 (2) ◽  
pp. 47-52
Author(s):  
H.V. Lukyantseva ◽  
O.M. Bakunovsky ◽  
S.S. Malyuga ◽  
T.M. Oliinyk ◽  
N.R. Manchenko ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Dynamic Loading ◽  
Vascular Resistance ◽  
Dynamic Load ◽  
Static Loading ◽  
Circulatory System ◽  
The Body ◽  
Central Hemodynamics ◽  
Early Recovery

The cardiovascular system is one of the most important functional systems of the body, which determine the level of physical performance of the body. Insufficient study of the response of the circulatory system to the combination of strength training with endurance exercises requires more detailed comparative studies of the impact of dynamic and static loads on the indicators of central hemodynamics. Accordingly, the aim of our study was to study the characteristics of the reaction of the cardiovascular system in the period of early recovery after dosed exercise of a dynamic and static nature. The study examined the response of the central hemodynamics of young men in the period of early recovery after dynamic loading (Martine functional test) and static loading (holding on the stand dynamometer DS-200 force with a power of 50% of maximum standing force). The change in circulatory system parameters was recorded using a tetrapolar thoracic impedance rheoplethysmogram on a computerized diagnostic complex “Cardio +”. It is established that the dynamic load in the period of early recovery does not cause a significant positive chronotropic effect, leads to a decrease in vascular resistance of blood flow, to an increase in pulse blood pressure. The increase in cardiac output is mainly due to the increase in stroke volume, which indicates a fairly high functional reserves of the heart. It is revealed that under conditions of static loading the reaction of central hemodynamics and the course of early recovery are radically different from the changes of indicators under dynamic loading. In persons with a normodynamic type of reaction to dynamic load, there are no significant changes in the minute volume of blood at a similar volume of active muscle mass static load. Meeting the metabolic needs of working skeletal muscles and compensating for the oxygen debt is realized by increasing the total peripheral vascular resistance and increasing systolic blood pressure in the postpartum period. The physiological meaning of this phenomenon is to maintain a sufficient level of venous return of blood to ensure the pumping function of the heart.

scholarly journals Post-sports career healthy ageing: The Janus-faced, high-performance sport

2020 ◽  
Author(s):  
A. Lelbach ◽  
G. Dörnyei ◽  
F. Ihász ◽  
A. Koller
Keyword(s):  
Blood Pressure ◽  
Mental Stress ◽  
High Performance ◽  
The Body ◽  
Competitive Sports ◽  
Elevated Blood ◽  
Cardiometabolic Diseases ◽  
Competitive Strength ◽  
Metabolic Systems ◽  
Regular Physical Exercise

AbstractBy now, there is no doubt that regular physical exercise has an overall beneficial effect on each organ of the body. However, the effects of highly competitive sports (HCS) are more complex, as they exert greater demands on the cardiovascular and metabolic systems, among others. Strength, athletic, and aesthetic sport types each has a different exercise intensity and nutritional loading, as well as a different prevalence of cardiometabolic diseases at a later age. HCS athletes experience hypertension and mental stress during competitions and high nutritional loads between them. The post-career effects of this behaviour on the heart, arteries, cellular metabolism, and risk of obesity, are not well known and are not often the focus of research. In this review, we aimed to summarize the post-career effects of HCS. Based on data in the literature, we propose that athletes involved in highly competitive strength sports progressively develop metabolic syndrome and sustained elevated blood pressure.

scholarly journals Dynamics of the functional state of the body of young athletes practicing sports games

2021 ◽  
Vol 100 (3) ◽  
pp. 268-273
Author(s):  
Serghei I. Cebanu ◽  
Raisa D. Deleu ◽  
Alisa V. Tabîrța ◽  
Ovidiu I. Tafuni ◽  
Grigore E. Friptuleac
Keyword(s):  
Blood Pressure ◽  
Arterial Pressure ◽  
Cardiovascular System ◽  
Functional State ◽  
Peripheral Resistance ◽  
Systolic Pressure ◽  
The Body ◽  
Motor Reaction ◽  
Young Athletes ◽  
Functional Changes

Introduction. Maintaining and strengthening young athletes’ health is very important since a growing body is more sensitive than an adult one. The overload on young athletes’ bodies’ functional systems is much higher compared to their peers who do not engage in intense physical activities and sports. This study aimed to assess the functional changes in the body of young athletes practicing sports games in the training process. Materials and methods. The functional state of the body of young athletes practicing five types of sports (volleyball, basketball, football, tennis, and handball) was studied on a representative group of 94 people, of which 50 (53.2%) males and 44 (46.8%) females with an average age of 17.7 ± 0.19 years. The cardiovascular system, central nervous system, respiratory system, and musculoskeletal system were investigated. The functional state assessment was carried out, taking into account the degree and direction of changes in the dynamics of training of individual indicators and integral indicators. It was determined the degree of risk of developing adverse functional changes. To identify premorbid states, we establish the type of self-regulation of blood circulation. Results. The obtained results in this study indicate that significant changes express the biological significance of the response of athletes to the conditions of training in the indices of the functions of the cardiovascular and central nervous systems and the musculoskeletal system. The indices of the functional state of the young athletes’ body at the end of the training changed in both directions. The degree of their severity fluctuated within limits from little too clearly expressed values. On the part of the cardiovascular system, an acceleration of heart rate from 60.1 ± 0.93 to 123.1 ± 0.93 beats/min (p < 0.001) was noted, an increase of systolic blood pressure from 101.1 ± 2.84 to 129.2 ± 1.40 mm Hg. (p <0.001), diastolic arterial pressure from 65.8 ± 1.60 to 76.3 ± 1.20 mm Hg. (p < 0.001), pulse pressure from 33.5 ± 2.35 to 71.5 ± 0.85 mm Hg. (p < 0.001), systolic pressure from 78.3 ± 1.75 to 84.2 ± 1.06 ml (p < 0.001), minutes volume from 4.3 ± 0.22 to 10.3 ± 0.11 l (p < 0.001), total peripheral resistance from 934.2 ± 42.11 to 1646.4 ± 37.61 dyn•s/cm5 (p < 0.001). On the part of the central nervous system, there was an increase in visual motor reaction from 236 ± 20.0 to 389 ± 5.3 ms (p < 0.001) and the auditory-motor reaction from 160 ± 3.8 to 256 ± 7.7 ms (p < 0.001). Young athletes who play volleyball have a higher load on the cardiovascular system. Functional changes are more pronounced in female athletes. The risk of developing unfavorable functional changes was noted for 15 physiological indices. The relative risk varied within 1.03-2.45 for boys and 1.04-2.90 for girls. The most pronounced risk is characteristic for total peripheral resistance (RR = 1.60), minutes volume (RR = 1.58), systolic pressure (RR = 1.55) in boys and systolic pressure (RR = 2.35), minutes volume (RR = 2.21), systolic arterial pressure (RR = 1.75), diastolic arterial pressure (RR = 1.73) and peripheral blood pressure (RR = 1.52) in girls. Conclusions. When playing sports games, a specific professional environment for different types of sports games is formed, this harming the functional state, performance, and health of young athletes.

The impact of regular long term physical load on cardiovascular functional parameters in children and adolescent athletes

2013 ◽  
Vol 23 (1) ◽  
pp. 53-59
Author(s):  
Aldona Bartkevičienė ◽  
Dalia Bakšienė ◽  
Pranas Šerpytis
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Cardiovascular System ◽  
The Body ◽  
Physical Load ◽  
Whole Body ◽  
Human Organism ◽  
Control Group ◽  
Functional Parameters ◽  
The Impact

Introduction. Regular physical load determines increase in functional capability of cardiovascular system. On the other hand, the cardiovascular system often appears as a conditional factor, which restricts organism adaptive abilities and limits general organism adaptation to the load. During physical load, not only cardiovascular system is activated, but also complex changes take place in the whole body. Therefore, with the aim to evaluate the functions of various systems, interrelation between them and systemic response of the body to physical load, a complex research on distinctive features of not only functional indices of the cardiovascular system, but also parameters reflecting interrelationship among functional systems of the body and speed of their changes is carried out. The goal of such complex research is the evaluation of adaptive and reserve capabilities of the athlete’s body and individualization and optimization of physical load. The aim of this study was to evaluate the speed of changes of parameters that characterize the functional condition of human organism of children and adolescents athletes and non-athletes controls. Materials and methods. One hundred sixty seven male athletes aged 14.8 (SD1.6, range 12-17 years) participating in basketball, rowing and cycling and168 healthy sedentary controls matched for age, sex and body surface area performed a graded exercise test (Mc. Master) on a cycle ergo-meter. 12 ECG standard derivations were synchronously recorded every second minute. During cycle ergo-meter integrated functional parameters, which could integrally and simple evaluate organism reaction to physical load, were assessed.Results. The present study demonstrates that before reaching the maximum of physical load, the speed of changes JT/RR in athletes and all functional parameters (HR, JT interval, RR interval, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse blood pressure (SBP-DBP), JT/RR ratio) in the control group decreased and in the last step of physical load has increased. That suggests that during intensive exercise training limits of physiological changes can be exceeded in athletes. Conclusions. Analysis of speed of changes in functional parameters during physical load can be applied for the evaluation of functional state of the human body and the cardiovascular system and aiming to optimize and individualize physical load in athletic children and adolescents.

scholarly journals Chemerin as a Driver of Hypertension: A Consideration

2020 ◽  
Vol 33 (11) ◽  
pp. 975-986 ◽  
Author(s):  
David J Ferland ◽  
Adam E Mullick ◽  
Stephanie W Watts
Keyword(s):  
Blood Pressure ◽  
Physiological Function ◽  
Serum Levels ◽  
The Body ◽  
Pathological Changes ◽  
Blood Pressure Determination ◽  
Antihypertensive Medications ◽  
Collective Work ◽  
Sympathetic Nervous ◽  
Relationship Of

Abstract The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with the goal of understanding whether and how chemerin drives (pathological) changes in blood pressure such that it could be interfered with therapeutically. We dissect the biosynthesis of chemerin and how current antihypertensive medications change chemerin metabolism. This is followed with a review of what is known about where chemerin is synthesized in the body and what chemerin and its receptors can do to the physiological function of organs important to blood pressure determination (e.g., brain, heart, kidneys, blood vessels, adrenal, and sympathetic nervous system). We synthesize from the literature our best understanding of the mechanisms by which chemerin modifies blood pressure, with knowledge that plasma/serum levels of chemerin may be limited in their pathological relevance. This review reveals several gaps in our knowledge of chemerin biology that could be filled by the collective work of protein chemists, biologists, pharmacologists, and clinicians.

Carotid baroreflex control of leg vascular conductance at rest and during exercise

2003 ◽  
Vol 94 (2) ◽  
pp. 542-548 ◽  
Author(s):  
David M. Keller ◽  
Wendy L. Wasmund ◽  
D. Walter Wray ◽  
Shigehiko Ogoh ◽  
Paul J. Fadel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Tone ◽  
Knee Extension ◽  
Vascular Conductance ◽  
Baroreflex Control ◽  
Carotid Baroreflex ◽  
Neck Pressure ◽  
Induced Changes ◽  
Knee Extension Exercise ◽  
Rest And Exercise

We sought to test the hypothesis that the carotid baroreflex (CBR) alters mean leg blood flow (LBF) and leg vascular conductance (LVC) at rest and during exercise. In seven men and one woman, 25 ± 2 (SE) yr of age, CBR control of LBF and LVC was determined at rest and during steady-state one-legged knee extension exercise at ∼65% peak O2 uptake. The application of 5-s pulses of +40 Torr neck pressure and −60 Torr neck suction significantly altered mean arterial pressure (MAP) and LVC both at rest and during exercise. CBR-mediated changes in MAP were similar between rest and exercise ( P > 0.05). However, CBR-mediated decreases in LVC (%change) to neck pressure were attenuated in the exercising leg (16.4 ± 1.6%) compared with rest (33 ± 2.1%) and the nonexercising leg (23.7 ± 1.9%) ( P < 0.01). These data suggest CBR control of blood pressure is partially mediated by changes in leg vascular tone both at rest and during exercise. Furthermore, despite alterations in CBR-induced changes in LVC during exercise, CBR control of blood pressure was well maintained.

scholarly journals HYGIENIC ASSESSMENT OF THE INFLUENCE OF ELECTRONIC CIGARETTES ON THE BLOOD PRESSURE IN MEDICAL STUDENTS’ ORGANISM

2020 ◽  
Vol 117 (3) ◽  
pp. 10-16
Author(s):  
Sergej Derkach ◽  
Anna Blagaіa
Keyword(s):  
Blood Pressure ◽  
Medical Students ◽  
Cardiovascular System ◽  
Diastolic Pressure ◽  
Electronic Cigarettes ◽  
Physiological State ◽  
Modern Medicine ◽  
The Body ◽  
Compensatory Mechanisms ◽  
Short Period

Blood pressure is one of the critical indicators of a person's physiological state. This indicator and the pulse reflect the state of the cardiovascular system. Their values can directly or indirectly determine the presence of diseases of the heart and blood vessels, and other organs. Therefore, determination of blood pressure among people of different levels of health is an urgent task of modern medicine. The aim of the work: hygienic assessment and monitoring of blood pressure in medical students smoking e-cigarettes. Materials and methods: Quantitative and qualitative analysis of the level of systolic, diastolic pressure, mean arterial and pulse pressure in medical students aged 18-23 years, before and after smoking e-cigarettes was carried out. Results: The findings of the study fully reflect the importance of tonometry. Thus, the level of systolic blood pressure increased after 10 minutes by an average of 7.7%, but after 50 minutes returned to optimal value. The level of diastolic blood pressure increased after 10 minutes by an average of 8.8%, but after 50 minutes – an increase of 4%. Conclusions: This type of changes in the short period are not critical, as the body’ compensatory mechanisms stabilize hemodynamic parameters, but daily smoking can lead to the development of COPD, as well as pathology of the cardiovascular system, including myocardial ischemia or heart failure. Therefore, smoking e-cigarettes cannot be attributed to a harmless type of habit.

scholarly journals Central neural control of the cardiovascular system: current perspectives

2016 ◽  
Vol 40 (3) ◽  
pp. 283-296 ◽  
Author(s):  
Roger A. L. Dampney
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Defensive Behavior ◽  
Neural Control ◽  
Blood Oxygenation ◽  
The Body ◽  
Regulatory Mechanisms ◽  
Central Command ◽  
American Physiological Society ◽  
The Brain

This brief review, which is based on a lecture presented at the American Physiological Society Teaching Refresher Course on the Brain and Systems Control as part of the Experimental Biology meeting in 2015, aims to summarize current concepts of the principal mechanisms in the brain that regulate the autonomic outflow to the cardiovascular system. Such cardiovascular regulatory mechanisms do not operate in isolation but are closely coordinated with respiratory and other regulatory mechanisms to maintain homeostasis. The brain regulates the cardiovascular system by two general means: 1) feedforward regulation, often referred to as “central command,” and 2) feedback or reflex regulation. In most situations (e.g., during exercise, defensive behavior, sleep, etc.), both of these general mechanisms contribute to overall cardiovascular homeostasis. The review first describes the mechanisms and central circuitry subserving the baroreceptor, chemoreceptor, and other reflexes that work together to regulate an appropriate level of blood pressure and blood oxygenation and then considers the brain mechanisms that defend the body against more complex environmental challenges, using dehydration and cold and heat stress as examples. The last section of the review considers the central mechanisms regulating cardiovascular function associated with different behaviors, with a specific focus on defensive behavior and exercise.

Abstract 206: Small GTPase Rap1 Transmits Mechanical Signals to Control Vascular Tone and Blood Pressure

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Sribalaji Lakshmikanthan ◽  
Xiaodong Zheng ◽  
Bartosz J Zieba ◽  
Yoshinori Nishijima ◽  
Zhi-Dong Ge ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Shear Stress ◽  
Vascular Tone ◽  
Small Gtpase ◽  
Intracellular Camp ◽  
No Production ◽  
Elevated Blood ◽  
Main Determinant ◽  
Multiple Receptors ◽  
No Release

Smooth muscle (SM)-mediated vessel contraction and endothelium-dependent vessel dilation are major mechanisms controlling basal vascular tone. Increased vascular tone leads to arterial hypertension, a risk factor for cardiovascular diseases. Agonist-induced, Ca2+-dependent SM contraction is modulated by intracellular cAMP, which promotes SM relaxation by inhibition of Rho-mediated myosin regulatory light chain (RLC20) phosphorylation and actomyosin contractility. In response to elevated blood flow, endothelium releases dilator substances that relax vascular SM, and in particular defects in production of nitric oxide (NO) lead to hypertension. Rap1 is a small GTPase that integrates signals from multiple receptors and two Rap1 isoforms, Rap1a and Rap1b are ubiquitously expressed. We found global Rap1b deletion leads to cardiac hypertrophy and hypertension and examined the effect of Rap1-deficiency on vascular tone. Using SM and endothelium tissue-restricted Rap1 knockout mice we show that deletion of Rap1, via distinct mechanisms in the two tissues, contributes to elevated vascular tone. In SM Rap1 regulates basal contraction level and mediates cAMP-induced desensitization of contraction. Rap1 suppresses RhoA-mediated RLC20 phosphorylation, Ca+2 sensitization and relaxation, signaling that is further enhanced upon cAMP-dependent activation of Rap1 by Rap1 GEF Epac. In endothelium, we find Rap1 is essential for regulation of NO-dependent vasodilation, as deletion of three of the four Rap1 alleles leads to a significant decrease in NO-dependent vasodilation. Significantly, we find that Rap1 is required for normal shear stress-induced NO release and Rap1-deficency in endothelium leads to elevated blood pressure in mice. Mechanistically, we show that Rap1 is required for transducing signals from the endothelial mechanosensing complex triggering signaling leading to NO production. Because shear stress from flowing blood is the main determinant of NO release, this novel finding positions Rap1 as a key regulator of endothelial function. In conclusion, Rap1 in SM and endothelium, via distinct mechanisms, plays a key role in maintaining normal vascular tone and blood pressure.

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