Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal Group

Background. Alopecia areata (AA) is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair.Materials and Methods. Sixteen female patients with AA (14–40 years old) and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15.Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron (r=0.504, P=0.001), zinc (r=0.684, P=0.0001), and copper (r=0.759,P=0.0001) in patients and controls.Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients.

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A randomised, open label comparative study of hydroxychloroquine with betamethasone oral mini pulse in the management of patients with alopecia areata

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20210189 ◽

2021 ◽

Vol 10 (2) ◽

pp. 187

Author(s):

Jeyasudha Jambusayee ◽

Kulur Mukhyaprana Sudha

Keyword(s):

Alopecia Areata ◽

Life Quality ◽

Autoimmune Disorder ◽

Study Groups ◽

Pulse Therapy ◽

The Body ◽

Control Group ◽

Study Group ◽

Open Label ◽

Significant Difference

Background: Alopecia areata is an autoimmune disorder causing patchy hair loss on scalp and other parts of the body and leading to poor self-esteem and anxiety in patients. Treatment with topical or systemic drugs like steroids or other immunosuppressants is associated with adverse effects. Hydroxychloroquine is an antimalarial drug, with T cell modulating function. This study was undertaken to assess the safety, efficacy and tolerability of Hydroxychloroquine in Alopecia areata compared to betamethasone oral mini pulse (OMP) therapy. Methods: 60 patients with alopecia areata were randomized into two groups of 30 each. Control group received tab. betamethasone 5 mg/day on two consecutive days of week for 12 weeks and Study group received tab. hydroxychloroquine 200 mg/day for 12 weeks. They were followed-up for further 12 weeks. Scale of alopecia tool, dermatology life quality index and global assessment at baseline, 12 weeks and 24 weeks were used to assess the outcome.Results: 94 patients were screened and 60 patients were included. All patients completed the study. At the end of 12 weeks, there was a statistically significant reduction in SALT and DLQI scores in both control and study groups. But at the end of 24 weeks, the study group showed an increase in the scores. Relapses were more in the study group. No significant difference in the incidence of adverse events was noted between the two groups.Conclusions: Hydroxychloroquine 200 mg/day is less efficacious in the management of alopecia areata in comparison to betamethasone oral mini pulse therapy.

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A Comparative Study Between Conventional ICP-OES and the Innovative PLS Model-Assisted ICP-OES for the Assay of Trace Elements

Journal of AOAC International ◽

10.1093/jaoacint/qsaa090 ◽

2020 ◽

Author(s):

Adel M Michael ◽

Ahmed A Mohamed ◽

Yousef A Abdelaziz ◽

Nesma M Fahmy

Keyword(s):

Trace Elements ◽

Elemental Analysis ◽

Inductively Coupled Plasma ◽

Optical Emission ◽

Official Method ◽

Icp Oes ◽

Inductively Coupled ◽

Flame Emission ◽

Significant Difference ◽

Student’S T

Abstract Background Inductively coupled plasma is widely used for elemental analysis with the advantage of being eco-friendly since the discharge is free of contaminants. Objective A rapid, novel method was developed for the quantitation of trace elements using inductively coupled plasma with optical emission spectrometry.This method has the advantage of simultaneous calibration compared to the conventional method. Method The assay was carried out for iron, copper, zinc, and molybdenum using the linear regression model partial least-squares. Results The method was optimized and validated as per the International Conference on Harmonization guidelines, showing highly accurate and precise results. The linearity range was 0.25–4 ppm for all trace elements under investigation. The method was applied for the assay of the cited elements in non-chelated and amino acid chelated multi-mineral preparations in the Egyptian market with acceptable mean percent recovery. Conclusions In comparison with the official method by flame emission, statistical analysis showed no significant difference with Student’s t-test and F-values. Highlights Inductively coupled plasma is superior as all of the elements can be measured simultaneously. The method was found to have a high degree of specificity and can be easily applied in routine elemental analysis in laboratories.

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Are Primo Vessels (PVs) on the Surface of Gastrointestine Involved in Regulation of Gastric Motility Induced by Stimulating Acupoints ST36 or CV12?

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/787683 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Xiaoyu Wang ◽

Hong Shi ◽

Hongyan Shang ◽

Yangshuai Su ◽

Juanjuan Xin ◽

...

Keyword(s):

Gastric Motility ◽

Electric Stimulation ◽

Circulatory System ◽

The Body ◽

Inhibition Rate ◽

Anatomical Basis ◽

Significant Difference ◽

Acupuncture Meridian ◽

The Relationship ◽

Stimulation Of

Previous studies showed primo vessels (PVs), which were referred to as Bonhan ducts (BHDs) and a part of circulatory system by Kim, located in different places of the body. The BHDs system was once considered as the anatomical basis of classical acupuncture meridian but not clearly identified by other investigators. In the present study, we tried to address the relationship between PVs and meridians through detecting the modulation of gastric motility by stimulating the PVs on the surface of stomach or intestine, as well as acupoints Zusanli (ST36) and Zhongwan (CV12). The results showed electric stimulation of the PVs had no effect on the gastric motility. While stimulating CV12 inhibited gastric motility significantly in PVs-intact and PVs-cut rats, there is no significant difference between the inhibition rate of the PVS-intact and the PVS-cut rats. Stimulating at ST36 increased gastric motility significantly in both the PVs-intact and the PVs-cut rats, yet there was no significant difference between the facilitation rate of the both groups. Taken together, the PVs on the surface of stomach or intestine did not mediate the regulation of gastric motility induced by stimulating at the acupoints ST36 or CV12.

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Relationship Between Gender, Age, Duration And Frequency Of Hemodialysis Therapy With The Creatinine Level reduction Of Pre And Post Hemodialysis

Medical Laboratory Technology Journal ◽

10.31964/mltj.v5i1.222 ◽

2019 ◽

Vol 5 (1) ◽

pp. 41

Author(s):

Anny Thuraidah ◽

Misbawati Misbawati ◽

Nurlailah Nurlailah ◽

Haitami Haitami

Keyword(s):

Creatinine Level ◽

Sampling Technique ◽

The Body ◽

P Value ◽

Acid Base Balance ◽

Cross Sectional ◽

Significant Difference ◽

Patient Will ◽

Base Balance ◽

The Relationship

The kidneys are organs of the body that function to regulate water balance in the body, the concentration of electrolytes in the blood and acid-base balance and secretion of waste material. If the kidney fails to function, the patient will need immediate treatment and even undergo hemodialysis (HD) therapy. A critical indicator in determining whether a person with impaired kidney function requires HD therapy is to know the creatinine level. The study aimed to ascertain the differences in creatinine levels pre and post HD also study the relationship between the age, gender, duration and frequency of HD therapy of respondents with the decrease of creatinine levels pre and post. Type of research detailed survey with a cross-sectional design. The sample was taken using a total sampling technique of 35 respondents from H BadaruddinKasimHospitalin Tanjung with a sample examination technique using the Jaffe method. The examination results of creatinine levels average for pre and post hemodialysis was11,36 and 5,58 mg/dl, which decreased 51%. The analysis statistically used Paired T-Test has a p-value = 0,000, indicating a significant difference for creatinine levels pre and post HD. Relationship between Age, Gender, Duration, and Frequency of HD Therapy with the decrease of creatinine levels pre and post HD was analyzed with Spearmen correlation and had p values more than 0,05. It means there was no relation between them. Conclusion there were significant differences in creatinine levels reduction pre and post HD while the relationship between the four of respondent characteristics to the magnitude of creatinine reduction show that there was no significant relationship.

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PHYSICAL ACTIVITY AND TRACE ELEMENT METABOLISM

Trace Elements in Medicine (Moscow) ◽

10.19112/2413-6174-2020-21-2-3-12 ◽

2020 ◽

Vol 21 (2) ◽

pp. 3-12

Author(s):

A.A. Skalny ◽

Keyword(s):

Physical Activity ◽

Trace Elements ◽

Trace Element ◽

The Body ◽

Cobalt Chromium ◽

Essential Trace Elements ◽

Trace Element Metabolism ◽

The Impact ◽

The Relationship ◽

Insight Into

Currently, there is no doubt about the prevailing influence of the level of physical activity of an individual on the functional state of the body. However, the available literature data on the impact of physical stress on the body's supply of trace elements and their distribution in tissues are largely contradictory. This review of available literature data provides an insight into the relationship between physical activity and microelement homeostasis. The influence of human physical activity on the exchange of toxic (lead, cadmium, Nickel, etc.) and essential trace elements, such as iron, selenium, copper, cobalt, chromium, and zinc is reviewed. Based on the analyzed works, it is concluded that in order to correct the metabolic and microelement status of a person during physical activity, the most reasonable and necessary is the modulation of homeostasis of zinc and selenium.

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The trend of cowmilk yield, its compostion and the body condition during the lactation

Acta Agraria Debreceniensis ◽

10.34101/actaagrar/37/2784 ◽

2009 ◽

pp. 69-73

Author(s):

Edit Mikó Józsefné Jónás ◽

Imre Mucsi ◽

István Komlósi

Keyword(s):

Dairy Cows ◽

Body Condition ◽

Milk Fat ◽

Milk Protein ◽

Milk Composition ◽

Fat Content ◽

The Body ◽

Significant Difference ◽

The Relationship ◽

Body Condition Scores

The authors examined the data of 2767 trial milkings andthe months Body Condition Scores of 479 Holstein dairy cows. The condition loss was significant between the 30-60th days. The improvement of BCS begins only after the 120th day. The change in the milk protein and milk fat content were close after the condition changing. In each period of the lactation the closeness of the relationship among the condition, the milk quantity and the milk composition were different. In the aspect of the milk quantity the most significant difference was between the 2.5 and 4 BCS cows (6.68 kg) in the last period of the lactation.

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The Relationship between Body Weight Change and Body Constitutions of Traditional Chinese Medicine in Patients with Schizophrenia

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/9585968 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Jui-Fen Cheng ◽

Xuan-Yi Huang ◽

Te-Le Liu ◽

Ruey-Yun Wang ◽

Han-Yi Ching

Keyword(s):

Body Weight ◽

Weight Gain ◽

Waist Circumference ◽

Health Care Providers ◽

Weight Change ◽

The Body ◽

Care Providers ◽

Body Constitution ◽

Significant Difference ◽

The Relationship

Objective. To explore the relationship between body constitution (BC) types and weight change in patients with schizophrenia and who underwent second-generation antipsychotics (SGAs) treatment.Method. Body weight and waist circumference of eighty-five participants were measured for 6 consecutive weeks. Constitutions of Yin-Xu, Yang-Xu, and Stasis were assessed using the Body Constitution Questionnaire (BCQ).Results. Participants with body constitutions Yin-Xu (50.6%), Yang-Xu (49.4%), or Stasis (38.8%) exhibited worse physical condition and unhealthy daily habits, particularly in Stasis constitution. Moreover, Stasis constitution was significantly associated with several factors, including BMI, body weight, waist circumference, perception of stress, perception of health, staying up late, and less physical exercise. However, perception of stress showed significant difference in Yin-Xu, Yang-Xu, and Stasis. Generalized estimating equation (GEE) analysis revealed that significant time effects in body weight increase in the imbalanced BC types and gentleness BC type. SGAs induced weight gain in imbalanced BC type as well as gentleness BC type, especially treated with olanzapine.Conclusions. This is the first study to explore the longitudinal relationship between BC and weight gain in schizophrenia patients undergoing SGAs treatment. Health care providers should focus on weight gain problems in schizophrenia patients who underwent SGAs treatment.

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The Relationship between Balance, Muscles, and Anthropomorphic Features in Young Adults

Anatomy Research International ◽

10.1155/2012/146063 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Ragıba Zagyapan ◽

Cihan Iyem ◽

Ayla Kurkcuoglu ◽

Can Pelin ◽

Mustafa Agah Tekindal

Keyword(s):

Subcutaneous Fat ◽

The Body ◽

Thigh Circumference ◽

Posture Analysis ◽

Clinical Assessments ◽

Significant Difference ◽

Subcutaneous Fat Thickness ◽

Fat Thickness ◽

Lateral Posture ◽

The Relationship

Posture can be defined as the form of the body when sitting, walking, or standing. There would be no problem if muscles interact in harmony with musculoskeletal system or nervous system. Posture analysis is crucial for clinical assessments in physical medicine and rehabilitation. However, studies into this issue are limited. In this study, the relationship between static standing balance and anthropomorphic features in healthy subjects was investigated. The study was carried out with a total of 240 students at Baskent University (116 females, 124 males) aged between 18 and 25 years. Type of balance of the subjects was determined with lateral posture analysis. Additionally, muscle shortness tests, subcutaneous fat thickness, and waist and thigh circumference were measured. As the results of lateral posture analysis, 107 subjects (71 males, 36 females) were detected to have anterior balance, 89 (41 males, 48 females) posterior balance, and 44 (12 males, 32 girls) neutral balance. Values of waist circumference, thigh circumference, and waist/thigh ratio were compared with all three balance types. A statistically significant difference was detected between these values in the subjects who had anterior balance (P<0.05). In conclusion, a significant relationship was detected between muscle shortness, waist and thigh circumferences, and postural balance type.

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Examination of Body Areas Satisfaction Levels and Gender Roles of Female Wrestlers

Journal of Education and Learning ◽

10.5539/jel.v8n1p229 ◽

2019 ◽

Vol 8 (1) ◽

pp. 229

Author(s):

Aykut Dündar ◽

Mine Koç

Keyword(s):

Gender Roles ◽

Gender Role ◽

Normal Weight ◽

The Body ◽

Upper Body ◽

Data Collection Tool ◽

Significant Difference ◽

And Gender ◽

Body Self ◽

The Relationship

The aim of this study is to determine the relationship between the Body Areas Satisfaction Levels and Gender Roles of female wrestlers. The sample of the study is constituted by 39 female wrestlers in Turkey Olympic Preparation Center in Edirne in 2017. As the data collection tool in the research; to determine the Body Areas Satisfaction Levels “Multidimensional Body-Self Relations Scale”, to determine the gender roles “BEM Gender Role Inventory” was used. In the evaluation of the data obtained, SPSS 20.0 statistics program was used. In the analysis of data, descriptive statistics; in paired comparisons, t-test; and in multiple comparisons, ANOVA test was used. As a result of statistical analysis made, it was observed that, of the female wrestlers; 15.4% had masculine, 35.9% had feminine, 17.9% had androgynous and 30.8% had unclear gender role behaviours. Significant differences were found between the score of femininity characteristics and score of masculinity characteristics and score of social acceptability characteristics (p<0.05). According to body mass index (BMI), regarding the clauses on satisfaction with body areas, there is significant difference; between the normal weight and the over weight as per the clause “I am satisfied with my lower body”; between the overweight and the thin and the normal weight as per the clause “I am satisfied with my central body”; between the weak athletes and normal weight athletes as per the clause “I am satisfied with muscle structure”; between the normal weight and over weight athletes as per the clause “I am satisfied with my weight” (P<0.05). There was no significant difference according to BMI variable in the clauses “I’m satisfied with my face”, “I’m satisfied with my hair”, “I’m satisfied with my upper body”, “I’m satisfied with my height” and “I’m satisfied with my overall appearance”.

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Some Biogeochemical Characteristics of the Trace Element Bioaccumulation in the Benthic Fauna of the Piip Volcano (The Southwestern Bering Sea)

Minerals ◽

10.3390/min11111233 ◽

2021 ◽

Vol 11 (11) ◽

pp. 1233

Author(s):

Liudmila L. Demina ◽

Sergey V. Galkin ◽

Elena M. Krylova ◽

Dmitry F. Budko ◽

Aleksandra S. Solomatina

Keyword(s):

Trace Elements ◽

Bering Sea ◽

Benthic Fauna ◽

Distribution Patterns ◽

The Body ◽

Total Carbon ◽

Biological Communities ◽

Nickel Copper ◽

Significant Difference ◽

Lower Temperature

The Piip Volcano is a submarine volcanic edifice occupying the central part of the Volcanologists Massif in the southwestern Bering Sea, with two tops, southern and northern. The minimum depth of the northern top is located at 368 m, and of the southern at 464 m. Active hydrothermal venting occurring at both summits of the volcano supports diverse biological communities, including animals specific for chemosynthetic habitats. In benthic organisms inhabiting the northern and southern tops of the Piip Volcano, for the first time, we examined distribution patterns of the following trace elements: titanium, vanadium, chromium, manganese, iron, nickel, copper, zinc, arsenic, selenium, zirconium, molybdenum, silver, cadmium, antimony, barium, tungsten, lead, bismuth, and uranium. The element contents were quantified by the ICP-MS. Total carbon (TC) and total inorganic carbon (TIC) were determined using a Shimadzu TOC-L-CPN and mineral composition of sediment was determined using the XRD. In the water of the biotope from the northern top, concentrations of Mn, Zn, Ag, Cd, Sb, W, Pb were 2–6 times, and Ba was 50 times higher than those from the southern top. This was attributed to the lower temperature of fluids emanating at the southern top. An abundant population of Calyptogena pacifica (Bivalvia: Vesicomyidae: Pliocardiinae) was found only at the southern top. The main target of most trace elements, such as Fe, V, Cr, Co, Ni, Zn, As, Mo, Ag, Cd, W, Pb, Bi, and U were the soft parts of Calyptogena pacifica (with high TOC content, on average 53.1% in gills and 49.6% in the rest of the body). Gills were characterized by particular high contents (>100 µg g-1 dry w.) of Zn, Cd, Fe, Ni, Cu, and Pb, which can form sulphides or be associated with them. Shells of C. pacifica, as well as Brachiopoda, were depleted in these elements, as well as tissues of the carnivores Paguridae (Crustacea) and Actiniaria (Anthozoa). In suspension feeders from both tops, the lower contents of most elements were detected. Estimation of Biological Concentration Factor (BCF) for most elements varied from 102 to 104, reaching n105 for Ni, Zn, Ag, Ca, and Pb. A significant difference in BCF values between Fe and Mn was revealed.

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