Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents
Objective. To identify the frequency of obesity and metabolic complications in child and adolescent users of risperidone. Potential associations with clinical parameters and SNPs of theHTR2C,DRD2,LEP,LEPR,MC4R, andCYP2D6genes were analyzed.Methods. Samples from 120 risperidone users (8–20 years old) were collected and SNPs were analyzed, alongside assessment of chronological and bone ages, prescribed and weight-adjusted doses, use of other psychotropic drugs, waist circumference, BMIz-scores, blood pressure, HOMA-IR index, fasting levels of serum glucose, insulin, cholesterol, triglycerides, transaminases, and leptin.Results. Thirty-two (26.7%) patients were overweight and 5 (4.2%) obese. Hypertension was recorded in 8 patients (6.7%), metabolic syndrome in 6 (5%), and increased waist circumference in 20 (16.7%). The HOMA-IR was high for 22 patients (18.3%), while total cholesterol and triglycerides were high in 20 (16.7%) and 41 (34.2%) patients, respectively. SNP associations were found forLEP,HTR2C, andCYP2D6with BMI;CYP2D6with blood pressure, ALT, and HOMA-IR;HTR2CandLEPRwith leptin levels;MC4RandDRD2with HOMA-IR;HTR2Cwith WC; andLEPwith ALT.Conclusions. Although not higher than in the general pediatric population, a high frequency of patients was overweight/obese, with abnormalities in metabolic parameters and some pharmacogenetic associations.