Ethnopharmacology, Phytochemistry, and Pharmacology of Syzygium nervosum

Syzygium nervosum, which belongs to the Myrtaceae plant family, is widely distributed and cultivated in South East Asian countries. The decoction of S. nervosum leaves and flower buds has been consumed regularly as a beverage among the Vietnamese and Chinese communities. In addition, it has also been used in traditional medicine for a variety of purposes, notably for influenza, skin diseases, and digestive conditions. To date, there has been a considerable number of publications on chemical profiling and pharmacological activities of S. nervosum crude extract and pure isolated compounds. Our analysis indicated the characteristic chemical scaffolds and potential bioactivities on cancer, diabetes, and inflammatory diseases of this plant. The review aims to summarize up-to-date past study results and suggest future research direction on this species, in order to promote clinical applications of S. nervosum.

Download Full-text

Advances in the Production of Minor Ginsenosides Using Microorganisms and Their Enzymes

BIO Integration ◽

10.15212/bioi-2020-0007 ◽

2020 ◽

Vol 1 (1) ◽

pp. 15-24 ◽

Cited By ~ 1

Author(s):

Almando Geraldi

Keyword(s):

Mass Production ◽

Research Direction ◽

Future Research ◽

Pharmacological Activities ◽

Production Methods ◽

Microbial Enzymes ◽

Cell Factories ◽

Anti Cancer ◽

Production Strategies ◽

Minor Ginsenoside

Abstract Minor ginsenodes are of great interest due to their diverse pharmacological activities such as their anti-cancer, anti-diabetic, neuroprotective, immunomodulator, and anti-inflammatory effects. The miniscule amount of minor ginsenosides in ginseng plants has driven the development of their mass production methods. Among the various production methods for minor ginsenosides, the utilization of microorganisms and their enzymes are considered as highly specific, safe, and environmentally friendly. In this review, various minor ginsenosides production strategies, namely utilizing microorganisms and recombinant microbial enzymes, for biotransforming major ginsenosides into minor ginsenoside, as well as constructing synthetic minor ginsenosides production pathways in yeast cell factories, are described and discussed. Furthermore, the present challenges and future research direction for producing minor ginsenosides using those approaches are discussed.

Download Full-text

Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Molecules ◽

10.3390/molecules25184294 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4294 ◽

Cited By ~ 1

Author(s):

Jianmei Zhang ◽

Stephanie Triseptya Hunto ◽

Yoonyong Yang ◽

Jongsung Lee ◽

Jae Youl Cho

Keyword(s):

Skin Diseases ◽

Fungal Infections ◽

Scientific Evidence ◽

Inflammatory Activity ◽

Future Research ◽

Pharmacological Activities ◽

Traditional Uses ◽

New Strategy ◽

Anti Inflammatory ◽

Underlying Mechanisms

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

Download Full-text

Medical Cannabis for the Treatment of Inflammation

Natural Product Communications ◽

10.1177/1934578x1801300304 ◽

2018 ◽

Vol 13 (3) ◽

pp. 1934578X1801300 ◽

Cited By ~ 1

Author(s):

Dvory Namdar ◽

Hinanit Koltai

Keyword(s):

Ulcerative Colitis ◽

Skin Diseases ◽

Inflammatory Diseases ◽

Chemical Compounds ◽

Future Research ◽

Specific Information ◽

Medical Cannabis ◽

Inflammatory Skin Diseases ◽

Wide Range ◽

Bowel Diseases

The connection between Cannabis sativa‘s chemical compounds and their ability to treat three different inflammatory ailments including bowel diseases, (IBD, e.g., Crohn's and ulcerative colitis), neuronal diseases (IND, e.g., Parkinson and Alzheimer), and a wide range of inflammatory skin diseases (ISD, e.g., atopic dermatitis and psoriasis) is presented. We review the range of experiments conducted over the last decade using either the whole extract of cannabis or separated mono-phytocannabinoids in the attempt to decipher the lead molecules, the receptors involved, the effects on genes and proteins, and especially the therapeutic potency of cannabis-derived compounds for treating these different inflammatory diseases. Along with the specifications for its current cutting-edge potential, the drawbacks and the designated needs for additional specific information from future research are indicated.

Download Full-text

Teachers’ Perceived Factors of Deviant Behavior among Secondary School Students in Kwara State: Implication for Educational Managers

International Journal of Synergy and Research ◽

10.17951/ijsr.2018.7.0.59-79 ◽

2019 ◽

Vol 7 ◽

pp. 59

Author(s):

Yusuf Suleiman ◽

Jamiu Mahmood Suleiman ◽

Mahmud Aremu Musa ◽

Yusuf Abiola Abubakar

Keyword(s):

Deviant Behavior ◽

Descriptive Analysis ◽

Research Direction ◽

Partial Least Square ◽

Least Square ◽

Future Research ◽

Font Size ◽

School Students ◽

Deviant Behaviors ◽

Study Results

This study investigates students’ deviant behaviors as perceived by their teachers in secondary schools with the aim of knowing the factors responsible for such behaviors. The study adopts the quantitative approach to carry out the research. Stratifid and simple random techniques were usednto select 380 participants that participated in the study. An instrument tagged “Factors of Deviant Behaviors and Measures Questionnaire" (FDBMQ) was used to elicit data from the respondents. Partial Least Square (PLS) software was used to assess the psychometric properties of the items contained in the questionnaire, while Statistical Package for Social Sciences (SPSS) was used to do the descriptive analysis. In addition, the analysis of variance (ANOVA) was used to test the three hypotheses formulated for the study. Results of the study revealed three factors (parent, society and school) that contribute to deviant behaviors. Findings also indicate measures that can be used to minimize deviant behaviors. Also, the results of the ANOVA showed a signifiant difference, while Duncan’s Multiple Range Test (DMRT) was used as a post-hoc test to determine the group that contributes to the signifiant difference. The results of the three hypotheses confimed that signifiant difference exists on the basis of religion, age, and educational qualifiations. Based on the fidings of the study, implication for educational managers and future research direction were provided.<br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" />

Download Full-text

Investigating Personality and Psychopathology in Patients With Psoriasis

Rorschachiana Journal of the International Society for the Rorschach ◽

10.1027/1192-5604/a000092 ◽

2017 ◽

Vol 38 (2) ◽

pp. 87-107 ◽

Cited By ~ 2

Author(s):

Chiara Vari ◽

Patrizia Velotti ◽

Alessandro Crisi ◽

Silvana Carlesimo ◽

Antonio G. Richetta ◽

...

Keyword(s):

Skin Diseases ◽

Clinical Importance ◽

Self Report ◽

Psychological Issues ◽

Self Evaluation ◽

Affective Quality ◽

Millon Clinical Multiaxial Inventory ◽

Study Results ◽

Completion Test ◽

Skin Conditions

Abstract. A broad range of literature reported higher rates of psychopathology and personality disorders among patients affected by skin conditions. Specifically, depression, anxiety, and suicidal ideations are more frequently reported by patients affected by skin diseases. This study aimed to examine psychopathology and personality in a group of patients affected by psoriasis by means of a self-report measure (Millon Clinical Multiaxial Inventory – MCMI-III) and a performance-based technique (Wartegg Drawing Completion Test [WDCT], CWS). Study results showed a higher rate of passive-aggressiveness and paranoia among psoriatic patients (MCMI-III). When assessing patients through the performance-based technique (WDCT, CWS), a higher rate of global rejection (GR) – linked by previous literature to suicidal ideation – and a lower affective quality of the drawings emerged. We discuss the clinical importance of detecting psychological issues in dermatology patients by means of a multimethod assessment that goes beyond patients’ self-evaluation of their symptoms and emotions.

Download Full-text

Moderating Role of Gender in the Relationship between Cognitive Errors and Anxiety among Adolescents

Foundation University Journal of Psychology ◽

10.33897/fujp.v4i1.68 ◽

2020 ◽

Vol 4 (1) ◽

pp. 86-102

Author(s):

Tasnim Rehna ◽

Rubina Hanif ◽

Muhammad Aqeel

Keyword(s):

Mental Health Problems ◽

Adolescent Psychopathology ◽

Future Research ◽

Cognitive Errors ◽

Adolescent Anxiety ◽

Study Results ◽

The Status ◽

Manifest Anxiety ◽

The Relationship

Background: Widespread social paradigms on which the status variances are grounded in any society, gender plays pivotal role in manifestation of mental health problems (Rutter, 2007). A hefty volume of research has addressed the issue in adults nonetheless, little is vividly known about the role of gender in adolescent psychopathology. Sample: A sample of 240 adolescents (125 boys, 115 girls) aging 12-18 years was amassed from various secondary schools of Islamabad with the approval of the Federal Directorate of Education (FDE), relevant authorities of the schools and the adolescents themselves. Instruments: Taylor Manifest Anxiety Scale (Taylor & Spence, 1953) and Children’s Negative Cognitive Errors Questionnaire (CNCEQ) by Leitenberg et al., (1986) were applied in present study. Results: Multiple regression analysis revealed that cognitive errors jointly accounted for 78% of variance in predicting anxiety among adolescents. Findings also exhibited that gender significantly moderated the relationship between cognitive errors and adolescent anxiety. Implications of the findings are discoursed for future research and clinical practice.

Download Full-text

ECONOMIC GROWTH ANALYSIS: A STUDY ON MALAYSIAN MARKET

e-Academia Journal ◽

10.24191/e-aj.v9i2.7379 ◽

2019 ◽

Vol 8 (2) ◽

Author(s):

Suhaily Maizan Abdul Manaf ◽

Shuhada Mohamed Hamidi ◽

Nur Shafini Mohd Said ◽

Siti Rapidah Omar Ali ◽

Nur Dalila Adenan

Keyword(s):

Economic Growth ◽

Foreign Direct Investment ◽

Direct Investment ◽

Inflation Rate ◽

Government Expenditure ◽

Correlation Method ◽

Research Direction ◽

Least Square ◽

Future Research ◽

Internal And External Factors

Economic performance of a country is mostly determined by the growth and any other internal and external factors. In this study, researchers purposely focused on Malaysian market by examining the relationship between export, inflation rate, government expenditure and foreign direct investment towards economic growth in Malaysia by applying the yearly data of 47 years from 1970 to 2016 using descriptive statistics, regression model and correlation method analysis. By applying Ordinary Least Square (OLS) method, the result suggests that export, government expenditure and foreign direct investment are positively and significantly correlated with the economic growth. However, inflation rate has negative and insignificant relationship with the economic growth. The outcome of the study is suggested to be useful in providing the future research direction towards the economic growth in Malaysia. Keywords: economic growth; export; inflation rate; government expenditure

Download Full-text

Review of Research Trends on Coaching Studies and Recommendations for Future Research Direction in Korea - Progress from 1995 to 2017 and Challenges -

Korean Journal of Resources Development ◽

10.24991/kjhrd.2018.09.21.3.249 ◽

2018 ◽

Vol 21 (3) ◽

pp. 249-313

Author(s):

Seong Jhin Joh ◽

Yi Su Jung

Keyword(s):

Research Direction ◽

Research Trends ◽

Future Research ◽

Future Research Direction

Download Full-text

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

Mini-Reviews in Organic Chemistry ◽

10.2174/1570178617999200629155204 ◽

2020 ◽

Vol 17 ◽

Author(s):

Vijay Kumar

Keyword(s):

Therapeutic Potential ◽

Wide Spectrum ◽

Chemical Constituents ◽

Future Research ◽

Mimosa Pudica ◽

Pharmacological Activities ◽

Medicinal Uses ◽

Traditional Medicines ◽

Crude Extracts ◽

Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

Download Full-text

Natural Products for Regulating Macrophages M2 Polarization

Current Stem Cell Research & Therapy ◽

10.2174/1574888x14666190523093535 ◽

2020 ◽

Vol 15 (7) ◽

pp. 559-569 ◽

Cited By ~ 1

Author(s):

Zhen Chang ◽

Youhan Wang ◽

Chang Liu ◽

Wanli Smith ◽

Lingbo Kong

Keyword(s):

Molecular Mechanisms ◽

Inflammatory Diseases ◽

Therapeutic Strategies ◽

Research Progress ◽

Cellular Mechanisms ◽

Pharmacological Activities ◽

Current Review ◽

M2 Polarization ◽

Macrophages Polarization ◽

Herbal Plants

Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

Download Full-text