A Single-Center Clinical Study to Evaluate Shenxiong Glucose Injection Combined with Edaravone in the Treatment of Acute Large-Area Cerebral Infarction

Objectives. To investigate the clinical efficacy and safety of Shenxiong glucose injection combined with edaravone in the treatment of acute large-area cerebral infarction. Methods. 156 patients with acute large-area cerebral infarction admitted to our hospital from July 2015 to January 2017 were included in the analysis. The patients were randomly divided into experimental (78 cases) and control (78 cases) groups. Patients in the experimental group were given a 30 mg injection of edaravone in 100 ml of 0.9% sodium chloride solution by intravenous drip, twice a day within 30 minutes and a daily 200 ml injection of Shenxiong glucose by intravenous drip. Patients in the control group were given a 30 mg edaravone injection in 100 ml of 0.9% sodium chloride solution by intravenous drip, twice a day, and the drip was completed within 30 minutes. Patients in both groups were treated for 2 weeks. The levels of fibrinogen (FIB), D-dimer, interleukin 6 (IL-6), P-selectin (CD62P), and hypersensitive C-reactive protein (hs-CRP) were evaluated in the two groups of patients. Neurological disability was evaluated using the modified Rankin scale (mRS) and the neurological deficit score (National Institute of Health Stroke Scale, NIHSS). Adverse reactions to the treatments were also recorded. Results. No significant differences in age, gender, medical histories, and blood biochemical indices were observed between the two groups before treatment ( P > 0.05 ). After treatment, the levels of FIB, D-dimer, IL-6, CD62P, and hs-CRP were significantly lower following treatment and compared to the control group ( P < 0.05 ). Also, the mRS and NIHSS scores were significantly lower after treatment and compared with the control group ( P < 0.05 ). The total effective rate of the treatment in the experimental group was significantly higher compared to the control group ( P < 0.05 ). During the treatment period, no obvious adverse reactions were observed in the two groups of patients. Conclusions. In addition to the routine basic treatment of acute large-area cerebral infarction, the addition of Shenxiong glucose injection combined with edaravone injection can improve platelet aggregation and reduce inflammation by affecting P-selectin, D-dimer, and FIB. This treatment approach promotes the recovery of nerve defect function without obvious adverse reactions in patients with acute large-area cerebral infarction.

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Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.4.1831 ◽

2020 ◽

Vol 36 (4) ◽

Author(s):

Xuewen Wo ◽

Jinyan Han ◽

Jiajia Wang ◽

Xinmin Wang ◽

Xiaoying Liu ◽

...

Keyword(s):

Plasma Level ◽

Cerebral Infarction ◽

Antiplatelet Therapy ◽

Adverse Reactions ◽

Dual Antiplatelet Therapy ◽

Acute Cerebral Infarction ◽

Control Group ◽

Observation Group ◽

Significant Difference ◽

Better Than

Objective: To observe the clinical efficacy of sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of elderly patients with acute cerebral infarction (ACI). Methods: One hundred and twenty-two elderly patients with ACI who were admitted to the department of neurology of our hospital at May 2016-August 2018 were selected grouped into a control group and an observation group by random number table method, 61 in each group. On the basis of conventional treatment, the patients in the control group were given dual antiplatelet therapy (aspirin enteric-coated tablets + clopidogrel bisulfate tablets), while the patients in the observation group were given sequential butylphthalide therapy on the basis of the control group. The clinical effects of the two groups were compared after four weeks of treatment, and the changes of National Institutes of Health Stroke Scale (NIHSS), ADL score, plasma 3-mercaptopyruvate sulphurtransferase (3-MST) and Amyloid β42 (Aβ42) levels and the occurrence of adverse reactions during treatment were recorded. Results: The clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no significant difference in NIHSS and ADL scores between the two groups before treatment (P>0.05). After treatment, the NIHSS and ADL scores of the observation group were better than those of the control group (P<0.05). There was no significant difference in plasma levels of 3-MST and AB42 between the two groups before treatment (P>0.05). The level of plasma 3-MST in the observation group was higher than that in the control group, and the level of plasma Aβ42 was lower than that in the control group (P<0.05). No serious adverse reactions occurred during the treatment period in both groups. Conclusion: Butylphthalide sequential therapy combined with dual antiplatelet therapy is effective in the treatment of elderly ACI. It can effectively improve the plasma level of 3-MST and decrease the plasma level of Aβ42, which is conducive to improving the living ability and neurological function of patients and has high safety. doi: https://doi.org/10.12669/pjms.36.4.1831 How to cite this:Wo X, Han J, Wang J, Wang X, Liu X, Wang Z. Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1831 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/8030521 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Liao Wu ◽

Ying Sun ◽

Guihua Ni ◽

Bo Sun ◽

Xiaoyu Ni ◽

...

Keyword(s):

Cerebral Infarction ◽

Neurological Deficit ◽

Daily Living ◽

Adverse Reactions ◽

Neurological Impairment ◽

Acute Cerebral Infarction ◽

Control Group ◽

Nihss Score ◽

Cerebral Hemodynamic ◽

Life Function

Objective. This research aimed at investigating the efficacy of edaravone combined with clopidogrel on acute cerebral infarction (ACI) and its influence on the neurological deficit and life function. Methods. Totally, 154 ACI cases were included and then divided into the control group (CG) (n = 71) and research group (RG) (n = 83) according to the treatment methods. Patients in the CG were treated with clopidogrel alone, and those in the RG were under edaravone-clopidogrel combination therapy. The efficacy, adverse reactions, NIHSS score, cerebral hemodynamic indexes, and Fugl-Meyer scale (FMA) and Barthel index (BI) of activities of daily living (ADL) scores were observed. Results. Compared with before treatment, the symptoms of both groups were improved after treatment: the NIHSS scores decreased, FMA and ADL scores increased, and cerebral hemodynamic indexes were improved. Compared with the CG, the efficacy and cerebral hemodynamic indexes of the RG were better, the adverse reactions were equivalent, the NIHSS score was lower, and the ADL and FMA scores were higher. Conclusion. Edaravone combined with clopidogrel can effectively treat ACI and improve the neurological deficit and life function of patients.

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Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v2i6.671 ◽

2018 ◽

Vol 2 (6) ◽

Author(s):

Xiaoye Wang

Keyword(s):

Blood Pressure ◽

Coronary Heart Disease ◽

Heart Disease ◽

Elderly Patients ◽

Adverse Reactions ◽

Effective Rate ◽

Control Group ◽

Significant Difference ◽

Pre Treatment ◽

Experimental Group

ã€Abstractã€‘Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

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Early path nursing on neurological function recovery of cerebral infarction

Translational Neuroscience ◽

10.1515/tnsci-2019-0028 ◽

2019 ◽

Vol 10 (1) ◽

pp. 160-163

Author(s):

Ling Chen ◽

Zhena Han ◽

Junjie Gu

Keyword(s):

Cerebral Infarction ◽

Conventional Treatment ◽

Neurological Function ◽

Early Rehabilitation ◽

Control Group ◽

P Value ◽

Treatment Methods ◽

Rehabilitation Care ◽

Function Recovery ◽

Experimental Group

Abstract Purpose to study the application of path type early rehabilitation nursing in the nursing of patients with cerebral infarction and to explore its impact on the recovery of neurological function. Methods Patients with acute cerebral infarction in our hospital were randomly divided into two groups. The control group used conventional treatment methods. The experimental group used path type early rehabilitation care based on conventional treatment methods and observed the curative effect. ResultsThe NIHSS scores in the experimental group were significantly lower than those in the control group, and the P value was less than 0.05, which was statistically significant. Conclusion Path type early rehabilitation nursing has a positive effect on the treatment of patients with cerebral infarction, which contributes to the recovery of neurological function of patients and is worthy of promotion in treatment.

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Application Effects of Whole Course High-Quality Nursing on Patients with Liver Cancer during Radiotherapy

Iranian Journal of Public Health ◽

10.18502/ijph.v48i10.3483 ◽

2020 ◽

Author(s):

Ling PANG ◽

Yunxia WANG ◽

Yuexin XING ◽

Chunxia ZHAO

Keyword(s):

Liver Cancer ◽

Adverse Reactions ◽

Depression Scale ◽

Control Group ◽

High Quality ◽

Nursing Satisfaction ◽

Self Rating ◽

Total Incidence ◽

Before And After ◽

Experimental Group

Background: To explore the application effects of whole course high-quality nursing on patients with liver cancer during radiotherapy. Methods: One hundred and five patients with liver cancer who received radiotherapy in Liaocheng People’s Hospital, Liaocheng, China from March 2010 to February 2012 were selected and divided into a control group (42 cases with routine nursing) and an experimental group (63 cases with whole course high-quality nursing). The two groups of patients were observed and compared in terms of clinical data and the Activity of Daily Living (ADL) score before and after nursing (1 course of treatment/6 week). The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate and compare the patients’ anxiety and depression before and after nursing. Adverse reactions during radiotherapy and nursing satisfactory of patients were observed and compared between the two groups. Results: After nursing, the ADL score and the nursing satisfaction in the experimental group was significantly higher than that in the control group (P<0.05). The SDS and SAS scores in the 2 groups before nursing were significantly higher than those after nursing (P<0.05). The total incidence of adverse reactions in the control group was significantly higher than that in the experimental group (P<0.05). Conclusion: Whole course high-quality nursing can improve the negative emotions, quality of life and nursing satisfaction, and reduce adverse reactions of patients with liver cancer during radiotherapy.

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Clinical effects of Apatinib combined with DOS neoadjuvant chemotherapy regimen in neoadjuvant chemotherapy for LAGC

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.37.7.4265 ◽

2021 ◽

Vol 37 (7) ◽

Author(s):

Peng-zhe Zhou ◽

Lei Gao ◽

Wei Wu ◽

Ying-xia Hao

Keyword(s):

Neoadjuvant Chemotherapy ◽

Tumor Markers ◽

Adverse Reactions ◽

Chemotherapy Regimen ◽

Locally Advanced ◽

Control Group ◽

Clinical Effects ◽

Resection Rate ◽

Operative Complications ◽

Experimental Group

Objective: To evaluate the clinical effects of apatinib combined with DOS regimen in the neoadjuvant chemotherapy for locally advanced gastric cancer (LAGC). Methods: Eighty patients with LAGC admitted to Baoding first Central Hospital from January 2018 to October 2020 were randomly divided into two groups (n=40, respectively). The control group received DOS chemotherapy regimen alone. The experiment group additionally orally took apatinib mesylate tablets. The changes in CEA, CA19-9 and other tumor markers, RO resection rate, incidence of operative complications, adverse reactions, and other indicators were compared between the two groups. Results: The overall response rate (ORR) of the experimental group was 72.5%, which was significantly better than that of the control group (50%) (p=0.03). After the treatment, the CEA and CA19-9 in the experiment group were significantly lower than those in the control group (p=0.00). The Ro resection rate was 77.5% in the experiment group and 57.5% in the control group (p=0.03). The operation time was shortened and amount of bleeding decreased in the experiment group, and the differences were statistically significant (p=0.00). The incidence of surgical complications in the experimental group was 17.5%, significantly lower than that in the control group (37.5%) (p=0.04). Conclusion: Apatinib combined with DOS regimen is effective for patients with LAGC without significantly increasing adverse reactions. Meanwhile, tumor markers are reduced significantly. Besides, the Ro resection rate and the incidence of operative complications are obviously superior to the DOS neoadjuvant chemotherapy regimen alone. doi: https://doi.org/10.12669/pjms.37.7.4265 How to cite this:Zhou P, Gao L, Wu W, Hao Y. Clinical effects of Apatinib combined with DOS neoadjuvant chemotherapy regimen in neoadjuvant chemotherapy for LAGC. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4265 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

Journal of Oncology ◽

10.1155/2021/9162346 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Yonghuan Yu ◽

Xinfeng Cui ◽

Jingjing Zhao ◽

Ting Jia ◽

Baofeng Ren ◽

...

Keyword(s):

Liver Fibrosis ◽

Hepatitis B ◽

Liver Function ◽

Adefovir Dipivoxil ◽

Adverse Reactions ◽

Statistical Significance ◽

Effective Rate ◽

Control Group ◽

Tnf Α ◽

Experimental Group

Objective. The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis. Methods. A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patients in the experimental group received entecavir combined with adefovir dipivoxil. After that, the effective rate of treatment, the incidence of adverse reactions, liver function indexes, liver fibrosis condition, and TNF-α and IL-6 expression levels were all compared between the two groups. Results. The effective rate of treatment in the experimental group was significantly higher than that in the control group, with statistical significance ( p < 0.001 ); the incidence of adverse reactions of the patients in the experimental group was significantly lower than that in the control group, with statistical significance ( p < 0.001 ); the liver function indexes in the experimental group were significantly better than those in the control group, with statistical significance ( p < 0.001 ); the number of patients with liver fibrosis in the experimental group was significantly less than that in the control group, with statistical significance ( p < 0.001 ); the TNF-α and IL-6 expression levels in the experimental group were significantly lower than those in the control group, with statistical significance ( p < 0.001 ). Conclusion. Entecavir combined with adefovir dipivoxil in the treatment of hepatitis B cirrhosis can effectively improve the therapeutic effect and reduce the serum inflammatory factor levels, with high safety, which is worthy of application and popularization.

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Efficacy and Safety of Tongning Gel for Knee Osteoarthritis: A Multicentre, Randomized, Double-Blinded, Parallel, Placebo-Controlled, Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/8707256 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Ye Zhao ◽

Zhi Bi Shen ◽

Ji Rong Ge ◽

Wen Gang Liu ◽

Jun Xing Yang ◽

...

Keyword(s):

Clinical Trial ◽

Adverse Events ◽

Knee Osteoarthritis ◽

Physical Function ◽

Pain Score ◽

Adverse Reactions ◽

Control Group ◽

Womac Pain ◽

Womac Pain Score ◽

Experimental Group

Objective. To evaluate the efficacy and safety of Tongning Gel (TNG) compared to placebo-controlled (PC) for knee osteoarthritis (KOA). Methods. A multicentre, randomized, double-blinded, parallel, placebo-controlled, clinical trial was performed in 576 patients (432 patients in the TNG group, 144 patients in the PC group), and 1 in the experimental group withdrew due to nonuse of drug. Patients were randomized to receive TNG or PC applied to knee skin at 3g per time, 2 times per day, which lasted for 3 weeks. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score was used to evaluate the primary efficacy of TNG and WOMAC stiffness and physical function and total scores were used to evaluate the secondary efficacy of TNG. All participants who received at least one dose of study drug were included in the safety analysis. This trial has been registered in Chinese Clinical Trial Registry (no. CTR20131276). Results. Primary efficiency outcome: there were significant differences in the decreased value of WOMAC pain score between two groups (P<0.05), and the decreased value of WOMAC pain score in the TNG group were better than those in the PC group (P<0.05). Secondary efficiency outcome: the WOMAC total score, WOMAC stiffness score, WOMAC physical function score, and the decrease of the above indexes of the two groups of patients after treatment were statistically significant (P<0.05), and the improvement of the above indexes in the TNG group was better than that of the PC group (P<0.05). Safety Evaluation. A total of 42 adverse events were reported by 29 patients: 25 adverse events reported by 16 patients (3.71%) in the experimental group and 17 adverse events were reported by 13 patients (9.03%) in the control group. And 8 adverse reactions were reported by 6 patients including 2 adverse reactions by 2 patients (0.46%) in the experimental group and 6 adverse reactions by 4 patients (2.78%) in the control group. Two cases of significant adverse events occurred in the experimental group. Both groups had one serious adverse event, respectively, which were not relevant to the intervention. Conclusion. These results of the trial demonstrate that TNG is superior to placebo in the treatment of patients with KOA, and TNG can improve other symptoms of KOA, such as stiffness and physical function. TNG is safe for the treatment of knee osteoarthritis as a whole.

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Effect of Standardized Pain Management Combined with Clinical Teaching on the Adverse Reactions and Nursing Efficacy in Patients with Rotator Cuff Injury after Surgery

Tobacco Regulatory Science ◽

10.18001/trs.7.5.1.34 ◽

2021 ◽

Vol 7 (5) ◽

pp. 2640-2647

Author(s):

Xiaoli Liu ◽

Xiao Xu ◽

Jiajia Jin ◽

Yanyan Chen ◽

Shiming Rao ◽

...

Keyword(s):

Pain Management ◽

Rotator Cuff ◽

Adverse Reactions ◽

Clinical Teaching ◽

Control Group ◽

Shoulder Abduction ◽

Rotator Cuff Injury ◽

Shoulder Scores ◽

And Control ◽

Experimental Group

To study the effect of standardized pain management combined with clinical teaching on the adverse reactions and nursing efficacy in patients with rotator cuff injury after surgery. 104 patients with rotator cuff injury treated in our hospital (April 2019-April 2020) were chosen as study subjects and randomly split into experimental group (n=52) and control group (n=52). After all the patients received arthroscopic revision surgery, the experimental and control group received standardized pain management combined with clinical teaching and routine pain management postoperatively, respectively. After that, the effect of different pain management modes on the adverse reactions and nursing efficacy in patients with rotator cuff injury after surgery was analyzed by comparing various indexes between two groups. No obvious differences in sex ratio, average age, mean BMI, injury severity, injury cause, education level and residence were found between two groups (P > 0.05); no obvious differences in numeric rating scale (NRS) scores at T1 were found between the two groups (P > 0.05), and the NRS scores at T2 and T3 in experimental group were obviously lower compared with control group (P < 0.001); no obvious differences in the angle of shoulder abduction, anterior flexion and extension were found between the two groups before intervention (P > 0.05), and angle of shoulder abduction, anterior flexion and extension in experimental group at 3 and 6 months after surgery was obviously greater compared with control group (P < 0.001); no obvious differences in the constant shoulder scores were found between the two groups before the intervention (P > 0.05), and the constant shoulder scores in experimental group at 3 and 6 months after surgery were obviously higher compared with control group (P < 0.001); the nursing satisfaction in experimental group was obviously higher compared with control group (P < 0.05); the clinical effective rate in experimental group was obviously higher compared with control group (P < 0.05); the incidence of adverse reactions in experimental group after surgery was obviously lower compared with control group (P < 0.05). Standardized pain management combined with clinical teaching in treating rotator cuff injury of patients can significantly reduce shoulder pain severity and improve shoulder mobility, with significant efficacy and high safety, which is worthy of application and promotion.

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The Effects of Music as Therapy on the Overall Well-Being of Elderly Patients on Maintenance Hemodialysis

Biological Research For Nursing ◽

10.1177/1099800411413259 ◽

2011 ◽

Vol 14 (3) ◽

pp. 277-285 ◽

Cited By ~ 18

Author(s):

Yen-Ju Lin ◽

Kuo-Cheng Lu ◽

Ching-Min Chen ◽

Chia-Chi Chang

Keyword(s):

Elderly Patients ◽

Adverse Reactions ◽

Well Being ◽

Complementary Therapy ◽

Maintenance Hemodialysis ◽

Control Group ◽

Music Listening ◽

Finger Temperature ◽

Convenience Sample ◽

Experimental Group

In this study, the authors explored the use of music during hemodialysis (HD) as a complementary therapy to improve overall well-being in elderly patients. The authors recruited a convenience sample of 88 patients on maintenance HD from a teaching hospital in northern Taiwan and randomly assigned them to either an experimental group ( n = 44) or a control group ( n = 44). In the first week, participants in the experimental group created their own music playlists. During the second week, these participants listened to music from their own playlists during each HD session (three times/week). The authors evaluated the effects of music as therapy by assessing its impact on perceived stressors and adverse reactions during HD (HD Adverse Reactions Self-Assessment Scale and HD Stressor Scale [HSS]) and measuring changes in physiological indices during the course of the music listening. After 1 week of the use of music as therapy during HD, the authors noted significant reductions in the frequency and severity of adverse reactions during dialysis and in scores on the HSS, p < .001. The authors also observed significantly decreased respiratory rate and significantly increased finger temperature and oxygen saturation, p < .001, during the same period. In conclusion, listening to music during HD may promote overall patient well-being. It may thus serve as a complementary form of therapy that facilitates care and delivery of adequate dialysis and thus improves overall patient well-being in the long run.

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