Plasma Amino Acids and Risk of Impaired Lower-Extremity Function and Role of Dietary Intake: A Nested Case-Control Study in Older Adults

Gerontology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Francisco Félix Caballero ◽  
Ellen A. Struijk ◽  
Antonio Buño ◽  
Verónica Vega-Cabello ◽  
Fernando Rodríguez-Artalejo ◽  
...  
Keyword(s):  
Older Adults ◽  
Amino Acids ◽  
Amino Acid ◽  
Lower Extremity ◽  
Essential Amino Acids ◽  
Case Control ◽  
Plasma Amino Acids ◽  
Lower Extremity Function ◽  
Incident Cases

<b><i>Introduction:</i></b> Amino acids are key elements in the regulation of the aging process which entails a progressive loss of muscle mass. The health effects of plasma amino acids can be influenced by dietary intake. This study assessed the prospective association between amino acid species and impaired lower-extremity function (ILEF) in older adults, exploring the role of diet on this association. <b><i>Methods:</i></b> This is a case-control design comprising 43 incident cases of ILEF and 85 age- and sex-matched controls. Plasma concentrations of 20 amino acid species were measured at baseline using liquid chromatography-tandem mass spectrometry, and incident cases of ILEF were measured after 2 years by means of the Short Physical Performance Battery. Conditional logistic regression models were used to assess longitudinal relationships. <b><i>Results:</i></b> After adjusting for potential confounders, higher levels of tryptophan were associated with a decreased 2-year risk of ILEF (OR per 1-SD increase = 0.64, 95% CI = [0.42, 0.97]), while glutamine and total essential amino acids were linked to higher ILEF risk (OR = 1.57, 95% CI = [1.01, 2.45]; OR = 1.89, 95% CI = [1.18, 3.03], respectively). Those with a lower adherence to a Mediterranean diet, a higher BMI, a higher consumption of red meat, and a lower consumption of nuts and legumes had an increased risk of ILEF associated with higher levels of essential amino acids. <b><i>Discussion/Conclusion:</i></b> Some amino acid species could serve as risk markers for physical function decline in older adults, and healthy diet might attenuate the excess risk of ILEF linked to essential amino acids.

scholarly journals Effects of essential amino acids on food and water intake of rats

1994 ◽  
Vol 72 (8) ◽  
pp. 841-848 ◽  
Author(s):  
G. Harvey Anderson ◽  
Shuqin Luo ◽  
Leonidas Trigazis ◽  
Greta Kubis ◽  
Edmund T. S. Li
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Water Intake ◽  
Essential Amino Acids ◽  
Time Period ◽  
Food And Water Intake ◽  
Intake Water ◽  
Comparable Magnitude

This study examined the effects of selected groups of essential amino acids (EAAs), given by gavage, on short-term food and water intake. Amino acid groups were selected on the basis of their common physiologic functions in relation to current hypotheses on the role of amino acids in food intake control, and the quantities given were based on the proportions in 1.5 g of the EAA content of albumin. The complete EAA mixture (1.5 g) suppressed food intake by an average of 60 and 37% during the 1st and 2nd h of feeding, respectively, but had no influence on feeding in the subsequent 12 h. Total daily (14 h) intake was decreased by 9%. With the exception of the aromatic amino acid (Phe + Tyr + Trp, 0.34 g) group, all groups significantly decreased food intake by a comparable magnitude (32%) during the 1st h. In this time period, rats given the EAAs, Arg + Met + Val (0.38 g), and Arg + His + Lys (0.44 g) mixtures increased their water intake, whereas intake by rats given the Phe + Tyr + Trp + Thr (0.46 g) and Ile + Leu + Val (0.45 g) mixtures was unchanged. Thus, the food intake suppression caused by EAAs was not accounted for by an equal effect of its component amino acid groups. As well, food intake suppression by amino acid groups was not explained by increased water consumption, nor was it simply related to the quantity of nitrogen provided by the treatment.Key words: food intake, water intake, essential amino acids.

scholarly journals Plasma Ceramides and Risk of Impaired Lower-Extremity Function in Older Adults: A Nested Case–Control Study

2020 ◽  
Author(s):  
Francisco Félix Caballero ◽  
Ellen A Struijk ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
Esther Lopez-Garcia
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Lower Extremity ◽  
Body Mass ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Lower Extremity Function ◽  
Extremity Function ◽  
Control Study

Abstract Background Higher levels of ceramides have been linked to several chronic diseases; also there is emerging cross-sectional evidence that ceramides are associated with lower physical functioning. This research assessed for the first time the prospective relationship between ceramide species and impaired lower-extremity function (ILEF) in older adults. Methods Case–control study with 43 cases of ILEF and 86 age- and sex-matched controls, which was nested in the Seniors-ENRICA cohort of community-dwelling older adults. Incident ILEF from 2015 to 2017 was ascertained with the Short Physical Performance Battery. In 2015, 27 ceramide species were measured in plasma by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to assess the longitudinal relationship between ceramides concentration and incidence of ILEF. Results After adjusting for education level, body mass index, alcohol and total energy intake, physical activity, and presence of chronic conditions, some ceramide species were related to 2-year incidence of ILEF. Specifically, the odds ratios of ILEF per 1-SD increase in ceramide concentration were: 1.66 [95% CI = (1.03, 2.68)] for ceramide C14:0, 1.61 (1.00, 2.59) for ceramide C16:0, and 1.64 (1.03, 2.60) for ceramide C16:1 (n-7). In the case of ceramides C16:0 and C16:1 (n-7), a stronger relationship was found in those with a higher body mass index; systolic blood pressure could also mediate the relationship between ceramide C16:1 (n-7) and ILEF (p for interaction = .03). Conclusions Higher plasma levels of ceramides C14:0, C16:0, and C16:1 (n-7) are associated with higher risk of ILEF, and might serve as risk markers for functional decline in older adults.

scholarly journals The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer

2019 ◽  
Vol 20 (10) ◽  
pp. 2428 ◽  
Author(s):  
Pascal Häfliger ◽  
Roch-Philippe Charles
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Cancer Cells ◽  
Cell Mass ◽  
Essential Amino Acids ◽  
Amino Acid Transporter ◽  
Membrane Transporters ◽  
Preclinical Studies ◽  
Acid Transporter

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.

scholarly journals Amino acid homeostasis and signalling in mammalian cells and organisms

2017 ◽  
Vol 474 (12) ◽  
pp. 1935-1963 ◽  
Author(s):  
Stefan Bröer ◽  
Angelika Bröer
Keyword(s):  
Amino Acids ◽  
Protein Synthesis ◽  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acids ◽  
Acid Oxidation ◽  
Plasma Amino Acids ◽  
Amino Acid Oxidation ◽  
Amino Acid Levels ◽  
Amino Acid Depletion

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of essential amino acids with non-essential amino acids and the transfer of amino groups from oxidised amino acids to amino acid biosynthesis. This homeostatic condition is maintained through an active mTORC1 complex. Under amino acid depletion, mTORC1 is inactivated. This increases the breakdown of cellular proteins through autophagy and reduces protein biosynthesis. The general control non-derepressable 2/ATF4 pathway may be activated in addition, resulting in transcription of genes involved in amino acid transport and biosynthesis of non-essential amino acids. Metabolism is autoregulated to minimise oxidation of amino acids. Systemic amino acid levels are also tightly regulated. Food intake briefly increases plasma amino acid levels, which stimulates insulin release and mTOR-dependent protein synthesis in muscle. Excess amino acids are oxidised, resulting in increased urea production. Short-term fasting does not result in depletion of plasma amino acids due to reduced protein synthesis and the onset of autophagy. Owing to the fact that half of all amino acids are essential, reduction in protein synthesis and amino acid oxidation are the only two measures to reduce amino acid demand. Long-term malnutrition causes depletion of plasma amino acids. The CNS appears to generate a protein-specific response upon amino acid depletion, resulting in avoidance of an inadequate diet. High protein levels, in contrast, contribute together with other nutrients to a reduction in food intake.

Role of Essential Amino Acids in the Early Formation of Avian Liver Xanthine Dehydrogenase Activity

1957 ◽  
Vol 191 (2) ◽  
pp. 355-358 ◽  
Author(s):  
Gerald Litwack ◽  
Hans Fisher
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Specific Activity ◽  
Essential Amino Acids ◽  
Xanthine Dehydrogenase ◽  
Dietary Proteins ◽  
Specific Amino Acid ◽  
Adequate Diet ◽  
Limiting Amino Acid

Avian liver xanthine dehydrogenase (LXD) has been shown to be sensitive to dietary proteins and amino acids particularly when measured during the first 3 weeks of life. Feeding an adequate diet for the first 7 days of life produces a condition wherein LXD is very resistant to single essential amino acid deficiencies. When an amino acid-deficient regimen is fed directly, without prefeeding an adequate diet, a rapid and marked decrease is seen which is inversely proportional to the amount of available limiting amino acid. This mechanism has also been demonstrated by LXD depletion with low dietary protein and repletion with diets high in protein but limiting in a specific amino acid. In the case of l-threonine deficiency, a dietary level of threonine above that required to saturate a growth response produced a continuous rise in LXD specific activity similar to induction.

scholarly journals Role of Amino Acid Arginine for Broiler Production: A Review

2018 ◽  
Vol 2 (3) ◽  
pp. 1-6
Author(s):  
Keyword(s):  
Amino Acids ◽  
Immune Response ◽  
Amino Acid ◽  
Urea Cycle ◽  
Essential Amino Acids ◽  
Fat Deposition ◽  
Significant Component ◽  
Body Protein ◽  
Nitrogenous Compounds

Amino acids are known as anabolic factors that are essential for formation of muscle by stimulating protein synthesis while inhibiting proteolysis, and they are significant component for the synthesis of various nitrogenous compounds. There are 20 amino acids are essential to require in cell for formation of body protein of which about 10 amino acids, which cannot be synthesized by the birds are termed essential. Among the essential amino acid arginine one of the essential amino acids for chickens because, like other birds, they are unable to obtain Arginine from endogenous sources due to the absence of most of the enzymes involved in the urea cycle. This amino acid involved in synthesis of proline, hydroxyl proline and polyamines which are essential for connective tissue synthesis as well as increased growth of chicken. Moreover, L-arginine (L-Arg) is effective for reducing fat deposition in broiler. Moreover, it decrease heat stress increase meat quality and increase immune response of broiler. This re-view presents the recent advances in the relevance of the inclusion of excess L-Arginine in broiler ration to growth, fat deposition and immune response in broiler.

scholarly journals Effects of Amino Acid Supplementation on Liver Lipid Content: A Randomized, Double-Blinded, Placebo-Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 33-33
Author(s):  
Nicholas Hurren ◽  
Elena Volpi ◽  
Michael Kinsky ◽  
Gohar Azhar ◽  
Elisabet Børsheim
Keyword(s):  
Older Adults ◽  
Amino Acids ◽  
Amino Acid ◽  
Lipid Content ◽  
Liver Lipid ◽  
Essential Amino Acids ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Liver Lipid Content ◽  
Double Blinded

Abstract Objectives To test whether chronic ingestion of essential amino acids (EAAs) plus arginine lowers liver lipid content when compared with a placebo (non-essential amino acids; NEAAs). Methods Older adults (50–75 y) with elevated fasting plasma triacylglycerol (TAG) concentrations were recruited into the study. After screening (week -2), all participants ingested placebo (NEAAs; alanine, aspartic acid, and serine) capsules twice daily (between meals) for two weeks and 3 T nuclear magnetic resonance spectroscopy scans were used to determine baseline (week 0) liver lipid percentage. Participants were then randomised to receive capsules containing 11 g of EAAs plus arginine (n = 10) or NEAAs (n = 9) twice daily for eight weeks, using a double-blinded design. Follow-up NMR spectroscopy scans were conducted at eight weeks after the onset of randomised supplementation (week 8) to determine the impact on liver lipids. Results Liver lipid percentage (mean ± standard deviation) was not significantly altered by randomised supplementation in either the EAAs plus arginine group (Pre: 9.08 ± 7.90%; Post: 8.94 ± 6.91%; P = 0.65) or the NEAAs group (Pre: 10.23 ± 7.20%; Post: 9.65 ± 7.70%; P = 0.18). Change in fasting plasma TAG during placebo run-in (Week 0 minus screening) was significantly negatively correlated with change in liver lipid content (week 8 minus week 0) for the EAAs plus arginine group (r = −0.722; P = 0.02), but not for the NEAAs group A (r = −0.479; P = 0.19). Conclusions Eight weeks of essential amino acids plus arginine ingestion did not significantly lower liver lipid content in older adults. However, ingestion of non-essential amino acids during the run-in period may have influenced the effect on liver fat of subsequent randomised amino acid supplementation, suggesting further investigation is warranted. Funding Sources The study was sponsored by NIH/NIA (award to EB), and the Roy and Christine Sturgis Charitable Trust (award to NMH). Screenings and study visits were undertaken within the ITS-Clinical Research Center at UTMB, funded by NIH/NCRR, and within the UAMS Donald W. Reynolds Institute on Aging at UAMS, funded by NIH/NIA. NMH and EB were also funded by the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000.

Regional amino acid transport into brain during diabetes: effect of plasma amino acids

1987 ◽  
Vol 253 (5) ◽  
pp. E575-E583 ◽  
Author(s):  
A. M. Mans ◽  
M. R. DeJoseph ◽  
D. W. Davis ◽  
R. A. Hawkins
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Transport ◽  
Basic Amino Acid ◽  
Essential Amino Acids ◽  
Diabetic Rats ◽  
Transport Systems ◽  
Plasma Amino Acids ◽  
Acid Transport ◽  
Branched Chain

Transport of phenylalanine and lysine into the brain was measured in 4-wk streptozotocin-diabetic rats to assess the effect on the neutral and basic amino acid transport systems at the blood-brain barrier. Amino acid concentrations in plasma and brain were also measured. Regional permeability-times-surface area (PS) products and influx were determined using a continuous infusion method and quantitative autoradiography. The PS of phenylalanine was decreased by an average of 40% throughout the entire brain. Influx was depressed by 35%. The PS of lysine was increased by an average of 44%, but the influx was decreased by 27%. Several plasma neutral amino acids (branched chain) were increased, whereas all basic amino acids were decreased. Brain tryptophan, phenylalanine, tyrosine, methionine, and lysine contents were markedly decreased. The transport changes were almost entirely accounted for by the alterations in the concentrations of the plasma amino acids that compete for the neutral and basic amino acid carriers. The reduced influx could be responsible for the low brain content of some essential amino acids, with possibly deleterious consequences for brain function.

Screening of amino acid constituents from date palm fruits

2016 ◽  
Vol 5 (10) ◽  
pp. 4972
Author(s):  
Lata Birlangi
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
United Arab Emirates ◽  
Nutritional Value ◽  
Date Palm ◽  
Amino Acid Content ◽  
Essential Amino Acids ◽  
Cultivated Plants ◽  
Palm Fruits ◽  
Social Part

The date palm (Phoenix dactylifera L.) is one of mankind’s oldest cultivated plants. The fruit of the date palm is an important crop of the hot arid and semi-arid regions of the world. It has always played a genuine economic and social part in the lives of the people of these areas. The present objective in examining the amino acid content of different varieties of date palm fruits from Middle-East region; is to determine whether its protein could effectively supplement the nutritional value and it is also aimed in finding which variety is rich in number of amino acids. The phytochemical screening revealed the presence of eight essential amino acids and five non-essential amino acids in the date fruits. Among all the date fruit varieties taken as samples for the study, Dabbas cultivar of United Arab Emirates found to exhibit eight types of amino acids which includes five as non-essential ones. Total of thirteen amino acids were detected in the seven date cultivars. Determination of amino acid can serve as a guide to the possible nutritional value.

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