Abstract MP16: Prevalence of Dyslipidemia Patterns among US Hispanics: Results from the Hispanic Community Health Study / Study of Latinos

Background: Prevalence and determinants of dyslipidemia among Hispanics/Latinos are not well known. Methods: Lipid and lipoprotein data from the HCHS/SOL -- a population-based cohort study of 16,415 US Hispanic/Latino participants, ages 18-74, from Cuban, Dominican, Mexican, Puerto Rican, and Central and South American backgrounds -- were used. Criteria for dyslipidemia are based on National Cholesterol Education Program Adult Treatment Panel III guidelines as low density lipoprotein-cholesterol (LDL-C) >130 mg/dl, triglycerides (TG) >200 mg/dl, non-high density lipoprotein (non-HDL-C) >160 mg/dl, or low HDL-C (<40 mg/dl for men and <50 mg/dl for women). Differences across Hispanic/Latino groups were tested using Mantel- Haenszel Chi-square and analysis of variance for categorical and continuous variables, respectively. Demographics, anthropometric measurements, lifestyle factors, dietary and metabolic profiles in those with abnormal vs. normal lipid components were compared using multivariable logistic regression models. Results: Mean age was 40.7 years (SE 0.23) and 48.3% are male. The overall prevalence of any dyslipidemia was 65.1%; prevalence of elevated LDL-C was 35.5%, and highest among Cubans (44.5%; p<0.001). Low HDL-C was present in 41.9% overall, Central Americans had the highest prevalence (44.1%) but not significantly different from other groups (p=0.09). High TGs were seen in 14.9% overall, most commonly among Cubans (17.5%; p<0.001). Elevated non-HDL-C was seen in 34.3% of the sample, and highest among Cubans (43.2%). Dominicans had the lowest prevalence of all four types of dyslipidemia. Multivariate analyses, across all Hispanics, show that prevalence of any dyslipidemia was significantly associated with increasing body mass index and diabetes diagnosis. Higher age was associated with a significantly lower prevalence of low HDL but a higher prevalence of all other dyslipidemia types. Female sex was associated with higher prevalence of low HDL-C but a lower prevalence of elevated TGs, non-HDL-C or LDL-C. Low physical activity was significantly associated with elevated TGs and low HDL-C. Alcohol use was associated with a lower prevalence of low HDL-C only. Conclusion: Dyslipidemia is very common among Hispanics/Latinos; Cubans seem particularly at risk. Low HDL-C and elevated LDL-C are most commonly seen. Across all Hispanics, determinants of dyslipidemia varied depending on the type of dyslipidemia. To prevent dyslipidemias, effective public health measures among the Hispanic/Latino population are needed.

Download Full-text

Discordance between LDL-C and Apolipoprotein B Levels and Its Association with Renal Dysfunction: Insights from a Population-Based Study

Journal of Clinical Medicine ◽

10.3390/jcm11020313 ◽

2022 ◽

Vol 11 (2) ◽

pp. 313

Author(s):

Mohsen Mazidi ◽

Richard J. Webb ◽

Gregory Y. H. Lip ◽

Andre P. Kengne ◽

Maciej Banach ◽

...

Keyword(s):

Logistic Regression ◽

Apolipoprotein B ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Population Based ◽

Categorical Variables ◽

Atherosclerotic Cardiovascular Disease ◽

Model Assessment ◽

Logistic Regression Models

Low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) are established markers of atherosclerotic cardiovascular disease (ASCVD), but when concentrations are discordant ApoB is the superior predictor. Chronic kidney disease (CKD) is associated with ASCVD, yet the independent role of atherogenic lipoproteins is contentious. Four groups were created based upon high and low levels of ApoB and LDL-C. Continuous and categorical variables were compared across groups, as were adjusted markers of CKD. Logistic regression analysis assessed association(s) with CKD based on the groups. Subjects were categorised by LDL-C and ApoB, using cut-off values of >160 mg/dL and >130 mg/dL, respectively. Those with low LDL-C and high ApoB, compared to those with high LDL-C and high ApoB, had significantly higher body mass index (30.7 vs. 30.1 kg/m2) and waist circumference (106.1 vs. 102.7 cm) and the highest fasting blood glucose (117.5 vs. 112.7 mg/dL), insulin (16.6 vs. 13.1 μU/mL) and homeostatic model assessment of insulin resistance (5.3 vs. 3.7) profiles (all p < 0.001). This group, compared to those with high LDL-C and high ApoB, also had the highest levels of urine albumin (2.3 vs. 2.2 mg/L), log albumin-creatinine ratio (2.2 vs. 2.1 mg/g) and serum uric acid (6.1 vs. 5.6 mg/dL) and the lowest estimated glomerular filtration rate (81.3 vs. 88.4 mL/min/1.73 m2) (all p < 0.001). In expanded logistic regression models, using the low LDL-C and low ApoB group as a reference, those with low LDL-C and high ApoB had the strongest association with CKD, odds ratio (95% CI) 1.12 (1.08–1.16). Discordantly high levels of ApoB are independently associated with increased likelihood of CKD. ApoB remains associated with metabolic dysfunction, regardless of LDL-C.

Download Full-text

The Prevalence of Metabolic Syndrome, Scoring and Comparison in People with and without COPD: Evidence From Shahrekord PERSIAN Cohort Study

10.21203/rs.3.rs-502427/v1 ◽

2021 ◽

Author(s):

Fatemeh Zeynab Kiani ◽

Ali Ahmadi

Keyword(s):

Metabolic Syndrome ◽

Density Lipoprotein ◽

Population Based ◽

Chronic Obstructive ◽

P Value ◽

Chi Square ◽

Common Component ◽

Respiratory Problems ◽

Logistic Regression Models ◽

Significant Difference

Abstract Background Comorbidities are common in patients with Chronic obstructive pulmonary disease (COPD), including metabolic syndrome (MetS). This study aimed to determine the prevalence of MetS and its components in people with and without COPD. Methods This population-based study was performed on 6961 adult years in the Shahrekord Prospective epidemiological research studies in Iran. Data collection, spirometry indexes and COPD diagnosis were performed according to the cohort protocol from 2015 to 2019. The data were analyzed by two-independent sample t-tests, chi-square, and logistic regression models. P-value < 0.05 was considered as statistically significant. All analyses were conducted using stata statistical software: release 16 (stata Corp, College Station, Texas 77845 USA). Result The prevalence of MetS in patients with and without COPD was 28.4% and 31%, respectively. The most common component of MetS in people with COPD was low high-density lipoprotein cholesterol (HDL-c) (47.4%), waist circumference (WC) (43.9%), and High fasting blood sugar (FBS) (39.3%). There was a statistically significant difference in the frequency of respiratory problems between people with and without MetS. The age above 60 years (OR = 2.20, 95% CI: 1.72–2.80), woman gender (OR = 1.36, 95%CI: 1.49–1.97), obesity (OR = 11.17, 95%CI: 9.02–13.62), illiterate education (OR = 1.80, 95%CI: 1.49–2.17), and living in urban (OR = 1.96, 95%CI: 1.64–2.35) are stronger predictors of MetS in this population. Conclusion There was no significant difference in the prevalence of MetS between patients with and without COPD. spirometry parameters and respiratory problems in subjects with and without metabolic syndrome were significance.

Download Full-text

6-Year trends in lipids among adults in Shenzhen, China

Journal of Public Health ◽

10.1093/pubmed/fdz113 ◽

2019 ◽

Vol 42 (4) ◽

pp. e468-e476 ◽

Cited By ~ 2

Author(s):

Xueli Yuan ◽

Wenqing Ni ◽

Rui Wang ◽

Hongshan Chi ◽

Yuanying Sun ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Blood Lipid ◽

Current Smoker ◽

Lipoprotein Cholesterol ◽

Chi Square ◽

Cross Sectional ◽

Low Hdl ◽

Chi Square Test

Abstract Background There may be a beneficial effect on lipid levels in Shenzhen in recent years. In this study, we aimed to examine trends in serum lipids in population in Shenzhen between 2009 and 2015. Methods We enrolled 2210 adults aged 18–70 years from two independent cross-sectional studies conducted in 2009 and 2015. Blood lipid profiles, such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were measured. Chi-square test, t-test and multivariate logistic regression analysis were applied for data analysis. Results From 2009 to 2015, mean LDL-C declined from 3.05 ± 0.76 mmol/L in 2009 to 2.27 ± 0.75 mmol/L in 2015 (P < 0.001). Similarly, a significant 7.09% decrease in the prevalence of high LDL-C was observed over the same period (P < 0.001). There was an increasing trend in the prevalence of low HDL-C among adults in Shenzhen (P < 0.001). A no-significant increase in prevalence of dyslipidemia was also observed over this 6-year interval (P = 0.139). The prevalence of dyslipidemia was closely related with increasing age, male gender, current smoker, diabetes, obesity and overweight. Conclusion This study shows a favourable downward trend in LDL-C concentration in Shenzhen. However, more intense strategies are needed to control dyslipidemia.

Download Full-text

Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)

Journal of Clinical Medicine ◽

10.3390/jcm10143098 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3098

Author(s):

Shota Okutsu ◽

Yoshifumi Kato ◽

Shunsuke Funakoshi ◽

Toshiki Maeda ◽

Chikara Yoshimura ◽

...

Keyword(s):

Weight Gain ◽

General Population ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Population Based ◽

Lipid Lowering ◽

Low Density ◽

Obesity Hypertension ◽

Old Men

The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, p = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese.

Download Full-text

Transitions in hookah (Waterpipe) smoking by U.S. sexual minority adults between 2013 and 2015: the population assessment of tobacco and health study wave 1 and wave 2

BMC Public Health ◽

10.1186/s12889-021-10389-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Mary Rezk-Hanna ◽

Ian W. Holloway ◽

Joy Toyama ◽

Umme Shefa Warda ◽

Lorree Catherine Berteau ◽

...

Keyword(s):

Multinomial Logistic Regression ◽

Health Study ◽

Chi Square ◽

Population Assessment ◽

Logistic Regression Models ◽

Global Epidemic ◽

Product Use ◽

Hookah Smoking ◽

Nationally Representative ◽

And Gender

Abstract Background Tobacco smoking using a hookah (i.e., waterpipe) is a global epidemic. While evidence suggests that sexual minorities (SM) have higher odds of hookah use compared to heterosexuals, little is known about their hookah use patterns and transitions. We sought to examine transitions between hookah smoking and use of other tobacco and electronic (e-) products among SM adults aged 18 years of age and older versus their heterosexual counterparts. Methods We analyzed nationally representative data of ever and current hookah smokers from Wave 1 (2013–2014; ever use n = 1014 SM and n = 9462 heterosexuals; current use n = 144 SM and n = 910 heterosexuals) and Wave 2 (2014–2015; ever use n = 901 SM and n = 8049 heterosexuals; current use n = 117 SM and n = 602 heterosexuals) of the Population Assessment of Tobacco and Health Study. Comparisons between groups and gender subgroups within SM identity groups were determined with Rao-Scott chi-square tests and multivariable survey-weighted multinomial logistic regression models were estimated for transition patterns and initiation of electronic product use in Wave 2. Results Ever and current hookah smoking among SM adults (ever use Wave 1: 29% and Wave 2: 31%; current use Wave 1: 4% and Wave 2: 3%) was higher than heterosexuals (ever use Wave 1: 16% and Wave 2: 16%; current use Wave 1: 1% and Wave 2: 1%; both p < 0.0001). Among SM adults who reported hookah use at Wave 1, 46% quit hookah use at Wave 2; 39% continued hookah use and did not transition to other products while 36% of heterosexual adults quit hookah use at Wave 2 and 36% continued hookah use and did not transition to other products. Compared with heterosexuals, SM adults reported higher use of hookah plus e-products (Wave 2 usage increased by 65 and 83%, respectively). Conclusions Compared to heterosexuals, in addition to higher rates of hookah smoking, higher percentages of SM adults transitioned to hookah plus e-product use between 2013 and 2015. Results have implications for stronger efforts to increase awareness of the harmful effects of hookah as well as vaping, specifically tailored among SM communities.

Download Full-text

Association between different types of plant-based diet and dyslipidemia in Korean adults

British Journal Of Nutrition ◽

10.1017/s0007114521003482 ◽

2021 ◽

pp. 1-17

Author(s):

Nara Shin ◽

Jihye Kim

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Multivariable Logistic Regression Analysis ◽

Nutrition Survey ◽

Korean Adults ◽

Different Types ◽

Low Hdl ◽

Nationally Representative ◽

Using Data

Abstract This study investigated the association between the different types of plant-based diets and dyslipidemia in Korean adults using data from the nationally representative sample. Using the 2012-2016 Korea National Health and Nutrition Survey data, a total of 14,167 adults (≥19 years old) participated in this study. Dietary intake was assessed by a semi-quantitative food frequency questionnaire. Three different plant-based diet indices (overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), unhealthful plant-based diet index (uPDI)), were calculated. Dyslipidemia and its components (hypertriglyceridemia, hypercholesterolemia, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C), use of anti-hyperlipidemia agent) were measured. Multivariable logistic regression analysis was used to examine the associations between plant-based diet and dyslipidemia and individual lipid disorders. Totally, 47% of overall population had dyslipidemia. Individual in the highest quintile of uPDI had 22% greater odds of dyslipidemia (95% CI: 1·05, 1·41) and 48 % higher odds of hypertriglyceridemia (95% CI: 1·21, 1·81) and 16% higher odds of low HDL-C (OR: 1·16, 95% CI: 1·00, 1·35) than those in the lowest quintile of uPDI. PDI was associated with 16 % higher odds of low HDL-C and hPDI were associated with 25% lower odds of high LDL-C. However, Neither PDI nor hPDI was significantly associated with the prevalence of dyslipidemia. Greater adherence to unhealthful plant-based diets was associated with greater odds of the dyslipidemia and its components suggesting the importance of the quality of plant-based diet in South Korean adults for dyslipidemia prevention.

Download Full-text

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192400802010052 ◽

2008 ◽

Vol 2 (1) ◽

pp. 52-59 ◽

Cited By ~ 1

Author(s):

Stavroulla Xenophontos ◽

Marilena Hadjivassiliou ◽

Alexandros Karagrigoriou ◽

Nafsika Demetriou ◽

George Miltiadous ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lipoprotein Cholesterol ◽

Greek Cypriot ◽

Low Hdl ◽

First Time ◽

Control Study

This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI.

Download Full-text

Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-β Transport: A Population-Based Cross-Sectional Study

Journal of Alzheimer s Disease ◽

10.3233/jad-210405 ◽

2021 ◽

pp. 1-12

Author(s):

Shan Wei, ◽

Suhang Shang ◽

Liangjun Dang ◽

Fan Gao ◽

Yao Gao ◽

...

Keyword(s):

High Density Lipoprotein ◽

Amyloid Β ◽

Density Lipoprotein ◽

Underlying Mechanism ◽

Population Based ◽

High Density ◽

Soluble Form ◽

Cross Sectional ◽

Low Hdl ◽

Positive Correlations

Background: Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. Objective: The aim was to investigate the effects of lipids on the relationships between plasma Aβ and transporter levels. Methods: This study included 1,436 adults aged 40 to 88 years old. Blood Aβ, sLRP1, sRAGE, and lipid levels were measured. Univariate and multivariate analyses were used to analyze the relationships between lipids and plasma Aβ, sLRP1, and sRAGE. Results: After adjusting for all possible covariates, high-density lipoprotein (HDL-c) was positively associated with plasma Aβ 42 and sRAGE (β= 6.158, p = 0.049; β= 121.156, p < 0.001, respectively), while triglyceride (TG) was negatively associated with plasma Aβ 40, Aβ 42, and sRAGE (β= –48.389, p = 0.017; β= –11.142, p = 0.020; β= –147.937, p = 0.003, respectively). Additionally, positive correlations were found between plasma Aβ and sRAGE in the normal TG (Aβ 40: β= 0.034, p = 0.005; Aβ 42: β= 0.010, p = 0.001) and HDL-c groups (Aβ 40: β= 0.023, p = 0.033; Aβ 42: β= 0.008, p = 0.002) but not in the high TG and low HDL-c groups. Conclusion: Abnormal levels of TG and HDL-c are associated with decreased Aβ and sRAGE levels. Positive correlations between plasma Aβ and sRAGE were only found in the normal TG and HDL-c groups but not in the high TG and low HDL-c groups. These results indicated that dyslipidemia contributing to plasma Aβ levels might also be involved in peripheral Aβ clearance.

Download Full-text

Lipids, lipoproteins, and atherogenesis

Hyperlipidaemia ◽

10.1093/med/9780199543502.003.0002 ◽

2011 ◽

pp. 11-24

Author(s):

Joanna Gouni-Berthold ◽

Wilhelm Krone

Keyword(s):

Risk Factor ◽

High Density Lipoprotein ◽

Independent Risk Factor ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Apolipoprotein A ◽

Low Hdl ◽

Lipids And Lipoproteins

• Lipids and lipoproteins have a central role in the pathogenesis of atherosclerosis. • The concentration of low-density lipoprotein (LDL) is strongly and directly related to risk of atherosclerosis whereas high-density lipoprotein (HDL) is inversly related, low HDL being an independent risk factor. • The role of plasma triglycerides is less well defined. • The ratio of apolipoprotein B (the major apolipoprotein of LDL) to apolipoprotein A-1 (the major apolipoprotein of HDL) is emerging as the best predictor of atherosclerotic risk.

Download Full-text

High HDL-C levels reduce the risk of obstructive coronary artery disease in asymptomatic diabetics who achieved optimal glycemic control

Scientific Reports ◽

10.1038/s41598-019-51732-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Gyung-Min Park ◽

Yongjik Lee ◽

Ki-Bum Won ◽

Yu Jin Yang ◽

Sangwoo Park ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Glycemic Control ◽

Obstructive Coronary Artery Disease ◽

Density Lipoprotein ◽

Computed Tomographic Angiography ◽

Health Examination ◽

Logistic Regression Models ◽

Low Hdl ◽

Artery Disease

Abstract The benefit of a high level of high-density lipoprotein cholesterol (HDL-C) against coronary atherosclerosis risk after achieving optimal glycemic control (OGC) in diabetics remains uncertain. We aimed to evaluate the association between HDL-C and obstructive coronary artery disease (CAD) according to OGC status in diabetics. We analyzed 1,114 asymptomatic diabetics who underwent coronary computed tomographic angiography in a health examination. OGC was defined as hemoglobin A1C <7.0%. Obstructive CAD was defined as the presence of plaques with ≥50% stenosis. Patients with a high HDL-C level (≥40 mg/dL and ≥50 mg/dL in males and females, respectively) showed a lower prevalence of obstructive CAD than those with a low HDL-C level in the OGC group (8.9% vs. 14.4%; p = 0.046), but not in the non-OGC group (22.3% vs. 23.2%, p = 0.850). Multiple logistic regression models showed that the risk for obstructive CAD was lower in patients with a high HDL-C level than in those with a low HDL-C level in the OGC group (odds ratio: 0.584, 95% confidence interval: 0.343–0.995; p = 0.048), but not in the non-OGC group. In conclusion, it may be necessary to maintain a high HDL-C level to reduce the risk of obstructive CAD in asymptomatic diabetics after OGC is achieved.

Download Full-text