Abstract 305: Glycated Hemoglobin Levels Predict Arterial Stiffness nad Endothelial Dysfunction in Resistant Hypertensive Diabetic Subjects

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Beatriz M Moreno ◽  
Rodrigo Modolo ◽  
Ana Paula Faria ◽  
Natalia Barbaro ◽  
Andréa Sabbatini ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Linear Regression ◽  
Endothelial Function ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Intima Media Thickness ◽  
Glycated Haemoglobin ◽  
Vascular Stiffness ◽  
Common Finding

Introduction: Endothelial function, intima-media thickness (IMT) and vascular stiffness are variables closely associated in normotensive subjects as well as in hypertensive and diabetic (DM) patients; however this correlation has not been tested in resistant hypertensive (RHTN) individuals. It is known that DM is a very common finding in RHTN, but it is controversial whether this condition causes some incremental impairment in vascular dysfunction in these patients. Also, it is controversial if glycated haemoglobin plasma levels predict arterial abnormalities in RHTN individuals. Methods: Two hundred and six RHTN patients were divided in two groups: RHTN+DM (HBglic=7.3%, age= 58.7y, BMI= 30.8, n= 134) and RHTN-nonDM (5.5%, age= 58.3y, BMI= 30.5, n=72). Blood pressure (ABPM and office) was similar between the 2 groups (RHTN+DM= 150/87/63 and RHTN-nonDM= 151/89/62 mmHg; p> 0.05). Arterial rigidity (PWV, m/s, Sphygmocor system), endothelial function (FMD,%) and carotid IMT (mm) were assessed and parametric tests (t Student, Pearson correlation and linear regression) used analyse the data. Results (mean±SD): RHTN-DM group had higher values of PWV (12.1±1.6 vs. 10.7±1.7 m/s; p< 0.001) and lower measurements of FMD (7.3±1.8 vs. 8.2±1.9%; p<0.001); however, IMT values were found similar in the 2 groups (1.02±0.2 vs. 1.01±0.2 mm; p= 0.77). Hbglyc levels correlated with PWV (R=0.31; p<0.001) and FMD (R=-0,52; p<0,0001) only in the RHTN-DM group (RHTN-nonDM: R=0.01, p= 0.93, and R=-0.03, p=0.79, respectively). Linear regression analysis showed statistical significance between HbGlyc and PWV and e FMD only in RHTN-DM patients (p<0.05). Conclusion: DM worsened endothelial dysfunction and vascular stiffness, but not IMT, in RHTN subjects. Glycated haemoglobin is an important predictor of arterial rigidity and endothelial function in diabetic RHTN subjects.

scholarly journals Comparison of biomarkers of endothelial dysfunction and microvascular endothelial function in patients with primary aldosteronism and essential hypertension

2021 ◽  
Vol 22 (1) ◽  
pp. 147032032199949
Author(s):  
Miaomiao Sang ◽  
Yu Fu ◽  
Chenmin Wei ◽  
Jing Yang ◽  
Xueting Qiu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Primary Aldosteronism ◽  
Cardiovascular Events ◽  
Statistical Significance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Microvascular Endothelial ◽  
Pai 1 ◽  
Microvascular Endothelial Function

Introduction: Studies have shown that primary aldosteronism (PA) has a higher risk of cardiovascular events than essential hypertension (EH). Endothelial dysfunction is an independent predictor of cardiovascular events. Whether PA and EH differ in the endothelial dysfunction is uncertain. Our study was designed to investigate the levels of biomarkers of endothelial dysfunction (Asymmetric dimethylarginine, ADMA; E-selectin, and Plasminogen activator inhibitor-1, PAI-1) and assess the microvascular endothelial function in patients with PA and EH, respectively. Methods: The biomarkers of endothelial dysfunction were measured by enzyme-linked immunosorbent assay (ELISA). Microvascular endothelial function was evaluated by Pulse amplitude tonometry (PAT). Results: Thirty-one subjects with EH and 36 subjects with PA including 22 with aldosterone-producing adenoma (APA) and 14 with idiopathic hyperaldosteronism (IHA) were enrolled in our study. The ADMA levels among the three groups were different (APA 47.83 (27.50, 87.74) ng/ml vs EH 25.08 (22.44, 39.79) ng/ml vs IHA 26.00 (22.23, 33.75) ng/ml; p = 0.04), however, when the APA group was compared with EH and IHA group, there was no statistical significance (47.83 (27.50, 87.74) ng/ml vs 25.08 (22.44, 39.79) ng/ml for EH, p = 0.11; 47.83 (27.50, 87.74) ng/ml vs IHA 26.00 (33.75) ng/ml, p = 0.07). The results of ADMA levels are presented as Median (p25, p75). Whereas, levels of PAI-1 and E-selectin, microvascular endothelial function were not significantly different between PA and EH subjects. Conclusions: Our study shows no significant differences between PA and EH in terms of biomarkers of endothelial dysfunction and microvascular endothelial function. The microvascular endothelial function of PA and EH patients is comparable.

scholarly journals Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

2009 ◽  
Vol 107 (4) ◽  
pp. 1249-1257 ◽  
Author(s):  
Jae Hyung Kim ◽  
Lukasz J. Bugaj ◽  
Young Jun Oh ◽  
Trinity J. Bivalacqua ◽  
Sungwoo Ryoo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Vascular Stiffness ◽  
Arginase Activity ◽  
Young Rats ◽  
Arginase 1 ◽  
Enos Uncoupling ◽  
Old Rats

There is increasing evidence that upregulation of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-redox balance, improves endothelial function, and increases vascular compliance in old rats. Arginase activity in old rats was significantly increased compared with that shown in young rats. Old rats had significantly lower nitric oxide (NO) and higher superoxide (O2−) production than young. Acute inhibition of both NOS, with NG-nitro-l-arginine methyl ester, and arginase, with 2( S)-amino- 6-boronohexanoic acid (ABH), significantly reduced O2− production in old rats but not in young. In addition, the ratio of eNOS dimer to monomer in old rats was significantly decreased compared with that shown in young rats. These results suggest that eNOS was uncoupled in old rats. Although the expression of arginase 1 and eNOS was similar in young and old rats, inducible NOS (iNOS) was significantly upregulated. Furthermore, S-nitrosylation of arginase 1 was significantly elevated in old rats. These findings support our previously published finding that iNOS nitrosylates and activates arginase 1 (Santhanam et al., Circ Res 101: 692–702, 2007). Chronic arginase inhibition in old rats preserved eNOS dimer-to-monomer ratio and significantly reduced O2− production and enhanced endothelial-dependent vasorelaxation to ACh. In addition, ABH significantly reduced vascular stiffness in old rats. These data indicate that iNOS-dependent S-nitrosylation of arginase 1 and the increase in arginase activity lead to eNOS uncoupling, contributing to the nitroso-redox imbalance, endothelial dysfunction, and vascular stiffness observed in vascular aging. We suggest that arginase is a viable target for therapy in age-dependent vascular stiffness.

scholarly journals Analysing Enabling Factors Affecting the On-site Productivity in Indian Construction Industry

2018 ◽  
Vol 49 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Saurav Dixit
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Reliability Analysis ◽  
Construction Industry ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Research Paper ◽  
Site Productivity ◽  
Factors Affecting ◽  
Construction Productivity

The growth in construction productivity is low and do not continue for a long span of time. The purpose of the present research paper is to analyse the factors affecting on-site construction productivity in Indian construction industry. The tools used for the analysis are reliability analysis to check the consistency of the data, Pearson correlation analysis to mathematically validate the factor analysis, and linear regression analysis to propose a framework of factors affecting construction productivity. The findings of the reliability analysis concludes that the all the factors having a value of more than 0.67, which is considered to be good for the study, and the findings of the study conclude that the most significant 3 attributes grouped in linear regression analysis change in scope (R2), revision in drawings (R15), and response to change orders (R3) having maximum impact over the construction productivity. The research paper attempts to provide an insight and better understanding of the factors affecting on-site construction productivity in India and the ways and means to control and improve construction productivity of construction projects."This paper is the revised version of the paper that has been published in the proceedings of the Creative Construction Conference 2018: Dixit, S., Mandal, S. N., Thanikal, J. V, & Saurabh, K. (2018). Critical Analysis of Factors Affecting the on-site Productivity in Indian Construction Industry, (July), 38–45. https://doi.org/10.3311/CCC2018-006"

scholarly journals 3D Imaging for Hindfoot Alignment: A Comparative Study between MRI and Weight Bearing CT

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0024
Author(s):  
Anil Haldar ◽  
Alessio Bernasconi ◽  
Syed E. Junaid ◽  
Matthew J. Welck ◽  
Asif Saifuddin
Keyword(s):  
Comparative Study ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Weight Bearing ◽  
Significant Negative Correlation ◽  
Common Finding ◽  
Foot And Ankle ◽  
Calcaneofibular Ligament ◽  
Hindfoot Alignment

Category: Hindfoot; Other Introduction/Purpose: Hindfoot malalignment is a common finding in multiple foot and ankle pathologies. In clinical practice, it is usually quantified through traditional weight bearing radiographs or, more recently, through cone beam weight bearing CT (CB- WBCT), which overcomes issues related to two-dimensional imaging. Interestingly, a few studies have suggested that hindfoot alignment can also be accurately assessed using non-weight bearing magnetic resonance imaging (MRI). The purpose of this study was to compare measurements of hindfoot alignment on non-weight bearing ankle MRI and CB-WBCT and to establish if there was any correlation. Methods: In this Level III retrospective comparative study, a database review identified 51 feet in 47 patients (27 males, 20 females; mean age of 45 (range 13-79)) which had both CB-WBCT and MRI scans on the same day as part of standard care at our specialist tertiary referral Foot and Ankle Unit. Hindfoot alignment was assessed by independent Consultant Musculoskeletal specialists. The foot ankle offset (FAO), calcaneal offset (CO) and hindfoot alignment angle (HA) were assessed on CB-WBCT using dedicated software. The tibiocalcaneal angle (TCA) and calcaneofibular ligament angle (CFLA) were assessed on non-weight bearing MRI. Pearson correlation was used to evaluate the correlation between these measurements. Results: We found a statistically significant positive correlation between TCA on non-weight bearing MRI and each measurement on CB-WBCT (Pearson correlation for TCA and FAO: 0.42, p=0.003; for TCA and CO: 0.46, p=0.001; and for TCA and HA: 0.40, p=0.005).We also demonstrated a moderate-to-low negative but significant correlation between CFLA and CO (Pearson correlation: -0.35; p=0.03). Conversely, the negative correlation between CFL and FAO (Pearson correlation: -0.29; p=0.07) and CFL with HA (Pearson correlation: -0.26; p=0.11) did not reach statistical significance. Conclusion: Weight bearing three-dimensional imaging has shown high degrees of accuracy and reproducibility for hindfoot alignment. The significant correlation between TCA on non-weight bearing MRI and hindfoot alignment measurements on CB- WBCT suggests that TCA should be reported during routine ankle MRI in order to put into context some of the soft-tissue findings. The CFLA shows a less significant negative correlation.

Endothelial dysfunction is an independent factor responsible for vasospastic angina

2001 ◽  
Vol 101 (6) ◽  
pp. 707-713 ◽  
Author(s):  
Hiroki TERAGAWA ◽  
Masaya KATO ◽  
Junichi KUROKAWA ◽  
Togo YAMAGATA ◽  
Hideo MATSUURA ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Coronary Stenosis ◽  
Intima Media Thickness ◽  
Control Group ◽  
Test Results ◽  
Independent Factor ◽  
Atherosclerotic Changes ◽  
Significant Coronary Stenosis

In order to evaluate peripheral endothelial function in patients with vasospastic angina (VSA), we measured flow-mediated dilation (FMD) of the brachial artery in patients with VSA and compared it with FMD in patients without VSA. Endothelial dysfunction is considered one of the mechanisms underlying VSA. However, its exact role remains to be clarified. The study included 30 patients with positive spasm-provocational test results without evidence of significant coronary stenosis (VSA group) and 30 patients with negative spasm-provocational test results without evidence of significant coronary stenosis (control group). In each patient, brachial artery diameter responses to hyperemic flow and glyceryl trinitrate spray were measured using high-resolution ultrasound. The carotid intima-media thickness was also measured as a marker of systemic atherosclerosis. FMD was lower in the VSA group (4.8±0.5%) compared with the control group (9.4±0.7%, P < 0.0001). In the VSA group, FMD was not affected by coronary risk factors or the presence of atherosclerotic changes on coronary angiography. Glyceryl trinitrate-induced dilation did not differ between the two groups. The intima-media thickness was comparable between the VSA (0.85±0.04mm) and control groups (0.81±0.05mm). These findings indicated that peripheral endothelial function is impaired only in the VSA group, whereas the atherosclerotic changes were similar in the two groups. We conclude that endothelial dysfunction may be an independent factor responsible for the development of VSA.

scholarly journals Cephalometric Floating Norms as a Guide toward a Harmonious Individual Craniofacial Pattern among Filipinos

2009 ◽  
Vol 79 (6) ◽  
pp. 1162-1168 ◽  
Author(s):  
Marian Almyra Sevilla-Naranjilla ◽  
Ingrid Rudzki-Janson
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Standard Error ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Regression Equations ◽  
Correlated Variables ◽  
The Individual

Abstract Objective: To construct a harmony box based on correlated cephalometric variables, which may serve as a valuable diagnostic tool in orthodontic treatment planning, by analyzing the harmonious relationships of existing individual craniofacial patterns among Filipinos. Materials and Methods: Eighty-one subjects, 37 females and 44 males, were selected from the student population of a University according to established inclusion criteria. Five cephalometric angular measurements were obtained and digitized. Pearson correlation coefficients described the high association among the five variables. The bivariate linear regression analysis was used to construct a harmony box, which contained the cephalometric floating norms of the five correlated variables. Multiple regression analysis and the standard error of the estimate were calculated to construct the harmony schema, which describes the individual craniofacial pattern. Results: Correlations between the five variables were significant at .001 and .05 levels. Linear regression equations with corresponding r2 and standard error of the estimate (SE) were illustrated as the harmony box. The multiple correlation coefficient R, the adjusted R2, and the SE when one of the five measured variables was predicted from the remaining four by means of a multiple regression analysis were displayed as the harmony schema. Conclusion: The cephalometric floating norms describing the individual craniofacial pattern among Filipinos were established based on five correlated variables in the form of a harmony box.

scholarly journals The Effect of Smoking and Respiration of Carbon Monoxide among Active Smokers in Palembang, Indonesia

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Rico Januar Sitorus ◽  
Imelda Gernauli Purba ◽  
Merry Natalia ◽  
Kraichat Tantrakarnapa
Keyword(s):  
Carbon Monoxide ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
The Body ◽  
Cross Sectional ◽  
Independent Variables ◽  
Cross Sectional Design

Smoking leads to disease and disability as well as harm nearly every organ of the body. Furthermore, smoking of tobacco is known to cause pulmonary dysfunction and lead to complications, pain, or even death. This study aims to measure the risk factors for the respiration of carbon monoxide among smokers. A cross-sectional design was implemented by involving 156 smokers in Karyajaya Subdistrict, Palembang City. The dependent variable was carbon monoxide levels (ppm), while the independent variables were smoking frequency, duration, and the last period of smoking. The carbon monoxide levels (ppm) measured with a PiCO + Smokerlyzer® device from Bedfont Scientific Limited were the research tool and the independent variables of the questionnaire. The pearson Correlation and multiple linear regression were used for the analysis. The results of the multiple linear regression analysis revealed that smoking duration assessment is related to carbon monoxide respiration after controlling smoking frequency, the last period of smoking, and the distance of residence to sources of exposure. The smoker's respiration of carbon monoxide level was 72.5% influenced by the duration, frequency, last period of smoking, and distance of residence to sources of exposure. Reducing the frequency of smoking and stopping may prevent and control carbon monoxide respiration.

scholarly journals Managing risk in ski resorts: Environmental factors affecting actual and estimated speed on signposted groomed slopes in a cohort of adult recreational alpine skiers

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256349
Author(s):  
Luis Carus ◽  
Isabel Castillo
Keyword(s):  
Wind Speed ◽  
Correlation Coefficient ◽  
Environmental Conditions ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Maximum Speed ◽  
Pearson Correlation Coefficient ◽  
Ski Resorts

Background Certain weather conditions are clearly harmful, increasing the risk of injury of winter sports participants substantially. The objective of this study was to investigate actual speeds of skiers on signposted groomed slopes and to measure their skill to accurately estimate them with regard to environmental conditions such as visibility, sky cover, snow quality, wind and temperature. Methods The data were obtained from a sample of 421 adult recreational skiers taking ski courses. The Pearson correlation coefficient was used to explore the relationship between actual and estimated speed for all participants. Multiple linear regression analysis was used to measure the effect of environmental conditions on both the skiers’ actual speeds and their errors of estimation. Values of 0.05 or less were considered to indicate statistical significance. Results The Pearson correlation coefficient between estimated and actual speed was 0.90 (P < 0.001). Skiers underestimated their actual speed on average by 13.06 km/h or 24.1%. Visibility, quality of snow and wind speed were shown to significantly affect both actual maximum speed and estimated speed. Good visibility, grippy snow and calm wind were associated with both the highest actual maximum speed and the lowest ability to estimate it. Conclusion Certain environmental conditions are associated with the actual speed at which skiers travel and with their ability to estimate it. Visibility, quality of snow and wind speed seem to influence both actual speed and the ability to estimate it while sky cover and temperature do not. A reinforced understanding of skiing speed on signposted groomed slopes is useful to gain insight into crashes and the mechanisms of resulting injuries, to evaluate means of protection and to devise successful prevention policies in ski resorts.

scholarly journals Impaired endothelial function irrespective of systemic inflammation or atherosclerosis in mastoscytosis

2020 ◽  
Author(s):  
Nida Oztop ◽  
Pelin Karaca Özer ◽  
semra demir ◽  
Sengul Beyaz ◽  
Tarık Tiryaki ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Systemic Inflammation ◽  
Subclinical Atherosclerosis ◽  
Elevated Serum ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Necrosis Factor Alpha ◽  
Endothelin 1 ◽  
Tnf Α

Background: Knowledge on endothelial dysfunction and its relation to atherosclerosis in mastocytosis is limited. Aim: To investigate the endothelial function in mastocytosis by flow mediated dilatation (FMD) and biomarkers related to vascular endothelia, the presence of subclinical atherosclerosis by carotid intima media thickness (CIMT). Method: Forty-nine patients with mastocytosis and 25 healthy controls (HCs) were included. FMD and CIMT during transthoracic echocardiography, biomarkers including endocan, endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) were measured in sera of participants. Tumor necrosis factor-alpha (TNF-α), interleukine-6 (IL-6) and high sensitive c-reactive protein (hsCRP) were determined as inflammatory biomarkers. Result: The mean FMD% was lower in the patients than HCs (11.26±5.85% vs 17.84±5.27% p<0.001) and was the lowest in the advSM and SSM group among the patients (p=0.03). The median value of VEGF was significantly higher in patients than HCs. [73.30 pg/mL; min-max (32.46-295.29) pg/mL vs (46.64 pg/mL; min-max 11.09-99.86 pg/mL; p:0.001] and it was the highest in the advSM and SSM group (p:0.01). FMD was inversely correlated with endocan (r:-.390, p:0.006), ET-1 (r:-.363, p:0.01) and VEGF (r:-.402, p:0.004) but there were no correlations between FMD and TNF-α, IL-6, and hsCRP. No differences in CIMT values between patients and HCs and no correlation between CIMT and the biomarkers were observed. Conclusion: Endothelial dysfunction in mastocytosis becomes evident with decreased FMD and elevated serum VEGF, in the absence of atherosclerosis or systemic inflammation and is related to disease severity. Keywords: CIMT, Endocan, Endothelial function, Endothelin-1, FMD, VEGF

scholarly journals Usability Evaluation of Android-Based Lecturer Research Publication Reporting System

2020 ◽  
Vol 4 (1) ◽  
pp. 123-134
Author(s):  
Fransiskus Panca Juniawan ◽  
Laurentinus ◽  
Dwi Yuny Sylfania
Keyword(s):  
Linear Regression ◽  
Reporting System ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Test Method ◽  
Simple Linear Regression ◽  
Research Publication ◽  
Research Section ◽  
Total Correlation ◽  
Regression Test

The research publication reporting system of the STMIK Atma Luhur lecturer is an android-based system used by the STMIK Atma Luhur lecturer to report their research publications to the LPPM Research Section. To find out whether the system used is running well, an evaluation is carried out. The evaluation focuses on the value of Usability which consists of five categories as independent variables, namely Efficiency (X1); Learnability (X2); Satisfaction (X3); Errors (X4); and Memorability (X5). In addition, the dependent variable is Overall Impression Usability (Y). We used 37 lecturers as respondents. The test method used is a validation test consisting of a correlation test and a reliability test; simple linear regression analysis test, and the comparison of the Significance value with the Alpha value used is 0.05. The tests conducted using SPSS version 25. From the validity test conducted, taken from the value of Pearson Correlation and Corrected Item - Total Correlation values ​​that have values ​​above 0.05 and the results are that all variables have values ​​above 0.05. From the reliability testing, all questions proved to be reliable from one to another according to Cronbach’s Alpha values ​​above 0.60. From the simple linear regression test, the results show that the Efficiency (X1), Learnability (X2), Satisfaction (X3), and Memorability (X5) variables have a significant effect on Overall Impression (Y). In addition, the Errors (X4) variable does not have a significant effect on the Overall Impressions (Y) variable.

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