scholarly journals Average Lifespan Shortened due to Stroke in Canada

Stroke ◽  
2021 ◽  
Author(s):  
Truong-Minh Pham ◽  
Nguyen Xuan Thanh ◽  
Tracy Wasylak ◽  
Michael D. Hill ◽  
Thomas Jeerakathil ◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Premature Mortality ◽  
Temporal Changes ◽  
World Health ◽  
Mortality Data ◽  
Years Of Life Lost ◽  
Modest Improvement ◽  
Average Lifespan ◽  
Canadian Population ◽  
The World

Background and Purpose: There are challenges in comparability when using existing life lost measures to examine long-term trends in premature mortality. To address this important issue, we have developed a novel measure termed average lifespan shortened (ALSS). In the present study, we used the ALSS measure to describe temporal changes in premature mortality due to stroke in the Canadian population from 1990 to 2015. Methods: Mortality data for stroke were obtained from the World Health Organization mortality database. Years of life lost was calculated using Canadian life tables. ALSS was calculated as the ratio of years of life lost in relation to the expected lifespan. Results: Over a 25-year timeframe, the age-standardized rates adjusted to the World Standard Population for deaths from all strokes and stroke types substantially decreased in both sexes. The ALSS measure indicated that men who died of stroke lost 12.1% of their lifespan in 1990 and 11.4% in 2015, whereas these values among women were 11.1% and 10.0%, respectively. Patients with subarachnoid hemorrhagic stroke lost the largest portion whereby both sexes lost about one-third of their lifespan in 1990 and one-fourth in 2015. Men with intracerebral hemorrhagic stroke lost around 18% of their lifespan in 1990 and 14% in 2015 as compared to women who lost about 16% and 12% over the same timeframe. The loss of lifespan for patients with ischemic stroke and other stroke types combined was relatively stable at about 10% throughout the study period. Conclusions: Our study demonstrated a modest improvement in lifespan among patients with stroke in Canada between 1990 and 2015. Our novel ALSS measure provides intuitive interpretation of temporal changes in lifespan among patients with stroke and helps to enhance our understanding of the burden of strokes in the Canadian population.

scholarly journals Premature Mortality Due to Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, and Leukemia in Canada: A Nationwide Analysis From 1980 to 2015

2020 ◽  
Vol 190 (1) ◽  
pp. 59-75 ◽  
Author(s):  
Truong-Minh Pham ◽  
Grace Shen-Tu ◽  
Khanh Hoa Nguyen ◽  
Shuang Lu ◽  
Douglas C Dover ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Life Span ◽  
Hodgkin Lymphoma ◽  
Premature Mortality ◽  
World Health ◽  
Mortality Data ◽  
Years Of Life Lost ◽  
Average Life Span ◽  
Non Hodgkin Lymphoma ◽  
Hematological Cancers

Abstract Recently, we introduced a novel measure of “average life span shortened” (ALSS) to improve comparability of premature mortality over time. In this study, we applied this novel measure to examine trends in premature mortality caused by hematological cancers in Canada from 1980 to 2015. Mortality data for Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, and leukemia were obtained from the World Health Organization mortality database. Years of life lost was calculated according to Canadian life tables. ALSS was defined as the ratio between years of life lost and expected life span. Over the study period, age-standardized rates of mortality decreased for all types of hematological cancers. Our new ALSS measure showed favorable trends in premature mortality for all types of hematological cancers among both sexes. For instance, men with non-Hodgkin lymphoma lost an average of 23.7% of their life span in 1980 versus 16.1% in 2015, while women with non-Hodgkin lymphoma lost an average of 21.7% of their life span in 1980 versus 15.5% in 2015. Results from this study showed that patients with hematological cancers experienced prolonged survival over a 35-year period although the magnitude of these life span gains varied by types of hematological cancers.

scholarly journals Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January–August 2020

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Maider Pagola Ugarte ◽  
Souzana Achilleos ◽  
Annalisa Quattrocchi ◽  
John Gabel ◽  
Ourania Kolokotroni ◽  
...  
Keyword(s):  
Age Groups ◽  
Premature Mortality ◽  
The United States ◽  
Cape Verde ◽  
Years Of Life Lost ◽  
Demographic Groups ◽  
The World ◽  
The Usa ◽  
Research Consortium ◽  
The Impact

Abstract Background Understanding the impact of the burden of COVID-19 is key to successfully navigating the COVID-19 pandemic. As part of a larger investigation on COVID-19 mortality impact, this study aims to estimate the Potential Years of Life Lost (PYLL) in 17 countries and territories across the world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, and the United States [USA]). Methods Age- and sex-specific COVID-19 death numbers from primary national sources were collected by an international research consortium. The study period was established based on the availability of data from the inception of the pandemic to the end of August 2020. The PYLL for each country were computed using 80 years as the maximum life expectancy. Results As of August 2020, 442,677 (range: 18–185,083) deaths attributed to COVID-19 were recorded in 17 countries which translated to 4,210,654 (range: 112–1,554,225) PYLL. The average PYLL per death was 8.7 years, with substantial variation ranging from 2.7 years in Australia to 19.3 PYLL in Ukraine. North and South American countries as well as England & Wales, Scotland and Sweden experienced the highest PYLL per 100,000 population; whereas Australia, Slovenia and Georgia experienced the lowest. Overall, males experienced higher PYLL rate and higher PYLL per death than females. In most countries, most of the PYLL were observed for people aged over 60 or 65 years, irrespective of sex. Yet, Brazil, Cape Verde, Colombia, Israel, Peru, Scotland, Ukraine, and the USA concentrated most PYLL in younger age groups. Conclusions Our results highlight the role of PYLL as a tool to understand the impact of COVID-19 on demographic groups within and across countries, guiding preventive measures to protect these groups under the ongoing pandemic. Continuous monitoring of PYLL is therefore needed to better understand the burden of COVID-19 in terms of premature mortality.

Antidepressants

2012 ◽  
pp. 1185-1198
Author(s):  
Zubin Bhagwagar ◽  
George R. Heninger
Keyword(s):  
Burden Of Disease ◽  
Antidepressant Drugs ◽  
Public Health Problem ◽  
Premature Mortality ◽  
Primary Treatment ◽  
World Health ◽  
Years Of Life Lost ◽  
Major Public Health Problem ◽  
Treatment Of Depression ◽  
Health Organization

Major depressive disorder is a serious, recurrent illness which levies a crippling toll on individuals, families, and society in general. The importance of depression as a major public health problem is emphasized by findings from the World Health Organization Global Burden of Disease survey in showing that in 1990 it was the fourth largest cause of burden of disease (i.e. years of life lost due either to premature mortality or to years lived with a disability). It has been estimated that by the year 2020 it is expected to be the second largest cause of burden of disease. Depression is underdiagnosed and frequently under-treated, and depressed individuals have a much higher risk for suicide. The primary treatment for depression involves the use of antidepressant drugs, and it is therefore important that clinicians become familiar with and adept in utilizing this important group of compounds. Although primarily used for the treatment of depression, drugs within this category also have a number of other important uses. A thorough understanding of the pharmacology of antidepressants will aid the clinician in the selective use of these drugs for patients with depression as well as patients with a number of other disorders.

The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database

2019 ◽  
Vol 78 (6) ◽  
pp. 844-848 ◽  
Author(s):  
Eden Sebbag ◽  
Renaud Felten ◽  
Flora Sagez ◽  
Jean Sibilia ◽  
Hervé Devilliers ◽  
...  
Keyword(s):  
Musculoskeletal Diseases ◽  
World Health ◽  
Years Of Life Lost ◽  
Future Health ◽  
Systematic Analysis ◽  
Median Proportion ◽  
Life Years ◽  
The World ◽  
Icd 10 ◽  
Health Organization

BackgroundMusculoskeletal (MSK) diseases are expected to have a growing impact worldwide.ObjectiveTo analyse the worldwide burden of MSK diseases from 2000 to 2015.MethodsDisability-adjusted life years (DALYs), which combines the years of life lost (YLLs) and the years lived with disability (YLDs), were extracted for 183 countries from the WHO Global Health Estimates Database. We analysed the median proportion of DALYS, YLLs and YLDs for MSK diseases (ICD-10: M00–M99) among the 23 WHO categories of diseases. Mixed models were built to assess temporal changes.ResultsWorldwide, the total number of MSK DALYs increased significantly from 80,225,634.6 in 2000 to 107,885,832.6 in 2015 (p < 0.001), with the total number of MSK YLDs increasing from 77,377,709.4 to 103,817,908.4 (p = 0.0008) and MSK diseases being the second cause of YLDs worldwide. YLLs due to MSK diseases increased from 2,847,925.2 to 4,067,924.2 (p = 0.03). In 2015, the median proportion of DALYs attributed to MSK diseases was 6.66% (IQR: 5.30 – 7.88) in Europe versus 4.66% (3.98 – 5.59) in the Americas (p < 0.0001 vs Europe), 4.17% (3.14 – 6.25) in Asia (p < 0.0001), 4.14% (2.65 – 5.57) in Oceania (p = 0.0008) and 1.33% (1.03 – 1.92) in Africa (p < 0.0001). We observed a significant correlation (r = 0.85, p < 0.0001) between the proportion of MSK DALYs and the gross domestic product per capita for the year 2015.ConclusionsThe burden of MSK diseases increased significantly between 2000 and 2015 and is high in Europe. These results are crucial to health professionals and policy makers to implement future health plan adjustments for MSK diseases.

Trends in lung cancer mortality between 2001 and 2017: An observational study in USA and EU.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19277-e19277
Author(s):  
Chinmay Jani ◽  
Dominic C Marshall ◽  
Harpreet Singh ◽  
Joseph Shalhoub ◽  
Justin Salciccioli
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
World Health ◽  
Mortality Data ◽  
Male Mortality ◽  
Standard Population ◽  
The World ◽  
Males And Females ◽  
The Eu

e19277 Background: The lung is the commonest site of cancer and has the highest worldwide cancer-related mortality. Past two decades has seen advancements in screening technologies and guidelines, as well as new modalities for treatment. Few studies have reported on lung cancer trends in the 21st century. Our study reports and compares trends in lung cancer mortality in the USA and European Union (EU). Methods: We utilized the World Health Organization (WHO) Mortality Database and Center for Disease Control (CDC) Wonder database. We extracted Lung Cancer mortality data from 2001 to 2017 based on ICD 10 system. Crude mortality rates were dichotomized by sex and reported by year. We computed Age Standardized Death Rates (ASDRs) per 100,000 population using the World Standard Population and USA Standard Population. Lung cancer mortality trends were compared using Joinpoint regression analysis. Results: We analyzed a data from a total of 26 EU countries and USA, of which 6 countries had data till 2017, 12 till 2016, 7 till 2015 and 2 till 2014. We observed that mortality in men was down-trending in all countries except Cyprus and Portugal. In females, there was an increase in mortality in 22 countries. Amongst EU nations, most recently (2017) Hungary had the highest ASDRs for both males and females (64.5/100,000 and 31.0/100,000), whereas the lowest mortality was in Sweden for males (17.3/100,000) and Lithuania for the females (7.58/100,000). Latvia had the highest Estimated Annual Percentage Change (EAPC) in male mortality (-9.6%). Based on recent most data, we saw that there was a significantly lower mortality in males amongst European nations that joined the EU pre-2004 as compared to those that joined the EU post-2004 (p = 0.006). In USA, ASDRs in males and females were 44.3/100,000 and 30.6/100,000, respectively, with EAPC of -5.1% and -4.2% in males and females, respectively. Conclusions: For the study period, we observed expected decrease in lung cancer mortality in males. In contrast, there was a gradual rising trend in lung cancer mortality amongst females. In addition, there was substantial variation between nations. USA has shown consistent downtrend since 2001 where as there have been fluctuations in trends in other EU nations.

scholarly journals EDUCATION IN THE DIGITAL AGE

2020 ◽  
Vol 4 (1) ◽  
pp. 225-230
Author(s):  
Elena Mădălina SAVU
Keyword(s):  
Online Learning ◽  
Civic Participation ◽  
Premature Mortality ◽  
Digital Age ◽  
Well Being ◽  
World Health ◽  
Academic Learning ◽  
Developmental Potential ◽  
The World ◽  
Health Organization

The World Health Organization has declared Covid-19 as a pandemic that has posed a contemporary threat to humanity. This pandemic has successfully forced global shutdown of several activities, including educational activities.The COVID-19 pandemic was a forceful reminder that education plays an important role in delivering not just academic learning, but also in supporting physical and emotional well-being. Education and the acquisition of skills are crucial to solving some of the world’s most pressing problems. Education is a basic right that promotes other rights such as health and civic participation. It is key to unlocking the developmental potential of children, communities, and countries. An educated workforce can help lift people out of poverty, reduce premature mortality, strengthen gender equality, and promote civic participation. Children must also learn skills that can be flexible and adaptable in the age of uncertainty and economic change. Workers will need breadth of skills such as literacy and numeracy as well as the ability to think critically and to solve problems collaboratively. In the digital age, citizens must be prepared to respond to the challenges presented by globalization, climate change, health epidemics, and economic uncertainty. The world needs to urgently rethink the way education is done, how it is delivered, and what skills children will need in a digital age to become healthy and productive members of society. Many agree that the delivery of education to marginalized children must be improved. It is evident that online learning is different from emergency remote teaching, online learning will be more sustainable while instructional activities will become more hybrid provided the challenges experienced during this pandemic are well explored and transformed to opportunities. However, there is little consensus on how to do so in a way that best reflects the challenges and opportunities facing young people today and on why education systems have largely failed to adapt to ensure that all children are receiving the support and learning opportunities they need.

scholarly journals Microscopic Examination Of Postcapillary Cerebral Venues In Hemorrhagic Stroke

2021 ◽  
Vol 03 (08) ◽  
pp. 69-73
Author(s):  
Khaidarov Nodir Kadyrovich ◽  
◽  
Shomurodov Kahramon Erkinovich ◽  
Kamalova Malika Ilhomovna ◽  
◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Surgical Intervention ◽  
Neurological Complications ◽  
World Health ◽  
Timely Manner ◽  
Global Response ◽  
Adequate Treatment ◽  
The World ◽  
Circulatory Disorders ◽  
Health Organization

Hemorrhagic stroke among acute cerebral circulatory disorders is characterized by severe neurological complications and the need to choose between surgical intervention or therapeutic therapy. According to the World Health Organization (WHO)". Globally, stroke deaths will reach 7.8 million by 2030 unless an aggressive global response to the epidemic is put in place" 1. Subarachnoid haemorrhage, which accounts for half of the non-traumatic intracerebral haemorrhage, affects the most active and able-bodied population. The most important medical and social objectives are to monitor the course of the disease from the first hours after the onset of stroke, to prescribe adequate treatment in a timely manner, and to reduce mortality and disability rates [5,9].

scholarly journals Global Public Health Guidelines on Physical Activity and Sedentary Behavior for People Living With Chronic Conditions: A Call to Action

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Paddy C. Dempsey ◽  
Christine M. Friedenreich ◽  
Michael F. Leitzmann ◽  
Matthew P. Buman ◽  
Estelle Lambert ◽  
...  
Keyword(s):  
Public Health ◽  
Physical Activity ◽  
World Health Organization ◽  
Sedentary Behavior ◽  
Chronic Conditions ◽  
Premature Mortality ◽  
World Health ◽  
Global Public Health ◽  
The World ◽  
Health Organization

Background: In 2020, the World Health Organization (WHO) released global guidelines on physical activity (PA) and sedentary behavior, for the first time providing population-based recommendations for people living with selected chronic conditions. This article briefly presents the guidelines, related processes and evidence, and, importantly, considers how they may be used to support research, practice, and policy. Methods: A brief overview of the scope, agreed methods, selected chronic conditions (adults living with cancer, hypertension, type 2 diabetes, and human immunodeficiency virus), and appraisal of systematic review evidence on PA/sedentary behavior is provided. Methods were consistent with World Health Organization protocols for developing guidelines. Results: Moderate to high certainty evidence (varying by chronic condition and outcome examined) supported that PA can reduce the risk of disease progression or premature mortality and improve physical function and quality of life in adults living with chronic conditions. Direct evidence on sedentary behavior was lacking; however, evidence extrapolated from adult populations was considered applicable, safe, and likely beneficial (low certainty due to indirectness). Conclusions: Clinical and public health professionals and policy makers should promote the World Health Organization 2020 global guidelines and develop and implement services and programs to increase PA and limit sedentary behavior in adults living with chronic conditions.

scholarly journals Leukemia mortality in children from Latin America: Trends and predictions to 2030

2020 ◽  
Author(s):  
J. Smith Torres-Roman ◽  
Bryan Valcarcel ◽  
Pedro Guerra-Canchari ◽  
Camila Alves Dos Santos ◽  
Isabelle Ribeiro Barbosa ◽  
...  
Keyword(s):  
Latin American ◽  
Mortality Rates ◽  
World Health ◽  
Mortality Data ◽  
Mortality Trends ◽  
Annual Percent Change ◽  
Universal Healthcare ◽  
The World ◽  
Health Organization ◽  
Universal Healthcare Coverage

Abstract Background: Reports suggest that Latin American and Caribbean (LAC) countries have not reduced in leukemia mortality compared to high-income countries. However, updated trends remain largely unknown in the region. Given that leukemia is the leading cause of cancer-related death in LAC children, we evaluated mortality trends in children (0-14y) from 15 LAC countries for the period 2000-2017 and predicted mortality to 2030.Methods: We retrieved cancer mortality data using the World Health Organization Mortality Database. Mortality rates (standardized to the world standard SEGI population) were analyzed for 15 LAC countries. We evaluated the average mortality rates for the last 5 years (2013-2017). Joinpoint regression analysis was used to evaluate leukemia mortality trends and provide an estimated annual percent change (EAPC). Nordpred was utilized for the calculation of predictions until 2030.Results: Between 2013 and 2017, the highest mortality rates were reported in Venezuela, Ecuador, Nicaragua, Mexico, and Peru. Upward mortality trends were reported in Nicaragua (EAPC by 2.9% in boys, and EAPC by 2.0% in girls), and Peru (EAPC by 1.4% in both sexes). Puerto Rico experienced large declines in mortality among both boys (EAPC by −9.7%), and girls (EAPC by −6.0%). Leukemia mortality will increase in Argentina, Ecuador, Guatemala, Panama, Peru, and Uruguay by 2030.Conclusion: Leukemia mortality is predicted to increase in some LAC countries by 2030. Interventions to prevent this outcome should be tailor to reduce the socioeconomic inequalities and ensure universal healthcare coverage.

scholarly journals Diabetes mellitus mortality in a municipality in the state of São Paulo, 2010 to 2014

2019 ◽  
Vol 53 ◽  
pp. 24 ◽  
Author(s):  
Rafael Aparecido Dias Lima ◽  
Plinio Tadeu Istilli ◽  
Carla Regina De Souza Teixeira ◽  
Maria Lúcia Zanetti ◽  
Maria Tereza Da Costa Gonçalves Torquato
Keyword(s):  
Diabetes Mellitus ◽  
Premature Mortality ◽  
Mortality Rates ◽  
Sao Paulo ◽  
The State ◽  
World Health ◽  
Years Of Life Lost ◽  
Local Health ◽  
Age Group ◽  
São Paulo

OBJECTIVE: To describe diabetes mellitus mortality according to sex and age in a municipality in the state of São Paulo, in the period ranging from 2010 to 2014. METHODS: This was a temporal series ecological study carried out in Ribeirão Preto, state of São Paulo. The data was comprised of information on 583 deaths of Ribeirão Preto residents – regardless of the place of death – from 2010 to 2014. The data source was the electronic system of the Epidemiological Surveillance of the Municipal Health Department of the evaluated municipality. Sex, age group, premature death and year of death were chosen as variables. Subsequently, age-standardized mortality rates were calculated using the World Health Organization’s standard population, in addition to total and average per death potential years of life lost. RESULTS: Mortality due to diabetes mellitus in the municipality increased during the studied period. There was a higher occurrence of female deaths, especially in the ≥ 80 years age group. The highest rates of age-standardized mortality were male. For both sexes, there was an annual mean increase of 9% in premature mortality during the studied period. Diabetes decreased life expectancy by 10 years. CONCLUSIONS: As a diagnosis of local health care, the significant increase in agestandardized mortality rates, premature mortality and potential years of life lost in the studied municipality point to the need for improvements in health promotion and disease prevention measures. It is our hope that the results presented in this study contribute to the monitoring of mortality rates in the coming years.

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