Synthesis, Characterization and Cell Compatibility of Novel Poly(ester urethane)s Based on Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Prepared by Melting Polymerization

2009 ◽  
Vol 20 (10) ◽  
pp. 1451-1471 ◽  
Author(s):  
Zhifei Chen ◽  
Shaoting Cheng ◽  
Zibiao Li ◽  
Kaitian Xu ◽  
Guo-Qiang Chen
Keyword(s):  
Cell Compatibility

scholarly journals Characteristics of Biodegradable Gelatin Methacrylate Hydrogel Designed to Improve Osteoinduction and Effect of Additional Binding of Tannic Acid on Hydrogel

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2535
Author(s):  
Ji-Bong Choi ◽  
Yu-Kyoung Kim ◽  
Seon-Mi Byeon ◽  
Jung-Eun Park ◽  
Tae-Sung Bae ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Water Absorption ◽  
Tannic Acid ◽  
Absorption Capacity ◽  
Animal Testing ◽  
High Concentration ◽  
Cell Compatibility ◽  
Property Evaluation ◽  
Bone Minerals ◽  
Cell Adhesion And Proliferation

In this study, a hydrogel using single and double crosslinking was prepared using GelMA, a natural polymer, and the effect was evaluated when the double crosslinked hydrogel and tannic acid were treated. The resulting hydrogel was subjected to physicochemical property evaluation, biocompatibility evaluation, and animal testing. The free radicals generated through APS/TEMED have a scaffold form with a porous structure in the hydrogel, and have a more stable structure through photo crosslinking. The double crosslinked hydrogel had improved mechanical strength and better results in cell compatibility tests than the single crosslinked group. Moreover, in the hydrogel transplanted into the femur of a rat, the double crosslinked group showed an osteoinductive response due to the attachment of bone minerals after 4 and 8 weeks, but the single crosslinked group did not show an osteoinductive response due to rapid degradation. Treatment with a high concentration of tannic acid showed significantly improved mechanical strength through H-bonding. However, cell adhesion and proliferation were limited compared to the untreated group due to the limitation of water absorption capacity, and no osteoinduction reaction was observed. As a result, it was confirmed that the treatment of high-concentration tannic acid significantly improved mechanical strength, but it was not a suitable method for improving bone induction due to the limitation of water absorption.

scholarly journals In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis

2007 ◽  
Vol 61 (2) ◽  
pp. 332-340 ◽  
Author(s):  
M. C. Haerdi-Landerer ◽  
M. M. Suter ◽  
A. Steiner ◽  
M. M. Wittenbrink ◽  
A. Pickl ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Septic Arthritis ◽  
Cell Compatibility

Antibacterial performance of Berberine loaded carrageenan/konjac glucomannan hydrogels

2021 ◽  
Vol 11 (9) ◽  
pp. 1516-1522
Author(s):  
Lei Jiang ◽  
Qiuxian Chen ◽  
Jia Liu ◽  
Zhongjie Zhu ◽  
Wei Shao
Keyword(s):  
Antibacterial Effect ◽  
Three Dimensional ◽  
Konjac Glucomannan ◽  
High Porosity ◽  
Release Behavior ◽  
Cell Compatibility ◽  
Antibacterial Materials ◽  
Antibacterial Performance ◽  
Dimensional Network ◽  
Good Cell

Carrageenan and konjac glucomannan are non-toxic polysaccharides which have been widely applied in the biomedical fields. Berberine as the antibacterial agent was successfully loaded into carrageenan/konjac glucomannan hydrogels. The Berberine loaded carrageenan/konjac glucomannan dried hydrogels display three-dimensional network structure, good swelling behavior and high porosity. These dried hydrogels also show controlled release behavior of Berberine. A good antibacterial effect towards S. aureus and C. albicans with good cell compatibility is exhibited. Thus, the fabricated Berberine loaded carrageenan/konjac glucomannan dried hydrogels could be considered as novel antibiotic alternative antibacterial materials.

Advances in Biodegradable Vascular Stent Materials

2020 ◽  
Vol 987 ◽  
pp. 93-98
Author(s):  
Jun Yan Liu ◽  
Jin Guo Wang ◽  
Yun Hai Yu ◽  
Na Wang
Keyword(s):  
Cell Growth ◽  
Blood Vessels ◽  
Human Blood ◽  
Blood Compatibility ◽  
Clinical Treatment ◽  
Vascular Stent ◽  
Cell Compatibility ◽  
Good Biocompatibility ◽  
Materials Used ◽  
Over Time

Biodegradable vascular stent is mainly made of materials that can be naturally decomposed. After implantation into human blood vessels, the vascular stent can be continuously degraded over time and eventually disappear completely after the treated blood vessels are healed and support from the vascular stent is not needed. The vascular stent materials used in clinic should have good biocompatibility, which mainly involves blood compatibility and cell compatibility. In terms of cell compatibility, the influence of materials on cell growth should be observed. The various biological materials should have good anticoagulant character, so as to reduce the tendency of thrombosis and avoid the occurrence of various risk events in clinical treatment.

Endothelial cell compatibility of clarithromycin for intravenous use

1998 ◽  
Vol 31 (8) ◽  
pp. 653-656 ◽  
Author(s):  
Harald Vorbach ◽  
Guenter Weigel ◽  
Bruno RobibaroO ◽  
Christine Armbruster ◽  
Reiner Schaumann ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Compatibility

scholarly journals Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3665 ◽  
Author(s):  
Haiyan Long ◽  
Kunlong Ma ◽  
Zhenghua Xiao ◽  
Xiaomei Ren ◽  
Gang Yang
Keyword(s):  
Cell Proliferation ◽  
Water Absorption ◽  
Crosslinking Agent ◽  
Microbial Transglutaminase ◽  
High Porosity ◽  
Cell Compatibility ◽  
High Viability ◽  
Good Biocompatibility ◽  
The Stability

Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges were assessed via hydrolysis and enzymolysis. To study the material degradation in vivo, subcutaneous implantations of sponges were performed on rats for 1–3 months, and the implanted sponges were analyzed. To evaluate the cell compatibility of the mTG crosslinked gelatin sponges (mTG sponges), adipose-derived stromal stem cells were cultured and inoculated into the scaffold. Cell proliferation and viability were measured using alamarBlue assay and LIVE/DEAD fluorescence staining, respectively. Cell adhesion on the sponges was observed by scanning electron microscopy (SEM). Results show that mTG sponges have uniform pore size, high porosity and water absorption, and good mechanical properties. In subcutaneous implantation, the material was partially degraded in the first month and completely absorbed in the third month. Cell experiments showed evident cell proliferation and high viability. Results also showed that the cells grew vigorously and adhered tightly to the sponge. In conclusion, mTG sponge has good biocompatibility and can be used in tissue engineering and regenerative medicine.

scholarly journals Generation of Biocompatible Titanium Alloy Surfaces Including Calcium and Phosphorus Elements by Laser-Induced Mist Spraying Wet Treatment

2020 ◽  
Vol 14 (4) ◽  
pp. 575-581
Author(s):  
Atsushi Ezura ◽  
Kazutoshi Katahira ◽  
Jun Komotori ◽  
◽  
◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Laser Irradiation ◽  
Hard Tissue ◽  
Complicated Shape ◽  
Osteoblast Cells ◽  
Cell Compatibility ◽  
P Elements ◽  
Test Pieces ◽  
Modified Surface ◽  
Contact Part

Titanium alloys are widely used for the hard tissue substitute implants. However, it is necessary to improve interfacial biocompatibility to reduce adhesion period. For improvement of biocompatibility of Ti-6Al-4V ELI alloys, texture and chemical composition on contact part with biological tissue play very important roles. In this research, micro texture was generated on the Ti-6Al-4V ELI alloy surfaces utilizing laser irradiation, in order to improve biocompatibility. The biocompatibility was evaluated by osteoblast cell culture assays. The results indicated the surface having micro texture improve biocompatibility as compared with untreated surface. This was considered in order the fact that the formed modified surface had hydrophilicity, thereby improving the cell compatibility, and the cell adhesion due to the complicated shape. In addition, mist of glycerophosphoric acid calcium aqueous solution was applied on the laser irradiated area. As result, micro texture including Ca and P elements was generated on the Ti-6Al-4V ELI alloy surfaces. When laser was irradiated, glycerophosphoric acid calcium aqueous solution was applied as mist flowed on the test pieces as droplet. The velocity of droplet fluid was relatively fast, so that laser irradiation was unhindered access to the surface of test pieces and the treatment was stable. In order to estimate biocompatibility, culture assays using osteoblast cells were conducted on the treated surface having micro texture including Ca and P elements. As results, it was clearly that biocompatibility of the specimen treated by laser with glycerophosphoric acid calcium aqueous solution mist more improved than either untreated specimen or treated specimen soaked in glycerophosphoric acid calcium aqueous solution.

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