Perturbations of the climate system caused by El Niño and La Niña events affect natural and managed systems in vast areas of the Pacific Ocean and far beyond it. (Other oscillations affect systems and sectors in wide swaths of the world as well.)1 El Niño–Southern Oscillation (ENSO) events have been associated with ecosystem disruptions and forest fires, crop failures and famines, disease epidemics, and even market fluctuations in various regions. The forms and degrees of impact depend not only on the strength and duration of an El Niño or La Niña event and its associated teleconnections, but also on the state, sensitivity, and vulnerability of the affected system and its biotic community, as well as its human population. The underlying characteristics of ecosystems and human societies in each region are important factors in their susceptibility to ENSO-related damages. Variation may be enhanced as ENSO effects ripple through natural and managed ecosystems. The underlying health of the affected biota, interrelationships among different biotic associations, and pressure by humans all affect marine as well as terrestrial ecosystem responses to ENSO events. Impacts on human systems can be both direct and indirect. Some ENSO phenomena, such as severe storms, affect human lives and infrastructures directly. Other impacts occur through alterations in the marine and terrestrial ecosystems and water supplies upon which human populations ultimately depend. In this chapter we consider some of the impacts that ENSO and other oscillations (described with their teleconnections in chapter 1) have on marine and terrestrial ecosystems and on human-managed systems apart from agriculture. The significant and geographically widespread changes that El Niño events induce in the Pacific Ocean alter conditions for various marine communities. These alterations include dramatic changes in the abundance and distribution of organisms, associated collapses of commercial fisheries, and ensuing consequences affecting human livelihood (Glantz, 2004; Lehodey et al., 2006). Some of the effects are well documented. Reductions in primary production of up to 95% were measured in the eastern equatorial Pacific in 1982–83 (Barber and Chavez, 1983.) Large changes in ecosystem structure and productivity have also been recorded in other parts of the Pacific Ocean, including the western Pacific and in the North Pacific subtropical gyre (north of the Hawaiian Islands) (Karl et al., 1995).