The Public Debate about Animal Experimentation

1995 ◽  
Vol 23 (3) ◽  
pp. 312-316
Author(s):  
Mark Matfield
Keyword(s):  
Public Attitudes ◽  
Animal Experimentation ◽  
Second Phase ◽  
The Public ◽  
The Third ◽  
Third Phase ◽  
The Three Rs ◽  
Part Model

The nature of campaigning against animal experimentation and its effects on public opinion and laboratory animal welfare are examined. A three-part model is proposed in which the activities of campaigning groups form the motivation phase which, in some circumstances, can produce the second phase: change of public attitudes. This leads to the third phase: making the change, in which the animal researchers, technicians and veterinarians change their practice. The role of organisations promoting the Three Rs is incorporated by viewing their role as catalysing the progression through the three phases. Some of the consequences of this model for the development of in vitro alternatives are examined.

Role of magnesium in contraction of glycerinated muscle fibers

1964 ◽  
Vol 207 (4) ◽  
pp. 800-808 ◽  
Author(s):  
Shizuo Watanabe ◽  
Tania Sargeant ◽  
Marita Angleton
Keyword(s):  
Muscle Fibers ◽  
Second Phase ◽  
Metal Chelators ◽  
The Third ◽  
Third Phase ◽  
Second Phases ◽  
Glycerinated Muscle

The first phase of the magnesium effect, the increase in tension with increasing concentration of magnesium, up to about 25 µm, is abolished by the metal chelators DCTA and EDTA, but not by EGTA. DCTA is much stronger than EDTA in abolishing this first phase. The second phase of the magnesium effect, the decrease in tension with increasing concentration of magnesium, from about 25 µm to about 1 mm, is reduced when the concentration of ATP is decreased from 5 mm to about 0.5 mm. The third phase, the increase in tension with increasing concentration of magnesium to above 1 mm, is also reduced by metal chelators. However, EGTA is the strongest and DCTA is the weakest in reducing this third phase. From these observations, it is suggested that the first and the second phases are due to Mg (probably in the form of Mg-ATP complex) and that the third phase reflects the effect of a small amount of Ca which has been well established ( J. Biochem., Tokyo 50: 236–244, 1961 and J. Biol. Chem. 234: 2764–2769, 1959).

scholarly journals Fra modmagt og kamp til velfærd. Forsamlingshuse, højskoler og idrætshaller i Sønderjylland

2004 ◽  
Vol 20 (1) ◽  
Author(s):  
Jørn Hansen
Keyword(s):  
High School ◽  
High Schools ◽  
Welfare State ◽  
Second Phase ◽  
The Third ◽  
Third Phase ◽  
Folk High School ◽  
Two Phases ◽  
The Welfare State

Idrætsfaciliteters og forsamlingshuses rolle og betydning for idrætten i Sønderjylland fra ca. år 1890 og frem.From resistance and struggle to welfare. Village halls, Folk high schools and sports halls in Southern Jutland Village halls and the gymnastics associated with them were established in the first instance as part of a cultural reaction against the attempt to extend the activities of German associations in Northern Schleswig. It is scarcely surprising, therefore, that they started in those areas with the strongest Danish affiliations close to Rødding Folk High School and the Kongeå border with, for instance, the first Danish village hall being built in Skrave. In the second phase, after the drawing up of the new border, it was important for Danish culture to get a foothold in those new areas of Southern Jutland with predominantly German affiliations, and an example of this was the construction of the Danish village hall in Jyndevad. In the third phase, when differences between those with German and those with Danish affiliations were resolved by cooperation, sports halls gradually took over the role of village halls, but there was an attempt, similar to that in the first two phases, to retain a principal of proximity in relation to the development of sport. The construction of the sports hall in Tønder is an exemplary expression of sport’s incursion into the welfare state, while the construction of the hall in Agerskov provides an example of the attempt on the part of popular forces to retain the same principal of proximity that applied to village halls.

Somatics Bodies on the Concert Stage

2020 ◽  
pp. 100-137
Author(s):  
Doran George
Keyword(s):  
New York ◽  
New York City ◽  
Real Time ◽  
York City ◽  
Second Phase ◽  
The Third ◽  
Third Phase ◽  
Relationship Of ◽  
The Relationship

This chapter looks at the relationship between Somatics training and the concert stage where its influence on dancers was increasingly evident. Focusing on New York City specifically, the chapter identifies three phases where Somatics impacted performance differently: first, as signaling the dancer’s real-time efforts to construct the dance in performance; second, as providing novel sources of movement; and third, as displaying a new standard of virtuosity. The chapter shows how in each of these phases the relationship of the choreographer to the performer shifted. In the first phase the choreographer and dancer were one and the same, processing the dance in real time, and this was seen as a radical alternative to midcentury modernist approaches in which the dancers showcased the choreographer’s vision. In the second phase, dancers deployed Somatics to demonstrate new vocabularies of movement and new ways of moving, not so much as a way to focus on dance making as to establish their unique artistic voices. In the third phase, the role of the choreographer was restored as the author of the dance, separate from the dancers, who then displayed the choreographer’s vision.

Listening for the “Still Small Voice” of Mendelssohn’s Domestic Elijah

2015 ◽  
Vol 32 (1) ◽  
pp. 40-77
Author(s):  
Peter Mercer-Taylor
Keyword(s):  
Second Phase ◽  
Divine Presence ◽  
Final Phase ◽  
Public And Private ◽  
The Public ◽  
The Third ◽  
Interpretive Approach ◽  
Will To Live ◽  
Three Phases

The notion that there might be autobiographical, or personally confessional, registers at work in Mendelssohn’s 1846 Elijah has long been established, with three interpretive approaches prevailing: the first, famously advanced by Prince Albert, compares Mendelssohn’s own artistic achievements with Elijah’s prophetic ones; the second, in Eric Werner’s dramatic formulation, discerns in the aria “It is enough” a confession of Mendelssohn’s own “weakening will to live”; the third portrays Elijah as a testimonial on Mendelssohn’s relationship to the Judaism of his birth and/or to the Christianity of his youth and adulthood. This article explores a fourth, essentially untested, interpretive approach: the possibility that Mendelssohn crafts from Elijah’s story a heartfelt affirmation of domesticity, an expression of his growing fascination with retiring to a quiet existence in the bosom of his family. The argument unfolds in three phases. In the first, the focus is on that climactic passage in Elijah’s Second Part in which God is revealed to the prophet in the “still small voice.” The turn from divine absence to divine presence is articulated through two clear and powerful recollections of music that Elijah had sung in the oratorio’s First Part, a move that has the potential to reconfigure our evaluation of his role in the public and private spheres in those earlier passages. The second phase turns to Elijah’s own brief sojourn into the domestic realm, the widow’s scene, paying particular attention to the motivations that may have underlain the substantial revisions to the scene that took place between the Birmingham premiere and the London premiere the following year. The final phase explores the possibility that the widow and her son, the “surrogate family” in the oratorio, do not disappear after the widow’s scene, but linger on as “para-characters” with crucial roles in the unfolding drama.

PENERAPAN MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR AUTOCAD SISWA KELAS X TEKNIK PEMESINAN SMK NEGERI 1 STABAT

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdul Hasan Saragih
Keyword(s):  
Positive Response ◽  
Phase 1 ◽  
First Grade ◽  
Learning Model ◽  
Second Phase ◽  
Phase 2 ◽  
Phase 3 ◽  
The Third ◽  
Third Phase ◽  
Quantum Learning

This classroom research was conducted on the autocad instructions to the first grade of mechinary class of SMK Negeri 1 Stabat aiming at : (1) improving the student’ archievementon autocad instructional to the student of mechinary architecture class of SMK Negeri 1 Stabat, (2) applying Quantum Learning Model to the students of mechinary class of SMK Negeri 1 Stabat, arising the positive response to autocad subject by applying Quantum Learning Model of the students of mechinary class of SMK Negeri 1 Stabat. The result shows that (1) by applying quantum learning model, the students’ achievement improves significantly. The improvement ofthe achievement of the 34 students is very satisfactory; on the first phase, 27 students passed (70.59%), 10 students failed (29.41%). On the second phase 27 students (79.41%) passed and 7 students (20.59%) failed. On the third phase 30 students (88.24%) passed and 4 students (11.76%) failed. The application of quantum learning model in SMK Negeri 1 Stabat proved satisfying. This was visible from the activeness of the students from phase 1 to 3. The activeness average of the students was 74.31% on phase 1,81.35% on phase 2, and 83.63% on phase 3. (3) The application of the quantum learning model on teaching autocad was very positively welcome by the students of mechinary class of SMK Negeri 1 Stabat. On phase 1 the improvement was 81.53% . It improved to 86.15% on phase 3. Therefore, The improvement ofstudent’ response can be categorized good.

Mixed-Methods Evaluation as Scaffold to the Development of a Mobile Health Application to Support the Prescription of Wheelchairs and Postural Support Devices (Preprint)

2020 ◽  
Author(s):  
Adriana Klein ◽  
Roseli de Deus Lopes ◽  
Rodrigo Suigh
Keyword(s):  
Mixed Methods ◽  
Mobile Health ◽  
Second Phase ◽  
The Third ◽  
Evaluation Approach ◽  
Mixed Methods Evaluation ◽  
Usability Tests ◽  
Third Phase ◽  
Postural Support ◽  
Support Devices

BACKGROUND EasySeating is a mobile health (mHealth) app that supports the prescription of wheelchair and postural support devices (WPSD). It can be used by occupational therapists (OT) and physiotherapists (PT) who prescribe WPSD. The app offers a standardization of the prescription procedure, showing images, metrics and details that guide the prescriber to decide on the best equipment. It was developed with an iterative mixed-methods evaluation approach. Objective: The aim of this study was to investigate the processes involved in the prescription of WPSD and to propose, develop and evaluate a mHealth to support OT and PT prescribers. OBJECTIVE The aim of this study was to investigate the processes involved in the prescription of WPSD and to propose, develop and evaluate a mHealth to support OT and PT prescribers. METHODS This study was divided into three phases and was carried out as an iterative process composed of user consulting/testing (using a mixed-methods evaluation approach), system (re)design and software development. The first phase consisted of the collection of qualitative and quantitative data to map and understand the users requirements and of the development of the first prototype (v1) of the app. This data collection was performed through semi-structured interviews with 14 OT and PT prescribers, 5 specialized technicians and 5 WPSD users. The second phase aimed at improving the overall functionality of the app and consisted in the development, test and evaluation of the prototypes v1, v2, v3 and v4. A total of 59 prescribers tested and evaluated these prototypes by means of open interviews, semi-structured questionnaires and focus groups. The third phase focused in the usability aspects of the app. It consisted in the development and test of the prototype v5. Eight technology specialists assessed its usability through heuristics evaluation. RESULTS Data collected in phase one indicated there is a lack of standardization on the prescription of postural support devices (PSD). A divergent nomenclature for the PSDs was also found and classified in eight categories. These information guided the development of the first prototype of the EasySeating app. Phase two results pointed that the prescribers value the insertion of the app into their clinical practice, as it accelerates and increases the quality of the evaluation process and improves the organization of the prescription information. Significant suggestions for the improvement of the app were given during the users tests, including the use of images to represent the PSDs. The usability tests from the third phase revealed two strong issues that must be solved: the need of greater feedback and failures in the persistence of the input data. CONCLUSIONS This study demonstrated that there is a lack of systematization of the WPSD prescription process. The evaluation of the developed EasySeating app demonstrated that there is a potential to standardize, integrate and organize the WPSD prescription information, supporting and facilitating the decision making process of the prescribers. CLINICALTRIAL This study was approved by the Research Ethics Board of the Universidade de São Paulo (registered protocol n°53929516.6.0000.0065) URL - http://plataformabrasil.saude.gov.br/login.jsf

Foucault as Superauthor

2019 ◽  
Vol 29 (2) ◽  
pp. 104-125
Keyword(s):  
Free Speech ◽  
Second Phase ◽  
Contemporary Society ◽  
Sovereign Power ◽  
Ancient Greek ◽  
Main Motivation ◽  
Critical Attitude ◽  
The Third ◽  
Third Phase ◽  
Lecture Courses

Three phases in Foucault’s examination of authorship and free speech were essential to him throughout his life. They can be linked to such texts as the three lectures “What is an Author?” (first phase), “What is Critique?,” and “What is Revolution?” (second phase), and the two lecture courses, “Fearless Speech,” and “The Courage of Truth” (third phase). Initially, Foucault merely describes the founders of discursivity (hence, “superauthors”), among whom he reckoned only Marx and Freud, as the sole alternative to his own conceptualization of the author function, which is exhibited en masse in contemporary society. He then modifies his views on superauthorship by making Kant the paradigm and by linking his own concept of free speech to a Kan-tian critical attitude. However, Foucault claims only the half of Kant’s philosophical legacy that is related to the study of the ontology of the self.The article advances the hypothesis that the sovereign power of speech, which can be found in Marx and Heidegger and in generally in the concept of “superauthorship,” becomes unacceptable for Foucault. During the third phase, the danger of a tyrannical use of free speech compels Foucault to make a number of fruitful but questionable choices in his work. He focuses on a single aspect of free speech in which a speaker is in a weaker position and therefore has to overcome his fear in order to tell the truth. Foucault associates this kind of free speech with the ancient Greek notion of parrhesia, which according to his interpretation means “fearless speech”; however, this reading is not always supported by the ancient Greek sources. Foucault’s deliberations bring him to the radical conclusion that free speech transforms into performative “aesthetics of existence.” Foucault’s main motivation for pursuing this line of thought all through his life was to investigate his own abilities and powers as an author

scholarly journals Role of HMGB1 in apoptosis-mediated sepsis lethality

2006 ◽  
Vol 203 (7) ◽  
pp. 1637-1642 ◽  
Author(s):  
Shixin Qin ◽  
Haichao Wang ◽  
Renqi Yuan ◽  
Hui Li ◽  
Mahendar Ochani ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
High Mobility ◽  
Organ Damage ◽  
The United States ◽  
Apoptotic Cells ◽  
Caspase Inhibitor ◽  
Common Pathway ◽  
The Third

Severe sepsis, a lethal syndrome after infection or injury, is the third leading cause of mortality in the United States. The pathogenesis of severe sepsis is characterized by organ damage and accumulation of apoptotic lymphocytes in the spleen, thymus, and other organs. To examine the potential causal relationships of apoptosis to organ damage, we administered Z-VAD-FMK, a broad-spectrum caspase inhibitor, to mice with sepsis. We found that Z-VAD-FMK–treated septic mice had decreased levels of high mobility group box 1 (HMGB1), a critical cytokine mediator of organ damage in severe sepsis, and suppressed apoptosis in the spleen and thymus. In vitro, apoptotic cells activate macrophages to release HMGB1. Monoclonal antibodies against HMGB1 conferred protection against organ damage but did not prevent the accumulation of apoptotic cells in the spleen. Thus, our data indicate that HMGB1 production is downstream of apoptosis on the final common pathway to organ damage in severe sepsis.

Towards a post-secular political order?

2009 ◽  
Vol 1 (3) ◽  
pp. 317-340 ◽  
Author(s):  
Mariano Barbato ◽  
Friedrich Kratochwil
Keyword(s):  
Public Sphere ◽  
Political Process ◽  
Political Order ◽  
Social Phenomenon ◽  
Clash Of Civilizations ◽  
The Public ◽  
The Third ◽  
Secular Society ◽  
Role Of Religion

The ‘return of religion’ as a social phenomenon has aroused at least three different debates, with the first being the ‘clash of civilizations’, the second criticizing ‘modernity’, and the third focusing on the public/private distinction. This article uses Habermas’ idea of a post-secular society as a prism through which we examine the return of religion and impact on secularization. In doing so, we attempt to understand the new role of religion as a challenger of the liberal projects following the decline of communism. Against this background, section four focuses on Habermas’s central arguments in his proposal for a post-secular society. We claim that theproblematiquein Habermas’s analysis must be placed within the wider framework of an emerging global public sphere. In this context we examine the problem of religion’s place in political process and the two readings of Habermas as suggested by Simone Chambers.

scholarly journals PROFESSIONAL IDENTITY QUESTIONNAIRE FOR PSYCHOLOGICAL HELP PROVIDERS: DEVELOPMENT AND VALIDATION

2021 ◽  
Vol 7 ◽  
pp. 13-23
Author(s):  
Elīna Akmane ◽  
Kristīne Mārtinsone ◽  
Zane Krieķe ◽  
Viktorija Perepjolkina ◽  
Agnese Drunka ◽  
...  
Keyword(s):  
Focus Group ◽  
Professional Identity ◽  
Psychometric Properties ◽  
Social Workers ◽  
Group Discussion ◽  
Psychological Help ◽  
Second Phase ◽  
The Third ◽  
Third Phase ◽  
Development And Validation

The aim of this research was to develop multiscale questionnaire of professional identity (PI) and to test its psychometric properties. This research was conducted in 3 phases. During the first phase a scoping review, a focus group discussion, and a rapid literature review were conducted to identify the criteria of PI. Survey items were constructed and assessed in the second phase. The data were collected, and the psychometric properties were examined in the third phase. The survey was completed by 239 psychological help providers in Latvia (psychiatrists (n = 13), nurses (n = 37), psychotherapists (n = 8), art therapists (n = 45), psychologists (n = 55), psychotherapy specialists (n = 28) and social workers (n = 53)) aged between 22 and 80 years (M = 45.8; SD = 10.6) of which 95% women (n = 227) and 5% men (n = 12). As a result, 8 factors structure was confirmed (k = 38). Overall, it can be concluded that the survey examines a unified phenomenon, and the items are internally consistent on all scales (α = .715 - .873). The development of this questionnaire is an important step towards the research of PI.   

Sign in / Sign up

Export Citation Format

Share Document