Plasma d-glutamate levels for detecting mild cognitive impairment and Alzheimer’s disease: Machine learning approaches

2021 ◽  
Vol 35 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Chun-Hung Chang ◽  
Chieh-Hsin Lin ◽  
Chieh-Yu Liu ◽  
Chih-Sheng Huang ◽  
Shaw-Ji Chen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Random Forest ◽  
Naive Bayes ◽  
Mmse Score ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Healthy Controls ◽  
Peripheral Plasma

Background: d-glutamate, which is involved in N-methyl-d-aspartate receptor modulation, may be associated with cognitive ageing. Aims: This study aimed to use peripheral plasma d-glutamate levels to differentiate patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) from healthy individuals and to evaluate its prediction ability using machine learning. Methods: Overall, 31 healthy controls, 21 patients with MCI and 133 patients with AD were recruited. Serum d-glutamate levels were measured using high-performance liquid chromatography (HPLC). Cognitive deficit severity was assessed using the Clinical Dementia Rating scale and the Mini-Mental Status Examination (MMSE). We employed four machine learning algorithms (support vector machine, logistic regression, random forest and naïve Bayes) to build an optimal predictive model to distinguish patients with MCI or AD from healthy controls. Results: The MCI and AD groups had lower plasma d-glutamate levels (1097.79 ± 283.99 and 785.10 ± 720.06 ng/mL, respectively) compared to healthy controls (1620.08 ± 548.80 ng/mL). The naïve Bayes model and random forest model appeared to be the best models for determining MCI and AD susceptibility, respectively (area under the receiver operating characteristic curve: 0.8207 and 0.7900; sensitivity: 0.8438 and 0.6997; and specificity: 0.8158 and 0.9188, respectively). The total MMSE score was positively correlated with d-glutamate levels ( r = 0.368, p < 0.001). Multivariate regression analysis indicated that d-glutamate levels were significantly associated with the total MMSE score ( B = 0.003, 95% confidence interval 0.002–0.005, p < 0.001). Conclusions: Peripheral plasma d-glutamate levels were associated with cognitive impairment and may therefore be a suitable peripheral biomarker for detecting MCI and AD. Rapid and cost-effective HPLC for biomarkers and machine learning algorithms may assist physicians in diagnosing MCI and AD in outpatient clinics.

scholarly journals Prediction of COVID-19 Risk in Public Areas Using IoT and Machine Learning

Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1677
Author(s):  
Ersin Elbasi ◽  
Ahmet E. Topcu ◽  
Shinu Mathew
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Bayes Classifier ◽  
Social Distancing ◽  
Public Areas ◽  
Iot Devices

COVID-19 is a community-acquired infection with symptoms that resemble those of influenza and bacterial pneumonia. Creating an infection control policy involving isolation, disinfection of surfaces, and identification of contagions is crucial in eradicating such pandemics. Incorporating social distancing could also help stop the spread of community-acquired infections like COVID-19. Social distancing entails maintaining certain distances between people and reducing the frequency of contact between people. Meanwhile, a significant increase in the development of different Internet of Things (IoT) devices has been seen together with cyber-physical systems that connect with physical environments. Machine learning is strengthening current technologies by adding new approaches to quickly and correctly solve problems utilizing this surge of available IoT devices. We propose a new approach using machine learning algorithms for monitoring the risk of COVID-19 in public areas. Extracted features from IoT sensors are used as input for several machine learning algorithms such as decision tree, neural network, naïve Bayes classifier, support vector machine, and random forest to predict the risks of the COVID-19 pandemic and calculate the risk probability of public places. This research aims to find vulnerable populations and reduce the impact of the disease on certain groups using machine learning models. We build a model to calculate and predict the risk factors of populated areas. This model generates automated alerts for security authorities in the case of any abnormal detection. Experimental results show that we have high accuracy with random forest of 97.32%, with decision tree of 94.50%, and with the naïve Bayes classifier of 99.37%. These algorithms indicate great potential for crowd risk prediction in public areas.

scholarly journals Data Driven Approach for Eye Disease Classification with Machine Learning

2019 ◽  
Vol 9 (14) ◽  
pp. 2789 ◽  
Author(s):  
Sadaf Malik ◽  
Nadia Kanwal ◽  
Mamoona Naveed Asghar ◽  
Mohammad Ali A. Sadiq ◽  
Irfan Karamat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Naïve Bayes ◽  
Machine Learning Algorithms ◽  
Multiple Features ◽  
Standard Format ◽  
Free Data

Medical health systems have been concentrating on artificial intelligence techniques for speedy diagnosis. However, the recording of health data in a standard form still requires attention so that machine learning can be more accurate and reliable by considering multiple features. The aim of this study is to develop a general framework for recording diagnostic data in an international standard format to facilitate prediction of disease diagnosis based on symptoms using machine learning algorithms. Efforts were made to ensure error-free data entry by developing a user-friendly interface. Furthermore, multiple machine learning algorithms including Decision Tree, Random Forest, Naive Bayes and Neural Network algorithms were used to analyze patient data based on multiple features, including age, illness history and clinical observations. This data was formatted according to structured hierarchies designed by medical experts, whereas diagnosis was made as per the ICD-10 coding developed by the American Academy of Ophthalmology. Furthermore, the system is designed to evolve through self-learning by adding new classifications for both diagnosis and symptoms. The classification results from tree-based methods demonstrated that the proposed framework performs satisfactorily, given a sufficient amount of data. Owing to a structured data arrangement, the random forest and decision tree algorithms’ prediction rate is more than 90% as compared to more complex methods such as neural networks and the naïve Bayes algorithm.

scholarly journals Machine-Learning Algorithms Based on Screening Tests for Mild Cognitive Impairment

2020 ◽  
Vol 35 ◽  
pp. 153331752092716
Author(s):  
Jin-Hyuck Park
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Test Data ◽  
Learning Algorithms ◽  
Test System ◽  
Machine Learning Algorithms ◽  
Screening Tools ◽  
Screening Tests ◽  
Data Set

Background: The mobile screening test system for mild cognitive impairment (mSTS-MCI) was developed and validated to address the low sensitivity and specificity of the Montreal Cognitive Assessment (MoCA) widely used clinically. Objective: This study was to evaluate the efficacy machine learning algorithms based on the mSTS-MCI and Korean version of MoCA. Method: In total, 103 healthy individuals and 74 patients with MCI were randomly divided into training and test data sets, respectively. The algorithm using TensorFlow was trained based on the training data set, and then its accuracy was calculated based on the test data set. The cost was calculated via logistic regression in this case. Result: Predictive power of the algorithms was higher than those of the original tests. In particular, the algorithm based on the mSTS-MCI showed the highest positive-predictive value. Conclusion: The machine learning algorithms predicting MCI showed the comparable findings with the conventional screening tools.

scholarly journals An Effective Stratified K-Fold Algorithm with Logistic Regression for Drug Feedback Data

2020 ◽  
Vol 8 (6) ◽  
pp. 1964-1968
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Random Forest ◽  
Pharmaceutical Industry ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
New Approach ◽  
Feedback Data ◽  
Drug Review

Drug reviews are commonly used in pharmaceutical industry to improve the medications given to patients. Generally, drug review contains details of drug name, usage, ratings and comments by the patients. However, these reviews are not clean, and there is a need to improve the cleanness of the review so that they can be benefited for both pharmacists and patients. To do this, we propose a new approach that includes different steps. First, we add extra parameters in the review data by applying VADER sentimental analysis to clean the review data. Then, we apply different machine learning algorithms, namely linear SVC, logistic regression, SVM, random forest, and Naive Bayes on the drug review specify dataset names. However, we found that the accuracy of these algorithms for these datasets is limited. To improve this, we apply stratified K-fold algorithm in combination with Logistic regression. With this approach, the accuracy is increased to 96%.

scholarly journals Artificial Intelligence and Machine Learning Algorithms For Informing the Diagnostic Process of Mild Cognitive Impairment and Dementia

2019 ◽  
Vol 34 (6) ◽  
pp. 838-838
Author(s):  
J Gardner
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Sensitivity And Specificity ◽  
Clinical Judgment ◽  
Meta Analysis ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Bivariate Correlation

Abstract Objective Differentiating between a clinical diagnosis of Mild Cognitive Impairment (MCI) and dementia is difficult due to expansive data needs in concert with ambiguity of clinical criteria. Novel artificial intelligence (AI) and machine learning algorithms provide potential avenues for efficiently analyzing data sets and informing clinical judgment in distinguishing MCI from dementia. To date no formal meta-analysis of extant studies has been conducted to compare the efficacy of such procedures. A meta-analysis was conducted to synthesize the sensitivity and specificity of AI and machine learning programs in distinguishing between MCI and dementia as compared to traditional diagnostic protocols. Data Selection A search of studies using EBSCOhost databases using the keywords: “artificial intelligence,” “machine learning,” “MCI,” and “dementia” retrieved a total of 127 studies. Excluded were 106 studies due to non-reporting of sensitivity and specificity data. In total, 21 studies were included in the present meta-analysis. Data Synthesis Sensitivity and specificity data as well as the number of true-false categorizations were extracted and analyzed using OpenMeta[Analyst]. A bivariate correlation produced a summary point with sensitivity of 82% and specificity of 82%. A follow-up Rutter-Gatsonis multivariate correlation HSROC curve was created to correct for significant correlations (47%), and produced an adjusted mean specificity of 79% and sensitivity of 83%. Conclusions Results suggest AI and machine-learning algorithms are effective in distinguishing MCI from dementia. AI procedures have potential in aiding clinical judgment given a larger body of empirical research.

Olfactory Phenotypes Differentiate Cognitively Unimpaired Seniors from Alzheimer’s Disease and Mild Cognitive Impairment: A Combined Machine Learning and Traditional Statistical Approach

2021 ◽  
pp. 1-10
Author(s):  
Jennifer Li ◽  
Andres M. Bur ◽  
Mark R. Villwock ◽  
Suraj Shankar ◽  
Gracie Palmer ◽  
...  
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Subjective Data ◽  
Disease States ◽  
Olfactory Testing

Background: Olfactory dysfunction (OD) is an early symptom of Alzheimer’s disease (AD). However, olfactory testing is not commonly performed to test OD in the setting of AD. Objective: This work investigates objective OD as a non-invasive biomarker for accurately classifying subjects as cognitively unimpaired (CU), mild cognitive impairment (MCI), and AD. Methods: Patients with MCI (n = 24) and AD (n = 24), and CU (n = 33) controls completed two objective tests of olfaction (Affordable, Rapid, Olfactory Measurement Array –AROMA; Sniffin’ Sticks Screening 12 Test –SST12). Demographic and subjective sinonasal and olfaction symptom information was also obtained. Analyses utilized traditional statistics and machine learning to determine olfactory variables, and combinations of variables, of importance for differentiating normal and disease states. Results: Inability to correctly identify a scent after detection was a hallmark of MCI/AD. AROMA was superior to SST12 for differentiating MCI from AD. Performance on the clove scent was significantly different between all three groups. AROMA regression modeling yielded six scents with AUC of the ROC of 0.890 (p <  0.001). Random forest model machine learning algorithms considering AROMA olfactory data successfully predicted MCI versus AD disease state. Considering only AROMA data, machine learning algorithms were 87.5%accurate (95%CI 0.4735, 0.9968). Sensitivity and specificity were 100%and 75%, respectively with ROC of 0.875. When considering AROMA and subject demographic and subjective data, the AUC of the ROC increased to 0.9375. Conclusion: OD differentiates CUs from those with MCI and AD and can accurately predict MCI versus AD. Leveraging OD data may meaningfully guide management and research decisions.

scholarly journals Feature Selection and Comparison of Machine Learning Algorithms in Classification of Grazing and Rumination Behaviour in Sheep

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3532 ◽  
Author(s):  
Nicola Mansbridge ◽  
Jurgen Mitsch ◽  
Nicola Bollard ◽  
Keith Ellis ◽  
Giuliana Miguel-Pacheco ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Time Budget ◽  
Learning Algorithms ◽  
Eating Behaviour ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Optimum Number ◽  
Eating Behaviours ◽  
Adaptive Boosting

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and welfare. However, surveillance performed by human operators is prone to human variance, time-consuming and costly, especially on animals kept at pasture or free-ranging. The use of sensors to automatically acquire data, and software to classify and identify behaviours, offers significant potential in addressing such issues. In this work, data collected from sheep by means of an accelerometer/gyroscope sensor attached to the ear and collar, sampled at 16 Hz, were used to develop classifiers for grazing and ruminating behaviour using various machine learning algorithms: random forest (RF), support vector machine (SVM), k nearest neighbour (kNN) and adaptive boosting (Adaboost). Multiple features extracted from the signals were ranked on their importance for classification. Several performance indicators were considered when comparing classifiers as a function of algorithm used, sensor localisation and number of used features. Random forest yielded the highest overall accuracies: 92% for collar and 91% for ear. Gyroscope-based features were shown to have the greatest relative importance for eating behaviours. The optimum number of feature characteristics to be incorporated into the model was 39, from both ear and collar data. The findings suggest that one can successfully classify eating behaviours in sheep with very high accuracy; this could be used to develop a device for automatic monitoring of feed intake in the sheep sector to monitor health and welfare.

scholarly journals Random Forest Model in the Diagnosis of Dementia Patients with Normal Mini-Mental State Examination Scores

2022 ◽  
Vol 12 (1) ◽  
pp. 37
Author(s):  
Jie Wang ◽  
Zhuo Wang ◽  
Ning Liu ◽  
Caiyan Liu ◽  
Chenhui Mao ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Random Forest ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Machine Learning Algorithms ◽  
Assessment Model ◽  
Test Time ◽  
Cognitive Screening ◽  
State Examination

Background: Mini-Mental State Examination (MMSE) is the most widely used tool in cognitive screening. Some individuals with normal MMSE scores have extensive cognitive impairment. Systematic neuropsychological assessment should be performed in these patients. This study aimed to optimize the systematic neuropsychological test battery (NTB) by machine learning and develop new classification models for distinguishing mild cognitive impairment (MCI) and dementia among individuals with MMSE ≥ 26. Methods: 375 participants with MMSE ≥ 26 were assigned a diagnosis of cognitively unimpaired (CU) (n = 67), MCI (n = 174), or dementia (n = 134). We compared the performance of five machine learning algorithms, including logistic regression, decision tree, SVM, XGBoost, and random forest (RF), in identifying MCI and dementia. Results: RF performed best in identifying MCI and dementia. Six neuropsychological subtests with high-importance features were selected to form a simplified NTB, and the test time was cut in half. The AUC of the RF model was 0.89 for distinguishing MCI from CU, and 0.84 for distinguishing dementia from nondementia. Conclusions: This simplified cognitive assessment model can be useful for the diagnosis of MCI and dementia in patients with normal MMSE. It not only optimizes the content of cognitive evaluation, but also improves diagnosis and reduces missed diagnosis.

scholarly journals Cyber Bullying Detection for Twitter Using ML Classification Algorithms

2021 ◽  
Vol 9 (11) ◽  
pp. 24-29
Author(s):  
Muskan Patidar
Keyword(s):  
Machine Learning ◽  
Social Media ◽  
Natural Language ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Naïve Bayes ◽  
Cyber Bullying ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Classification Algorithms

Abstract: Social networking platforms have given us incalculable opportunities than ever before, and its benefits are undeniable. Despite benefits, people may be humiliated, insulted, bullied, and harassed by anonymous users, strangers, or peers. Cyberbullying refers to the use of technology to humiliate and slander other people. It takes form of hate messages sent through social media and emails. With the exponential increase of social media users, cyberbullying has been emerged as a form of bullying through electronic messages. We have tried to propose a possible solution for the above problem, our project aims to detect cyberbullying in tweets using ML Classification algorithms like Naïve Bayes, KNN, Decision Tree, Random Forest, Support Vector etc. and also we will apply the NLTK (Natural language toolkit) which consist of bigram, trigram, n-gram and unigram on Naïve Bayes to check its accuracy. Finally, we will compare the results of proposed and baseline features with other machine learning algorithms. Findings of the comparison indicate the significance of the proposed features in cyberbullying detection. Keywords: Cyber bullying, Machine Learning Algorithms, Twitter, Natural Language Toolkit

Sign in / Sign up

Export Citation Format

Share Document