scholarly journals Longitudinal study of cerebral blood flow regulation during exercise in pregnancy

2019 ◽  
Vol 40 (11) ◽  
pp. 2278-2288 ◽  
Author(s):  
Brittany A Matenchuk ◽  
Marina James ◽  
Rachel J Skow ◽  
Paige Wakefield ◽  
Christina MacKay ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Exercise Test ◽  
Maximal Exercise ◽  
Visual Stimulation ◽  
First Trimester ◽  
Cerebrovascular Reactivity ◽  
Third Trimester ◽  
Volitional Fatigue ◽  
Exercise In Pregnancy ◽  
Cerebrovascular Regulation

Cerebrovascular adaptation to pregnancy is poorly understood. We sought to assess cerebrovascular regulation in response to visual stimulation, hypercapnia and exercise across the three trimesters of pregnancy. Using transcranial Doppler (TCD) ultrasound, middle and posterior cerebral artery mean blood velocities (MCAvmean and PCAvmean) were measured continuously at rest and in response to (1) visual stimulation to assess neurovascular coupling (NVC); (2) a modified Duffin hyperoxic CO2 rebreathe test, and (3) an incremental cycling exercise test to volitional fatigue in non-pregnant ( n = 26; NP) and pregnant women (first trimester [ n = 13; TM1], second trimester [ n = 21; TM2], and third trimester [ n = 20; TM3]) in total 47 women. At rest, MCAvmean and PETCO2 were lower in TM2 compared to NP. PCAvmean was lower in TM2 but not TM1 or TM3 compared to NP. Cerebrovascular reactivity in MCAvmean and PCAvmean during the hypercapnic rebreathing test was not different between pregnant and non-pregnant women. MCAvmean continued to increase over the second half of the exercise test in TM2 and TM3, while it decreased in NP due to differences in ΔPETCO2 between groups. Pregnant women experienced a delayed decrease in MCAvmean in response to maximal exercise compared to non-pregnant controls which was explained by CO2 reactivity and PETCO2 level.

scholarly journals Radioimmunoassay of plasma ouabain in healthy and pregnant individuals

2000 ◽  
Vol 165 (3) ◽  
pp. 669-677 ◽  
Author(s):  
O Vakkuri ◽  
SS Arnason ◽  
A Pouta ◽  
O Vuolteenaho ◽  
J Leppaluoto
Keyword(s):  
Pregnant Women ◽  
Human Plasma ◽  
High Performance ◽  
Chemical Nature ◽  
Solid Phase ◽  
Plasma Concentrations ◽  
First Trimester ◽  
Plasma Samples ◽  
Third Trimester ◽  
Endogenous Substances

Ouabain was recently isolated from human plasma, bovine hypothalamus and bovine adrenal in attempts to identify endogenous substances inhibiting the cell membrane sodium pump. A number of radioimmunoassays have been developed in order to study the clinical significance of ouabain. The results have been controversial with regard to the presence and chemical nature of plasma ouabain-like immunoreactivity. We have now measured ouabain in healthy and pregnant individuals using solid-phase extraction of plasma samples followed by a new radioimmunoassay with the extraordinary sensitivity of at least 2 fmol/tube (5 pmol/l). Plasma extracts, a previously isolated human plasma ouabain-like compound and bovine hypothalamic inhibitory factor displaced the tracer in parallel and eluted identically with ouabain in high-performance liquid chromatography. Plasma ouabain immunoreactivity was found to be much lower than reported previously: 12.6+/-1.3 pmol/l in healthy men (mean+/-s.e., n=20) and 9.4+/-0.7 pmol/l in women (n=14). In pregnant women (n=28) plasma ouabain concentration was 16.3+/-4.0 pmol/l during the first trimester, 18.8+/-4.3 pmol/l during the second trimester and 24.3+/-4.0 pmol/l during the third trimester (all P<0.01 compared with non-pregnant women). Plasma ouabain 3-5 days after the delivery was 13.6+/-1.1 pmol/l (n=10, P<0.05-0.01 compared with second and third trimesters). The pregnancy-related changes in the plasma concentrations of ouabain resembled those of cortisol. Therefore cortisol was measured from the same plasma samples and a significant positive correlation was found (r=0.512, P=0.006). The similar profiles of plasma ouabain and cortisol during pregnancy and their rapid decreases postpartum are consistent with the adrenal cortical origin of ouabain and also show that the secretions of these hormones are possibly under the control of same factors.

scholarly journals Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Estefania Aparicio ◽  
Carla Martín-Grau ◽  
Carmen Hernández-Martinez ◽  
Nuria Voltas ◽  
Josefa Canals ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Serum Concentration ◽  
Eicosapentaenoic Acid ◽  
Pregnant Women ◽  
First Trimester ◽  
Third Trimester ◽  
Total N

Abstract Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination. Results From the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters. Conclusion The circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.

scholarly journals Thrombin Generation in Chinese Pregnant Women and the Effect of Insulin Use on Thrombin Generation in Patients with GDM

2019 ◽  
Vol 25 ◽  
pp. 107602961986349
Author(s):  
Feng Dong ◽  
Longhao Wang ◽  
Chengbin Wang
Keyword(s):  
Blood Glucose ◽  
Pregnant Women ◽  
Thrombin Generation ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Third Trimester ◽  
Control Blood Glucose ◽  
Normal Ranges ◽  
Increased Risk ◽  
Significant Difference

Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis. Calibrated automated thrombogram (CAT) is a test to monitor the thrombin generation (TG), a laboratory marker of thrombosis risk, and increases during normal pregnancy, but it is still unclear whether TG is related to the use of insulin in pregnant women with gestational diabetes mellitus (GDM). We performed thrombin generation by CAT on 135 normal pregnant women, including 43 in first trimester, 32 in second trimester, 60 in third trimester, respectively; 68 pregnant women with GDM were also enrolled, 19 patients with GDM using insulin to control blood glucose and 49 patients control their blood glucose through diet and exercise with noninsulin treatment. The overall CAT parameters were calculated using descriptive statistics method with mean ± standard deviation. Mean endogenous thrombin potential, peak thrombin generation, and StartTail time increased significantly with the pregnancy. There was no significant difference in TG test parameters except StartTail time( P = .003) in insulin-treated GDM group when compared to those without insulin in the GDM group. The normal ranges for CAT parameters in pregnant women were determined. Thrombin generation increased significantly in first trimester and remains stable in second and third trimester. The use of insulin in patient with GDM did not affect thrombin generation test. Our study helps to establish the reference range of thrombin generation in Chinese normal pregnant population and provide more basis to predict the risk of thrombus complicating during pregnancy.

scholarly journals P21 PBPK modeling in pregnancy: achievements, shortcomings and future perspectives

2019 ◽  
Vol 104 (6) ◽  
pp. e25.2-e25
Author(s):  
A Dallmann ◽  
P Mian ◽  
P Annaert ◽  
M Pfister ◽  
K Allegaert ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pbpk Model ◽  
Multiple Pregnancy ◽  
First Trimester ◽  
Model Verification ◽  
Pbpk Modeling ◽  
Third Trimester ◽  
The Past ◽  
Pbpk Models

BackgroundPhysiologically-based pharmacokinetic (PBPK) models are considered a promising approach to better characterize and anticipate the effect of physiological changes on pharmacokinetics in pregnant women. Consequently, multiple pregnancy PBPK models have been developed and verified over the past years. Using acetaminophen (paracetamol) as example, PBPK modeling can provide specific insights into the expected pharmacokinetic changes throughout pregnancy.MethodsTo obtain an overview of pregnancy PBPK models, the scientific literature was systematically screened for publications with a focus on pharmaceutical applications using relevant keywords. Additionally, a pregnancy PBPK model for acetaminophen was developed with the Open Systems Pharmacology software suite (www.open-systems-pharmacology.org) following an established workflow. After model verification around gestational week 30, the model was scaled to earlier stages of pregnancy and molar dose fractions converted to acetaminophen metabolites were estimated for each trimester.ResultsOver the past years, more than 60 different pregnancy PBPK models for more than have 40 drugs been published. More than 70% of these models were developed for the third trimester, while few models have been applied to the first trimester. The developed PBPK model for acetaminophen indicated that the median dose fraction of acetaminophen converted to the reactive metabolite N-acetyl-p-benzoquinonimine (NAPQI) was 11%, 9.0% and 8.2% in the first, second and third trimester, respectively, while for non-pregnant women a value of 7.7% was simulated.ConclusionWhile the overall availability and quality of pregnancy PBPK models is varying considerably, the efforts to establish such models are promising in that they reflect an increased awareness of the necessity to better characterize pharmacokinetics during pregnancy. This is illustrated by the developed PBPK model for acetaminophen where information on NAPQI-formation in vivo is hitherto lacking. Although PBPK models are not a substitute for clinical trials, they constitute an important tool for clinicians in case of missing or incomplete information.Disclosure(s)Nothing to disclose

Gestation specific reference intervals for thyroid function tests in pregnancy

2016 ◽  
Vol 54 (8) ◽  
Author(s):  
Süleyman Akarsu ◽  
Filiz Akbiyik ◽  
Eda Karaismailoglu ◽  
Zeliha Gunnur Dikmen
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
First Trimester ◽  
Reference Intervals ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Second Trimester ◽  
Third Trimester ◽  
The Third ◽  
Function Tests

AbstractThyroid function tests are frequently assessed during pregnancy to evaluate thyroid dysfunction or to monitor pre-existing thyroid disease. However, using non-pregnant reference intervals can lead to misclassification. International guidelines recommended that institutions should calculate their own pregnancy-specific reference intervals for free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH). The objective of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function tests in pregnant Turkish women and to compare these with the age-matched non-pregnant women.Serum samples were collected from 220 non-pregnant women (age: 18–48), and 2460 pregnant women (age: 18–45) with 945 (39%) in the first trimester, 1120 (45%) in the second trimester, and 395 (16%) in the third trimester. TSH, FT4 and FT3 were measured using the Abbott Architect i2000SR analyzer.GRIs of TSH, FT4 and FT3 for first trimester pregnancies were 0.49–2.33 mIU/L, 10.30–18.11 pmol/L and 3.80–5.81 pmol/L, respectively. GRIs for second trimester pregnancies were 0.51–3.44 mIU/L, 10.30–18.15 pmol/L and 3.69–5.90 pmol/L. GRIs for third trimester pregnancies were 0.58–4.31 mIU/L, 10.30–17.89 pmol/L and 3.67–5.81 pmol/L. GRIs for TSH, FT4 and FT3 were different from non-pregnant normal reference intervals.TSH levels showed an increasing trend from the first trimester to the third trimester, whereas both FT4 and FT3 levels were uniform throughout gestation. GRIs may help in the diagnosis and appropriate management of thyroid dysfunction during pregnancy which will prevent both maternal and fetal complications.

scholarly journals Indeks DMF-T dan OHIS pada Ibu Hamil

2019 ◽  
Vol 1 (1) ◽  
pp. 12-22
Author(s):  
Applonia Leo Obi
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Sampling Technique ◽  
First Trimester ◽  
Second Trimester ◽  
Third Trimester ◽  
High Prevalence ◽  
Second Trimester Pregnancy ◽  
And Behavior ◽  
Descriptive Method

Abstract: DMF-T and OHIS index for pregnant women. Pregnancy is a physiological process that causes changes in a woman's body both physically and psychologically. During pregnancy physiological changes occur which are often accompanied by changes in attitude and behavior. The health behavior of pregnant women also has a very big influence on herself and the fetus. This research is a descriptive method. This study aims to determine the rates of DMF-T and OHIS in pregnant women at Oesapa Health Center, Kupang City. Sampling by accidental sampling technique, amounting to 97 pregnant women who visited the MCH polyclinic at the Kupang Oesapa Health Center. The results based on DMF-T figures show that the high prevalence of dental caries in the second-trimester pregnant women group (36.0%) than in the third trimester of pregnancy (28.8%) while OHIS most respondents in the second-trimester pregnancy (36, 1%) had an OHI-S index in the medium category with a ratio of trimester 3 there were 23 people (23.7%) and first trimester around 19 people (19.6%). It was concluded that the DMF-T index of pregnant women in the working area of ​​the Kupang City Oesapa health center was mostly carious and most of the pregnant women examined had caries of more than 4 teeth per person and all pregnant women who were examined for dental and oral hygiene levels showed moderate criteria. Abstrak: Indeks DMF-T dan OHIS pada Ibu Hamil. Kehamilan merupakan suatu proses fisiologis yang menimbulkan perubahan pada tubuh wanita baik fisik maupun psikis. Pada masa kehamilan terjadi perubahan fisiologis yang sering disertai dengan perubahan sikap dan perilaku. perilaku  kesehatan  ibu  hamil  juga  memiliki  pengaruh yang  sangat  besar  bagi  dirinya  sendiri  dan  janin. Penelitian ini adalah metode deskriptif. Penelitian ini bertujuan untuk mengetahui  angka DMF-T dan OHIS pada ibu hamil di Puskesmas Oesapa Kota Kupang. Pengambilan sampel dengan teknik accidental sampling, berjumlah 97 ibu hamil yang berkunjung ke poli KIA di Puskesmas Oesapa Kota Kupang. Hasil penelitian berdasarkan Angka DMF-T menunjukkan bahwa tingginya prevalensi karies gigi pada kelompok ibu hamil  trimester kehamilan kedua (36,0%) dari pada trimester kehamilan ke tiga (28,8%) sedangkan OHIS sebagian besar responden pada kehamilan trimester 2 (36,1%) memiliki indek OHI-S pada kategori sedang dengan perbandingan trimester 3 ada 23 orang (23,7%) dan trimester I sekitar 19 orang (19,6%). Disimpulkan bahwa indeks DMF-T ibu hamil diwilayah kerja puskesmas Oesapa Kota Kupang sebagian besar berkaries dan sebagian besar ibu hamil yang diperiksa mempunyai karies lebih dari 4 gigi per orang dan semua ibu hamil yang diperiksa tingkat kebersihan gigi dan mulutnya menunjukkan kriteria sedang.

scholarly journals Inter Trimester Hemoglobin Levels in Pregnant Women

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Bella Andira Safitri
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Secondary Data ◽  
First Trimester ◽  
Hemoglobin Level ◽  
Second Trimester ◽  
Third Trimester ◽  
Series Design ◽  
Abnormal Hemoglobin ◽  
Research Criteria

Hemoglobin functions to transport all oxygen from the lungs to the tissue cells. Hemoglobin contains iron and is still present in red blood cells. In pregnant women hemoglobin levels are often abnormal. According to PMK RI No. 97 of 2014 concerning health services, it stipulates that pregnant women are checked for hemoglobin at least once in the first trimester and once in the third trimester. This is done to determine the condition of pregnant women during pregnancy. Low hemoglobin levels cause anemia. Anemia in pregnant women can affect the process of fetal growth and development in the womb. The purpose of this study was to determine the hemoglobin level between trimesters in pregnant women at the Jatilawang Health Center, Banyumas Regency in 2020. The research criteria was a descriptive study using a retrospective time series design using secondary data. The results of inter-trimester hemoglobin levels in pregnant women at the Jatilawang Health Center, Banyumas Regency in 2020 are in the first trimester 40% normal hemoglobin levels and 60% abnormal hemoglobin levels, in the second trimester hemoglobin levels are 72% normal and 28% hemoglobin levels are not normal, in the second trimester the hemoglobin levels are normal and 28% are abnormal. III 96% normal hemoglobin level and 4% abnormal hemoglobin level. Inter-trimester hemoglobin levels in pregnant women at the Jatilawang Health Center, Banyumas Regency in 2020 tend to be higher based on trimesters I, II and III.

scholarly journals Comparison of Salivary Alpha-Amylase, Sialic Acid, and pH in Pregnant and Nonpregnant Subjects

2021 ◽  
Author(s):  
Masoomeh Shirzaiy ◽  
Zohreh Dalirsani
Keyword(s):  
Sialic Acid ◽  
Pregnant Women ◽  
First Trimester ◽  
Control Group ◽  
Case Group ◽  
Third Trimester ◽  
The Third ◽  
Significant Difference ◽  
Salivary Ph ◽  
The Mean

Abstract Objectives During pregnancy, systemic physiological alterations lead to some changes in the oral cavity, which could prepare the mouth environment for oral and dental problems. This study was aimed to investigate salivary α-amylase, sialic acid levels, and pH levels in pregnant and nonpregnant females. Materials and Methods In this analytical, case–control study, unstimulated saliva samples were collected with spiting method from 35 pregnant women (case group) and 35 nonpregnant women (control group) and transferred to the laboratory to assess salivary α-amylase, sialic acid, and pH levels. Data were analyzed by SPSS (version: 19) software through statistical methods of independent t-test and analysis of variance. Results The mean sialic acid levels were 2.285 ± 1.230 mg/dL in pregnant and 2.744 ± 1.326 in nonpregnant women without any significant difference (p = 0.138). The mean salivary α-amylase concentrations were 2.461 ± 1.869 U/L and 2.439 ± 2.058 U/L, respectively, in pregnant and nonpregnant women, with no significant difference (p = 0.963).The mean salivary pH in nonpregnant women was significantly more than that in pregnant women (7.845 ± 0.430 and 6.868 ± 0.413, respectively) (p < 0.001). Also, the mean salivary pH levels in pregnant women were 7.474 ± 0.420 in the first trimester, 6.868 ± 0.413 in the second trimester, and 6.568 ± 0.387 in the third trimester, which were significantly different (p < 0.001). Conclusion Salivary sialic acid and α-amylase levels among pregnant women were no different from those of other subjects. During pregnancy, the salivary pH significantly reduced, and the mean salivary pH during pregnancy had a decreasing trend from the first trimester to the third trimester.

scholarly journals Physiological changes in iron and blood parameters during different pregnancy trimesters in pregnant women in Baghdad

2018 ◽  
Vol 29 (1) ◽  
pp. 49
Author(s):  
Marwa Thamir Mohammed
Keyword(s):  
Pregnant Women ◽  
Maternal Education ◽  
Cell Mass ◽  
First Trimester ◽  
Blood Parameters ◽  
Blood Film ◽  
Clear Correlation ◽  
Second Trimester ◽  
Third Trimester ◽  
Examination Result

 SummaryThis work was carried out for four months in the province of Baghdad including many hospital in Bagdad during 1st of the November 2016 until 28 February 2017. 120 pregnant women included in the present study ranged in age from 14 - 42 years were randomly selected. Pregnant women were divided into three groups according to the different periods of pregnancy every trimester include 40 pregnant women divided to 20 pregnant women with anemia and 20 without anemia after taking a blood  film and hemoglobin as a good adoption indicator for diagnosis of anemia, also, history taken by previously diagnosis and by physical examination. Result of the three trimesters in indicators the blood of pregnant women with or without anemia, showed that the first trimester all of the parameters of indicators the blood (Hb, Hct, MCV, MCH and MCHC) were decreased in women with anemia compared with women without anemia, also in second and third trimester decreased. However, in second trimester the values of Hb, Hct, MCV, MCH and MCHC decreased in women with anemia on the values of the first trimester. On the other hand a values of indicators the blood in a third trimester less than the second trimester. Indicator of iron (SI, TIBC, TS and SF) for women with anemia in first trimester was less than from women without anemia. However, in second trimester the values of SI, TIBC, TS and SF decreased in women with anemia on the values of the first trimester. Father more, the values of indicator of iron in a third trimester less than in the second trimester. When comparison in blood parameters (Hb, Hct, MCV, MCH and MCHC) between 1st, 2nd, and 3rd trimester of pregnancy women noticed that the all parameters decreased gradually from the first trimesters to second to third trimester. Iron deficiency marked increase was famous in pregnant women in the second and third trimester of pregnancy, due to high fetal and placenta growth rates and development of red cell mass mother. Thus anemia affects up to 70% of pregnant women. Blood indicators RBC, RDW, platelet and MPV for all pregnant women in the first trimester was decreased in women with anemia compared with women without anemia in all parameters of this, also in second and third trimester. Further more in second decreased from first, also in third less that from second. White blood cell and their various types (NEU, LYM, Mono, ESO and BASO) were impressed with the pregnant women with anemia in first and second trimesters WBC and NEU% increased but LYM%, Mono%, ESO% and BASO% decreased. However, in the third trimester WBC, NEU% and BASO% decreased but LYM%, Mono%, and EOS% increased. The results of the study found out that the is a clear correlation between anemia in pregnant women and some social factors, such as: occupation, monthly income and maternal education.

scholarly journals PREDICTORS OF POOR PROGNOSIS IN PREGNANT WOMEN WITH COVID-19: A PROSPECTIVE COHORT STUDY IN THE MATERNITY MOTHER AND CHILD UNIVERSITY HOSPITAL OF CASABLANCA MOROCCO

2021 ◽  
Vol 9 (10) ◽  
pp. 735-741
Author(s):  
Lamrissi A. ◽  
◽  
Midyani H. ◽  
Khalloufi C. ◽  
Jalal M. ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Death Rate ◽  
Poor Prognosis ◽  
First Trimester ◽  
University Hospital ◽  
Maternity Unit ◽  
Second Trimester ◽  
Third Trimester ◽  
High Prevalence ◽  
Mother And Child

Objective: We aim to study the clinicalcharacteristics, the evolution of COVID-19 on pregnant women and survival factors. Study design: Its a prospective cohortstudy in a large tertiary maternity unit within the Mother and Child University Hospital Ibn Rochd of Casablanca with an average annual birth of over 6950 births. We prospectively collected and analyzed data for a cohort of 40 pregnant patients tested positive for COVID-19 between January 2020 and December 2020 inclusive to assess the effect of COVID-19 on pregnancy. Results: Forty pregnant patients testedpositive for COVID-19, 36 patients gave birth and 4 patients died pregnant. The severity of the symptoms ranged from mild in 20/40 (50%) of the patients, moderate in 7/40 (17,5%), and severe in 13/40 (32,5%). Thirteen of our patients were admitted to invasive care units, six were in their third trimester, and seven in their second trimester nine were intubated and ventilated prior to delivery and three of them required Extracorporeal membrane oxygenation. Among these patients intubated only two survived. Most common comorbidities were gestational diabetes 4/40 (10 %), asthma 4/40 (10 %), preeclampsia 7/40 (17,5%). Of the 40 pregnant patients 31 (77,5%) were in their third trimester, 8 (20%) women in their second trimester, and one in her first trimester. Of the 36 patients who delivered, 12/36 (33,3 %) were preterm delivered by elective C-sections. The death rate was 17,5% (7/40). Conclusion: COVID-19 is associated with high prevalence of preterm birth, caesarean section, and a high mortality rate.

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