Brain Injury With Prolonged Seizures in Children and Adults

1998 ◽  
Vol 13 (1_suppl) ◽  
pp. S3-S6 ◽  
Author(s):  
Solomon L. Moshé
Keyword(s):  
Temporal Lobe ◽  
Animal Studies ◽  
Science Studies ◽  
Hippocampal Sclerosis ◽  
Epidemiologic Studies ◽  
Late Childhood ◽  
Hippocampal Damage ◽  
Adult Rats ◽  
Spontaneous Seizures ◽  
The Brain

Some retrospective studies have suggested that there is a relationship between seizures early in life and the development of hippocampal damage (mesial temporal lobe hippocampal sclerosis) leading to intractable temporal lobe epilepsy in late childhood or adulthood. Recent prospective epidemiologic studies have not confirmed such a relationship, however, and many questions remain. Some of these questions are being addressed by animal studies. In adult rats, experimental seizures produce varying degrees of hippocampal damage and subsequent spontaneous seizures; the older the rat, the greater the hippocampal injury. The preponderance of available data indicate that such seizure-induced hippocampal damage may not occur in normally developing rats up to a certain age that may correspond to late childhood in humans. However, if the brain is already compromised, seizures early in life may produce hippocampal damage, depending on the nature of the initial lesion. Thus, the consequences of seizures appear to be age and etiology specific. Additional clinical and basic science studies are needed to clarify the neurobiology of seizure-induced hippocampal damage in children. (J Child Neurol 1998;13(Suppl 1):S3-S6).

scholarly journals Partial cortico-hippocampectomy in cats, as therapy for refractory temporal epilepsy: A descriptive cadaveric study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244892
Author(s):  
Jessica Zilli ◽  
Monika Kressin ◽  
Anne Schänzer ◽  
Marian Kampschulte ◽  
Martin J. Schmidt
Keyword(s):  
Temporal Lobe ◽  
Tissue Injury ◽  
Histopathological Examination ◽  
Hippocampal Sclerosis ◽  
Intraoperative Complications ◽  
Temporal Cortex ◽  
Cadaveric Study ◽  
Vascular Lesions ◽  
Temporal Epilepsy ◽  
The Brain

Cats, similar to humans, are known to be affected by hippocampal sclerosis (HS), potentially causing antiepileptic drug (AED) resistance. HS can occur as a consequence of chronic seizure activity, trauma, inflammation, or even as a primary disease. In humans, temporal lobe resection is the standardized therapy in patients with refractory temporal lobe epilepsy (TLE). The majority of TLE patients are seizure free after surgery. Therefore, the purpose of this prospective cadaveric study is to establish a surgical technique for hippocampal resection in cats as a treatment for AED resistant seizures. Ten cats of different head morphology were examined. Pre-surgical magnetic resonance imaging (MRI) and computed tomography (CT) studies of the animals’ head were carried out to complete 3D reconstruction of the head, brain, and hippocampus. The resected hippocampal specimens and the brains were histologically examined for tissue injury adjacent to the hippocampus. The feasibility of the procedure, as well as the usability of the removed specimen for histopathological examination, was assessed. Moreover, a micro-CT (mCT) examination of the brain of two additional cats was performed in order to assess temporal vasculature as a reason for possible intraoperative complications. In all cats but one, the resection of the temporal cortex and the hippocampus were successful without any evidence of traumatic or vascular lesions in the surrounding neurovascular structures. In one cat, the presence of mechanical damage (a fissure) of the thalamic surface was evident in the histopathologic examination of the brain post-resection. All hippocampal fields and the dentate gyrus were identified in the majority of the cats via histological examination. The study describes a new surgical approach (partial temporal cortico-hippocampectomy) offering a potential treatment for cats with clinical and diagnostic evidence of temporal epilepsy which do not respond adequately to the medical therapy.

The Brain Matrix and Multifocal Brain Damage following a Single Injection of Ketamine in Young Adult Rats: Conspicuous Changes in Old Age

2002 ◽  
Vol 95 (3) ◽  
pp. 897-900 ◽  
Author(s):  
M. A. Persinger ◽  
L. S. St-Pierre
Keyword(s):  
Adipose Tissue ◽  
Single Injection ◽  
Neuronal Loss ◽  
The Other ◽  
Male Rats ◽  
Adult Rats ◽  
Spontaneous Seizures ◽  
Seizure Model ◽  
One Year ◽  
The Brain

Male rats were seized with lithium and pilocarpine and then injected within 30 min. with either acepromazine or ketamine. These rats as well as age-matched normal rats were observed daily for one year. The rats which had received the ketamine after the seizures were significantly heavier than either the normal rats or the other group of seized rats. The bulk of this increased weight was due to the marked increase in white, extremely dense adipose tissue. Compared to the acepromazine-treated rats, the ketamine-treated rats did not exhibit spontaneous seizures and exhibited cerebral widths comparable to normal rats. These results suggest that the multifocal, graded neuronal loss associated with this seizure model may allow other “configurations” to emerge that can support normal behaviors as well as new characteristics.

Will caloric restriction and folate protect against AD and PD?

Neurology ◽  
2003 ◽  
Vol 60 (4) ◽  
pp. 690-695 ◽  
Author(s):  
Mark P. Mattson
Keyword(s):  
Folic Acid ◽  
Dietary Restriction ◽  
Neurodegenerative Disorders ◽  
Neurotrophic Factors ◽  
Animal Studies ◽  
Neuronal Damage ◽  
Epidemiologic Studies ◽  
Beneficial Effects ◽  
The Brain ◽  
High Calorie

Recent epidemiologic studies of different sample populations have suggested that the risk of AD and PD may be increased in individuals with high-calorie diets and in those with increased homocysteine levels. Dietary restriction and supplementation with folic acid can reduce neuronal damage and improve behavioral outcome in mouse models of AD and PD. Animal studies have shown that the beneficial effects of dietary restriction result, in part, from increased production of neurotrophic factors and cytoprotective protein chaperones in neurons. By keeping homocysteine levels low, folic acid can protect cerebral vessels and can prevent the accumulation of DNA damage in neurons caused by oxidative stress and facilitated by homocysteine. Although further studies are required in humans, the emerging data suggest that high-calorie diets and elevated homocysteine levels may render the brain vulnerable to neurodegenerative disorders.

Components of verbal learning and hippocampal damage assessed by T2 relaxometry

2000 ◽  
Vol 6 (5) ◽  
pp. 529-538 ◽  
Author(s):  
AMANDA G. WOOD ◽  
MICHAEL M. SALING ◽  
MARIE F. O'SHEA ◽  
SAMUEL F. BERKOVIC ◽  
GRAEME D. JACKSON
Keyword(s):  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Verbal Learning ◽  
Relaxation Times ◽  
Hippocampal Damage ◽  
T2 Relaxation ◽  
Verbal Recall ◽  
Two Factors ◽  
Left And Right ◽  
Components Analysis

We studied a group of 31 temporal lobe epilepsy patients (25 left, 6 right) with unilateral hippocampal sclerosis evident on magnetic resonance imaging. Single slice T2 relaxation times were acquired for the left and right hippocampi. Principal components analysis of preoperative memory data resulted in two factors that reflect a distinction between arbitrary and semantic forms of verbal recall. The former component correlated with left hippocampal T2 relaxation time, while the latter component did not. This study suggests that variation in left hippocampal integrity is more related to the acquisition of arbitrary associates than semantically structured material, and reinforces the possibility that the left temporal lobe is functionally heterogeneous with respect to memory. (JINS, 2000, 6, 529–538.)

Amnion's Horn or Hippocampal Sclerosis without Epilepsy in Mental Handicap

1984 ◽  
Vol 144 (5) ◽  
pp. 538-541 ◽  
Author(s):  
P. E. Sylvester
Keyword(s):  
Cerebral Palsy ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Down’S Syndrome ◽  
Mesial Temporal Sclerosis ◽  
Mentally Handicapped ◽  
Mental Handicap ◽  
The Brain ◽  
Neuropathological Examination

SummaryNeuropathological examination of the brain of eight adult mentally handicapped patients showed mesial temporal sclerosis. Three patients had cerebral palsy, one had Down's syndrome, three were retarded, and one had an unspecific mental handicap. Although there was a suspicion of fits in most patients, temporal lobe epilepsy was not diagnosed in life.

Dendrobium officinalis Flower Improves Learning and Reduces Memory Impairment by Mediating Antioxidant Effect and Balancing the Release of Neurotransmitters in Senescent Rats

2020 ◽  
Vol 23 (5) ◽  
pp. 402-410 ◽  
Author(s):  
Lin-Zi Li ◽  
Shan-Shan Lei ◽  
Bo Li ◽  
Fu-Chen Zhou ◽  
Ye-Hui Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Brain Aging ◽  
Morris Water Maze Test ◽  
Control Group ◽  
Histopathological Analysis ◽  
Hippocampal Damage ◽  
Common Belief ◽  
Mao B ◽  
Positive Effects ◽  
The Brain

Aim and Objective: The Dendrobium officinalis flower (DOF) is popular in China due to common belief in its anti-aging properties and positive effects on “nourish yin”. However, there have been relatively few confirmatory pharmacological experiments conducted to date. The aim of this work was to evaluate whether DOF has beneficial effects on learning and memory in senescent rats, and, if so, to determine its potential mechanism of effect. Materials and Methods: SD rats were administrated orally DOF at a dose of 1.38, or 0.46 g/kg once a day for 8 weeks. Two other groups included a healthy untreated control group and a senescent control group. During the 7th week, a Morris water maze test was performed to assess learning and memory. At the end of the experiment, serum and brain samples were collected to measure concentrations of antioxidant enzymes, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH-Px) in serum, and the neurotransmitters, including γ-aminobutyric acid (γ-GABA), Glutamic (Glu), and monoamine oxidase B (MAO-B) in the brain. Histopathology of the hippocampus was assessed using hematoxylin-eosin (H&E) staining. Results: The results suggested that treatment with DOF improved learning as measured by escape latency, total distance, and target quadrant time, and also increased levels of γ-GABA in the brain. In addition, DOF decreased the levels of MDA, Glu, and MAO-B, and improved SOD and GSHPx. Histopathological analysis showed that DOF also significantly reduced structural lesions and neurodegeneration in the hippocampus relative to untreated senescent rats. Conclusion: DOF alleviated brain aging and improved the spatial learning abilities in senescent rats, potentially by attenuating oxidative stress and thus reducing hippocampal damage and balancing the release of neurotransmitters.

scholarly journals Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy

2021 ◽  
Vol 22 (8) ◽  
pp. 3860
Author(s):  
Elisa Ren ◽  
Giulia Curia
Keyword(s):  
Animal Models ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Current Knowledge ◽  
Focal Epilepsy ◽  
Ex Vivo ◽  
Hippocampal Sclerosis ◽  
Control Group ◽  
Epileptogenic Zone ◽  
Epileptiform Discharges

Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy, characterized by recurrent spontaneous seizures originating in the temporal lobe(s), with mesial TLE (mTLE) as the worst form of TLE, often associated with hippocampal sclerosis. Abnormal epileptiform discharges are the result, among others, of altered cell-to-cell communication in both chemical and electrical transmissions. Current knowledge about the neurobiology of TLE in human patients emerges from pathological studies of biopsy specimens isolated from the epileptogenic zone or, in a few more recent investigations, from living subjects using positron emission tomography (PET). To overcome limitations related to the use of human tissue, animal models are of great help as they allow the selection of homogeneous samples still presenting a more various scenario of the epileptic syndrome, the presence of a comparable control group, and the availability of a greater amount of tissue for in vitro/ex vivo investigations. This review provides an overview of the structural and functional alterations of synaptic connections in the brain of TLE/mTLE patients and animal models.

scholarly journals (Ascorb)ing Pb Neurotoxicity in the Developing Brain

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1311
Author(s):  
Faraz Ahmad ◽  
Ping Liu
Keyword(s):  
Ascorbic Acid ◽  
Animal Studies ◽  
Redox Homeostasis ◽  
Special Role ◽  
Developmental Exposure ◽  
Brain Functions ◽  
Brain States ◽  
Pb Exposure ◽  
The Brain ◽  
Potent Therapeutic Agent

Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

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