Inflammation in Aging Part 1: Physiology and Immunological Mechanisms

2009 ◽  
Vol 11 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Katherine J. Hunt ◽  
Bronagh M. Walsh ◽  
David Voegeli ◽  
Helen C. Roberts
Keyword(s):  
Chronic Inflammation ◽  
Aging Process ◽  
Age Related ◽  
Immunological Mechanisms ◽  
Inflammatory Processes ◽  
Inflammatory Proteins ◽  
The Individual ◽  
Inflammatory Milieu ◽  
The Impact

During the aging process, remodeling of several body systems occurs, and these changes can have a startling effect upon the immune system. The reduction in sex steroids and growth hormones and declines in vitamin D concentration that accompany the aging process are associated with increases in the baseline levels of inflammatory proteins. At the same time, inflammation arising from atherosclerosis and other chronic diseases further contributes to the inflammatory milieu and effects a state of chronic inflammation. This chronic inflammation, or ‘‘inflammaging’’ as it has been termed, seems to be associated with a host of adverse effects contributing to many of the health problems that increase morbidity and decrease both quality of life and the ability to maintain independence in old age. For nurses to be truly informed when caring for older people and to ensure that they have a detailed understanding of the complexities of older people’s health needs, they must have a knowledge of the physiological and immunological changes with age. This is the first of a two-part article on inflammatory processes in aging. These age-related changes are presented here, including an examination of the impact of genetic and lifestyle factors. The effect of these changes on the health of the individual and implications for practice are described in Part 2.

scholarly journals Knowledge sharing in open source software communities: motivations and management

2015 ◽  
Vol 19 (4) ◽  
pp. 791-813 ◽  
Author(s):  
Zilia Iskoujina ◽  
Joanne Roberts
Keyword(s):  
Knowledge Sharing ◽  
Open Source ◽  
Open Source Software ◽  
Online Communities ◽  
Descriptive Analysis ◽  
Online Questionnaire ◽  
Content Type ◽  
The Individual ◽  
The Impact

Purpose – This paper aims to add to the understanding of knowledge sharing in online communities through an investigation of the relationship between individual participant’s motivations and management in open source software (OSS) communities. Drawing on a review of literature concerning knowledge sharing in organisations, the factors that motivate participants to share their knowledge in OSS communities, and the management of such communities, it is hypothesised that the quality of management influences the extent to which the motivations of members actually result in knowledge sharing. Design/methodology/approach – To test the hypothesis, quantitative data were collected through an online questionnaire survey of OSS web developers with the aim of gathering respondents’ opinions concerning knowledge sharing, motivations to share knowledge and satisfaction with the management of OSS projects. Factor analysis, descriptive analysis, correlation analysis and regression analysis were used to explore the survey data. Findings – The analysis of the data reveals that the individual participant’s satisfaction with the management of an OSS project is an important factor influencing the extent of their personal contribution to a community. Originality/value – Little attention has been devoted to understanding the impact of management in OSS communities. Focused on OSS developers specialising in web development, the findings of this paper offer an important original contribution to understanding the connections between individual members’ satisfaction with management and their motivations to contribute to an OSS project. The findings reveal that motivations to share knowledge in online communities are influenced by the quality of management. Consequently, the findings suggest that appropriate management can enhance knowledge sharing in OSS projects and online communities, and organisations more generally.

An Analysis on Human Resource Development Culture and Climate of Chemical Based Public Sector Enterprises in Kerala, India

2021 ◽  
Vol 2021 (6) ◽  
pp. 132-135
Author(s):  
Balakrishnan A ◽  
Dr. KVM Varambally
Keyword(s):  
Public Sector ◽  
Human Resource Development ◽  
Human Resource ◽  
Deep Structure ◽  
Positive Culture ◽  
Resource Development ◽  
The Individual ◽  
The Impact ◽  
Culture And Climate

The impact of Globalization creates a competitive horizon with new markets, new products, new mindsets, new competencies, and new ways of thinking about business. As an outcome of this, the market places become more complex, uncertain, competitive, and transformational. In this era, the major challenge faced by any organization is to maintain a peaceful as well positive culture and climate inside the organization. The human resource development climate of an organization plays a significant role in ensuring the competency, motivation, and development of its employees. Here the term climate denotes the quality of the internal environment. It influences morale and the attitudes of the individual toward his work and his environment. Culture refers to the deep structure of organizations, which is rooted in the values, beliefs, and assumptions held by organizational members. The study was aimed to analyze the Human Resource Development culture and climate of chemical-based public sector enterprises in Kerala. The results indicated that the Human Resource Development climate in an organization is average and the perception of employees regarding Human Resource Development culture and climate does not differs significantly based on age, job approval status, and qualification. But it differs significantly based on gender and experiences.

scholarly journals The Impact of Behavioral Intervention on Obesity Mediated Declines in Mobility Function: Implications for Longevity

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Joe Nocera ◽  
Thomas W. Buford ◽  
Todd M. Manini ◽  
Kelly Naugle ◽  
Christiaan Leeuwenburgh ◽  
...  
Keyword(s):  
Older Adults ◽  
Aging Process ◽  
Strong Predictor ◽  
Functional Limitations ◽  
Mobility Performance ◽  
Mobility Function ◽  
Age Related ◽  
Close Relationship ◽  
Primary Focus ◽  
The Impact

A primary focus of longevity research is to identify prognostic risk factors that can be mediated by early treatment efforts. To date, much of this work has focused on understanding the biological processes that may contribute to aging process and age-related disease conditions. Although such processes are undoubtedly important, no current biological intervention aimed at increasing health and lifespan exists. Interestingly, a close relationship between mobility performance and the aging process has been documented in older adults. For example, recent studies have identified functional status, as assessed by walking speed, as a strong predictor of major health outcomes, including mortality, in older adults. This paper aims to describe the relationship between the comorbidities related to decreased health and lifespan and mobility function in obese, older adults. Concurrently, lifestyle interventions, including diet and exercise, are described as a means to improve mobility function and thereby limit the functional limitations associated with increased mortality.

scholarly journals The Impact of the Quality Assessment of Optimal Assignment for Data Association in a Multitarget Tracking Context

2015 ◽  
Vol 15 (7) ◽  
pp. 88-98
Author(s):  
J. Dezert ◽  
A. Tchamova ◽  
P. Konstantinova
Keyword(s):  
Quality Assessment ◽  
Data Association ◽  
New Method ◽  
Multitarget Tracking ◽  
Belief Functions ◽  
Tracking Systems ◽  
Optimal Assignment ◽  
The Individual ◽  
The Impact

Abstract The main purpose of this paper is to apply and to test the performance of a new method, based on belief functions, proposed by Dezert et al. in order to evaluate the quality of the individual association pairings provided in the optimal data association solution for improving the performances of multisensor-multitarget tracking systems. The advantages of its implementation in an illustrative realistic surveillance context, when some of the association decisions are unreliable and doubtful and lead to potentially critical mistake, are discussed. A comparison with the results obtained on the base of Generalized Data Association is made.

scholarly journals Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging

2021 ◽  
Vol 12 ◽  
Author(s):  
Serena Dato ◽  
Paolina Crocco ◽  
Nicola Rambaldi Migliore ◽  
Francesco Lescai
Keyword(s):  
High Throughput ◽  
Aging Process ◽  
Single Cell Analysis ◽  
Physiological Age ◽  
Data Types ◽  
Aging Research ◽  
Digital World ◽  
Age Related ◽  
Critical Issues ◽  
The Individual

BackgroundAging is a complex phenotype influenced by a combination of genetic and environmental factors. Although many studies addressed its cellular and physiological age-related changes, the molecular causes of aging remain undetermined. Considering the biological complexity and heterogeneity of the aging process, it is now clear that full understanding of mechanisms underlying aging can only be achieved through the integration of different data types and sources, and with new computational methods capable to achieve such integration.Recent AdvancesIn this review, we show that an omics vision of the age-dependent changes occurring as the individual ages can provide researchers with new opportunities to understand the mechanisms of aging. Combining results from single-cell analysis with systems biology tools would allow building interaction networks and investigate how these networks are perturbed during aging and disease. The development of high-throughput technologies such as next-generation sequencing, proteomics, metabolomics, able to investigate different biological markers and to monitor them simultaneously during the aging process with high accuracy and specificity, represents a unique opportunity offered to biogerontologists today.Critical IssuesAlthough the capacity to produce big data drastically increased over the years, integration, interpretation and sharing of high-throughput data remain major challenges. In this paper we present a survey of the emerging omics approaches in aging research and provide a large collection of datasets and databases as a useful resource for the scientific community to identify causes of aging. We discuss their peculiarities, emphasizing the need for the development of methods focused on the integration of different data types.Future DirectionsWe critically review the contribution of bioinformatics into the omics of aging research, and we propose a few recommendations to boost collaborations and produce new insights. We believe that significant advancements can be achieved by following major developments in bioinformatics, investing in diversity, data sharing and community-driven portable bioinformatics methods. We also argue in favor of more engagement and participation, and we highlight the benefits of new collaborations along these lines. This review aims at being a useful resource for many researchers in the field, and a call for new partnerships in aging research.

scholarly journals ADAPTASI MODEL DELONE DAN MCLEAN YANG DIMODIFIKASI GUNA MENGUJI KEBERHASILAN IMPLEMENTASI APLIKASI OPERASIONAL BAITUL MAAL WAT TAMWIL (BMT) BAGI INDIVIDU PENGGUNA (Studi Empiris Pada BMT di Kota Semarang)

2016 ◽  
Vol 4 (2) ◽  
pp. 123
Author(s):  
Novita Anugrah Listiyana ◽  
Dedi Rusdi
Keyword(s):  
Path Analysis ◽  
User Satisfaction ◽  
Sampling Technique ◽  
Individual Performance ◽  
Quality System ◽  
Quality Of Information ◽  
Positive Direction ◽  
The Individual ◽  
The Impact

This study analyzed the relationship between humans as users of the system and application software as object an inseparable relationship. The purpose of this study was to analyze the effect of variable quality system to the perception of the quality system, the effect of perceived quality system and quality of information on the intensity of use and user satisfaction, and the influence of the intensity of use and user satisfaction of the impact of individual performance. This research is an empirical study using purposive sampling technique in data collection. Data were collected through  questionnaires to 39 BMT’s operational employees. Then, performed an analysis of the data obtained used path analysis. This included: testing hypotheses through path analysis. The results of tests performed using path analysis to get the results that each variable in the model of equation 4 had a coefficient with a positive direction. This means that the improvement of the quality of the system will be able to improve the quality of information for the individual impact of the use and satisfaction of employees through the use of the system.

Spa-therapy can improve quality of life in chronic musculoskeletal disorder subjects: a narrative review

2020 ◽  
Vol 96 (2) ◽  
pp. 3-6
Author(s):  
M.C. Maccarone ◽  
G. Magro ◽  
U. Solimene ◽  
S. Masiero
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Thermal Environment ◽  
Narrative Review ◽  
Spa Therapy ◽  
Age Related ◽  
Therapy Interventions ◽  
The Impact

Chronic Musculoskeletal Disorders (MSDs) are age-related conditions, linked to functional impairment and decreased quality of life (QoL). As a result of the increased life expectancy in Europe, great attention has been focused on investigating the impact of these diseases on QoL. Thermal environment is a suitable place for providing interventions (mud therapy, bath, exercise, etc.) for chronic MSD patients. Our narrative review aims to assess if Spa therapy may improve QoL in patients with chronic MSDs. We searched randomized clinical trials and clinical trials screening PubMed and Google Scholar databases from 2016 up to March 2020. We included 14 trials testing Spa therapy interventions concerning osteoarthritis, rheumatoid arthritis, chronic shoulder pain and fibromyalgia. In conclusion, even though limitations must be considered, evidence shows that Spa therapy, especially in combination with rehabilitation approach, can significantly improve QoL of patients with chronic MSDs.

Physical activity diminishes aging-related decline of physical and cognitive performance

2014 ◽  
Vol 155 (21) ◽  
pp. 817-821 ◽  
Author(s):  
Péter Apor ◽  
László Babai
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Life Expectancy ◽  
Aging Process ◽  
Muscle Force ◽  
Walking Speed ◽  
Prognostic Impact ◽  
Elderly Persons ◽  
The Impact

Aging-related decline of muscle force, walking speed, locomotor coordination, aerobic capacity and endurance exert prognostic impact on life expectancy. Proper use of training may diminish the aging process and it may improve the quality of life of elderly persons. This paper provides a brief summary on the impact of training on aging-related decline of physical and cognitive functions. Orv. Hetil., 2014, 155(21), 817–821.

scholarly journals Considerations for the Development of Innovative Foods to Improve Nutrition in Older Adults

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1275 ◽  
Author(s):  
Mariane Lutz ◽  
Guillermo Petzold ◽  
Cecilia Albala
Keyword(s):  
Older Adults ◽  
Functional Limitations ◽  
Chronic Illnesses ◽  
Consumer Market ◽  
Age Related ◽  
Swallowing Problems ◽  
Global Burden Of Diseases ◽  
The Impact

The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly to the development of coronary heart disease, hypertension, some types of cancer, and type 2 diabetes, among other diseases, while age-associated changes in body composition (bone and muscle mass, fat, sarcopenia) constitute risk factors for functional limitations affecting health status and the quality of life. Older adults present eating and swallowing problems, dry mouth, taste loss, and anorexia among other problems causing “anorexia of aging” that affects their nutritional status. The strategies to overcome these situations are described in this study. The impact of oral food processing on nutrition is discussed, as well as approaches to improve food acceptance through the design of innovative foods. These foods should supply a growing demand as this group represents an increasing segment of the consumer market globally, whose needs must be fulfilled.

scholarly journals Water Quality of Freshwater Ecosystems in a Temperate Climate

Water ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2643
Author(s):  
Piotr Klimaszyk ◽  
Ryszard Gołdyn
Keyword(s):  
Water Quality ◽  
Freshwater Ecosystems ◽  
Temperate Climate ◽  
Special Issue ◽  
Quality Of Water ◽  
Local Water ◽  
Water Ecosystems ◽  
The Individual ◽  
The Impact

Water is the substance that made life on Earth possible. It plays a key role in both the individual and population development of all species. Water is also a critical resource for humans as populations continue to grow and climate change affects global and local water cycles. Water is a factor limiting economic development in many regions of the world. Under these conditions, good water quality becomes an extremely important factor that determines its economic utility, including water supply, recreation, and agriculture. Proper water quality maintenance of freshwater ecosystems is also very important for preserving biodiversity. The quality of water depends on many factors, the most important of which are related to human impact on water ecosystems, especially the impact of various pollutants from municipal economy, industry and agriculture. Hydrotechnical changes, such as river damming, drainage processes and water transport between catchments also have a significant impact. Water quality is also dependent on the impact of natural conditions connected, e.g., with climate, catchment, water organisms and their interactions within the food-webs, etc. This Special Issue consists of fourteen original scientific papers concerning different problems associated with the water quality of freshwater ecosystems in a temperate climate. Most of the articles deal with the relations between water quality and the structure of ecosystem biocenoses. The conclusion of these articles confirms the fact that the deterioration of water quality has a direct impact on the quantitative and qualitative structure of biocenoses. This is accompanied by a decline in biodiversity and the disappearance of rare plant and animal species. They also draw attention to the particular importance of internal physical and chemical differentiation within the aquatic ecosystem, both in horizontal and vertical dimensions. The problem of ensuring proper ecological conditions and good quality of water in freshwater aquatic ecosystems is also raised, and methods for the restoration of water bodies are presented. The majority of the research presented in this Special Issue was carried out in Central Europe, and one of the papers concerns the area of West Africa—the edge of temperate climate zone.

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