scholarly journals Protective Effect of Aerobic Physical Activity on Sleep Behavior in Breast Cancer Survivors

2016 ◽  
Vol 16 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Eliana Roveda ◽  
Jacopo A. Vitale ◽  
Eleonora Bruno ◽  
Angela Montaruli ◽  
Patrizia Pasanisi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Circadian Rhythm ◽  
Activity Level ◽  
Control Group ◽  
Sleep Study ◽  
Wake Time ◽  
Increased Risk ◽  
Immobility Time ◽  
Risk Of Cancer

Hypotheses. Sleep disorders are associated with an increased risk of cancer, including breast cancer (BC). Physical activity (PA) can produce beneficial effects on sleep. Study design. We designed a randomized controlled trial to test the effect of 3 months of physical activity on sleep and circadian rhythm activity level evaluated by actigraphy. Methods. 40 BC women, aged 35-70 years, were randomized into an intervention (IG) and a control group (CG). IG performed a 3 month of aerobic exercise. At baseline and after 3 months, the following parameters were evaluated both for IG and CG: anthropometric and body composition measurements, energy expenditure and motion level; sleep parameters (Actual Sleep Time-AST, Actual Wake Time-AWT, Sleep Efficiency-SE, Sleep Latency-SL, Mean Activity Score-MAS, Movement and Fragmentation Index-MFI and Immobility Time-IT) and activity level circadian rhythm using the Actigraph Actiwatch. Results. The CG showed a deterioration of sleep, whereas the IG showed a stable pattern. In the CG the SE, AST and IT decreased and the AWT, SL, MAS and MFI increased. In the IG, the SE, IT, AWT, SL, and MAS showed no changes and AST and MFI showed a less pronounced change in the IG than in the CG. The rhythmometric analysis revealed a significant circadian rhythm in two groups. After 3 months of PA, IG showed reduced fat mass %, while CG had improved weight and BMI. Conclusion. Physical activity may be beneficial against sleep disruption. Indeed, PA prevented sleep worsening in IG. PA can represent an integrative intervention therapy able to modify sleep behaviour.

scholarly journals Pathological Significance of GLUT-1 Expression in Breast Cancer Cells in Diabetic and Obese Patients: The French Guiana Study

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 437
Author(s):  
Valentin Suteau ◽  
John Bukasa-Kakamba ◽  
Beatrice Virjogh-Cenciu ◽  
Antoine Adenis ◽  
Nadia Sabbah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Size ◽  
French Guiana ◽  
Proliferation Index ◽  
Control Group ◽  
Obese Patients ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Increased Risk ◽  
Risk Of Cancer

The prevalence of obesity and type 2 diabetes is higher in French Guiana compared to mainland France. These metabolic disorders are associated with an increased risk of cancer. One of the factors involved is hyperinsulinemia that promotes the action of glucose transporter 1 (GLUT-1). The objective of this study is to characterize the expression of GLUT-1 in breast cancers cells in diabetic and obese patients compared to those who are not and to describe the clinical and histological prognostic factors of breast cancer in this population. We conducted a monocentric study including patients with breast cancer diagnosed between 2014 and 2020. Patients were classified into three groups: diabetes, obesity, and control group. The GLUT-1 expression was assessed by immunohistochemistry. In total, 199 patients were included in this study. The median age was 53.5 years, and the median tumor size was 2.8 cm. Luminal A was the most frequent molecular type (58.1%), followed by the triple-negative type (19.9%). The breast cancer in our population was characterized by a younger age at diagnosis, more aggressive molecular types, and larger tumor size. Thus, we suggest the advancement of the age of breast cancer screening in this territory. A total of 144 patients (31 diabetes, 22 obese, and 91 control group) were included for the study of GLUT-1 expression. Overexpression of GLUT-1 was observed in 60.4% of cases and in all carcinoma in situ lesions. GLUT-1 overexpression was associated with more aggressive cancers. This overexpression is correlated with high histological grade, high proliferation index, and aggressive molecular types. Our study found no difference in GLUT-1 expression between the diabetic or obese patients and the control group. These results highlight the potential role of GLUT-1 as a tumor metabolic prognostic marker and also as an interesting target therapy, independently of patient metabolic disorder.

scholarly journals Disminución de la funcionalidad de miembro superior y bajo nivel de actividad física en supervivientes de cáncer de mama: Un estudio de caso-control (Decreased upper limb function and low level of physical activity following treatment for breast cancer -

Retos ◽  
2021 ◽  
Vol 44 ◽  
pp. 302-308
Author(s):  
Ivana Leao Ribeiro ◽  
Cecilia Rivera Mañán ◽  
Fabián García Sepúlveda ◽  
Miguel Fuentealba Naranjo ◽  
Nicolás Yáñez Benavides ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Upper Limb ◽  
Physical Activity Level ◽  
Handgrip Strength ◽  
Activity Level ◽  
Cáncer De Mama ◽  
Control Group ◽  
Shoulder Range Of Motion ◽  
Affected Side

  El presente estudio tiene como objetivo evaluar la funcionalidad de miembro superior, síntomas de fatiga y nivel de actividad física en mujeres post operatorio de cáncer de mama, grupo PO, en comparación a un grupo control de mujeres sanas. La funcionalidad de la extremidad superior se evaluó mediante el rango de movimiento (ROM) de flexión, abducción y rotación externa del hombro utilizando un inclinómetro digital; fuerza de prensión con un dinamómetro y discapacidad del miembro superior con el cuestionario Disabilities of the arm, shoulder and hand. La fatiga se evaluó con el Inventario Breve de Fatiga y el nivel de actividad física con el Cuestionario Internacional de Actividad Física. Treinta y cuatro mujeres (n=17, grupo PO; n=17, grupo control, GC) fueron evaluadas. El grupo PO presentó menor ROM del hombro y fuerza de prensión (diferencia de rango: 22,9°-22,9°; 5,6kgF, respectivamente) en comparación con el GC; el lado afectado presentó menor ROM del hombro en comparación con el lado no afectado (15°-21°). También hubo una mayor discapacidad en el lado afectado y un menor nivel de actividad física en el grupo PO. No hubo diferencias en la fatiga entre los grupos. Concluimos que el grupo PO presentó menor funcionalidad y un bajo nivel de actividad física en comparación con un grupo control. Abstract. This study aim to compare upper limb functionality, fatigue and physical activity level in women after breast cancer surgery in relation to a control group. Upper limb functionality was evaluated by mean of shoulder range of motion (ROM) of flexion, abduction and external rotation using a digital inclinometer; handgrip strength using a dynamometer and upper limb disability with the Disabilities of the arm, shoulder and hand questionnaire. Fatigue was assessed with the Brief Fatigue Inventory and physical activity level with the International Physical Activity Questionnaire. A thirty-four women (n=17, post-operated breast surgery group, PO; n=17, control group, CG) were recruited. PO group presented a decrease in both shoulder ROM and handgrip strength (range difference: 22.9°-22,9°; 5.6kgF, respectively) compared to CG; the affected side of the PO group presented with less shoulder ROM in comparison to the non-affected side (15°-21°). There was also greater disability on the affected side and a lower physical activity level in the PO group. There were no differences in the fatigue between the groups. We concluded that PO group presented with compromised functionality and low physical activity level compared to a control group.

Does Long-Term Exposure to Gel-Filled Silicone Implants Increase the Risk of Relapse after Breast Cancer?

1998 ◽  
Vol 84 (5) ◽  
pp. 525-528 ◽  
Author(s):  
Jean-Yves Petit ◽  
Monique Lê ◽  
Mario Rietjens ◽  
Geneviève Contesso ◽  
Andrée Lehmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Proportional Hazards Model ◽  
Silicone Implants ◽  
Control Group ◽  
Second Primary ◽  
Increased Risk ◽  
Risk Of Cancer

Background An increased risk of cancer and autoimmune diseases associated with gel-filled silicone implants, debated by FDA experts since 1991, has given rise to a profusion of literature on the subject. However, such effects have not been adequately investigated in patients with breast cancer. In a previous report we compared 146 breast cancer patients with gel-filled silicone implants for breast reconstruction to 146 control patients in whom no reconstruction had been performed. The observed results were reassuring, as the evolution of the disease after 10 years was better in the reconstruction group than in the control group. We now report the end results of this study with a median follow-up of 13 years after the breast reconstruction (range, 10-20 years). Method The relative risks of detrimental events were estimated with Cox's Proportional Hazards Model, with stratification according to age at diagnosis. Results The risks of locoregional recurrences and distant metastasis were significantly lower in the BR group than in the control group. The risks of death, of a second breast cancer and of a second primary cancer at a site other than the breast were not significantly different between the two groups of patients. Conclusion Long-term follow-up of patients exposed to gel-filled silicone implants confirms the absence of detrimental effects after breast cancer. The power of our study is, however, below that required to detect a very slight increase in the risks studied.

scholarly journals Effects of Scheduled Exercise on Cancer-Related Fatigue in Women with Early Breast Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Anne Marie Lunde Husebø ◽  
Sindre Mikal Dyrstad ◽  
Ingvil Mjaaland ◽  
Jon Arne Søreide ◽  
Edvin Bru
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Activity Level ◽  
Control Group ◽  
Activity Levels ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue

While physical activity during cancer treatment is found beneficial for breast cancer patients, evidence indicates ambiguous findings concerning effects of scheduled exercise programs on treatment-related symptoms. This study investigated effects of a scheduled home-based exercise intervention in breast cancer patients during adjuvant chemotherapy, on cancer-related fatigue, physical fitness, and activity level. Sixty-seven women were randomized to an exercise intervention group (n=33, performed strength training 3x/week and 30 minutes brisk walking/day) and a control group (n=34, performed their regular physical activity level). Data collection was performed at baseline, at completion of chemotherapy (Post1), and 6-month postchemotherapy (Post2). Exercise levels were slightly higher in the scheduled exercise group than in the control group. In both groups, cancer-related fatigue increased at Post1but returned to baseline at Post2. Physical fitness and activity levels decreased at Post1but were significantly improved at Post2. Significant differences between intervention and control groups were not found. The findings suggest that generally recommended physical activity levels are enough to relief cancer-related fatigue and restore physical capacity in breast cancer patients during adjuvant chemotherapy, although one cannot rule out that results reflect diminishing treatment side effects over time.

Risk of cancer treatment-related osteoporosis and fractures among women with breast cancer receiving aromatase inhibitors

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 557-557 ◽  
Author(s):  
B. Mincey ◽  
M. Duh ◽  
S. Thomas ◽  
E. Moyneur ◽  
M. Marynchencko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Relative Risk ◽  
Bone Loss ◽  
Aromatase Inhibitors ◽  
Univariate Analysis ◽  
Estrogen Therapy ◽  
Control Group ◽  
Estrogen Production ◽  
Increased Risk ◽  
Risk Of Cancer

557 Background: Aromatase inhibitors (AIs) are a novel hormonal therapy for breast cancer. However, AIs can cause bone loss by blocking estrogen production. This study aims to assess the association between AIs and treatment-related bone loss in a large managed care population of women with breast cancer. Methods: Using medical and pharmacy claims data from over 5 million beneficiaries between 01/01/1998 and 01/31/2005, we identified 12,368 patients with ≥ 2 breast cancer claims in a 6-month period, who also had no bone metastasis and no prior osteoporosis or fracture claims. Patients who received anti-estrogen therapy were also excluded to remove the protective confounding effects. 1,354 patients receiving an AI (anastrozole, exemestane, letrozole) were compared to 11,014 controls who did not receive an AI with respect to their risk of bone loss. The observation start date for the AI and control groups was defined as the service date of the first AI claim and breast cancer claim, respectively. The bone loss endpoints analyzed were osteoporosis (including osteopenia) and clinical fractures. Results: The univariate analysis found that the prevalence of osteoporosis was 8.7% in the AI group vs. 7.1% in the control group, resulting in a statistically significant relative risk of 1.3 (95% CI=1.1–1.6, p=0.01). The prevalence of bone fracture was also statistically significantly elevated in the AI group compared to the controls (13.5% vs. 10.3%) with a relative risk of 1.4 (95% CI=1.2–1.6, p=0.001). Multivariate Cox proportional hazards regressions showed that after adjusting for age and comorbidities, the risk of bone loss remained statistically significantly higher in the AI group than the non-AI group, with 27% (95% CI=4%-55%, p=0.02) and 21% (95% CI=3%-43%, p=0.02) increase in the risk of osteoporosis and fractures, respectively. Conclusions: This retrospective longitudinal analysis of a large cohort of breast cancer patients corroborates previous findings from smaller clinical trials and demonstrates that AI therapies carry an increased risk of bone loss. Monitoring and treatment management strategies to alleviate bone loss risk are warranted in women receiving AI for breast cancer. [Table: see text]

Impact of physical activity on insulin levels in breast cancer survivors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 555-555
Author(s):  
J. A. Ligibel ◽  
N. Campbell ◽  
H. Chen ◽  
T. Salinardi ◽  
W. Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Strength Training ◽  
Breast Cancer Survivors ◽  
Exercise Group ◽  
Control Group ◽  
Insulin Levels ◽  
Glucose Levels ◽  
Increased Risk

555 Background: Accumulating data suggest that body weight and physical activity may affect breast cancer risk and outcomes. Biological mechanisms underlying these relationships are not clear. Studies have demonstrated that high levels of insulin, often seen in obese and sedentary individuals, are also associated with an increased risk of breast cancer recurrence and breast cancer-related death. We sought to analyze whether exercise lowers insulin levels in a population of breast cancer survivors. Methods: Inactive women with early stage breast cancer who had completed adjuvant treatment were randomized to a 16 week, mixed cardiovascular and strength training exercise intervention, or to a normal care control group. Target exercise goals included 2 supervised strength training sessions and 90 minutes of unsupervised cardiovascular exercise each week. Fasting insulin and glucose levels, as well as measurement of weight, body composition, and circumference at the waist and hip, were collected at baseline and after 16 weeks in both groups, and changes in these measures were assessed. Results: One hundred and one women were randomized. Comparison of changes in anthropometric measures are presented in Table 1 . Baseline insulin levels were similar in the 2 groups. After the 16-week exercise or control period, insulin levels decreased by 2.86 μIU/ml in the exercise group (p=0.03), and by 0.27 μIU/ml in the control group (p=0.65). A comparison of the change in insulin levels across time in the 2 groups approached statistical significance (p=0.07). There was also a trend toward improvements in insulin sensitivity in the exercise group (p=0.09), with no change seen in fasting glucose levels. Conclusions: Physical activity was associated with a decrease in insulin levels and in hip circumference in breast cancer survivors. The relationship between physical activity and breast cancer prognosis may be mediated, at least partially, through changes in insulin levels and/or changes in fat mass or deposition. [Table: see text] No significant financial relationships to disclose.

scholarly journals Circadian rhythm for female entering old age: exploration on the effect of eating behavior

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 632-633
Author(s):  
Hsiao-Han Tang ◽  
Ching-Ju Chiu
Keyword(s):  
Physical Activity ◽  
Circadian Rhythm ◽  
Eating Behavior ◽  
Vigorous Physical Activity ◽  
Activity Level ◽  
Sleep Diary ◽  
Middle Aged ◽  
Convenience Sample ◽  
Wake Time ◽  
Waking Up

Abstract Unhealthy lifestyle and eating behavior are associated with circadian rhythm disruption which contributes to numerous harmful outcomes. The relationship between circadian rhythm and eating behavior remains unclear. The study aims to investigate different types of eating behavior in middle-aged women and their variation in circadian rhythm. A descriptive, cross-sectional design was used. We recruited a convenience sample of 150 female aged 45 years or over from the community in southern Taiwan. Sociodemographic status, sleep diary and eating behavior were collected by questionnaires; behavioral circadian rhythm were monitored with the wrist-worn application. Four middle-aged participants were interviewed. Preliminary data show three main findings: (1) Sleep efficiency was decrease with age, (2) First meal within 2 hours after waking up was associated with higher amplitude (2.24 vs 1.43 log count), relative amplitude (0.92 vs 0.71), middle to vigorous physical activity time (101.22 vs 58.41 minute), lower lowest active 5 hr midpoint (2.63 vs 4.34 hour) and acrophase (13.67 vs 15.75), (3) Participants with morning chronotype have less sedentary behavior and higher most active 10 hr during wake time. Age and timing of first meal after waking up seem dominating circadian rhythm. Chronotype might be a significant factor for physical activity level. More data is needed to further confirm the association.

scholarly journals Obesity Factors (Physical Activity and Usual Dietary Pattern) and Breast Cancer in Korea

2019 ◽  
Vol 26 (3) ◽  
pp. 29-34
Author(s):  
Myeong Seong Kim ◽  
Young Hee Nam
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Patients ◽  
Nutrient Intake ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Animal Fat ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopausal

AbstractIntroduction. This study sought to evaluate the association between obesity factors (food consumption and physical activity) and breast cancer incidence in Korean women.Material and methods. The study included breast cancer patients (250 women) and normal participants undergoing medical checkups (250 women) who visited a specialized cancer research hospital between August 1, 2016 and February 15, 2017. Nutrient intake was assessed using a validated food frequency questionnaire (FFQ) covering 112 dishes and foods that Koreans often eat. Physical activity was assessed according to the International Physical Activity Questionnaire (IPAQ) guidelines and was quantified as metabolic equivalent (MET) scores.Results. The results for nutrient intake obtained using the FFQ showed that the control group had a higher consumption of dietary fiber (p < 0.004) and a lower intake of animal fat (p < 0.02) than the breast cancer group. Among breast cancer patients, pre-menopausal women consumed more animal fat (18.6 g ± 11.9 vs. 14.7 g ± 8.5, p < 0.03) than post-menopausal ones. An analysis of the MET scores with logistic regression revealed that lower physical activity among cancer patients was associated with an increased risk of breast cancer, and this association was greater among post-menopausal (OR = 2.11, p < 0.001) than pre-menopausal women (OR = 0.85, p < 0.02).Conclusion. Having a high-fat diet and doing less exercise increases the risk of breast cancer, so it is important to prevent the accumulation of fat and maintain proper weight through regular physical activity to lower the incidence of breast cancer.

Association of different types of dietary fatty acids with breast cancer, a case-control study

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Maryam Gholamalizadeh ◽  
Hossain Shahdoosti ◽  
Effat Bahadori ◽  
Fatemeh BourBour ◽  
Mohammad Esmail Akbari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Dietary Fatty Acids ◽  
Control Group ◽  
Content Type ◽  
Increased Risk ◽  
Different Types ◽  
Omega 6

Purpose The purpose of this study is to explore the association between intake of different types of dietary fats with breast cancer (BC) risk in Iranian women. Design/methodology/approach A total of 540 women (180 women with BC and 360 healthy women) were recruited from Shohadaye Tajrish hospital, Tehran, Iran. Data on anthropometric measurements, physical activity, smoking and alcohol consumption were collected. The food frequency questionnaire was used to assess the intake of fatty acids including saturated fatty acids, mono unsaturated fatty acids, poly unsaturated fatty acids, macronutrients, total fat, cholesterol, and calorie. Findings The cases had significantly higher BMI (29.19 ± 3.2 vs 27.27 kg/m2 ± 2.8) and higher intake of calorie (2737 ± 925 vs 2315 ± 1066 kcal/d, P = 0.01), carbohydrate (402 ± 125 vs 312 ± 170 kcal/d, P = 0.01) and ω−6 fatty acids (5.45 ± 6.9 vs 3.39 ± 0.59 g/d, P = 0.001) compared to the control group . Higher consumption of ω−6 fatty acids was related with higher risk of BC (OR = 5.429, CI95%:2.5–11.79, P = 0.001) The association between BC and intake of omega-6 fatty acids remained significant after adjustments for age, BMI, for using alcohol drinks, smoking, physical activity, calorie intake, protein intake and carbohydrate intake. Originality/value There are insufficient studies to investigate the association of different types of fatty acids with BC. This study found that higher omega-6 fatty acids intake was associated with increased risk of BC in women.

scholarly journals Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)

2021 ◽  
Author(s):  
Jennifer A Ligibel ◽  
Luke Huebner ◽  
Hope S Rugo ◽  
Harold J Burstein ◽  
Debra L Toppmeyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Mass Index ◽  
Metastatic Breast Cancer ◽  
Body Mass ◽  
Hormone Receptor ◽  
Metastatic Breast ◽  
Hazard Ratio ◽  
First Line ◽  
Risk Of Cancer

Abstract Background Obesity and inactivity are associated with increased risk of cancer related- and overall mortality in breast cancer, but there are few data in metastatic disease. Methods CALGB 40502 was a randomized trial of first-line taxane-based chemotherapy for patients with metastatic breast cancer. Height and weight were collected at enrollment. After 299 patients enrolled, the study was amended to assess recreational physical activity (PA) at enrollment using the Nurses’ Health Study Exercise Questionnaire. Associations with progression-free survival (PFS) and overall survival (OS) were evaluated using stratified Cox modeling (strata included hormone receptor status, prior taxane, bevacizumab use, and treatment arm). Results 799 patients were enrolled and at the time of data lock, median follow-up was 60 months. At enrollment, median age was 56.7 years, 73.1% of participants had hormone receptor-positive cancers, 42.6% had obesity, and 47.6% engaged in less than 3 metabolic equivalents of task (MET)-hours of PA/week (&lt;1 hour of moderate PA). Neither baseline body mass index nor PA was statistically significantly associated with PFS or OS, although there was a marginally statistically significant increase in PFS (hazard ratio = 0.83, 95% confidence interval [CI] = 0.79, 1.02; p = .08) and OS (hazard ratio = 0.81, 95% CI = 0.65, 1.02; p = .07) in patients who reported PA greater than 9 MET-hours/week vs 0–9 MET-hours/week. Conclusions In a trial of first-line chemotherapy for metastatic breast cancer, rates of obesity and inactivity were high. There was no statistically significant relationship between body mass index and outcomes. More information is needed regarding the relationship between PA and outcomes.

Sign in / Sign up

Export Citation Format

Share Document