scholarly journals Electronic nicotine delivery system-induced alterations in oral health via saliva assessment

2020 ◽  
Vol 245 (15) ◽  
pp. 1319-1325
Author(s):  
Saeed Alqahtani ◽  
Bruce Cooper ◽  
Claire A Spears ◽  
Christa Wright ◽  
Jonathan Shannahan
Keyword(s):  
Risk Factor ◽  
Oral Health ◽  
Pilot Study ◽  
Periodontal Disease ◽  
Health Effects ◽  
Inflammatory Cytokines ◽  
Delivery Systems ◽  
Disease Development ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery

Use of electronic nicotine delivery systems (ENDS) is becoming increasingly prevalent. ENDS aerosols contain a variety of toxic components that may adversely impact health. Although exposure to traditional cigarette smoke is a risk factor for periodontal disease, the effects of ENDS on oral health have not been adequately examined. To evaluate potential oral health effects associated with ENDS use, a pilot study was performed with 14 current ENDS users and 16 never tobacco users. Participants completed questionnaires about their ENDS use and overall health. Saliva samples were assessed for differential biomarkers of inflammation, toxicity, and disease development. This included evaluation of specific inflammatory cytokines and the global assessment of alterations in metabolites. ENDS users were determined to have elevated saliva levels of interleukin-1β and tumor necrosis factor-α indicative of inflammation. Metabolite profiling determined 368 metabolites were differentially expressed in the saliva of ENDS users versus never tobacco users. Cotinine, the primary metabolite of nicotine, was the most significantly altered metabolite between the groups. Increased levels of prostaglandins and leukotrienes indicated that ENDS users exhibited increased arachidonic acid metabolism compared to never tobacco users. Additionally, a variety of other metabolites known to be involved in immune signaling such as gangliosides, ceramides, angiotensin, and others were also different between groups. Overall, our pilot study demonstrates differential saliva component profiles in current ENDS users, which may contribute to periodontal disease development. These alterations suggest specific pathways of oral disease induced by ENDS use and could be utilized as potential future biomarkers. Impact statement The use of traditional tobacco products is a known risk factor for the development of diseases including periodontal disease. To date, the potential oral health effects related to electronic nicotine delivery systems (ENDS) use is unknown. This study collected saliva from ENDS users and never tobacco users to examine differences in the oral cavity of inflammatory cytokines and metabolites. The identification and measurement of these ENDS-related changes provide insight into disease pathways potentially associated with ENDS use. The utilization of saliva samples collected from human participates enhances the application of the findings compared to the majority of studies using cell culture and animal models. In addition, these foundational findings can inform future studies to examining specific pathways identified, interventional approaches, and application of translatable biomarkers of ENDS use.

scholarly journals Explosions, Burn Injuries and Adverse Health Effects of Electronic Nicotine Delivery Systems: A Review of Current Regulations and Future Perspectives

2021 ◽  
Vol 24 ◽  
pp. 462-474
Author(s):  
Ayesha Rahman Ahmed ◽  
Beverly Etchey ◽  
Mahiba Ahmed
Keyword(s):  
Health Effects ◽  
Significant Risk ◽  
The United States ◽  
Delivery Systems ◽  
Long Term Effects ◽  
Safe Alternative ◽  
Electronic Nicotine Delivery Systems ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
Nicotine Delivery

Purpose: While there is a declining trend in the use of traditional methods of smoking tobacco, electronic nicotine delivery systems (ENDS) have gained popularity worldwide. ENDS are marketed as safe for the primary reason that they do not contain the well-established toxic ingredients found in traditional cigarettes. However, growing concerns over incidences of fire and explosion with specific types of ENDS, as well as their short and long-term effects, remain unaddressed. This review examines the under studied role of customized components such as batteries, e-liquid compositions, and methods of nicotine delivery that result in physical injuries and adverse health effects of ENDS. Methods: Using online reference databases (Web of Science, PubMed, Medline other, Google scholar, FDA website, FDA register), we analyzed the mechanisms through which ENDS may pose significant risk to human health. Results: An increase in the use and popularity of ENDS has been observed among youth and adults in the United States since 2007. The ENDS devices available to the public allow for custom alterations which can introduce incompatible components, resulting in overheating and explosion related injuries. Heavy metals have been found to leach from some devices into the e-liquid, and the heating of e-liquid ingredients can produce toxic byproducts. Conclusions: Overall, the current literature demonstrates that ENDS are not a safe alternative to traditional cigarettes due to explosion risks and negative health effects including addiction, adverse respiratory and cardiovascular effects, heavy metal leaching, and toxic byproducts exposure. These risks warrant regulation of ENDS devices and formulations, with urgency underscored by their increasing popularity among youth and adults.

scholarly journals New Challenges: Developing Gendered and Equitable Responses to Involuntary Exposures to Electronic Nicotine Delivery Systems (ENDS) and Cannabis Vaping

2018 ◽  
Vol 15 (10) ◽  
pp. 2097
Author(s):  
Natalie Hemsing ◽  
Lorraine Greaves
Keyword(s):  
Health Effects ◽  
Secondhand Smoke ◽  
New Products ◽  
Delivery Systems ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
New Challenges ◽  
Gendered Patterns ◽  
Specific Health ◽  
Research And Policy

Recreational cannabis use is in the process of being legalized in Canada, and new products and devices for both nicotine and cannabis vaping are being introduced. Yet, research on the harms of involuntary exposure to electronic nicotine delivery systems (ENDSs) and cannabis vaping is in its infancy, and there is a lack of investigation on sex-specific health effects and gendered patterns of exposure and use. We argue that responses to ENDS and cannabis vaping exposures should align with policy and progress on restricting exposure to tobacco secondhand smoke (SHS). Furthermore, we argue that sex, gender, and equity considerations should be integrated in both research and policy to benefit all Canadians.

scholarly journals Electronic Nicotine Delivery Systems (ENDS) and Their Relevance in Oral Health

Toxics ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 61 ◽  
Author(s):  
Gozde Isik Andrikopoulos ◽  
Konstantinos Farsalinos ◽  
Konstantinos Poulas
Keyword(s):  
Oral Health ◽  
Periodontal Diseases ◽  
Delivery Systems ◽  
Long Term Effects ◽  
Periodontal Health ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
Gingival Cells ◽  
Oral Cells

The number and popularity of electronic nicotine delivery systems (ENDS) and especially e-cigarettes (e-cigs) have been increasing in the last decade. Although ENDS owe their popularity to excluding the harmful chemicals that are present in tobacco smoke, there is a debate whether they are safe, regulated, and as harmless as they are assumed to be and have potential unknown long-term effects. Involvement of cigarette smoking to the progression of periodontal diseases, other adverse oral health outcomes, and its detrimental effects to oral health are well-described. ENDS producer companies claim that these products can improve oral health by providing alternatives to smoking. However, the effect of e-cigs on oral health is not fully understood and is still debated among many scientists and clinicians. The number of studies addressing the potential toxic effect of ENDS or e-cig aerosol on oral cells is limited along with the clinical studies which are still preliminary, and their sample size is limited. The long-term effects of inhaled aerosols and the potential synergistic effect of the e-cigs components are not known. It is essential and of utmost importance to determine whether exposure to ENDS aerosol contributes to the progression of periodontal diseases and how it affects periodontal ligament and gingival cells which are believed to be its first targets. This review briefly summarizes the available evidence about the effects of e-cigs on periodontal health including several pathophysiological events, such as oxidative stress, DNA damage, inflammation, cellular senescence, dysregulated repair, and periodontal diseases.

scholarly journals A qualitative exploration of information-seeking by electronic nicotine delivery systems (ENDS) users in New Zealand

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023375 ◽  
Author(s):  
Lindsay Robertson ◽  
Janet Hoek ◽  
Mei-Ling Blank ◽  
Rosalina Richards ◽  
Pamela Ling ◽  
...  
Keyword(s):  
New Zealand ◽  
Health Effects ◽  
Information Seeking ◽  
Information Needs ◽  
Delivery Systems ◽  
Scientific Data ◽  
Product Knowledge ◽  
Potential Health ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery

ObjectivesGiven recent increases in awareness and uptake of electronic nicotine delivery systems (ENDS), we aimed to explore ENDS users’ information needs and search behaviours and whether information gaps exist.DesignQualitative study using semistructured interviews that probed participants’ smoking behaviours and ENDS use; data in this study examine ENDS information-seeking behaviours. We used qualitative description to analyse interview transcripts.Participants and settingWe recruited 39 current ENDS users (20 dual users and 19 exclusive ENDS users who reported having previously smoked cigarettes regularly) aged 18 and over, from three urban centres in New Zealand.ResultsSeveral participants used Google to search for information on ENDS’ health effects, but described the material they retrieved as vague or contradictory. Some interpreted the absence of information on long-term health effects as evidence ENDS did not pose potential health risks, and several perceived e-liquids as benign. Many relied on information sourced from other ENDS users, gleaned from online forums, YouTube or from discussions with friends and acquaintances; these sources typically presented ENDS positively. Several participants found specialist ENDS retailers provided valuable advice; non-specialist store staff generally lacked detailed product knowledge and sometimes offered inaccurate information.ConclusionPeople seeking information on ENDS’ health effects are more likely to retrieve recommendations, product reviews and endorsements from online sources or through exchanges with other users, than they are to find scientific data. Health authorities could help meet potential users’ information needs by, first, creating and frequently updating objective lay summaries of the latest scientific evidence; second, by mandating licensing for retailers with guidelines to disclose uncertainty over ENDS’ efficacy for cessation and longer-term health effects, and the need for complete substitution of ENDS for combustible cigarettes among those who use these products.

scholarly journals Pilot Study of Electronic Nicotine Delivery Systems (ENDS) Cessation Methods

Pharmacy ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 21
Author(s):  
Michelle Sahr ◽  
Shelby Kelsh ◽  
Noah Blower ◽  
Minji Sohn
Keyword(s):  
Young Adults ◽  
Pilot Study ◽  
Replacement Therapy ◽  
Nicotine Replacement Therapy ◽  
Delivery Systems ◽  
Self Control ◽  
Behavioral Support ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
The U.S

Currently, 7.6% of the U.S. young adults aged 18–24 years old use e-cigarettes. This study piloted three methods of Electronic Nicotine Delivery Systems (ENDS) cessation by measuring cessation rates, motivational techniques that contributed to cessation success, and participants’ changes after decreasing vape use. Participants were randomized into three study arms (nicotine replacement therapy (NRT) + behavioral support, vape-taper + behavioral support, self-guided) in a 1:1:1 ratio. All participants were invited to attend nine in-person or phone appointments over the 6-month study period. At 12 weeks, 3 of 7 (42.9%) participants in the NRT + behavioral support arm, 6 of 8 (75%) vape-taper + behavioral support arm, and 7 of 9 (77.8%) self-guided arm self-reported being vape-free and nicotine-free. At 6 months, 3 of 7 (42.9%) participants in the NRT + behavioral support arm, 6 of 8 (75%) vape-taper + behavioral support arm, and 4 of 9 (44.4%) self-guided arm self-reported being vape-free and nicotine-free. A challenge to quitting and remain quit is social pressures, but participants identified self-control and establishing new habits to be the best methods to overcome the desire to vape. Participants who received behavioral support and a vape-taper plan from pharmacists were more likely to be vape-free and nicotine-free at 6 months.

scholarly journals Social Media Mentions of Electronic Nicotine Delivery Systems (ENDS) Battery-Related Overheating, Fires, and Explosions: Findings from a Pilot Study

2019 ◽  
Vol 16 (8) ◽  
pp. 1308 ◽  
Author(s):  
Sarah Trigger ◽  
Blair Coleman
Keyword(s):  
Social Media ◽  
Pilot Study ◽  
Delivery Systems ◽  
Surveillance Systems ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
Social Media Monitoring ◽  
Media Monitoring ◽  
The One ◽  
Over Time

Serious injuries may result from electronic nicotine delivery systems (ENDS) battery malfunctions, including overheating, fires, and explosions (O/F/E). This pilot study assessed the usefulness of social media monitoring as a tool for gathering information surrounding ENDS battery O/F/E, including changes in the volume and nature of social media mentions over time. Brandwatch, a social media monitoring tool, was queried to examine ENDS battery-related O/F/E over a one-month period, annually, from 2013–2017. Two researchers qualitatively coded the social media mentions for relevance and coded the relevant mentions by event type and theme. The total number of mentions coded as relevant (n = 947) for the one-month period increased each year. Mentions of first-person events were relatively infrequent (3.6% of relevant mentions), while mentions describing events that happened to someone else increased over time (60.4% of relevant mentions). A relatively small proportion of mentions expressed concern around a potential event and advice on how to prevent future events (4.8% and 10.5% of relevant mentions, respectively). Findings suggest that social media mentions around ENDS battery O/F/E events have increased over recent years. Social media monitoring can complement traditional surveillance systems to elucidate the extent to which ENDS O/F/E events are occurring.

scholarly journals Pharmacological Interventions for Vaping Cessation

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Sara D. Khangura ◽  
Sarah C. McGill
Keyword(s):  
Smoking Cessation ◽  
Health Effects ◽  
Delivery Systems ◽  
Evidence Based ◽  
Pharmacological Interventions ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
Evidence Based Guidelines

The use of electronic nicotine delivery systems and other vaping products is on the rise, and the health effects from these products remain uncertain. No evidence-based guidelines regarding the use of pharmacological vaping cessation interventions were identified. Some guidelines suggest that it may be reasonable to apply smoking cessation interventions and/or protocols for vaping cessation, but no guidance specific to the use of pharmacotherapy was identified.

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