scholarly journals Phytoconstituents and Biological Activities of Panax vietnamensis (Vietnamese Ginseng): A Precious Ginseng and Call for Further Research-A systematic review

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Quang-Ung Le ◽  
Horng-Liang Lay ◽  
Ming-Chang Wu ◽  
Thi Hong-Hanh Nguyen ◽  
Duy-Lam Nguyen
Keyword(s):  
Systematic Review ◽  
Panax Ginseng ◽  
Biological Activities ◽  
Folk Medicine ◽  
Future Prospects ◽  
Mountain Areas ◽  
Functional Attributes ◽  
Anti Cancer ◽  
The World ◽  
Medicinal Food

Panax vietnamensis Ha et Grushv., a Vietnamese ginseng, is a well-known plant, naturally distributed in the Ngoc Linh and Hoang Lien Son mountain areas in Vietnam. It is used as a tonic and medicinal food in traditional folk medicine because it possesses wondrous health benefits. To support its functional attributes, various investigations have been carried out to find out its anti-inflammatory, anti-cancer, anti-stress, anti-nociception, psychomotor and sedative-hypnotic effects and anxiolytic activities. Also similar to other ginsengs, Vietnamese ginseng is a rich source of saponins and it has higher content of protopanaxadiol-, protopanaxatrial- and ocotillol-type saponins compared to other ginsengs in the world. Majonoside R2 is a main saponin in Vietnamese ginseng but this compound does not exist in Panax ginseng. Based on this systematic review, we discussed for future prospects and suggest that thorough scientific scrutiny is necessary in future researches.

Helenalin - A Sesquiterpene Lactone with Multidirectional Activity

2019 ◽  
Vol 20 (4) ◽  
pp. 444-452 ◽  
Author(s):  
Joanna Drogosz ◽  
Anna Janecka
Keyword(s):  
Sesquiterpene Lactone ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Folk Medicine ◽  
Biological Properties ◽  
Pathological Conditions ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Minor Injuries

Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including antiinflammatory, anti-bacterial and anti-cancer properties. The best-known sesquiterpene lactones which are already used as drugs or are used in clinical trials are artemisinin, thapsigargin and parthenolide. Yet another sesquiterpene lactone, helenalin, an active component of Arnica montana, known for its strong anti-inflammatory activity, has been used for centuries in folk medicine to treat minor injuries. Unfortunately, helenalin’s ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development of this sesquiterpene lactone as an anticancer or anti-inflammatory drug. Recently, the new interest in the biological properties, as well as in the synthesis of helenalin analogs has been observed. This review describes helenalin's major biological activities, molecular mechanisms of action, its toxicity and potential for further research.

Medicinal Properties of Cinchona Alkaloids - A Brief Review

2021 ◽  
Vol 11 (3) ◽  
pp. 224-228
Author(s):  
Anubhav Dubey ◽  
Yatendra Singh
Keyword(s):  
Toxic Effect ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Cinchona Alkaloids ◽  
Literature Study ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties

Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasmodium Sp. Literature study revealed that along with the antimalarial activity the cinchona alkaloids has other potentiality like anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity. These article reviews the biological activities of cinchona alkaloids along with its toxic effect.

scholarly journals Ophiorrhiza, a promising herbaceous source of the anticancer compound camptothecin

2020 ◽  
Vol 7 (2) ◽  
pp. 240
Author(s):  
G Krishnakumar ◽  
K P Dintu ◽  
Sibi C Varghese ◽  
Deepthi S Nair ◽  
Geethu Gopinath ◽  
...  
Keyword(s):  
Woody Plants ◽  
Biological Activities ◽  
Growth Characteristics ◽  
Future Prospects ◽  
Alternative Source ◽  
Anti Cancer ◽  
Taxonomical Status ◽  
Phytochemical Constituents ◽  
Increasing Demand ◽  
Anticancer Compound

Camptothecin is an important source for the synthesis of some of the major anti-cancer agents such as irinotecan and topotecan. Traditional source of camptothecin are prominently woody plants such as Camptotheca acuminata Decne. and Nothopodytes nimmoniana (Graham) Mabb., and the increasing demand for camptothecin leads to the level of threatening their existence. Ophiorrhiza species composed of herbaceous plants with quick growth characteristics which are reported as alternative source of camptothecin. The present review focus on taxonomical status, traditional uses, biological activities and phytochemical constituents with a special attention in bioproduction of camptothecin from Ophiorrhiza species and its future prospects.

Bitter Melon: A Multifunctional Medicinal Plant with Powerful Bioactive Compounds

2021 ◽  
Author(s):  
Fadime Eryılmaz Pehlivan
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Folk Medicine ◽  
Bitter Melon ◽  
Comprehensive Overview ◽  
Tropical Regions ◽  
Beneficial Effects ◽  
Life Saving ◽  
The World ◽  
Treatment Of Diabetes

Nature is full of poisons as well as life-saving entities. Extracts of natural products in medicinal plants have been used for thousands of years in traditional medicine throughout the World. Bitter melon (Momordica charantia) is a member of Cucurbitaceae family, widely distributed in tropical regions of the World, that has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used as a vegetable for thousands of years. It contains phytochemicals, flavonoids, triterpenes, saponins, ascorbic acid, steroids, proteins, and polysaccharides. This plant is a traditional herbal medicine, possesses various biological, medicinal activities and pharmacological functions, namely antidiabetic, anthelmintic, contraceptive, antimalarial, laxative, antihyperglycemic, antimutagenic, antiulcer, antilipolytic, antifertility, hepatoprotective, anticancer, antibacterial, antiviral, antitumor, immunomodulation, antioxidant, antidiabetic, and anti-inflammatory activities of M. charantia have been reported. Its fruit has a special bitter taste, parts of M. charantia, such as fruits, vines, leaves and even roots have been used as folk medicine for the remedy of diseases like toothache, diarrhea, and diabetes. It is also used for the treatment of eczema, gout, jaundice, pneumonia, psoriasis, and rheumatism. These beneficial effects are attributed to the various bioactive components of M. charantia, which are important sources of phytoconstituents used to treat various diseases since ancient times. This chapter reviews various aspects of the results of investigations involving M. charantia in the recent years, providing a comprehensive overview of the phytochemical application of M. charantia to attract more attention to their biological activities for better utilization of M. charantia; focusing on the review of benefits that bitter melon offers in terms of its potential as a source of bioactive compounds and its role in the control of different diseases.

scholarly journals Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

2021 ◽  
Vol 22 (22) ◽  
pp. 12140
Author(s):  
Márcia Moraes Cascaes ◽  
Odirleny dos Santos Carneiro ◽  
Lidiane Diniz do Nascimento ◽  
Ângelo Antônio Barbosa de Moraes ◽  
Mozaniel Santana de Oliveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Essential Oils ◽  
Raw Materials ◽  
Biological Activities ◽  
Biological Effects ◽  
Economic Value ◽  
Folk Medicine ◽  
Cytotoxic Activities ◽  
Reference Drug ◽  
Annona Glabra

The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas—for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as Annona glabra L. and Xylopia sericea A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, (E)-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species Guatteria punctata (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.

Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets

2021 ◽  
pp. 153537022110625
Author(s):  
Hardeep Singh Tuli ◽  
Katrin Sak ◽  
Shubham Adhikary ◽  
Ginpreet Kaur ◽  
Diwakar Aggarwal ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
Natural Compound ◽  
Biological Activities ◽  
Chemotherapeutic Drugs ◽  
Lead Compounds ◽  
Molecular Oncology ◽  
Wide Range ◽  
Anti Cancer ◽  
The World

With the dramatic increase in cancer incidence all over the world in the last decades, studies on identifying novel efficient anti-cancer agents have been intensified. Historically, natural products have represented one of the most important sources of new lead compounds with a wide range of biological activities. In this article, the multifaceted anti-cancer action of propolis-derived flavonoid, galangin, is presented, discussing its antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, anti-angiogenic, and anti-metastatic effects in various cancer cells. In addition, co-effects with standard chemotherapeutic drugs as well as other natural compounds are also under discussion, besides highlighting modern nanotechnological advancements for overcoming the low bioavailability issue characteristic of galangin. Although further studies are needed for confirming the anti-cancer potential of galangin in vivo malignant systems, exploring this natural compound might open new perspectives in molecular oncology.

Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review

2020 ◽  
Vol 20 (5) ◽  
pp. 536-547
Author(s):  
Muhammad T. Islam ◽  
Eunus S. Ali ◽  
Shaikh J. Uddin ◽  
Ishaq N. Khan ◽  
Manik C. Shill ◽  
...  
Keyword(s):  
Apoptotic Cell ◽  
Human Cancer ◽  
Biological Activities ◽  
Folk Medicine ◽  
Asiatic Acid ◽  
Inhibition Of Proliferation ◽  
Anti Cancer ◽  
Cancer Tumor ◽  
Anti Inflammatory ◽  
Anti Tumor Activity

Background: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a triterpene and a known component of this herb, has been shown to display important biological activities, including anti-inflammatory, antibacterial, antidiabetic and antihyperlipidemic, neuroprotective, anxiolytic and antidepressant, hepatoprotective, pancreas protective, and cardio- protective. Objective: This review focuses on AA’s anti-cancer effects on the basis of published literature found in a number of databases such as PubMed and Science Direct. Emphasis has been given to the mechanisms of action of its anti-cancer effect. Methods: A literature survey was conducted using known databases such as PubMed and Science Direct using the keywords ‘Asiatic acid’, pairing with ‘cancer’, ‘tumor’, ‘anti-cancer effect’, ‘cytotoxic effect’, ‘anti-tumor activity’, ‘cell line’, ‘animal cancer’, and ‘human cancer’. Results: Findings suggest that AA exerts anti-cancer effects in several test systems through various pathways, including oxidative/antioxidant, anti-inflammatory, cytotoxicity, apoptotic cell death, necrosis, anti-angiogenesis, inhibition of proliferation and cell migration, and chemoprevention. Conclusions: AA may be an effective plant-based cancer chemotherapeutic agent and a promising lead for the development of potent anticancer drugs.

scholarly journals Recent Developments on the Synthetic and Biological Applications of Chalcones-A Review

2021 ◽  
Vol 12 (1) ◽  
pp. 180-195
Keyword(s):  
Physical Properties ◽  
Scientific Community ◽  
Biological Activities ◽  
Critical Discussion ◽  
Biological Applications ◽  
Wide Range ◽  
Anti Cancer ◽  
The World ◽  
Recent Developments ◽  
Optical Fluorescence

Chalcones are precursors of the biosynthesis of flavonoids present in plants. These motifs serve a wide range of applications, from synthetic to pharmacological to physical spheres. Chalcone derivatives attracted the scientific community all over the world in recent times due to their diversified applications. The presence of reactive α,β-unsaturated carbonyl moiety in chalcones makes them a versatile intermediate in synthesizing various classes of compounds of biological and physical interest. More importantly, the chalcones themselves have been known to possess enormous biological activities and physical properties like semiconductor, non-linear optical, fluorescence, and electronic properties. In this context, the present review summarises the overall developments in the synthetic, pharmacological, and physical applications of chalcones in recent fast. The critical discussion was attempted on the synthetic applications and biological potencies as anti-cancer, antidiabetic, antimicrobial, antioxidant, and anti-inflammatory.

scholarly journals Chemical constituents of Aglaia odorata and Aglaia hoaensis

2021 ◽  
Vol 5 (3) ◽  
pp. first
Author(s):  
Lien Hoa Dieu Nguyen ◽  
Hào Chí Lê ◽  
Thy Ngoc Diem Nguyen ◽  
Ly Thi Thao Nguyen ◽  
Le Thu Thi Nguyen ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Research Work ◽  
Octadecenoic Acid ◽  
2D Nmr ◽  
Chemical Structures ◽  
The World ◽  
First Time ◽  
Whole Tree

Aglaia is the largest genus of the Meliaceae family with about 120 species, which grow mainly in the tropical and subtropical regions. In Vietnam, the genus contains about 30 species. Many are used in folk medicine for the treatment of different diseases. Rocaglamides, bisamides, lignans, triterpenoids and steroids are the main classes of compounds found in the genus. Some of them exhibit diverse biological activities. This research work reports the isolation of four compounds from A. odorata and A. hoaensis. Extraction was carried out using Soxhlet extractors with organic solvents followed by concentration of the solvents to yield crude extracts. Isolation was performed using column chromatography on silica gel and gel permeation on Sephadex LH-20. Chemical structures were determined using 1D NMR (1H, 13C NMR, DEPT), 2D NMR (HSQC, HMBC, COSY, NOESY), IR and HRESIMS spectroscopic methods, and comparison of the spectral data with those in literature. Two triterpenoids, aglaiadoratol and 3b -friedelinol, were isolated from the whole tree of A. odorata. Two other compounds, (+)-syringaresinol lignan and threo-9,10-O-isopropylidene- 13-hydroxy-(11E)-octadecenoic acid, a derivative of fatty acid, were obtained from the bark of A. hoaensis. Among the four isolated compounds, this is the first time that aglaiadoratol has been reported in the world. In addition, (+)-syringares inol ligan and threo-9,10-O-isopropylidene-13- hydroxy-(11E)-octadecenoic acid are reported here for the first time in A. hoaensis.

ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE

2012 ◽  
pp. 84-89
Author(s):  
Quoc Hung Vo ◽  
Nguyen Phuong Nhi Doan ◽  
Dinh Quynh Phu Nguyen ◽  
Thi Dieu Tram Ho ◽  
Thi Hoai Nguyen
Keyword(s):  
Mass Spectrometry ◽  
Soft Coral ◽  
Normal Phase ◽  
Ionization Mass ◽  
Medical Field ◽  
Bioactive Substances ◽  
Anti Cancer ◽  
The World ◽  
Pure Compounds ◽  
Layer Chromatography

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.

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