Medicinal Properties of Cinchona Alkaloids - A Brief Review

2021 ◽  
Vol 11 (3) ◽  
pp. 224-228
Author(s):  
Anubhav Dubey ◽  
Yatendra Singh
Keyword(s):  
Toxic Effect ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Cinchona Alkaloids ◽  
Literature Study ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties

Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasmodium Sp. Literature study revealed that along with the antimalarial activity the cinchona alkaloids has other potentiality like anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity. These article reviews the biological activities of cinchona alkaloids along with its toxic effect.

Salidroside - Can it be a Multifunctional Drug?

2020 ◽  
Vol 21 (7) ◽  
pp. 512-524
Author(s):  
Sri Krishna Jayadev Magani ◽  
Sri Durgambica Mupparthi ◽  
Bhanu Prakash Gollapalli ◽  
Dhananjay Shukla ◽  
AK Tiwari ◽  
...  
Keyword(s):  
Biological Activities ◽  
Neuroprotective Activity ◽  
Pharmacological Activities ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Target Molecules ◽  
Medicinal Properties ◽  
Therapeutic Activities ◽  
Near Future ◽  
Phase I And Ii

Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It exhibits diverse biological and pharmacological properties. In the last decade, enormous research is conducted to explore the medicinal properties of salidroside; this research reported many activities like anti-cancer, anti-oxidant, anti-aging, anti-diabetic, anti-depressant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, etc. Objective: Despite its multiple pharmacological effects, a comprehensive review detailing its metabolism and therapeutic activities is still missing. This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions. This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside. Conclusion: Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEK/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decreased oxidative stress and increased antioxidant enzymes, Nrf2/HO-1 pathways, decreased inflammation through suppression of NF-κB pathway and PI3K/AKT pathways. These scientific findings will pave the way to clinically translate the use of salidroside as a multi-functional drug for various diseases and disorders in the near future.

A review on phyto-pharmacology of Oxalis corniculata

2021 ◽  
Vol 24 ◽  
Author(s):  
Iqra Sarfraz ◽  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Muhammad Ajmal Shah ◽  
Bushra Nageen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Current Effort ◽  
Isolation And Characterization ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Warm Temperate

: Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, phlobatannins along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, and cardioprotective. Moreover, bioactive phytochemicals from this plant possess significant wound healing potential. Our current effort intends to emphasize on the immense significance of this plant species, which have not been the subject matter of clinical trials and effective pharmacological studies, even though its favored usage has been stated. This review proposes that Oxalis corniculata possess potential for the cure of various diseases, however, further researches on isolation and characterization of bioactive compounds along with pre-clinical trials are compulsory to figure out its pharmacological applications.

scholarly journals REVIEW: Organosulphure compound of garlic (Allium sativum L.) and its biological activities

2003 ◽  
Vol 1 (2) ◽  
pp. 65-76 ◽  
Author(s):  
UDHI EKO HERNAWAN ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Platelet Aggregation ◽  
Side Effects ◽  
Allium Sativum ◽  
Urinary Infection ◽  
Biological Activities ◽  
Bioactive Compound ◽  
Traditional Medicines ◽  
Anti Cancer ◽  
Long Time ◽  
Anti Oxidant

Garlic has been used a long time ago as traditional medicines. The valuable bulb is used to treat hypertension, respiratory infection, headache, hemorrhoids, constipation, bruised injury or slice, insomnia, cholesterol, influenza, urinary infection, etc. Garlic bulbs can be used as anti-diabetic, anti-hypertension, anti-cholesterol, anti-atheroschlerosis, anti-oxidant, anti-cell platelet aggregation, fibrinolyse spur, anti-viral, anti-microbial, and anti-cancer. The ultimate bioactive compound of garlic is organo-sulphure components, i.e. alliin, allicin, ajoene, allyl sulphide groups, and allyl cystein. There was not any report of any side effects or toxicity of garlic.

scholarly journals Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

2020 ◽  
Vol 21 (3) ◽  
pp. 950 ◽  
Author(s):  
Nittiya Suwannasom ◽  
Ijad Kao ◽  
Axel Pruß ◽  
Radostina Georgieva ◽  
Hans Bäumler
Keyword(s):  
Protective Effect ◽  
Toxic Effect ◽  
Biological Effects ◽  
Health Benefits ◽  
Water Soluble ◽  
Medical Conditions ◽  
Protective Properties ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
B Vitamin

Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely studied for their anti-oxidant, anti-aging, anti-inflammatory, anti-nociceptive and anti-cancer properties. Moreover, the combination of RF and other compounds or drugs can have a wide variety of effects and protective properties, and diminish the toxic effect of drugs in several treatments. Research has been done in order to review the latest findings about the link between RF and different clinical aberrations. Since further studies have been published in this field, it is appropriate to consider a re-evaluation of the importance of RF in terms of its beneficial properties.

scholarly journals Medicinal properties of Abutilon indicum

2018 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
S Rajeshwari ◽  
SP Sevarkodiyone
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Phytochemical Analysis ◽  
Vaginal Infections ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Larvicidal Activities ◽  
Abutilon Indicum

Abutilon indicum is a common Indian shrub, belonging to the family Malvaceae; Also known as Mallow in english, Abutilon indicum is used as a medicinal plant. It has been extensively used as a traditional medicine as a laxative, emollient, analgesic, anti-diabetic, anti-inflammatory and blood tonic agent and also in the treatment of leprosy, urinary disease, jaundice, piles, relieving thirst, cleaning wounds and ulcers, vaginal infections, diarrhea, rheumatism, mumps, pulmonary tuberculosis, bronchitis, allergy, blood dysentery, some nervous and some ear problems. Various studies on the plant extract have been performed to confirm the anti-oxidant, anti-bacterial, analgesic, anti-inflammatory, anti-cancer, hepato-protective, immuno-modulatory and larvicidal activities of the plant. This plant is often used as a medicinal plant and is considered invasive on certain tropical islands. In traditional medicine, A. indicum is used as a aphrodisiac, demulcent, diuretic, laxative, pulmonary and sedative (leaves). The bark is astringent and diuretic; laxative, expectorant and demulcent (seeds); laxative and tonic, anti-inflammatory and anthelmintic (plant); analgesic (fixed oil); diuretic and for leprosy (roots). The plant is very much used in Siddha medicines. In fact, the bark, root, leaves, flowers and seeds are all used for medicinal purposes by Tamils. The leaves are also used to treat for pile complaints. The flowers are traditionally used to increase semen in men. The phytochemical analysis showed the Presence of Alkaloid, Saponins, Amino acid, Flavonoids, Glycosides and steroids. This plant exhibits several potential pharmacological activities. A review on the various studies on the plant has been provided for the purpose of understanding its medicinal properties.

Helenalin - A Sesquiterpene Lactone with Multidirectional Activity

2019 ◽  
Vol 20 (4) ◽  
pp. 444-452 ◽  
Author(s):  
Joanna Drogosz ◽  
Anna Janecka
Keyword(s):  
Sesquiterpene Lactone ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Folk Medicine ◽  
Biological Properties ◽  
Pathological Conditions ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Minor Injuries

Sesquiterpene lactones, secondary metabolites of plants, present in a large number of species mostly from the Asteracea family, are used in the traditional medicine of many countries for the treatment of various pathological conditions. They exert a broad range of activities, including antiinflammatory, anti-bacterial and anti-cancer properties. The best-known sesquiterpene lactones which are already used as drugs or are used in clinical trials are artemisinin, thapsigargin and parthenolide. Yet another sesquiterpene lactone, helenalin, an active component of Arnica montana, known for its strong anti-inflammatory activity, has been used for centuries in folk medicine to treat minor injuries. Unfortunately, helenalin’s ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development of this sesquiterpene lactone as an anticancer or anti-inflammatory drug. Recently, the new interest in the biological properties, as well as in the synthesis of helenalin analogs has been observed. This review describes helenalin's major biological activities, molecular mechanisms of action, its toxicity and potential for further research.

scholarly journals Phytochemical profiling, and anti-oxidant, anti-bacterial, and anti-inflammatory properties of Viburnum coriaceum Blume

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Vijayakumar Vijaytha ◽  
R. V. Anupama ◽  
M. Haridas
Keyword(s):  
Methanol Extract ◽  
Biological Activities ◽  
Zone Of Inhibition ◽  
Agar Gel ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Drug Leads ◽  
Diffusion Assay

Abstract Background Viburnums comprise a taxonomic group of plants distributed all over the world and were reported to have many biological activities. Viburnum coriaceum Blume is one of the least explored members of the group. The present study was aimed to explore the phytochemical profile of the plant, Viburnum coriaceum Blume with special emphasis to its anti-oxidant, anti-bacterial, and anti-inflammatory activities. Results Extracts of all parts of plants were found to possess a spectrum of chemicals in considerable amount, including triterpenoids and glycosides. Anti-oxidant property was found in extracts made of any part of the plant. Methanol extract of root expressed a prominent zone of inhibition in agar gel well-diffusion assay involving many microorganisms. Inhibition of enzymes, LOX, and trypsin showed by the hexane extract of root suggested a prominent anti-inflammatory potential of the plant under investigation. Conclusion Phytochemical profiling and the other assays using the plant extracts provide us with a plant having many valuable medicinal properties. Viburnum coriaceum Blume could be noted as a promising material for drug leads.

scholarly journals Hydrazones and their metal complexes: A short review on their biological potentia

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1440-1447
Author(s):  
KushalNath Mishra ◽  
Shambaditya Goswami ◽  
Kumudhavalli M.V ◽  
Kamal Saini ◽  
Nikita Pal ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Development Process ◽  
Biological Activities ◽  
Pharmaceutical Formulations ◽  
Short Review ◽  
Low Molecular Weight ◽  
New Drug ◽  
Anti Cancer ◽  
Metallic Compounds ◽  
Medicinal Properties

Hydrazones belong to complexes are beneficial in different fields for their essential role in the development of a range of stable complexes in the coordination chemistry. Different researchers have reported the various medicinal properties of hydrazones. Hydrazone and its metal complexes are useful for the detection of some organic components from pharmaceutical formulations. These metallic compounds act as a catalyst for conducting various chemical reactions and help in making different chemical complexes that are effective against bacteria, fungi, and many other microbes. Aromatic hydrazone derivatives can measure the concentration of low molecular weight aldehyde and ketone complexes. Hydrazones possess numerous medicinal properties, including antimicrobial, anti-cancer, antidepressant, anti-tubercular, anti-viral, etc. For the new drug discovery, hydrazones/azomethines are considered to be an important class of compound. From molecular biology to pharmaceutical formulation, organic chemistry, new drug development process, the importance of hydrazone and its metal complexes is immense. The present review aims to highlight the reported biological activities related to hydrazones for the last decade.

scholarly journals Ganoderma lucidum - from tradition to modern medicine

2017 ◽  
pp. 151-161
Author(s):  
Jasmina Cilerdzic ◽  
Mirjana Stajic ◽  
Jelena Vukojevic
Keyword(s):  
Ganoderma Lucidum ◽  
Biological Activities ◽  
Folk Medicine ◽  
Far East ◽  
Scientific Basis ◽  
Modern Medicine ◽  
The Body ◽  
Chemical Components ◽  
Spiritual Power ◽  
Positive Effects

Ganoderma lucidum has a long tradition of use in folk medicine of the Far East, which is documented in the oldest Chinese pharmacopoeia, written in the first century B.C, declaring it a superior medicine. The healing properties of G. lucidum reflected on folk names such as: Reishi, Mannentake, Ling Zhi etc., which mean ?herb of spiritual power?, ?mushroom of immortality? or ?10,000-year mushroom?, respectively. It has been known, for thousands of years, that this species extends life span, increases youthful vigour and vitality and it was used in the treatments of hepatitis, kidneys? disease, hypertension, arthritis, asthma, bronchitis, arteriosclerosis, ulcers and various types of cancer. However, Western civilisation did not discover its healing properties until the 20th century. Modern scientific researches and numerous clinical trails, conducted in recent decades, have confirmed the ancient knowledge of Eastern nations and given them a scientific basis. These studies have demonstrated many biological activities of G. lucidum extracts and compounds, including: immunomodulating, antioxidative, cytotoxic, hypoglycaemic, anti-inflammatory, antiallergic, antimicrobial, etc. It has been reported that its extracts play important role in detoxification of the body and protecton of the liver, as well as in reducing cardiovascular problems, stress and anxiety. However, its most important effect is undoubtedly immunostimulating one as it is the basis of many other positive effects. The Japanese government introduced G. lucidum on the official list of auxiliary agents for the treatments of various cancers, Alzheimer?s disease, diabetes and chronic bronchitis. Many chemical components have been isolated from G. lucidum, but polysaccharides and terpenoids are the main carriers of its bioactivities.

scholarly journals Effects on mammalian cell transcriptome reveal a plant extract's medicinal properties: Potential anti-COVID-19 and anti-cancer properties of Sarcopoterium spinosum

2022 ◽  
Author(s):  
Valid Gahramanov ◽  
Moria Oz ◽  
Tzemach Aouizerat ◽  
Mali Salmon-Divon ◽  
Tovit Rosenzweig ◽  
...  
Keyword(s):  
Mammalian Cell ◽  
Plant Extract ◽  
Biological Activities ◽  
Biological Effects ◽  
Gene Set Enrichment Analysis ◽  
Functional Screening ◽  
Pharmacological Activities ◽  
Anti Cancer ◽  
Medicinal Properties ◽  
Sarcopoterium Spinosum

Abstract Plants with medicinal properties are usually identified based on traditional medicine knowledge or using low-throughput screens for specific pharmacological activities. Here, we suggest a different approach to uncover a range of pharmacological activities of a chosen plant extract without the need for functional screening. This tactic predicts biological activities of a plant extract based on pathway analysis of transcriptome changes caused by the extract in mammalian cell culture. In this work, we identified transcriptome changes after exposure of cultured cells to an extract of the medicinal plant Sarcopoterium spinosum. Gene Set Enrichment Analysis (GSEA) confirmed known anti-inflammatory and anti-cancer activities of the extract and predicted novel biological effects on oxidative phosphorylation and interferon pathways. Experimental validation of these pathways uncovered strong activation of autophagy, including mitophagy, and astounding protection from SARS-CoV-2 infection. Our study shows that gene expression analysis alone is insufficient for predicting biological effects since some of the changes reflect compensatory effects, and additional biochemical tests provide necessary corrections. In conclusion, this study defines the advantages and limitations of an approach towards predicting the biological and medicinal effects of plant extracts based on transcriptome changes caused by these extracts in mammalian cells.

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