Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas—for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as Annona glabra L. and Xylopia sericea A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, (E)-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species Guatteria punctata (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.

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Vapors of Volatile Plant-Derived Products Significantly Affect the Results of Antimicrobial, Antioxidative and Cytotoxicity Microplate-Based Assays

Molecules ◽

10.3390/molecules25246004 ◽

2020 ◽

Vol 25 (24) ◽

pp. 6004

Author(s):

Marketa Houdkova ◽

Genesis Albarico ◽

Ivo Doskocil ◽

Jan Tauchen ◽

Klara Urbanova ◽

...

Keyword(s):

Essential Oils ◽

Nigella Sativa ◽

Biological Activities ◽

Biological Effects ◽

Ethylene Vinyl Acetate ◽

Biological Properties ◽

Cytotoxic Activities ◽

Microtiter Plates ◽

In Series ◽

Volatile Agents

Volatile plant-derived products were observed to exhibit broad spectrum of biological effects. However, due to their volatility, results of conventional microplate-based bioassays can be significantly affected by the vapors. With aim to demonstrate this phenomenon, antimicrobial, antioxidant, and cytotoxic activities of three essential oils (Alpinia elegans, Cinnamomum iners, and Xanthostemon verdugonianus), one supercritical CO2 extract (Nigella sativa), and four plant-derived compounds (capsaicin, caryophyllene oxide, 8-hydroxyquinoline, and thymoquinone) were evaluated in series of experiments including both ethylene vinyl acetate (EVA) Capmat sealed and nonsealed microplates. The results clearly illustrate that vapor transition to adjoining wells causes false-positive results of bioassays performed in nonsealed microtiter plates. The microplate layout and a duration of the assay were demonstrated as the key aspects defining level of the results affection by the vapors of volatile agents. Additionally, we reported biological activities and chemical composition of essential oils from A. elegans seeds and X. verdugonianus leaves, which were, according to our best knowledge, analyzed for the first time. Considering our findings, certain modifications of conventional microplate-based assays are necessary (e.g., using EVA Capmat as vapor barrier) to obtain reliable results when biological properties of volatile agents are evaluated.

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Rose Flowers—A Delicate Perfume or a Natural Healer?

Biomolecules ◽

10.3390/biom11010127 ◽

2021 ◽

Vol 11 (1) ◽

pp. 127

Author(s):

Milka Mileva ◽

Yana Ilieva ◽

Gabriele Jovtchev ◽

Svetla Gateva ◽

Maya Margaritova Zaharieva ◽

...

Keyword(s):

Essential Oils ◽

Food Industry ◽

Raw Materials ◽

Biological Activities ◽

Biological Properties ◽

Rosa Damascena ◽

Oil Sand ◽

Rosa Gallica ◽

Therapeutic Properties ◽

Phytochemical Profile

Plants from the Rosacea family are rich in natural molecules with beneficial biological properties, and they are widely appreciated and used in the food industry, perfumery, and cosmetics. In this review, we are considering Rosa damascena Mill., Rosa alba L., Rosa centifolia L., and Rosa gallica L. as raw materials important for producing commercial products, analyzing and comparing the main biological activities of their essential oils, hydrolates, and extracts. A literature search was performed to find materials describing (i) botanical characteristics; (ii) the phytochemical profile; and (iii) biological properties of the essential oil sand extracts of these so called “old roses” that are cultivated in Bulgaria, Turkey, India, and the Middle East. The information used is from databases PubMed, Science Direct, and Google Scholar. Roses have beneficial healing properties due to their richness of beneficial components, the secondary metabolites as flavonoids (e.g., flavones, flavonols, anthocyanins), fragrant components (essential oils, e.g., monoterpenes, sesquiterpenes), and hydrolysable and condensed tannins. Rose essential oils and extracts with their therapeutic properties—as respiratory antiseptics, anti-inflammatories, mucolytics, expectorants, decongestants, and antioxidants—are able to act as symptomatic prophylactics and drugs, and in this way alleviate dramatic sufferings during severe diseases.

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Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

Forests ◽

10.3390/f10070539 ◽

2019 ◽

Vol 10 (7) ◽

pp. 539 ◽

Cited By ~ 1

Author(s):

Marcos Fernández-Cervantes ◽

María José Pérez-Alonso ◽

José Blanco-Salas ◽

Ana Cristina Soria ◽

Trinidad Ruiz-Téllez

Keyword(s):

Essential Oils ◽

Biological Activities ◽

Folk Medicine ◽

Gas Chromatography Mass Spectrometry ◽

Distribution Area ◽

Endemic Plant ◽

Plant Materials ◽

Whole Plant ◽

First Time ◽

Scientific Validation

Chamaemelum fuscatum (Brot.) Vasc. is a south west Iberian chamomile that has been traditionally used as folk medicine in its natural distribution area but currently it is underestimated regarding its biological activities. For this reason, it is proposed in this paper to get insight into the scientific validation of the traditional knowledge of this plant with the aim of taking advantage of its anti-inflammatory, gastroprotective and antinociceptive activities, among others. To this aim, the chemical composition of the essential oil from the whole plant, the flowers and the green parts of this plant has been evaluated by gas chromatography–mass spectrometry (GC–MS). Plant materials were collected in Badajoz (Spain). A total of 61 components including monoterpenoids, sesquiterpenoids and aliphatic esters were identified. (E)-2-Methyl-2-butenyl methacrylate (27.57%–18.53%) and 2-methylallyl isobutyrate (9.79%–7.51%) were the most abundant compounds in the essential oils of flowers and of the whole plant, whereas α-curcumene, trans-pinocarveol, α-bergamotene and pinocarvone were the major terpenoids irrespective of the plant part considered. Certain compounds showing a relative high abundance as isobutyl methacrylate, isoamyl butyrate, α-bergamotene and pinocarvone were identified for the first time in this species. Finally, we have reviewed the bioactivity of several compounds to relate the ethnobotanical use of this plant in Spain with its volatile profile. This work is a preliminary contribution to reinforce the use to this Mediterranean endemic plant as a natural source of bioactives.

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Biological Effects of Glucosinolate Degradation Products from Horseradish: A Horse that Wins the Race

Biomolecules ◽

10.3390/biom10020343 ◽

2020 ◽

Vol 10 (2) ◽

pp. 343 ◽

Cited By ~ 3

Author(s):

Marijana Popović ◽

Ana Maravić ◽

Vedrana Čikeš Čulić ◽

Azra Đulović ◽

Franko Burčul ◽

...

Keyword(s):

Cytotoxic Activity ◽

Cell Lines ◽

Cancer Cell ◽

Degradation Products ◽

Human Cancer ◽

Biological Activities ◽

Biological Effects ◽

Cancer Cell Lines ◽

Cytotoxic Activities ◽

Minimal Inhibitory Concentrations

Horseradish degradation products, mainly isothiocyanates (ITC) and nitriles, along with their precursors glucosinolates, were characterized by GC-MS and UHPLC-MS/MS, respectively. Volatiles from horseradish leaves and roots were isolated using microwave assisted-distillation (MAD), microwave hydrodiffusion and gravity (MHG) and hydrodistillation (HD). Allyl ITC was predominant in the leaves regardless of the isolation method while MAD, MHG, and HD of the roots resulted in different yields of allyl ITC, 2-phenylethyl ITC, and their nitriles. The antimicrobial potential of roots volatiles and their main compounds was assessed against sixteen emerging food spoilage and opportunistic pathogens. The MHG isolate was the most active, inhibiting bacteria at minimal inhibitory concentrations (MICs) from only 3.75 to 30 µg/mL, and fungi at MIC50 between <0.12 and 0.47 µg/mL. Cytotoxic activity of volatile isolates and their main compounds were tested against two human cancer cell lines using MTT assay after 72 h. The roots volatiles showed best cytotoxic activity (HD; IC50 = 2.62 μg/mL) against human lung A549 and human bladder T24 cancer cell lines (HD; IC50 = 0.57 μg/mL). Generally, 2-phenylethyl ITC, which was tested for its antimicrobial and cytotoxic activities along with two other major components allyl ITC and 3-phenylpropanenitrile, showed the best biological activities.

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Essential oils in experimental models of neuropsychiatric disorders: A review

Current Neuropharmacology ◽

10.2174/1570159x19666210421091734 ◽

2021 ◽

Vol 19 ◽

Author(s):

Luciana Cristina B. Fernandes ◽

Ianara Mendonça Costa ◽

Marco Aurelio M. Freire ◽

Francisca Overlânia V. Lima ◽

Francisca Idalina Neta ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Cerebral Ischemia ◽

Essential Oils ◽

Neurological Disorders ◽

Biological Effects ◽

Neuroprotective Effect ◽

Experimental Models ◽

Sensory Loss ◽

Cochrane Library

Background: Neural cells undergo functional or sensory loss due to neurological disorders. In addition to environmental or genetic factors, oxidative stress is a major contributor to neurodegeneration. In this context, there has been a growing interest in investigating the effects of essential oils (EOs) in recent years, especially in the treatment of neuropathologies. The chemical and biological effects of EOs have led to important treatment tools for the management of various neurological disorders. Objective: In the present study we performed a systematic review that sought to comprehend the neuroprotective effects of different EOs. Method: This work is a systematic review where an electronic search was performed on PubMed, Science direct, Cochrane Library and SciELO (Scientific Electronic Library Online) databases, covering the last 10 years, using “Essential oil” and “Neuroprotective effect” as reference terms. Results: A total of 9 articles were identified, in which the efficacy of EOs was described in experimental models of anxiety, dementia, oxidative stress, cerebral ischemia, Alzheimer’s disease and oxidative toxicity. Conclusion: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.

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In vitro Methods to Study Antioxidant and Some Biological Activities of Essential Oils: a Review

Biointerface Research in Applied Chemistry ◽

10.33263/briac123.33323347 ◽

2021 ◽

Vol 12 (3) ◽

pp. 3332-3347

Keyword(s):

Essential Oils ◽

Biological Activities ◽

Biological Effects ◽

The Other ◽

Present Review ◽

In Vitro Methods ◽

Potential Benefits ◽

Experimental Protocols ◽

The One

As essential oils (EOs) represent a new source of efficient and safe agents for health nowadays, the present review brings together the in vitro methods widely used to evaluate the antioxidant and some biological activities especially, antidiabetic, anticancer, antimicrobial, and anti-inflammatory activities of EOs, in order to valorize these EOs and to highlight their potential benefits. Moreover, each method cited is along with its aim, principle, advantages and limitations, experimental protocols, and notes. Hence, this review will help researchers working on EOs, to save time while accessing this summary document on the one hand, and on the other hand, it will contribute to scientific approval of in vitro antioxidant and biological effects of EOs for future useful purposes.

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Biological Activities and Pharmacological Applications of Cyclodextrins Complexed with Essential Oils and Their Volatile Components: A Systematic Review

Current Pharmaceutical Design ◽

10.2174/1381612824666181120093634 ◽

2019 ◽

Vol 24 (33) ◽

pp. 3951-3963 ◽

Cited By ~ 1

Author(s):

Rosueti Diógenes de Oliveira-Filho ◽

Angelo Roncalli Avles e Silva ◽

Renato de Azevedo Moreira ◽

Nadia Accioly Pinto Nogueira

Keyword(s):

Systematic Review ◽

Essential Oils ◽

Biological Activities ◽

Volatile Components

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The Essential Oil Components of Helichrysum pallasii Flowers

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v9isp.2591-2593.4941 ◽

2022 ◽

Vol 9 (sp) ◽

pp. 2591-2593

Author(s):

Emine Yurteri ◽

Fatih Seyis ◽

Haydar Kuplemez

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Solid Phase ◽

Raw Materials ◽

Natural Habitat ◽

Folk Medicine ◽

Antimicrobial Activities ◽

Volatile Components ◽

Full Flowering ◽

Aromatic Components

The genus Helichrysum contains many species displaying therapeutical effects and use in folk medicine. Helichrysum pallasii (Spreng.) Ledeb. is one of these species, used in the region for traditional medicine and ornamental purposes. Plants have been used in the treatment in folk medicines since the earliest times of human history. Chemical composition, antimicrobial and other medicinal properties of plants are being investigated in laboratories throughout the world using the extracts and essential oils derived from medicinal plants. Essential oils are usually complex mixtures of natural compounds of both polar and apolar structure. Essential oils consist mainly of terpenoids and their oxygenated derivatives. Essential oils, which have antioxidant and antimicrobial activities, have therapeutic properties and are the raw materials of cosmetics, as well as acting as natural additives in foods and food products. In this study, the volatile components of the H. pallasii plants were investigated which collected from its natural habitat in the Armutlu district of Bayburt province (Turkey) at the time of flowering. The proportion of essential oils of the plant harvested during the full flowering period and the aromatic components in the essential oil of the plant were determined using the SPME (Solid Phase Microextraction) method in a Gas Chromatography (GC-MS) device. Almost 37 different components were found as a result of the analysis. The main components were found as α-Springene (34.89%), (-)-Isoledene (7.11%), δ-Selinene (5.79%) and Aristolene (5.09).

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Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2018/5295619 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Catia A. Almeida ◽

Mariana M. B. Azevedo ◽

Francisco C. M. Chaves ◽

Marcelo Roseo de Oliveira ◽

Igor A. Rodrigues ◽

...

Keyword(s):

Essential Oils ◽

Biofilm Formation ◽

Inhibitory Concentration ◽

Rhizopus Oryzae ◽

Biological Activities ◽

Folk Medicine ◽

Planktonic Cells ◽

Total Inhibition ◽

Activity Screening ◽

Bioactive Potential

Piper is the largest genus of the Piperaceae family. The species of this genus have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica, and Mexico. In Brazil, Piper species are distributed throughout the national territory, making this genus a good candidate for biological activity screening. During our studies with Piper essential oils, we evaluated its activity against Rhizopus oryzae, the main agent of mucormycosis. The main compounds of seven Piper essential oils analyzed were Piper callosum—safrole (53.8%), P. aduncum—dillapiole (76.0%), P. hispidinervum—safrole (91.4%), P. marginatum—propiopiperone (13.2%), P. hispidum—γ-terpinene (30.9%), P. tuberculatum—(E)-caryophyllene (30.1%), and Piper sp.—linalool (14.6%). The minimum inhibitory concentration of Piper essential oils against R. oryzae ranged from 78.12 to >1250 μg/mL. The best result of total inhibition of biofilm formation was obtained with Piper sp. starting from 4.88 μg/mL. Considering the bioactive potential of EOs against planktonic cells and biofilm formation of R. oryzae could be of great interest for development of antimicrobials for therapeutic use in treatment of fungal infection.

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Chemical Composition and Biological Activities of Essential Oils in the Family Lauraceae: A Systematic Review of the Literature

Planta Medica ◽

10.1055/a-0943-1908 ◽

2019 ◽

Vol 85 (13) ◽

pp. 1054-1072 ◽

Cited By ~ 7

Author(s):

Carolina Sette Barbosa Damasceno ◽

Natasha Tiemi Fabri Higaki ◽

Josiane de Fátima Gaspari Dias ◽

Marilis Dallarmi Miguel ◽

Obdulio Gomes Miguel

Keyword(s):

Systematic Review ◽

Biological Activity ◽

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Web Of Science ◽

Biological Activities ◽

Review Of The Literature ◽

Inclusion Criteria ◽

The Family

AbstractThe Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from the Lauraceae family. Medline, Scielo, Web of Science, Lilacs, and Scopus were employed to identify articles published between 2000 and 2018, using “Lauraceae”, “essential oil”, and “biological activity” as key words. From 177 studies identified, 53 met the inclusion criteria. These studies indicated a predominance of the compounds β-caryophyllene and 1,8-cineole in Lauraceae species, and highlighted the antioxidant, antifungal, antibacterial, and anti-inflammatory activities. Essential oils extracted from this family thus have high potential for pharmacological applications.

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