A first case report of nasopharyngeal Mycobacterium abscessus subspecies massiliense infection

Abstract Background Mycobacterium abscessus subspecies massiliense is a non-tuberculous mycobacteriosis and was subdivided from Mycobacterium abscessus in 2006. This article is the first report on nasopharyngitis caused by Mycobacterium abscessus subspecies massiliense. Case presentation A 45-year-old woman had an 18-month history of recurrent nasopharyngitis and presented with pain in the throat. Mycobacterial tissue culture and polymerase chain reaction testing revealed the presence of Mycobacterium abscessus subspecies massiliense in the nasopharyngeal tissue. This patient underwent surgery, followed by multiple rounds of chemotherapy with oral and intravenous antibiotic agents for 16 weeks. She has had no recurrence during the 56 weeks since treatment. Conclusion It is difficult to detect the presence of Mycobacterium abscessus subspecies massiliense in a culture from the swabbing sample. The tissue culture from a biopsy specimen is mandatory for the identification of the species. Currently, no definite treatment policy is available and only empirical treatment is applied. This case is an important for the diagnosis and treatment of this bacterial infection on nasopharynx.

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A first case report of nasopharyngeal mycobacterium abscessus ssp. massilliense infection

10.21203/rs.3.rs-319844/v1 ◽

2021 ◽

Author(s):

Yamato Oki ◽

Hiromitsu Hatakeyama ◽

Masanori Komatsu ◽

Yasuhiro Isono ◽

Hidetaka Ikemiyagi ◽

...

Keyword(s):

Tissue Culture ◽

Medical Center ◽

Neck Region ◽

Mycobacterium Abscessus ◽

Supporting Evidence ◽

Head And Neck Region ◽

First Case ◽

Nasopharyngeal Tissue ◽

History Of ◽

Antibiotic Agents

Abstract BackgroundMycobacterium abscessus ssp. massiliense is a non-tuberculous mycobacteriosis and was subdivided from Mycobacterium abscessus in 2006. There are no reports to date on nasopharyngitis caused by Mycobacterium abscessus ssp. massiliense.Case PresentationA 45-year old woman was referred to Yokohama City University Medical Center with an 18-month history of recurrent nasopharyngitis and presented with pain in the throat. Mycobacterial tissue culture and polymerase chain reaction testing revealed the presence of Mycobacterium abscessus ssp. massiliense in the nasopharyngeal tissue. This patient underwent surgery, followed by multiple rounds of chemotherapy with oral and intravenous antibiotic agents for four months. She has had no recurrence during the 8 months since treatment.ConclusionThere are few reports on Mycobacterium abscessus ssp. massiliense infection in the head and neck region, and none in the pharynx. To our knowledge, this is the first report of a patient with a nasopharyngeal Mycobacterium abscessus ssp. massiliense infection. It is difficult to prove the presence of Mycobacterium abscessus ssp. massiliense in a pharyngeal “swab,” and tissue culture from a biopsy specimen is mandatory for the identification of the species. Currently, no definite treatment policy is available and only empirical treatment is applied. Further reports are needed to accumulate supporting evidence.

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Hoarseness of Voice as a Rare Presentation of Tuberculosis: A Case Report Study

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.817 ◽

2019 ◽

Vol 7 (19) ◽

pp. 3262-3264

Author(s):

Taher Felemban ◽

Abdullah Ashi ◽

Abdullah Sindi ◽

Mohannad Rajab ◽

Zuhair Al Jehani

Keyword(s):

Laryngeal Carcinoma ◽

Incidental Finding ◽

Chain Reaction ◽

Rare Presentation ◽

Case Presentation ◽

X Ray ◽

History Of ◽

Chest X Ray ◽

Polymerase Chain ◽

Laryngeal Tuberculosis

BACKGROUND: Having hoarseness of voice as the first clinical manifestation of tuberculosis is rare. This atypical presentation causes some confusion since other more common conditions, such as laryngeal carcinoma, present similarly and might require more invasive tests to confirm the diagnosis. CASE PRESENTATION: A 38-year-old male presented to the otorhinolaryngology clinic with a four-month history of change in voice. Laryngoscopy demonstrated a right glottic mass, raising suspicion of laryngeal cancer. The computed tomography showed a mass and incidental finding of opacities in lung apices. Chest x-ray demonstrated findings suggestive of tuberculosis. Polymerase chain reaction and culture of sputum samples confirmed the diagnosis and the patient was started on anti-tuberculosis treatment. CONCLUSION: Despite accounting for only 1% of pulmonary tuberculosis cases and having a similar presentation to laryngeal carcinoma, we recommend considering laryngeal tuberculosis when evaluating hoarseness of voice in endemic areas.

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Transient benign hyperphosphatasemia due to COVID-19: the first case report

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0503 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Tugba Erat ◽

Müge Atar ◽

Tugba Kontbay

Keyword(s):

Polymerase Chain Reaction ◽

Alkaline Phosphatase ◽

Case Report ◽

Rt Pcr ◽

Chain Reaction ◽

Benign Condition ◽

Case Presentation ◽

Normal Ranges ◽

First Case ◽

Polymerase Chain

AbstractObjectivesCoronavirus disease (COVID-19) rapidly spread worldwide in a few months and was declared as a worldwide pandemic by WHO in March 2020. Transient benign hyperphosphatasemia (THI) is a benign condition associated with marked elevation of alkaline phosphatase (ALP) without any other kidney, bone, and liver pathologies.Case presentationHerein, we report a previously healthy 16-month-old female patient who developed a secondary transient benign hyperphosphatasemia associated with SARS-CoV-2. Patient whole family’s SARS-CoV-2 real-time reverse transcription-polymerase chain reaction (RT-PCR) results were positive. Since THI is a diagnosis of exclusion, other reasons that may cause ALP elevation should be ruled out. ALP activity decreased and turned to normal ranges within the following month. THI has been reported to be in association with various conditions. Its relationship with many viruses has been reported previously.ConclusionsIf ALP elevation is detected in patients with COVID 19 due to the increasing number of infections, THI should be considered if there is no other accompanying pathology.

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Vibrio cholerae non-O1 - the first reported case of keratitis in a healthy patient

BMC Infectious Diseases ◽

10.1186/s12879-019-4475-4 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 3

Author(s):

Wei-Dar Chen ◽

Li-Ju Lai ◽

Wei-Hsiu Hsu ◽

Tsung-Yu Huang

Keyword(s):

Vibrio Cholerae ◽

Corneal Ulcer ◽

Positive Outcome ◽

Ocular Injury ◽

Significant Morbidity ◽

Chain Reaction ◽

Case Presentation ◽

First Case ◽

Polymerase Chain ◽

The Right

Abstract Background Vibrio cholerae non-O1 is a virulent pathogen that causes significant morbidity and mortality in humans. Herein, we report a case of corneal ulcer caused by this pathogen. Case presentation A 59-year-old fisherman with no systemic history was struck in the right eye by a marine shrimp and developed keratitis. Corneal scrapping culture revealed the presence of the V. cholerae non-O1, and its identification was confirmed by Analytical Profile Index 20E system and polymerase chain reaction. He was successfully treated with topical levofloxacin (0.3%) and fortified amikacin (12.5 mg/mL) for 2 weeks. The visual acuity recovered to 20/25 after treatment without complications. Conclusions This is the first case report of keratitis caused by V. cholerae non-O1 strain. Ocular injury by marine creatures and contaminated seawater can contribute to severe corneal ulcer. Early diagnosis can be achieved by meticulous history taking and a comprehensive laboratory workup. Simultaneously, an effective antibiotic therapy can lead to a positive outcome.

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Meningitis induced by severe acute respiratory syndrome coronavirus 2: A case report

10.32592/ircmj.2021.23.6.293 ◽

2021 ◽

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Computed Tomography Scan ◽

Chain Reaction ◽

Emergency Center ◽

Case Presentation ◽

First Case ◽

Polymerase Chain ◽

The Brain ◽

Tomography Scan

Introduction: Coronavirus disease 2019 (COVID-19) emerged in December 2019 in China and caused a catastrophic pandemic in 2020. Significant manifestations of COVID-19 are related to the respiratory system; however, other organs, such as the brain and heart, can also be involved. Case presentation: A 44-year-old-male was hospitalized in our referral emergency center due to being febrile and confused. He experienced five episodes of convulsion in the hospital. Within a day, the respiratory symptoms developed. The polymerase chain reaction of cerebrospinal fluid (CSF) was positive for COVID-19. The analysis of CSF and findings of chest computed tomography scan revealed that the case was infected with meningitis induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pneumonia. Conclusions: It has been reported that neurological symptoms of COVID-19 can appear earlier than other symptoms. To the best of our knowledge, few articles have represented COVID-induced meningitis. This case study reported the first case of meningitis induced by SARS-CoV-2 in Iran

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The First Case of COVID-19 Reinfection in Duhok City, Kurdistan Region of Iraq: A Case Report

Journal of Kermanshah University of Medical Sciences ◽

10.5812/jkums.111454 ◽

2020 ◽

Vol 24 (4) ◽

Author(s):

Nawfal Rasheed Hussein ◽

Dildar H Musa ◽

Ibrahim Abdulqader Naqid ◽

Zana Sidiq M.Saleem ◽

Nashwan Ibrahim

Keyword(s):

Real Time ◽

Antiviral Treatment ◽

Kurdistan Region ◽

Prevention Strategies ◽

Rt Pcr ◽

Chain Reaction ◽

Community Based ◽

Case Presentation ◽

First Case ◽

Polymerase Chain

Introduction: Coronavirus disease (COVID-19) causes a severe acute respiratory syndrome and is known as coronavirus 2 (SARS-CoV-2), which was first discovered in December, 2019 in Wuhan, China. The question of whether the COVID-19 patients that recover from the disease acquire immunity or are still susceptible to reinfection remains unanswered. Case Presentation: In this study, we presented the case of a 46-year-old male who recovered from the first round of COVID-19 infection. After symptom resolution, two consecutives negative real-time reverse transcription-polymerase chain reaction (RT-PCR) tests confirmed the negativity of the patient. Seven weeks after the first infection, the patient presented with fever and dry cough, and the infection was confirmed using real-time RT-PCR. The reinfection was associated with more severe symptoms, which required antiviral treatment. Conclusions: Our study indicated the possibility of COVID-19 reinfection. If the occurrence of reinfections is confirmed, it may implicate changes in the vaccine and community-based disease prevention strategies. Further studies are required to confirm the possibility of COVID-19 reinfection.

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A genome epidemiological study of SARS-CoV-2 introduction into Japan

10.1101/2020.07.01.20143958 ◽

2020 ◽

Cited By ~ 2

Author(s):

Tsuyoshi Sekizuka ◽

Kentaro Itokawa ◽

Masanori Hashino ◽

Tetsuro Kawano-Sugaya ◽

Rina Tanaka ◽

...

Keyword(s):

Network Analysis ◽

Haplotype Network ◽

Epidemiological Surveillance ◽

Genome Sequences ◽

Chain Reaction ◽

First Case ◽

A Genome ◽

History Of ◽

Polymerase Chain ◽

National Emergency

AbstractBackgroundAfter the first case of COVID-19 in Japan on 15 January 2020, multiple nationwide COVID-19 clusters were identified by the end of February. The Japanese government focused on mitigating emerging COVID-19 clusters by conducting active nationwide epidemiological surveillance. However, an increasing number of cases appeared until early April, many with unclear infection routes exhibiting no recent history of travel outside Japan. We aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from COVID-19 cases until early April and characterise the genealogical networks to demonstrate possible routes of spread in Japan.MethodsNasopharyngeal specimens were collected from patients and a quantitative reverse transcription polymerase chain reaction testing for SARS-CoV-2 was performed. Positive RNA samples were subjected whole genome sequencing and a haplotype network analysis was performed.FindingsSome of the primary clusters identified during January and February in Japan directly descended from Wuhan-Hu-1-related isolates in China and other distinct clusters. Clusters were almost contained until mid-March; the haplotype network analysis demonstrated that COVID-19 cases from late March through early April may have caused an additional large cluster related to the outbreak in Europe, leading to additional spread within Japan. National self-restraint during February was effective in mitigating the COVID-19 spread, but late action on stopping immigration and declaring national emergency in Japan might be involved in the later increase in cases.InterpretationGenome surveillance suggested that at least two distinct SARS-CoV-2 introductions from China and other countries occurred.FundingJapan Agency for Medical Research and Development.

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Immediate post partum macular subretinal bleeding in a highly myopic patient: a case report

BMC Ophthalmology ◽

10.1186/s12886-021-01814-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Karen Bitton ◽

J.-L. Bacquet ◽

F. Amoroso ◽

S. Mrejen ◽

M. Paques ◽

...

Keyword(s):

Valsalva Maneuver ◽

Post Partum ◽

Pathologic Myopia ◽

Pathological Myopia ◽

Case Presentation ◽

Sudden Loss ◽

Corrected Visual Acuity ◽

First Case ◽

History Of ◽

Macular Hemorrhage

Abstract Background Pathologic myopia is a major cause of visual impairment and blindness. Case presentation We report a case of an immediate post partum macular subretinal bleeding observed in a highly myopic patient. A 30-years-old woman presented two days after childbirth for sudden loss of vision in her right eye. Multimodal imaging showed macular hemorrhage masking a subtle yellowish linear lesion corresponding to lacker crack. Due to the lack of evidence for choroidal neovascularization, a simple clinical and imaging monitoring was recommended. Six weeks later, we noted an improvement in her best-corrected visual acuity and a decreased in size of the macular hemorrhage. Conclusions This is the first case reporting a macular subretinal bleeding on macular lacquer cracks in a highly myopic patient in immediate post partum. Valsalva maneuver associated with vaginal delivery could explain the occurrence of the hemorrhage associated with lacquer crack. However, natural history of pathological myopia could not be excluded.

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Seroprevalence of SARS-CoV-2 Antibodies Among Health Care Personnel at a Health Care System in Pakistan

Asia Pacific Journal of Public Health ◽

10.1177/10105395211011010 ◽

2021 ◽

pp. 101053952110110

Author(s):

Salma Abbas ◽

Aun Raza ◽

Ayesha Iftikhar ◽

Aamir Khan ◽

Shahzaib Khan ◽

...

Keyword(s):

Health Care ◽

Control Measures ◽

Health Care Personnel ◽

Test Results ◽

Antibody Testing ◽

Chain Reaction ◽

Past Infection ◽

Infection Control Measures ◽

History Of ◽

Polymerase Chain

Health care personnel (HCP) are at high risk for coronavirus disease-2019 acquisition. Serum antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicate past infection. Our institution offered SARS-CoV-2 antibody testing to HCP. We surveyed HCP with positive test results to explore past exposure to SARS-CoV-2, details of symptoms during the preceding 6 months, and a history of SARS-CoV-2 polymerase chain reaction testing. A total of 2162 HCP underwent antibody testing. Eight hundred fifty-seven (39.6%) employees tested positive and, of these, 820 (95.7%) participated in the survey. When adjusted for age, males had higher odds of testing positive for SARS-CoV-2 antibodies compared with females (OR = 1.68; 95% CI = 1.37-2.05; P = .00) and clinical staff had higher odds of SARS-CoV-2 seropositivity compared with nonclinical staff (OR = 1.273; 95% CI = 1.06-1.53; P = .01). Implementation of effective infection control measures is essential to protect HCP from coronavirus disease-2019.

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Complicated cutaneous leishmaniasis caused by an imported case of Leishmania tropica in Japan: a case report

Tropical Medicine and Health ◽

10.1186/s41182-021-00312-4 ◽

2021 ◽

Vol 49 (1) ◽

Author(s):

Hiroyuki Kitano ◽

Chizu Sanjoba ◽

Yasuyuki Goto ◽

Kazumasa Iwamoto ◽

Hiroki Kitagawa ◽

...

Keyword(s):

Cutaneous Leishmaniasis ◽

Skin Lesions ◽

Leishmania Tropica ◽

Case Presentation ◽

Imported Case ◽

Imported Cases ◽

History Of ◽

Hematoxylin And Eosin ◽

Polymerase Chain ◽

Positive Results

Abstract Background Leishmaniasis is not endemic in Japan, and imported cases are rare. However, there are increasing concerns regarding imported cases of cutaneous leishmaniasis from endemic countries to Japan. This report describes a case of imported cutaneous leishmaniasis that was diagnosed and treated in Japan. Case presentation A 53-year-old Pakistani man presented with skin lesions on both malleoli of his right ankle and the dorsum of the left foot. The skin lesions manifested as erythematous nodules surrounding an ulcer in the center of the lesion. The lesions of the malleoli of his right ankle each measured 3 × 3 cm, and the lesion on the top of his left foot measured 5 × 4 cm. He had been living and working in Japan but had a history of a visit to Pakistan for about 2 months in 2018. The skin lesions were biopsied. Giemsa and hematoxylin and eosin staining of biopsy samples showed amastigotes of Leishmania in macrophages, and the presence of Leishmania was confirmed by skin tissue culture. Polymerase chain reaction using biopsy specimens identified Leishmania parasites, and DNA sequence analysis revealed that the species was Leishmania tropica. The patient was treated with intravenous liposomal amphotericin B for 6 days. The erythema disappeared, and the erythematous nodules resolved within 3 weeks. Conclusion This is the first report of imported cutaneous leishmaniasis caused by L. tropica from Pakistan, and it is interesting that all three testing modalities showed positive results in this case.

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