scholarly journals Propolis: a new frontier for wound healing?

2015 ◽  
Vol 3 ◽  
pp. 1-7 ◽  
Author(s):  
Simona Martinotti ◽  
Elia Ranzato

Abstract Propolis is a resin produced by honeybees by mixing wax, pollen, salivary secretions, and collected natural resins. The precise composition of propolis varies with the source, and over 300 chemical components belonging to the flavonoids, terpenes, and phenolic acids have been identified in propolis. Moreover, its chemical composition is subjected to the geographical location, botanical origin, and bee species. Propolis and its compounds have been the focus of many works due to their antimicrobial and anti-inflammatory activity; however, it is now recognized that propolis also possesses regenerative properties. There is an increasing interest in the healing potential of natural products, considering the availability and low cost of these products. Propolis contains a huge number of compounds that explicate some biological effects that speeds up the healing process and is widely used in folk remedies. This review aims to condense the results on the mechanism of activity of propolis and its compounds.

Antibiotics ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 251 ◽  
Author(s):  
Victoria C. Nolan ◽  
James Harrison ◽  
Jonathan A. G. Cox

Honey is a complex sweet food stuff with well-established antimicrobial and antioxidant properties. It has been used for millennia in a variety of applications, but the most noteworthy include the treatment of surface wounds, burns and inflammation. A variety of substances in honey have been suggested as the key component to its antimicrobial potential; polyphenolic compounds, hydrogen peroxide, methylglyoxal and bee-defensin 1. These components vary greatly across honey samples due to botanical origin, geographical location and secretions from the bee. The use of medical grade honey in the treatment of surface wounds and burns has been seen to improve the healing process, reduce healing time, reduce scarring and prevent microbial contamination. Therefore, if medical grade honeys were to be included in clinical treatment, it would reduce the demand for antibiotic usage. In this review, we outline the constituents of honey and how they affect antibiotic potential in a clinical setting. By identifying the key components, we facilitate the development of an optimally antimicrobial honey by either synthetic or semisynthetic production methods.


Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 225
Author(s):  
Asma Ghorab ◽  
María Shantal Rodríguez-Flores ◽  
Rifka Nakib ◽  
Olga Escuredo ◽  
Latifa Haderbache ◽  
...  

This study aimed to characterize the honeys of Babors Kabylia through sensory, melissopalynological and physico-chemical parameters. Thirty samples of honey produced in this region were collected over a period of two years and analyzed. All the samples presented physico-chemical parameters in conformity with legislation on honey quality, with few exceptions, linked mainly to beekeeping management. The pollen spectrum revealed a great diversity with 96 pollen types. The main pollen types were spontaneous species as Fabaceae (Hedysarum, Trifolium, Genisteae plants), Asteraceae plants, Ericaceae (Erica arborea L.) or Myrtus and Pistacia. The sensory properties of samples showed a high tendency to crystallization, the colors were from white to brown, but most of them had gold color. Smell and odor corresponded mainly to vegetal and fruity families and in taste perceptions besides sweetness highlighted sourness and saltiness notes. Seventeen samples were polyfloral, one was from honeydew and twelve were monofloral from heather, genista plants, sulla, blackberry or Asteraceae. Heather and the honeydew samples showed the darkest color, the highest electrical conductivity and phenol and flavonoid content. A statistical analysis based on the most representative pollen types, sensory properties and some physico-chemical components allowed the differentiation of honey samples in terms of botanical origin.


Author(s):  
Natali Vega-Magaña ◽  
Rocío Sánchez-Sánchez ◽  
Jorge Hernández-Bello ◽  
Alberto Antony Venancio-Landeros ◽  
Marcela Peña-Rodríguez ◽  
...  

BackgroundSeveral variants of the SARS-CoV-2 have been documented globally during the current COVID-19 pandemic. The N501Y, 69-70del, K417N, and E484K SARS-CoV-2 mutations have been documented among the most relevant due to their potential pathogenic biological effects. This study aimed to design, validate, and propose a fast real-time RT-qPCR assay to detect SARS-CoV-2 mutations with possible clinical and epidemiological relevance in the Mexican population.MethodsTargeting spike (S) gene mutations of SARS-CoV-2 (N501Y, 69-70del, K417N, and E484K), specific primers, and probes for three specific quantitative reverse transcription PCR (RT-qPCR) assays were designed, and validated using Sanger sequencing. These assays were applied in clinical samples of 1060 COVID-19 patients from Jalisco Mexico.ResultsIn silico analyzes showed high specificity of the three assays. Amplicons of samples were confirmed through sequencing. The screening of samples of COVID-19 patients allowed the identification of the E484K mutation in nine individuals and the identification of P.2 Brazilian variant in Mexico.ConclusionThis work provides low-cost RT-qPCR assays for rapid screening and molecular surveillance of mutations with potential clinical impact. This strategy allowed the detection of E484K mutation and P.2 variant for the first time in samples from the Mexican population.


2018 ◽  
pp. 666-670
Author(s):  
Olha Bohomolets

The article studies the history and the current stage of Russia’s aggression to-wards countries with lower military potential. The collapse of the post-war system of international relations and collective security has become apparent: the aggression of Russia against Moldova, Georgia and Ukraine has testified to the fact that there are no longer any tools to protect countries subjected to discrimination from super powers. Today discrimination affects not only people or social groups, but also some countries. Such countries are not capable of pursuing an independent policy as to major centres of international power they have to deal with. Peculiar to these countries are uncompetitive economy, low quality of life and undeveloped civil society, they hence become a target for “vital interests”, namely bidding by so-called super powers. “Giants” are attracted by the geographical location of a possible “victim”, access to the sea, transit facilities, natural resources, especially energy, low-cost labour, etc. It is often that “discriminated” countries become grounds for ignition of burning or frozen conflicts provoked by powerful neighbours’ influence, or are exposed to open aggression and become subject to occupation or hybrid war. This has all started after the Second World War, when super powers of the USSR and China, on the one hand, and the United States, Great Britain, Australia, and others, on the other, have made Korea fall into two states. In addition, there was subsequently a division of Germany, the Caribbean crisis…However, such conflicts then were not that wide-ranging, since the post-war collective security system was quite effective. Things, though, have changed dramatically in recent decades. One of the largest global players − Russia – has decisively begun to create around itself a buffer zone formed of countries, where it fuels frozen conflicts and in such a way keeps them under the radar and hinders their integration into the Western world. Initially, Russia ignited a conflict in Nagorno-Karabakh, supporting Armenia and assisting it to invade a considerable part of the territory in Azerbaijan, and then initiated the war in Transnistria by virtually occupying part of Moldova’s territory and asserting itself there on the pretext of deploying a peacekeeping mission. Later, there was a war in Abkhazia and then − in South Ossetia aiming to detach part of Georgia’s territory. And lastly, the turn of Ukraine has come… Regrettably, Ukraine is a typical and another example of a country that has fallen victim of multifaceted interests of the leading global players − Russia, the United States and the EU, and has faced all possible forms of discrimination. Keywords: war in eastern Ukraine, military aggression, geopolitics, conflicts, buffer zones.


Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3076 ◽  
Author(s):  
Bo Cao ◽  
Xi-Chuan Wei ◽  
Xiao-Rong Xu ◽  
Hai-Zhu Zhang ◽  
Chuan-Hong Luo ◽  
...  

For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation and cancer. In the West, frankincense and myrrh have been used as incense in religious and cultural ceremonies since ancient times; in traditional Chinese and Ayurvedic medicine, they are used mainly for the treatment of chronic diseases. The main chemical constituents of frankincense and myrrh are terpenoids and essential oils. Their common pharmacological effects are anti-inflammatory and anticancer. More interestingly, in traditional Chinese medicine, frankincense and myrrh have been combined as drug pairs in the same prescription for thousands of years, and their combination has a better therapeutic effect on diseases than a single drug. After the combination of frankincense and myrrh forms a blend, a series of changes take place in their chemical composition, such as the increase or decrease of the main active ingredients, the disappearance of native chemical components, and the emergence of new chemical components. At the same time, the pharmacological effects of the combination seem magically powerful, such as synergistic anti-inflammation, synergistic anticancer, synergistic analgesic, synergistic antibacterial, synergistic blood-activation, and so on. In this review, we summarize the latest research on the main chemical constituents and pharmacological activities of these two natural resins, along with chemical and pharmacological studies on the combination of the two.


2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Zhang ◽  
Yuewu Wang ◽  
Song Yang ◽  
Yunfeng Xiao ◽  
Haibin Guan ◽  
...  

As a well-known Chinese herb medicine, the Cistanche deserticola has been used for the treatment of kidney deficiency syndrome in China for thousands of years. Both the raw product of Cistanche deserticola slices (RCD) and its Wine Steam-Processed Product (WSCD) are used clinically for different effects. In this study, the influences of steaming process with wine (SPW) from Cistanche deserticola on chemical compositions and biological effects were investigated. The principal component analysis (PCA) and quantitative analysis were used to study the differences of the chemical compositions. The effects of nourishing kidney were also investigated to compare the differences between the RCD and the WSCD. The PCA results indicated that the obvious separation was achieved in the RCD and WSCD. The results of quantitative analysis showed that the WSCD has higher amounts of total polysaccharides, total PhGs, isoacteoside, and osmanthuside B than RCD, while the content of 2′-acetylacteoside and acteoside decreased after the SPW. The comparison of RCD and WSCD on biological activities showed that both could restore the level of sex hormone in the model of kidney-yang deficiency and improve the antioxidant effect. The WSCD were much better in increasing the viscera weight of kidney and seminal vesicle. The results indicated that SPW changed its chemical components and enhanced its biological activities.


2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Daolei Zhang ◽  
Xuezhi Li ◽  
Jian Zhao

High-yield pulps (HYPs), such as CTMP (chemi-thermo-mechanical pulp), are attractive due to their low cost and high wood utilization. However, their drawback of rapid brightness reversion (yellowing) limits wide use of the HYPs. In this study, a fungus, Fusarium concolor X4, was applied to treat poplar CTMP for exploring the effects of biotreatment on brightness and light-induced yellowing of the pulp. The results indicated that the biotreatment with Fusarium concolor X4 could improve the brightness of poplar CTMP and inhibit light-induced yellowing of the pulp. The yellowing inhibition mechanism was explored by the analysis of enzyme production regularity during biotreatment, changes in chemical components, and the UV-Vis absorption spectra and FTIR-ATR spectra of pulps before and after biotreatment.


2018 ◽  
Vol 27 (Sup2) ◽  
pp. S19-S25 ◽  
Author(s):  
André Oliveira Paggiaro ◽  
Andriws Garcia Menezes ◽  
Alexandra Donizetti Ferrassi ◽  
Viviane Fernandes De Carvalho ◽  
Rolf Gemperli

Objective: The amniotic membrane has biological properties that are beneficial to the wound healing process of diabetic foot ulcers (DFU). Our aim is to analyse the scientific evidence found in literature on the use of the amniotic membrane to stimulate DFU healing. Method: A systematic review of amniotic membrane's influence was undertaken, using the search terms ‘placenta’ ‘diabetic foot’ ‘amnion’ and biological dressing’, assessing the outcomes ‘wound healing’ and ‘wound healing time’, in DFU. Following the inclusion and exclusion criteria, randomised controlled trials (RCT) were identified, and the risk of bias was analysed according to the Cochrane risk of bias tool. We conducted a meta-analysis of the two outcomes to evaluate the level of evidence. Results: We identified six clinical trials, with a total of 331 patients. The most common risks of bias in the studies were selection, attrition, and detection biases. From the meta-analysis, the difference of the intervention group (amnion) in relation to the control group was statistically significant. We found that wound healing in the group treated with amniotic membrane occurs 2.32 times more often and is 32 days faster in comparison with the group that used conventional dressings. Conclusion: There is statistical evidence to support the effectiveness of amniotic membrane in comparison with other conventional dressings. In addition, there is a clear tendency for the use of amniotic membrane treatment to result in a larger number of DFUs healing at a quicker rate.


2020 ◽  
Vol 12 (1) ◽  
pp. 49 ◽  
Author(s):  
Sarah Ireland ◽  
Suzanne Belton ◽  
Frances Doran

ABSTRACT INTRODUCTIONRegardless of geographical location, safe and legal abortion is an essential reproductive health service. Accessing an abortion is problematic for women in rural areas. Although telemedicine is globally established as safe and effective for medical abortion in urban settings, there is a paucity of research exploring access to telemedicine abortion for women in rural locations. AIMThe aim of this qualitative research is to explore and better understand women’s access to telemedicine abortion in Australian rural areas. METHODSStructured interviews were conducted with women (n=11) living in rural areas who had experienced a telemedicine abortion within the last 6 months. Phone interviews were recorded and transcribed verbatim. Data underwent a Patient-Centred Access framework analysis and were coded according to the domain categories of approachability/ability to perceive, acceptability/ability to seek, availability/ability to reach, affordability/ability to pay, and appropriateness/ability to engage. RESULTSRural women had severely limited access to abortion care. The five domains of the Patient-Centred Access model demonstrated that when women with the prerequisite personal skills and circumstances are offered a low-cost service with compassionate staff and technical competence, telemedicine can innovate to ensure rural communities have access to essential reproductive health services. DISCUSSIONTelemedicine offers an innovative model for ensuring women’s access to medical abortion services in rural areas of Australia and likely has similar applicability to international non-urban contexts. Strategies are needed to ensure women with lower literacy and less favourable situational contexts, can equitably access abortion services through telemedicine.


2019 ◽  
Vol 54 (2) ◽  
pp. 155-160
Author(s):  
S Tabassum ◽  
MS Bashar ◽  
MS Islam ◽  
A Sharmin ◽  
SC Debnath ◽  
...  

Solar thermal energy is an alternative source of energy which can be used for drying vegetables, fishes, fruits or other kinds of material, such as wood. In Bangladesh, there exist significant post-harvest losses of agricultural products due to lack of the use of proper preservation system. Drying by using solar thermal energy can be an effective solution for this loss. As Bangladesh is situated in latitude 23°43’N and longitude 90°26’E, this is very much suitable to use solar thermal energy. To reduce the limitations of the natural sun drying e.g. exposure of the foodstuff to rain and dust; uncontrolled drying; exposure to direct sunlight; infestation by insects etc., two types of solar dryer (low cost solar dryer for small production and solar dryer for large production) were developed. The design was based on the geographical location of Dhaka, Bangladesh. The experiments were conducted to dry vegetables and fishes. The obtained results revealed that the temperatures inside the dryer were much higher than the ambient temperature. The rapid rate of drying proves its ability to dry food to keep in safe moisture level in a hygienic environment. Microbiological and nutritional values ensure a superior quality of the dried product also. Bangladesh J. Sci. Ind. Res.54(2), 155-160, 2019


Sign in / Sign up

Export Citation Format

Share Document