scholarly journals Dissecting the Antimicrobial Composition of Honey

Antibiotics ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 251 ◽  
Author(s):  
Victoria C. Nolan ◽  
James Harrison ◽  
Jonathan A. G. Cox
Keyword(s):  
Microbial Contamination ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Geographical Location ◽  
Healing Time ◽  
Antibiotic Usage ◽  
Botanical Origin ◽  
Production Methods ◽  
Sweet Food ◽  
Medical Grade

Honey is a complex sweet food stuff with well-established antimicrobial and antioxidant properties. It has been used for millennia in a variety of applications, but the most noteworthy include the treatment of surface wounds, burns and inflammation. A variety of substances in honey have been suggested as the key component to its antimicrobial potential; polyphenolic compounds, hydrogen peroxide, methylglyoxal and bee-defensin 1. These components vary greatly across honey samples due to botanical origin, geographical location and secretions from the bee. The use of medical grade honey in the treatment of surface wounds and burns has been seen to improve the healing process, reduce healing time, reduce scarring and prevent microbial contamination. Therefore, if medical grade honeys were to be included in clinical treatment, it would reduce the demand for antibiotic usage. In this review, we outline the constituents of honey and how they affect antibiotic potential in a clinical setting. By identifying the key components, we facilitate the development of an optimally antimicrobial honey by either synthetic or semisynthetic production methods.

scholarly journals Propolis: a new frontier for wound healing?

2015 ◽  
Vol 3 ◽  
pp. 1-7 ◽  
Author(s):  
Simona Martinotti ◽  
Elia Ranzato
Keyword(s):  
Biological Effects ◽  
Low Cost ◽  
Healing Process ◽  
Geographical Location ◽  
Chemical Components ◽  
Botanical Origin ◽  
Huge Number ◽  
New Frontier ◽  
Natural Resins ◽  
Folk Remedies

Abstract Propolis is a resin produced by honeybees by mixing wax, pollen, salivary secretions, and collected natural resins. The precise composition of propolis varies with the source, and over 300 chemical components belonging to the flavonoids, terpenes, and phenolic acids have been identified in propolis. Moreover, its chemical composition is subjected to the geographical location, botanical origin, and bee species. Propolis and its compounds have been the focus of many works due to their antimicrobial and anti-inflammatory activity; however, it is now recognized that propolis also possesses regenerative properties. There is an increasing interest in the healing potential of natural products, considering the availability and low cost of these products. Propolis contains a huge number of compounds that explicate some biological effects that speeds up the healing process and is widely used in folk remedies. This review aims to condense the results on the mechanism of activity of propolis and its compounds.

Wound With Diabetes: Present Scenario And Future

2020 ◽  
Vol 16 ◽  
Author(s):  
Kuldeep B. Pawar ◽  
Shivani Desai ◽  
Ramesh R. Bhonde ◽  
Ritesh P. Bhole ◽  
Atul A. Deshmukh
Keyword(s):  
Wound Healing ◽  
Blood Flow ◽  
Healing Process ◽  
Endocrine System ◽  
Healing Time ◽  
Special Focus ◽  
Diabetic Wound ◽  
Management Options ◽  
And Migration ◽  
Proliferation And Migration

: Diabetes is a chronic metabolic disorder of endocrine system characterized by increase in blood glucose level. Several factors such as pancreatic damage, oxidative stress, infection, genetic factor, obesity, liver dysfunction play a vital role in pathogenesis of diabetes which further lead to serious diabetic complications. Diabetic wound is one such complication where the wound formation occurs, especially due to pressure and its healing process is disrupted due to factors such as hyperglycemia, neuropathy, nephropathy, peripheral vascular disease, reduction of blood flow, atherosclerosis, impaired fibroblast. Process of wound healing is delayed due to different abnormalities like alteration in nitric oxide level, increase in aldose reductase, sorbitol and fructose. Therefore, diabetic wound requires more time to heal as compare to normal wound. Healing time is delayed in diabetic wound due to many factors such as stress, decreased oxygenation supply, infection, decreased blood flow, impaired proliferation and migration rate, impaired growth factor production, impaired keratinocytes proliferation and migration, and altered vascular endothelial mediators. The current treatment for diabetic wound includes wound patches, oxygenation therapy, hydrogel patches, gene therapy, laser therapy, and stem cell therapy. Medications with phytoconstituents is also one way to manage diabetic wound, but it is not more effective for quick healing. The objective of this review is to understand the potential of various management options which are available for diabetic wound, with a special focus on biological cells.

scholarly journals Relationships Linking the Colour and Elemental Concentrations of Blossom Honeys with Their Antioxidant Activity: A Chemometric Approach

Agriculture ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 702
Author(s):  
Monika Kędzierska-Matysek ◽  
Anna Teter ◽  
Małgorzata Stryjecka ◽  
Piotr Skałecki ◽  
Piotr Domaradzki ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Physicochemical Properties ◽  
Black Locust ◽  
Antioxidant Properties ◽  
Principal Component ◽  
Botanical Origin ◽  
Antioxidant Parameters ◽  
Colour Parameters ◽  
Hue Angle ◽  
Chemometric Approach

The antioxidant activity of honey depends on the botanical origin, which also determines their physicochemical properties. In this study, a multivariate analysis was used to confirm potential relationships between the antioxidant properties and colour parameters, as well as the content of seven elements in five types of artisanal honey (rapeseed, buckwheat, linden, black locust, and multifloral). The type of honey was found to significantly influence most of its physicochemical properties, colour parameters, and the content of potassium, manganese and copper. Antioxidant parameters were shown to be significantly positively correlated with redness and concentrations of copper and manganese, but negatively correlated with the hue angle and lightness. The principal component analysis confirmed that the darkest buckwheat honey had the highest antioxidant activity in combination with its specific colour parameters and content of antioxidant minerals (manganese, copper and zinc). The level of these parameters can be potentially used for the identification of buckwheat honey.

scholarly journals Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds—A Prospective Case Series

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 918
Author(s):  
Adéla Holubová ◽  
Lucie Chlupáčová ◽  
Lada Cetlová ◽  
Niels A. J. Cremers ◽  
Andrea Pokorná
Keyword(s):  
Antibiotic Treatment ◽  
Healing Process ◽  
Case Series ◽  
Wound Dehiscence ◽  
Surgical Wound Dehiscence ◽  
Infected Wounds ◽  
Healing Wounds ◽  
Anti Inflammatory ◽  
Prospective Case Series ◽  
Medical Grade

Non-healing wounds are usually colonised by various types of bacteria. An alternative to antibiotic treatment in patients with infected wounds with local signs of inflammation may be medical-grade honey (MGH), which favourably affects the healing process with its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. The objective of this study was to evaluate the effect of MGH therapy on the healing process of non-healing wounds of various aetiologies and different wound colonisations. Prospective, observation–intervention case studies (n = 9) of patients with wounds of various aetiologies (venous leg ulcers, diabetic foot ulcers, surgical wound dehiscence) are presented. All wounds were treated with MGH and the healing trajectory was rigorously and objectively monitored. In all cases, pain, odour, and exudation were quickly resolved, which led to an improvement in the quality of life of patients. Despite the proven bacterial microflora in wounds, antibiotic treatment was not necessary. The effects of MGH alleviated the signs of local infection until their complete elimination. In eight out of nine cases, the non-healing wound was completely healed. MGH has antimicrobial, anti-inflammatory, and antioxidant effects in wounds of various aetiologies and forms an effective alternative for the use of antibiotics for treating locally infected wounds.

scholarly journals Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Jianhua Zhang ◽  
Junfei Hu ◽  
Baoshu Chen ◽  
Tianbao Zhao ◽  
Zhipeng Gu
Keyword(s):  
Wound Healing ◽  
Acrylic Acid ◽  
Protein Denaturation ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Skin Damage ◽  
Hybrid Hydrogel ◽  
Hydrogel Scaffolds ◽  
Hybrid Hydrogels ◽  
Poly Acrylic Acid

Abstract Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

scholarly journals Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 691
Author(s):  
Jan Barcik ◽  
Devakara R. Epari
Keyword(s):  
Fracture Healing ◽  
Bone Healing ◽  
Mechanical Stimulation ◽  
Callus Formation ◽  
Weight Bearing ◽  
Healing Process ◽  
Healing Time ◽  
Mechanical Environment ◽  
Clinically Significant ◽  
The Impact

The impact of the local mechanical environment in the fracture gap on the bone healing process has been extensively investigated. Whilst it is widely accepted that mechanical stimulation is integral to callus formation and secondary bone healing, treatment strategies that aim to harness that potential are rare. In fact, the current clinical practice with an initially partial or non-weight-bearing approach appears to contradict the findings from animal experiments that early mechanical stimulation is critical. Therefore, we posed the question as to whether optimizing the mechanical environment over the course of healing can deliver a clinically significant reduction in fracture healing time. In reviewing the evidence from pre-clinical studies that investigate the influence of mechanics on bone healing, we formulate a hypothesis for the stimulation protocol which has the potential to shorten healing time. The protocol involves confining stimulation predominantly to the proliferative phase of healing and including adequate rest periods between applications of stimulation.

Use of therapeutic laser in the veterinary field

2021 ◽  
Vol 12 (8) ◽  
pp. 374-377
Author(s):  
Brianna Summers
Keyword(s):  
Veterinary Medicine ◽  
Healing Process ◽  
Daily Basis ◽  
Healing Time ◽  
Natural Healing

Therapeutic laser is an increasingly popular tool used in veterinary medicine. Therapeutic laser for veterinary patients aids the body's natural healing process, decreases healing time, alleviates pain and inflammation, and helps to delay progressive diseases. Therapeutic laser can be used immediately following procedures, in postoperative healing, and in a variety of disease processes. Therapeutic lasers are potentially dangerous tools and should be used with caution by trained veterinary nurses. When used properly, the therapeutic laser penetrates the patient's tissues to aid in cell regrowth and reduce pain and inflammation. In order to properly utilise this tool, the veterinary nurse must know what a therapeutic laser is, how it works, and how to handle it properly for each case. Once these concepts are mastered, therapeutic laser can be used by the veterinary nurse, under the supervision of the veterinarian, on a daily basis to help patients with a variety of needs.

scholarly journals Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers

2017 ◽  
Vol 78 (1) ◽  
pp. 98-107 ◽  
Author(s):  
J. A. Ávila-Reyes ◽  
N. Almaraz-Abarca ◽  
A. I. Chaidez-Ayala ◽  
D. Ramírez-Noya ◽  
E. A. Delgado-Alvarado ◽  
...  
Keyword(s):  
Quality Control ◽  
Phenolic Compounds ◽  
Wild Species ◽  
Antioxidant Properties ◽  
Dependent Manner ◽  
Botanical Origin ◽  
Herbal Preparations ◽  
Quality Control Tool ◽  
The Family ◽  
Phenolic Profiles

Abstract The family Verbenaceae hosts important species used in traditional medicine of many countries. The taxonomic controversies concerning the specific delimitation of several of its species make it difficult to guarantee the botanical origin of herbal preparations based on species of this family. To contribute to the development of both specific chemomarkers and a quality control tool to authenticate the botanical origin of herbal preparations of Verbenacea species, we determined the foliar HPLC-DAD phenolic profiles and the antioxidant properties of 10 wild species of this family occurring in Mexico. The contents of phenols and flavonoids varied significantly among species. Priva mexicana showed the highest levels of total phenolics (53.4 mg g-1 dry tissue) and Verbena carolina had the highest levels of flavonoids (17.89 mg g-1 dry tissue). Relevant antioxidant properties revealed by antiradical and reducing power were found for the analyzed species. These properties varied significantly in a species-dependent manner. The phenolic compounds accumulated were flavones and phenolic acids. Flavones were the only type of flavonoids found. The results of a cluster analysis showed that the compounds were accumulated in species-specific profiles. The phenolic profiles are proposed as valuable chemomarkers that can become a useful tool for the quality control concerning the botanical origin of herbal medicinal preparations based on the species analyzed. In addition, phenolic profiles could contribute importantly to solve the taxonomic controversies concerning species delimitation in the family Verbenaceae.

scholarly journals Bee Pollen as a Promising Agent in the Burn Wounds Treatment

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Paweł Olczyk ◽  
Robert Koprowski ◽  
Justyna Kaźmierczak ◽  
Lukasz Mencner ◽  
Robert Wojtyczka ◽  
...  
Keyword(s):  
Quantitative Research ◽  
Healing Process ◽  
Physiological Saline ◽  
Healing Time ◽  
Wound Healing Process ◽  
Burn Treatment ◽  
Bee Pollen ◽  
Domestic Pigs ◽  
Burn Wounds ◽  
Number Of Microorganisms

The aim of the present study was to visualize the benefits and advantages derived from preparations based on extracts of bee pollen as compared to pharmaceuticals commonly used in the treatment of burns. The bee pollen ointment was applied for the first time in topical burn treatment. Experimental burn wounds were inflicted on two white, domestic pigs. Clinical, histopathological, and microbiological assessment of specimens from burn wounds, inflicted on polish domestic pigs, treated with silver sulfadiazine or bee pollen ointment, was done. The comparative material was constituted by either tissues obtained from wounds treated with physiological saline or tissues obtained from wounds which were untreated. Clinical and histopathological evaluation showed that applied apitherapeutic agent reduces the healing time of burn wounds and positively affects the general condition of the animals. Moreover the used natural preparation proved to be highly effective antimicrobial agent, which was reflected in a reduction of the number of microorganisms in quantitative research and bactericidal activity of isolated strains. On the basis of the obtained bacteriological analysis, it may be concluded that the applied bee pollen ointment may affect the wound healing process of burn wounds, preventing infection of the newly formed tissue.

scholarly journals EFFECT OF ALENDRONATE ON THE HEALING TIME OF DISTAL RADIAL FRACTURES TREATED CONSERVATIVELY: AN OBSERVATIONAL STUDY

2017 ◽  
Vol 10 (11) ◽  
pp. 168
Author(s):  
Nidhin Koshy ◽  
Deepak Pinto ◽  
Premjit Sujir ◽  
Varghese Joe ◽  
Ghanashyam Kamath K
Keyword(s):  
Observational Study ◽  
Distal Radius ◽  
Healing Process ◽  
Tertiary Care ◽  
Fragility Fractures ◽  
Osteoporosis Treatment ◽  
Healing Time ◽  
Active Movement ◽  
Distal Radial Fractures ◽  
P Values

  Objective: Although fragility fractures of the distal radius are common, osteoporosis treatment requires exploration as attempts to improve postfracture investigations have been only partially successful. Bisphosphonates may help minimize the risk of secondary fractures but being a potent antiresorptive agent; it raises concerns about adverse effects on the healing process. This observational study examines the effect of bisphosphonate (alendronate) on healing of acute fractures of distal radius through 66 patients aged >45 years admitted to two tertiary care hospitals in Mangalore from May 2014 to September 2016.Methods: The methodology consists of purposive sampling from two groups: Control having 33 patients not on alendronate therapy and cases comprising 33 who are on alendronate as part of prophylaxis for osteoporosis before fracture occurrence, with outpatient reviews at 2-week intervals starting from the 6th till fracture union seen. At each visit, plain radiographs of the involved wrist were taken to yield time to cortical bridging, with range of active movement of the affected wrist taken using a goniometer. Data were analyzed using Statistical Package for the Social Sciences software version 17.0 for t values, p values and correlations and results were presented in the form of graphs and tables.Results: No significant differences were observed in the groups (as per p values) w.r.t. gender (0.804), age (0.835), time to healing (1.000), dorsiflexion (0.956), palmar flexion (0.670), ulnar deviation (0.441), radial deviation (1.000), supination (0.132), or pronation (0.302). Quick Disabilities of the Arm, Shoulder and Hand score did not differ by >95% between the groups over the analysis period.Conclusion: It was observed that alendronate administration in distal radius fractures did not appear to delay fracture healing times radiologically or clinically.

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