scholarly journals Ethanol effects on 68Ga-radiolabelling efficacy and radiolysis in automated synthesis utilizing NaCl post-processing

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Michael Meisenheimer ◽  
Stefan Kürpig ◽  
Markus Essler ◽  
Elisabeth Eppard
Keyword(s):  
Clinical Application ◽  
Standard Procedure ◽  
Practical Interest ◽  
Post Processing ◽  
Buffer Solution ◽  
Positive Effects ◽  
Whole Process ◽  
Labelling Procedure ◽  
Gallium 68 ◽  
Positive Effect

Abstract Objective Recent studies showed that ethanol in the reaction mixture improves radiolabelling with trivalent radiometals in terms of precursor amount, reaction time, reaction temperature and radiolysis. With regard to clinical application, this effect is of practical interest in radiopharmacy. The aim of this study was to evaluate whether the positive effect of ethanol can be exploited in automated systems utilizing NaCl-post processing. Methods Gallium-68 was obtained from a 1.85 GBq 68Ge/68Ga-generator. Radiolabelling was performed on an automated 68Ga-labelling cassette module. The standard labelling protocol was used without modifications. 0–40 vol% ethanol were added to the reaction mixture. Quality control was performed using radioHPLC and radioTLC. Results Utilization of additional ethanol on an automated cassette module can be achieved by adding ethanol directly to the buffer solution without further modifications of the standard procedure. Radiolysis was decreased significantly as analysed by radioHPLC. Conclusion It was possible to combine the positive effects of ethanol on radiolabelling efficacy and radiolysis with the standard labelling procedure of an automated cassette module system. The whole process guarantees safe preparation of highly pure 68Ga-peptide for clinical application.

Impact of Digitalization on Service Work in Knowledge-Intensive Business Services: An Empirical Study in Tax Consultancies

2019 ◽  
Vol 3 (4) ◽  
pp. 209-222
Author(s):  
Philipp K. Görs ◽  
Henning Hummert ◽  
Anne Traum ◽  
Friedemann W. Nerdinger
Keyword(s):  
Work Engagement ◽  
Service Work ◽  
Psychological Consequences ◽  
Business Services ◽  
Knowledge Intensive Business Services ◽  
Positive Effects ◽  
Knowledge Intensive ◽  
The Impact ◽  
Positive Effect ◽  
Special Case

Digitalization is a megatrend, but there is relatively little knowledge about its consequences for service work in general and specifically in knowledge-intensive business services (KIBS). We studied the impact of digitalization on psychological consequences for employees in tax consultancies as a special case of KIBS. We compare two tax consulting jobs with very different job demands, those of tax consultants (TCs) and assistant tax consultants (ATCs). The results show that the extent of digitalization at the workplace level for ATCs correlates significantly positively with their job satisfaction. For TCs, the same variable correlates positively with their work engagement. These positive effects of digitalization are mediated in the case of ATCs by the impact on important job characteristics. In the case of TCs, which already have very good working conditions, the impact is mediated by the positive effect on self-efficacy. Theoretical and practical consequences of these results are discussed.

scholarly journals The Structural Relationship among Perceived Service Quality, Perceived Value, and Customer Satisfaction-Focused on Starbucks Reserve Coffee Shops in Shanghai, China

2021 ◽  
Vol 13 (15) ◽  
pp. 8633
Author(s):  
Yuhan Ge ◽  
Qing Yuan ◽  
Yaxi Wang ◽  
Keunsoo Park
Keyword(s):  
Customer Satisfaction ◽  
Service Quality ◽  
Behavioral Intention ◽  
Perceived Value ◽  
Significant Positive Effect ◽  
Coffee Shop ◽  
Perceived Service Quality ◽  
Positive Effects ◽  
Coffee Shops ◽  
Positive Effect

In today’s increasingly competitive coffee industry, the point of running a good coffee shop is no longer to run a coffee and beverage shop simply, but to focus on the quality of service and the value that customers feel as a result. Previous studies have mainly discussed the customer satisfaction and behavioral intention of restaurants, while few studies have explored the influencing factors of customer satisfaction and behavioral intention of chain coffee shops. Given that the perceived service quality theory and DINESERV model can effectively predict customer satisfaction and behavioral intention, this study took 385 consumers in the first Starbucks Reserve flagship store in China as survey objects. SmartPLS 3.0 software was used to explore the relationship among respondents’ perceived service quality, customer perceived value, satisfaction, and behavioral intention. The results show that service quality has a partially significant positive effect on perceived value. Perceived service quality and customers’ perceived value both have significant positive effects on satisfaction. Customers’ satisfaction has a significant positive effect on their behavioral intention. These results indicate that enterprises should strengthen the emotional bond between consumers and enterprises and improve the reliability, assurance, and empathy of perceived service quality to create a better emotional resonance between consumers and the Starbucks brand to improve customer satisfaction. At the same time, it should also promote the symbolic perceived value of Chinese consumers to Starbucks to realize the sustainable development of coffee-shop operation and consumer repurchase. This study expands the research on the service quality, perceived value, and behavioral intention of coffee chain enterprises in the context of non-habitual coffee-drinking countries. Moreover, it provides case support for the operation and research of regional cultural consumption habits of international catering chain enterprises.

scholarly journals The Influence of Dynamic and Adaptive Marketing Capabilities on the Performance of Portuguese SMEs in the B2B International Market

2021 ◽  
Vol 13 (2) ◽  
pp. 579
Author(s):  
Caroline Reimann ◽  
Fernando Carvalho ◽  
Marcelo Duarte
Keyword(s):  
Positive Impact ◽  
International Marketing ◽  
International Market ◽  
Marketing Capabilities ◽  
Moderating Effects ◽  
Competitive Intensity ◽  
Positive Effects ◽  
Marketing Performance ◽  
Market Learning ◽  
Positive Effect

The present investigation aims study the sustainability of the business model of the Portuguese SMEs operating in the B2B International market analyzing the influence of dynamic marketing capabilities and adaptive marketing capabilities in their international marketing performance. It will also analyze the moderating effects of Competitive Intensity within this international scenario. A quantitative study was developed, using a questionnaire as a research method. In total, 335 valid responses were collected from Portuguese SMEs in June 2020. To test the hypotheses, multiple hierarchical regressions were performed. As for the analyzes involving Competitive Intensity environments, namely low and high intensity, dummies were developed to evaluate the different effects produced by the capacities in the International Marketing Performance. This study shows the positive impact of the dynamic marketing capabilities and adaptive marketing capabilities on the international marketing performance of the surveyed companies, essentially from the product development management, supply chain management, vigilant market learning and open marketing. when in a low competitive intensity environment only dynamic marketing capabilities had a positive effect on performance, but in a high, competitive, intensity environment both dynamic marketing capabilities and adaptive marketing capabilities showed positive effects in relation to performance. This study innovates by bringing international marketing, through two marketing capacities, from the perspective of SMEs that perform B2B activities.

scholarly journals Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry

2021 ◽  
Vol 22 (14) ◽  
pp. 7410
Author(s):  
Matteo Mari ◽  
Debora Carrozza ◽  
Erika Ferrari ◽  
Mattia Asti
Keyword(s):  
Nuclear Medicine ◽  
Early Diagnosis ◽  
Clinical Application ◽  
Medicinal Chemistry ◽  
Biological Properties ◽  
Present Review ◽  
Chemical Modifications ◽  
Technetium 99M ◽  
Curcumin Derivatives ◽  
Gallium 68

Curcumin is a natural occurring molecule that has aroused much interest among researchers over the years due to its pleiotropic set of biological properties. In the nuclear medicine field, radiolabelled curcumin and curcumin derivatives have been studied as potential radiotracers for the early diagnosis of Alzheimer’s disease and cancer. In the present review, the synthetic pathways, labelling methods and the preclinical investigations involving these radioactive compounds are treated. The studies entailed chemical modifications for enhancing curcumin stability, as well as its functionalisation for the labelling with several radiohalogens or metal radionuclides (fluorine-18, technetium-99m, gallium-68, etc.). Although some drawbacks have yet to be addressed, and none of the radiolabelled curcuminoids have so far achieved clinical application, the studies performed hitherto provide useful insights and lay the foundation for further developments.

scholarly journals Weaning Holstein Calves at 17 Weeks of Age Enables Smooth Transition from Liquid to Solid Feed

Animals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1132
Author(s):  
Sarah Schwarzkopf ◽  
Asako Kinoshita ◽  
Jeannette Kluess ◽  
Susanne Kersten ◽  
Ulrich Meyer ◽  
...  
Keyword(s):  
Metabolic Stress ◽  
Live Weight ◽  
The Other ◽  
Smooth Transition ◽  
Blood Metabolites ◽  
Positive Effects ◽  
Weaning Age ◽  
Holstein Calves ◽  
Positive Effect ◽  
Over Time

Development of calves depends on prenatal and postnatal conditions. Primiparous cows were still maturing during pregnancy, which can lead to negative intrauterine conditions and affect the calf’s metabolism. It is hypothesized that weaning calves at higher maturity has positive effects due to reduced metabolic stress. We aimed to evaluate effects of mothers’ parity and calves’ weaning age on growth performance and blood metabolites. Fifty-nine female Holstein calves (38.8 ± 5.3 kg birth weight, about 8 days old) were used in a 2 × 2 factorial experiment with factors weaning age (7 vs. 17 weeks) and parity of mother (primiparous vs. multiparous cows). Calves were randomly assigned one of these four groups. Live weight, live weight gain and morphometry increased over time and were greater in calves weaned later. Metabolic indicators except total protein were interactively affected by time and weaning age. Leptin remained low in early-weaned calves born to primiparous cows, while it increased in the other groups. The results suggest that weaning more mature calves has a positive effect on body growth, and calves born to primiparous cows particularly benefit from this weaning regimen. It also enables a smooth transition from liquid to solid feed, which might reduce the associated stress of weaning.

Preparation of Calcium Phosphate Glasses Containing Nb2O5 and TiO2

2018 ◽  
Vol 782 ◽  
pp. 47-52
Author(s):  
Patrícia Suemi Sato ◽  
Hirotaka Maeda ◽  
Akiko Obata ◽  
Toshihiro Kasuga
Keyword(s):  
Controlled Release ◽  
Calcium Phosphate ◽  
Calcium Titanate ◽  
Chemical Durability ◽  
Phosphate Glasses ◽  
Dissolution Test ◽  
Buffer Solution ◽  
High Chemical ◽  
Positive Effects ◽  
Tris Buffer Solution

60CaO-30P2O5-(10 ̶ x)Nb2O5-xTiO2 (x = 0 ~ 10, mol%) glasses were prepared in order to obtain biomaterials with high chemical durability and therapeutic ions releasability. Dissolution test of these glasses using Tris buffer solution showed the controlled release of niobate ions from Nb2O5-containing glasses and the formation of calcium titanate in some of them. These behavior might induce positive effects for bone regeneration.

Brokerage and SME Innovation

2012 ◽  
Vol 26 (5) ◽  
pp. 381-391 ◽  
Author(s):  
Paolo Cattapan ◽  
Mariacarmela Passarelli ◽  
Michele Petrone
Keyword(s):  
Best Practice ◽  
Job Creation ◽  
Science Park ◽  
Revenue Growth ◽  
Positive Effects ◽  
Industry Collaboration ◽  
Product And Process Innovation ◽  
Product And Process ◽  
Positive Effect ◽  
Micro Enterprises

This paper contributes to the literature on innovation brokerage by analysing the effects of brokerage activities on the innovation and growth of small and medium-sized enterprises (SMEs). The authors provide a detailed description of the Technology Transfer Service (TTS), credited as a European best-practice innovation broker, at Area Science Park in Italy. They then carry out an exploratory econometric analysis, the results of which show that the support provided by the TTS enables research–industry collaboration and has positive effects on product and process innovation in SMEs, but it appears not to affect the generation of new patents in SMEs. The results also suggest that the growth in innovation enabled by the support of TTS has a positive effect on the SMEs' revenue growth and job creation. However the innovation broker is more effective in relation to larger firms than it is for micro-enterprises.

Modern aspects of the use of drugs of microbial origin

2021 ◽  
Author(s):  
I. O. Pasichna ◽  
V. I. Vdovychenko
Keyword(s):  
Intestinal Microflora ◽  
Antibacterial Properties ◽  
Low Molecular Weight ◽  
Positive Effects ◽  
Microbial Origin ◽  
Transient Nature ◽  
Immunological Effects ◽  
Positive Effect ◽  
Intestinal Microbiocenosis

The recent scientific researches provide evidence of the important role of microbiota for human health. The microbiome is a very complex system, that exists in an equilibrium state and performs multiple functions. The intestinal microflora is disturbed under the influence of iatrogenic factors, and products of microbial origin are used to correct this. The first group of such drugs include probiotics. Their positive effect is associated with immunological and non‑immunological effects. The results of many studies proved the positive effects of probiotics in clinical practice, however publications of recent years outline their low effectiveness and transient nature of the effect, even with prolonged use. Another group of preparations refers to prebiotics, which selectively stimulate the growth of colon microflora. A combination of probiotics and prebiotics, called synbiotics, also in use. Currently, much attention is paid to metabiotics. This group includes various low molecular weight molecules with various chemical manifestations. The components of metabiotics are cellular elements, metabolites and signaling molecules of probiotic cultures. Metabiotics provide the optimal conditions of homeostasis in the contact zone, which are necessary for the normal interaction of the epithelium and microflora, as well as directly affect the physiological functions and biochemical reactions of the macroorganism. The antibacterial properties of metabiotics allow to fight pathogenic and opportunistic flora, without affecting the beneficial microorganisms of the intestine. Creation of targeted metabiotics is a novel promising direction in this area. The possibility of creating a programmed metabiotic drug is considered, depending on the type of disorders of the intestinal microbiocenosis and the peculiarities of the life of specific pathogenic or opportunistic strains.

scholarly journals The Relationship among Emotional Leadership, Job Satisfaction and Organizational Commitment: Taking China’s Hotel Industry as an Example

2020 ◽  
Vol 218 ◽  
pp. 04014
Author(s):  
Yixing Jin ◽  
Peiying Wu ◽  
Cheng Lin ◽  
Yingda Wang
Keyword(s):  
Job Satisfaction ◽  
Organizational Commitment ◽  
Hotel Industry ◽  
Mediating Role ◽  
Positive Effects ◽  
Emotional Leadership ◽  
The Impact ◽  
The Relationship ◽  
Positive Effect

This study investigated the impact of emotional leadership of leaders on organizational commitment of hotel employees, as well as the mediating role of job satisfaction. The results indicate that: (1) Emotional leadership and job satisfaction have positive effects on organizational commitment. (2) Emotional leadership has a positive effect on job satisfaction. (3) Job satisfaction plays a mediating role between emotional leadership and organizational commitment.

scholarly journals Probiotics for paediatric functional abdominal pain disorders: A rapid review

2019 ◽  
Vol 24 (6) ◽  
pp. 383-394 ◽  
Author(s):  
Fang Chao Linda Ding ◽  
Mohammad Karkhaneh ◽  
Liliane Zorzela ◽  
Hsing Jou ◽  
Sunita Vohra
Keyword(s):  
Abdominal Pain ◽  
Lactobacillus Rhamnosus ◽  
Paediatric Population ◽  
Preliminary Evidence ◽  
Rapid Review ◽  
Functional Abdominal Pain ◽  
Rome Criteria ◽  
Positive Effects ◽  
Irritable Bowel ◽  
Positive Effect

Abstract Background Functional abdominal pain disorders (FAPD) are prevalent in the paediatric population, however, there is currently no consensus regarding best practices for treatment. The use of probiotics is becoming popular to treat FAPD. The goal of this rapid review is to synthesize the best evidence on the use of probiotics in children with FAPD. Methods Searches were conducted on five main databases. Randomized controlled trials (RCTs) of probiotic use in children (0 to 18 years) with FAPD were searched. Populations of interest were patients with functional abdominal pain (FAP), irritable bowel syndrome (IBS), and functional dyspepsia (FD), recruited based on Rome criteria. Outcomes of interest were changes in abdominal pain severity, frequency, and duration. Findings Eleven RCTs with 829 participants with the diagnosis of FAP (n=400), IBS (n=329), FD (n=45), and mixed population (n=55) were included. Of six studies of children with FAP, two (n=103) used Lactobacillus rhamnosus GG (LGG) and reported no significant effects on pain, and four (n=281) used Lactobacillus (L) reuteri DSM 17938, of which three (n=229) reported significant positive effects on either severity or frequency of pain. Of six trials of children with IBS, four (n=219) used LGG, of which three (n=168) reported a positive effect. One (n=48) used bifidobacteria and one used VSL #3 (n=59), both demonstrating positive effects with probiotics. Two studies of FD reported no benefit. No adverse events were attributed to probiotics. Conclusions There is preliminary evidence for use of probiotics, particularly LGG, in reducing abdominal pain in children with IBS. There are inconsistent positive effects of other probiotics, including L. reuteri DSM 17938, in reducing pain in patients with FAP, IBS, or FD. More RCTs with rigorous methodology using single or combination probiotics are warranted.

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