The Genetics of Personality Disorder

1992 ◽  
Vol 160 (1) ◽  
pp. 12-23 ◽  
Author(s):  
Peter McGuffin ◽  
Anita Thapar
Keyword(s):  
Family Environment ◽  
Complex Traits ◽  
Direct Evidence ◽  
Adoption Studies ◽  
Genetic Studies ◽  
Normal Personality ◽  
Psychophysiological Research ◽  
Sources Of Variation ◽  
Positive Effect ◽  
Shed Light

Most measurable aspects of normal personality appear to be at least moderately heritable, with direct evidence coming from family, twin and adoption studies and indirect support deriving from psychophysiological research and breeding experiments on animals. Interestingly, genetic studies also shed light on the environmental sources of variation in personality and suggest that shared family environment rarely, if ever, has any positive effect on similarity between relatives. Despite problems of classification, and variations in the use of terms, a survey of the literature provides reasonably consistent evidence of a genetic contribution to several categories of abnormal personality, which we here divide into three groups, antisocial, anxious/avoidant, and schizoid–schizotypal personalities. However, personality disorders are complex traits that do not show simple mendelian patterns of inheritance and so far molecular genetics has been of no help in understanding their aetiology. Fortunately, techniques are now becoming available that enable the detection and potential localisation of genes of small effect and which may help elucidate the molecular basis even of (probably) polygenic traits such as abnormal personality.

scholarly journals Shared associations identify causal relationships between gene expression and immune cell phenotypes

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Christiane Gasperi ◽  
Sung Chun ◽  
Shamil R. Sunyaev ◽  
Chris Cotsapas
Keyword(s):  
Complex Traits ◽  
Direct Evidence ◽  
Immune Cell ◽  
Genetic Locus ◽  
Causal Variant ◽  
Causal Relationships ◽  
Genetic Studies ◽  
Two Factors ◽  
Gene Regulatory ◽  
Cell Phenotypes

AbstractGenetic mapping studies have identified thousands of associations between common variants and hundreds of human traits. Translating these associations into mechanisms is complicated by two factors: they fall into gene regulatory regions; and they are rarely mapped to one causal variant. One way around these limitations is to find groups of traits that share associations, using this genetic link to infer a biological connection. Here, we assess how many trait associations in the same locus are due to the same genetic variant, and thus shared; and if these shared associations are due to causal relationships between traits. We find that only a subset of traits share associations, with many due to causal relationships rather than pleiotropy. We therefore suggest that simply observing overlapping associations at a genetic locus is insufficient to infer causality; direct evidence of shared associations is required to support mechanistic hypotheses in genetic studies of complex traits.

scholarly journals Shared associations identify causal relationships between gene expression and immune cell phenotypes

2020 ◽  
Author(s):  
Christiane Gasperi ◽  
Sung Chun ◽  
Shamil R. Sunyaev ◽  
Chris Cotsapas
Keyword(s):  
Complex Traits ◽  
Direct Evidence ◽  
Immune Cell ◽  
Genetic Locus ◽  
Causal Variant ◽  
Causal Relationships ◽  
Genetic Studies ◽  
Two Factors ◽  
Gene Regulatory ◽  
Cell Phenotypes

AbstractGenetic mapping studies have identified thousands of associations between common variants and hundreds of human traits. Translating these associations into mechanisms is complicated by two factors: they fall into gene regulatory regions; and they are rarely mapped to one causal variant. One way around these limitations is to find groups of traits that share associations, using this genetic link to infer a biological connection. Here, we assess how many trait associations in the same locus are due to the same genetic variant, and thus shared; and if these shared associations are due to causal relationships between traits. We find that only a subset of traits share associations, with most due to causal relationships rather than pleiotropy. We therefore suggest that simply observing overlapping associations at a genetic locus is insufficient to infer causality; direct evidence of shared associations is required to support mechanistic hypotheses in genetic studies of complex traits.

Bishop Hryhorii Khomyshyn: Family Environment and Early Years of Life

2017 ◽  
Vol 1 (45) ◽  
pp. 25-31
Author(s):  
Oleksandr Rusnak
Keyword(s):  
Family Environment ◽  
Early Years ◽  
The Family ◽  
Positive Effect

In the article is highlighted the influence of family environment on the formation of personality of Hryhorii Khomyshyn. Are systematized and analyzed previous research on the issue. Are disclosed milestones of early biography of future Bishop. Are characterized his first steps in studying. Is marked a positive effect of relatives surroundings. On the base of metric books and family legends is traced genealogy of Beatific. It is noted on the proximity of worldview of H. Khomyshyn and the family of Simovych. Keywords: Hryhorii Khomyshyn, Beatific, martyr, Bishop, family environment, early biography

scholarly journals The limits of normal approximation for adult height

2021 ◽  
Author(s):  
Sergei A. Slavskii ◽  
Ivan A. Kuznetsov ◽  
Tatiana I. Shashkova ◽  
Georgii A. Bazykin ◽  
Tatiana I. Axenovich ◽  
...  
Keyword(s):  
Complex Traits ◽  
Adult Height ◽  
Normal Approximation ◽  
Classical Model ◽  
Model Complexity ◽  
Test Case ◽  
Genetic Studies ◽  
Quantitative Genetic ◽  
Profound Influence ◽  
Log Normal

AbstractAdult height inspired the first biometrical and quantitative genetic studies and is a test-case trait for understanding heritability. The studies of height led to formulation of the classical polygenic model, that has a profound influence on the way we view and analyse complex traits. An essential part of the classical model is an assumption of additivity of effects and normality of the distribution of the residuals. However, it may be expected that the normal approximation will become insufficient in bigger studies. Here, we demonstrate that when the height of hundreds of thousands of individuals is analysed, the model complexity needs to be increased to include non-additive interactions between sex, environment and genes. Alternatively, the use of log-normal approximation allowed us to still use the additive effects model. These findings are important for future genetic and methodologic studies that make use of adult height as an exemplar trait.

scholarly journals The integrative force of political institutions? Direct democracy and voter turnout across ethnic and nativity groups

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Anita Manatschal
Keyword(s):  
Voter Turnout ◽  
Political Institutions ◽  
Direct Democracy ◽  
First Generation ◽  
The Us ◽  
Alternative Measures ◽  
Hispanic Voters ◽  
Democratic Elections ◽  
Positive Effect ◽  
Shed Light

AbstractMuch has been written on the positive effect of direct democracy (initiatives, referendums) on voter turnout. However, we have limited knowledge about potential differential effects on voters belonging to various ethnic groups. The paper argues that depending on a group’s responsiveness to the political context, direct democracy can (dis-)integrate voters (from) into the electorate. Empirical analysis of Current Population Survey (CPS) voting supplement survey data, together with data on the absolute use of direct democracy across US states, corroborates this theoretical expectation, however lending more support for the disintegrating assumption. Frequent direct democratic elections further widen the negative voting gap between first-generation Asian voters and voters living in the US for three generations or longer, whereas they tend to diminish this voting gap for first-generation Hispanic voters. The disintegrative pattern for first-generation Asian voters remains even significant when excluding California from the state sample, yet not the integrative tendency for first-generation Hispanics. Additional analyses using alternative measures of direct democracy and voting, and applying statistical adjustments to address causality concerns, confirm the robustness of these findings, which shed light on the so-far underexplored (dis-)integrative potential of political institutions.

Finding new QTL for yield traits based on a high-density genetic map in the super hybrid rice Nei2You No.6

2019 ◽  
Author(s):  
Miao Zhang ◽  
Zhengping Zhou ◽  
Yuyu Chen ◽  
Yongrun Cao ◽  
Chenwei Deng ◽  
...  
Keyword(s):  
Complex Traits ◽  
Yield Components ◽  
Average Density ◽  
High Density ◽  
Yield Traits ◽  
Target Region ◽  
Effect On Yield ◽  
Positive Effect ◽  
High Density Linkage Map ◽  
1000 Grain Weight

Abstract Background Rice is one of the most important food crops in the world. To determine the genetic basis of yield components in super rice Nei2You No.6, 387 recombinant inbred sister lines (RISLs) were obtained for mapping quantitative trait loci (QTL) responsible for yield-associated traits, such as 1000-grain weight (TGW), grain number per plant (GNP), number of panicles per plant (NP), and grain yield per plant (GYP). Results Using whole genome re-sequencing, a high-density linkage map consisting of 3203 bin markers was constructed with total genetic coverage of 1951.1 cM and an average density of 0.61 cM. As a result of the multi-environment test, 43 yield-related QTL were mapped to all 12 chromosomes, among which 28 inherited from Nei2B showed a positive effect on yield traits. Nine QTL, qTGW-1a, qTGW-5, qTGW-7, qTGW-10b, qTGW-10c, qTGW-12, qNP-7, qGNP-6c, and qGYP-6b, showed stable effects across multiple environments. Five of the nine QTL were co-located with previously reported QTL, and four novel loci, qTGW-7, qTGW-12, qGNP-6c, and qNP-7, were identified in the present study. Subsequently, qNP-7, qTGW-12, and qTGW-7 were validated using corresponding paired lines which differed only in the target region. Conclusions the RISL population is an effective tool for mapping and validating QTL of complex traits, for instance, yield-associated traits, and newly detected QTL provide new genetic resources for research of yield components and molecular breeding in rice.

scholarly journals The Ascidian-Derived Metabolites with Antimicrobial Properties

Antibiotics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 510 ◽  
Author(s):  
Marcello Casertano ◽  
Marialuisa Menna ◽  
Concetta Imperatore
Keyword(s):  
Direct Evidence ◽  
Marine Invertebrates ◽  
Antimicrobial Properties ◽  
Therapeutic Agents ◽  
Symbiotic Association ◽  
Heterogeneous Habitat ◽  
Microbial Infections ◽  
Sulfur Containing ◽  
Shed Light ◽  
Antibacterial Potential

Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feeding organisms is an attractive reservoir of varied and peculiar bioactive compounds. Most secondary metabolites isolated from ascidians stand out for their potential as putative therapeutic agents in the treatment of several illnesses like microbial infections. In this review, we present and discuss the antibacterial activity shown by the main groups of ascidian-derived products, such as sulfur-containing compounds, meroterpenes, alkaloids, peptides, furanones, and their derivatives. Moreover, the direct evidence of a symbiotic association between marine ascidians and microorganisms shed light on the real producers of many extremely potent marine natural compounds. Hence, we also report the antibacterial potential, joined to antifungal and antiviral activity, of metabolites isolated from ascidian-associate microorganisms by culture-dependent methods.

Searching for genes in Schizophrenia

1999 ◽  
Vol 11 (2) ◽  
pp. 50-53 ◽  
Author(s):  
D.B. Wildenauer ◽  
S.G. Schwab ◽  
W. Maier ◽  
B. Lerer
Keyword(s):  
Genetic Variation ◽  
Human Genome Project ◽  
Complex Traits ◽  
Genetic Factors ◽  
Genetic Disorders ◽  
Genome Project ◽  
Turn Of The Century ◽  
Adoption Studies ◽  
Targeted Treatments ◽  
The Human Genome Project

Decades of research into the etiology of schizophrenia on a phenotypic level, i.e. studies of neuroanatomy, neuropathology, neurophysiology and other areas such as immunology have yielded only fragmentary results. A contribution of genetic factors, has been consistently shown, however, beginning with E. Kraepelin's pioneering studies at the turn of the century. Evidence has accumulated from family-, twin-, and adoption studies. Identical twins have a 48% risk of developing schizophrenia if one of them is affected. In contrast, a 17 % risk is reported for nonidentical twins. These rates are similar to other complex genetic disorders such as diabetes, hypertension and asthma. Advances in the genetic analysis of complex traits as well as progress in the Human Genome Project should provide a basis for uncovering the molecular causes of schizophrenic disorders and for investigating the neuropathology of this individually and socially devastating neuropsychiatrie disorder. There is no doubt, that discovery of the genetic variation associated with the illness would help in identifying specific targets for development of more effective, targeted treatments.

scholarly journals The association between the serotonin and dopamine neurotransmitters and personality traits

2016 ◽  
Vol 25 (2) ◽  
pp. 109-112 ◽  
Author(s):  
G. Delvecchio ◽  
M. Bellani ◽  
A. C. Altamura ◽  
P. Brambilla
Keyword(s):  
Personality Traits ◽  
Psychiatric Disorders ◽  
Candidate Genes ◽  
Genetic Polymorphisms ◽  
Complex Traits ◽  
Healthy Subjects ◽  
Mental Illnesses ◽  
Biological Mechanisms ◽  
Normal Personality ◽  
The Impact

Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

scholarly journals PAWE-3D: visualizing power for association with error in case-control genetic studies of complex traits

2005 ◽  
Vol 21 (20) ◽  
pp. 3935-3937 ◽  
Author(s):  
D. Gordon ◽  
C. Haynes ◽  
J. Blumenfeld ◽  
S. J. Finch
Keyword(s):  
Complex Traits ◽  
Case Control ◽  
Genetic Studies
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