Schizophrenia with onset after age 50 years

1999 ◽  
Vol 175 (5) ◽  
pp. 416-421 ◽  
Author(s):  
Perminder Sachdev ◽  
Henry Brodaty ◽  
Noelene Rose ◽  
Stuart Cathcart
Keyword(s):  
Test Performance ◽  
Late Onset ◽  
Neuropsychological Test ◽  
Brain Magnetic Resonance Imaging ◽  
Empirical Support ◽  
Control Group ◽  
Periventricular White Matter ◽  
Drug Induced ◽  
Speed Of Information Processing ◽  
Age Related

BackgroundLate-onset schizophrenia (LOS) may have a basis in age-related coarse brain disease, but empirical support for this is conflicting.AimsIs LOS characterised by more neurological disease than early-onset schizophrenia (EOS)?MethodDSM–III–R–defined LOS subjects (n=27) were compared with 30 EOS and 34 volunteer control subjects on neurological status, neuropsychological test performance and brain magnetic resonance imaging (MRI)ResultsLOS and EOS groups had more ‘soft’ neurological signs and drug-induced movement abnormalities, and performed more poorly on tests assessing speed of information processing, memory and frontal executive functioning. On MRI, the LOS and EOS groups had greater lateral ventricular size than the control group. The LOS subjects also had more signal hyperintensities in periventricular white matter and subcortical nuclei than controls.ConclusionsLOS and EOS subjects were very similar on neuropsychological, neurological and structural neuroimaging parameters, except that there were more MRI periventricular hyperintensities in LOS subjects.

scholarly journals Assessment of in Obsessive Compulsive Disorder

2021 ◽  
pp. 105-114
Author(s):  
Sarah Alaa Mohsen ◽  
Fatma Ahmed El Deeb ◽  
Ehab Sayed Ramadan ◽  
Mai Abd El-Raouf Eissa
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Test Performance ◽  
Age Of Onset ◽  
Neuropsychological Test ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Group I ◽  
Significant Difference

Background: Obsessive compulsive disorder (OCD) is a common and potentially debilitating disorder. Neuropsychological assessment provides unique complementary information that is critical for evaluating higher cortical abilities. This study aimed to assess the neuropsychological functions in OCD patients which can then point to the brain structures or pathways and to study the correlation between these assessments and different clinical variables. Methods: This cross-sectional case control study had included sixty patients who were divided into two groups, Group I: thirty OCD patients diagnosed by DSM-IV and Group II: thirty healthy controls who were recruited from the community, matched with patients’ age, gender, and education. Results: The age of onset in our study was 19.13 ± 0.35 years, the mean duration was 7.44 ± 3.88 years, 40% of the studied cases had severe OCD symptoms and 33.3% of them were compulsive cleaners. There was a high significant difference between the two groups regarding WCST in favor of the control group. There was a high significant difference between the two groups regarding ROCF where the control group showed better results than the OCD patients. Conclusions: Neuropsychological test performance remains an informative and objective means of investigation, especially when applied to psychiatric disorders. The executive functions in OCD patients were impaired in comparison to the normal study subjects.

scholarly journals Effect of Age-Related Hearing Loss on Neuropsychological Test Performance

2020 ◽  
Vol 73 (3) ◽  
pp. 16
Author(s):  
Christina G. Wong ◽  
Lisa J. Rapport ◽  
Brad A. Stach ◽  
Virginia Ramachandran
Keyword(s):  
Hearing Loss ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Age Related ◽  
Age Related Hearing Loss ◽  
Effect Of Age

scholarly journals The Dissociation between Early and Late Selection in Older Adults

2013 ◽  
Vol 25 (12) ◽  
pp. 2189-2206 ◽  
Author(s):  
Brittany R. Alperin ◽  
Anna E. Haring ◽  
Tatyana Y. Zhuravleva ◽  
Phillip J. Holcomb ◽  
Dorene M. Rentz ◽  
...  
Keyword(s):  
Older Adults ◽  
Information Processing ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Early Selection ◽  
Attention Task ◽  
Age Related ◽  
Different Color ◽  
Task Irrelevant ◽  
Late Selection

Older adults exhibit a reduced ability to ignore task-irrelevant stimuli; however, it remains to be determined where along the information processing stream the most salient age-associated changes occur. In the current study, ERPs provided an opportunity to determine whether age-related differences in processing task-irrelevant stimuli were uniform across information processing stages or disproportionately affected either early or late selection. ERPs were measured in young and old adults during a color-selective attention task in which participants responded to target letters in a specified color (attend condition) while ignoring letters in a different color (ignore condition). Old participants were matched to two groups of young participants on the basis of neuropsychological test performance: one using age-appropriate norms and the other using test scores not adjusted for age. There were no age-associated differences in the magnitude of early selection (attend–ignore), as indexed by the size of the anterior selection positivity and posterior selection negativity. During late selection, as indexed by P3b amplitude, both groups of young participants generated neural responses to target letters under the attend versus ignore conditions that were highly differentiated. In striking contrast, old participants generated a P3b to target letters with no reliable differences between conditions. Individuals who were slow to initiate early selection appeared to be less successful at executing late selection. Despite relative preservation of the operations of early selection, processing delays may lead older participants to allocate excessive resources to task-irrelevant stimuli during late selection.

scholarly journals Predictors of Neuropsychological Improvement Following Cognitive Rehabilitation in Patients with Gliomas

2010 ◽  
Vol 17 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Karin Gehring ◽  
Neil K. Aaronson ◽  
Chad M. Gundy ◽  
Martin J.B. Taphoorn ◽  
Margriet M. Sitskoorn
Keyword(s):  
Test Performance ◽  
Cognitive Rehabilitation ◽  
Practical Implication ◽  
Neuropsychological Test ◽  
Patient Characteristics ◽  
Rehabilitation Program ◽  
Control Group ◽  
Specific Patient ◽  
Individual Level ◽  
The Individual

AbstractThis study investigated the specific patient factors that predict responsiveness to a cognitive rehabilitation program. The program has previously been demonstrated to be successful at the group level in patients with gliomas, but it is unclear which patient characteristics optimized the effect of the intervention at the individual level. Four categories of possible predictors of improvement were selected for evaluation: sociodemographic and clinical variables, self-reported cognitive symptoms, and objective neuropsychological test performance. Hierarchical logistic regression analyses were conducted, beginning with the most accessible (sociodemographic) variables and ending with the most difficult (baseline neuropsychological) to identify in clinical practice. Nearly 60% of the participants of the intervention were classified as reliably improved. Reliable improvement was predicted by age (p = .003) and education (p = .011). Additional results suggested that younger patients were more likely to benefit specifically from the cognitive rehabilitation program (p = .001), and that higher education was also associated with improvement in the control group (p = .024). The findings are discussed in light of brain reserve theory. A practical implication is that cognitive rehabilitation programs should take the patients’ age into account and, if possible, adapt programs to increase the likelihood of improvement among older participants. (JINS, 2011, 17, 256–266)

scholarly journals Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative data from the Dutch 100-plus Study

2018 ◽  
Author(s):  
Nina Beker ◽  
Sietske A.M. Sikkes ◽  
Marc Hulsman ◽  
Ben Schmand ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Test Performance ◽  
Normative Data ◽  
Neuropsychological Test ◽  
Cognitive Testing ◽  
Hearing Impairments ◽  
Age Related ◽  
Dementia Incidence ◽  
Sensory Impairments ◽  
Linear Regressions

ABSTRACTBackgroundThe population who reaches the extreme age of 100 years is growing. At this age, dementia incidence is high and cognitive functioning is variable and influenced by sensory impairments. Appropriate cognitive testing requires normative data generated specifically for this group. Currently, these are lacking. We set out to generate norms for neuropsychological tests in cognitively healthy centenarians while taking sensory impairments into account.MethodsWe included 235 centenarians (71.5% female) from the 100-plus Study, who self-reported to be cognitively healthy, which was confirmed by an informant and a trained researcher. Normative data were generated for 15 tests that evaluate global cognition, pre-morbid intelligence, attention, language, memory, executive and visuo-spatial functions by multiple linear regressions and/or percentiles. Centenarians with vision and/or hearing impairments were excluded for tests that required these faculties.ResultsSubjects scored on average 25.6±3.1 (range 17-30, interquartile-range 24-28) points on the MMSE. Vision problems and fatigue often complicated the ability to complete tests, and these problems explained 41% and 22% of the missing test scores respectively, whereas hearing problems (4%) and task incomprehension (6%) only rarely did. Sex and age showed a limited association with test performance, whereas educational level was associated with performance on the majority of the tests.ConclusionsNormative data for the centenarian population is provided, while taking age-related sensory impairments into consideration. Results indicate that, next to vision impairments, fatigue and education level should be taken into account when assessing cognitive functioning in centenarians.

Recovery from mild concussion in high school athletes

2003 ◽  
Vol 98 (2) ◽  
pp. 296-301 ◽  
Author(s):  
Mark R. Lovell ◽  
Michael W. Collins ◽  
Grant L. Iverson ◽  
Melvin Field ◽  
Joseph C. Maroon ◽  
...  
Keyword(s):  
High School ◽  
Mental Status ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Return To Play ◽  
Control Group ◽  
High School Athletes ◽  
Post Injury ◽  
Content Type ◽  
Fine Print

Object. A computerized neuropsychological test battery was conducted to evaluate memory dysfunction and self-reporting of symptoms in a group of high school athletes who had suffered concussion. Methods. Neuropsychological performance prior to and following concussion was compared with the test performance of an age-matched control group. Potentially important diagnostic markers of concussion severity are discussed and linked to recovery within the 1st week of injury. Conclusions. High school athletes who had suffered mild concussion demonstrated significant declines in memory processes relative to a noninjured control group. Statistically significant differences between preseason and postinjury memory test results were still evident in the concussion group at 4 and 7 days postinjury. Self-reported neurological symptoms such as headache, dizziness, and nausea resolved by Day 4. Duration of on-field mental status changes such as retrograde amnesia and posttraumatic confusion was related to the presence of memory impairment at 36 hours and 4 and 7 days post-injury and was also related to slower resolution of self-reported symptoms. The results of this study suggest that caution should be exercised in returning high school athletes to the playing field following concussion. On-field mental status changes appear to have prognostic utility and should be taken into account when making return-to-play decisions following concussion. Athletes who exhibit on-field mental status changes for more than 5 minutes have longer-lasting postconcussion symptoms and memory decline.

Everyday memory: Self-perception and structural brain correlates in a healthy elderly population

2010 ◽  
Vol 16 (6) ◽  
pp. 1115-1126 ◽  
Author(s):  
ASTRID BJØRNEBEKK ◽  
LARS T. WESTLYE ◽  
KRISTINE B. WALHOVD ◽  
ANDERS M. FJELL
Keyword(s):  
Verbal Memory ◽  
Test Performance ◽  
Medial Temporal Lobe ◽  
Standardized Test ◽  
Daily Life ◽  
Neuropsychological Test ◽  
Brain Morphology ◽  
Everyday Memory ◽  
Healthy Elderly ◽  
Age Related

AbstractMapping the cerebral structural correlates of age-related cognitive decline is a growing area of research. The aim of the present study was to investigate the relationship between healthy elderly’s perceived memory functioning in daily life, neuropsychological test performance on a standardized test on verbal memory, and cortical thickness and subcortical volumes in brain regions implicated in memory networks, including the medial temporal lobe (MTL). Eighty-three healthy and cognitively well-functioning volunteers aged 60–85 years underwent MRI scans, Everyday Memory Questionnaire (EMQ), and neuropsychological assessment. Both self-perceived memory in daily life related to attention and executive functions and an objective measure of verbal recall (CVLT) were, independently, associated with thickness of the left MTL. The two cognitive variables were uncorrelated, and including both measures in the model nearly doubled the amount of explained variance on MTL thickness. This suggests that measures of perceived everyday memory might substantially inform and supplement studies investigating the relationships between neuropsychological test performance and brain morphology. The results are consistent with a bigger-is-better relationship in the MTL and suggest that EMQ and neuropsychological test performance have detectable and comparable structural correlates in a region critically involved in memory functions in the well-functioning elderly. (JINS, 2010, 16, 1115–1126.)

scholarly journals Differential Involvement of the Locus Coeruleus in Early- and Late-Onset Alzheimer’s Disease: A Potential Mechanism of Clinical Differences?

2021 ◽  
pp. 089198872110447
Author(s):  
Corey J. Bolton ◽  
Joyce W. Tam
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Locus Coeruleus ◽  
Test Performance ◽  
Late Onset ◽  
Neuropsychological Test ◽  
Attentional Functioning ◽  
Early Onset Alzheimer’S Disease ◽  
Differential Involvement ◽  
Performance Results

Sporadic early-onset Alzheimer’s disease (sEOAD) is often associated with atypical clinical features, yet the cause of this heterogeneity remains unclear. This study investigated post-mortem atrophy of the locus coeruleus (LC) in sEOAD and late-onset Alzheimer’s disease (LOAD). Levels of LC atrophy, as estimated by pathologist-rating of hypopigmentation, were compared between sEOAD (n = 115) and LOAD (n = 672) participants while controlling for other measures of pathological progression. Subsequent analyses compared low vs. high LC atrophy sEOAD subgroups on neuropsychological test performance. Results show nearly 4 times greater likelihood of higher LC atrophy in sEOAD as compared to LOAD ( p < .005). sEOAD participants with greater LC atrophy displayed significantly worse performance on various baseline measures of attentional functioning ( p < .05), despite similar global cognition ( p = .25). These findings suggest the LC is an important potential driver of clinical and pathological heterogeneity in sEOAD.

The Effects of Music-Contingent Gait Training on Cognition and Mood in Parkinson Disease: A Feasibility Study

2019 ◽  
Vol 34 (1) ◽  
pp. 82-92 ◽  
Author(s):  
Jacqueline Burt ◽  
Einat (Natalie) Ravid ◽  
Sandra Bradford ◽  
Nancy J. Fisher ◽  
Yiye Zeng ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Test Performance ◽  
Neuropsychological Test ◽  
Training Group ◽  
Gait Training ◽  
Individual Performance ◽  
Biofeedback Training ◽  
Control Group ◽  
Nonmotor Symptoms ◽  
Step Size

Background. In Parkinson disease (PD), gait impairments often coexist with nonmotor symptoms such as anxiety and depression. Biofeedback training may improve gait function in PD, but its effect on nonmotor symptoms remains unclear. This study explored the cognitive and global effects of Ambulosono, a cognitive gait training method utilizing step size to contingently control the real-time play of motivational music. Objective. This study examined the feasibility of music-contingent gait training and its effects on neuropsychological test performance and mood in persons with PD. Methods. A total of 30 participants with mild to moderate PD were semirandomized via sequential alternating assignment into an experimental training group or control music group. The training group received 12 weeks of music-contingent training, whereby music play was dependent on the user achieving a set stride length, adjusted online based on individual performance. The control group received hybrid training beginning with 6 weeks of noncontingent music walking, whereby music played continuously regardless of step size, followed by 6 weeks of music-contingent training. Global cognition, memory, executive function, attention, and working memory assessments were completed by blinded assessors at baseline, 6 weeks, and 12 weeks. Motor function, mood, and anxiety were assessed. Results. Average training adherence was 97%, with no falls occurring during training sessions. Improvements on cognitive measures were not clinically significant; however, significant decreases in depression and anxiety were observed in both groups over time ( P < .05). Conclusions. Music-contingent gait training is feasible and safe in individuals with PD. Further investigation into potential therapeutic applications of this technology is recommended.

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