Significance of Inter aorto-caval lymph nodes in gall bladder cancer management.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16607-e16607
Author(s):  
Kishore Singh ◽  
Anurita Srivastava ◽  
Siddharth Srivastava ◽  
Aditi Aggarwal ◽  
Varshu Goel ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Radical Surgery ◽  
Radical Resection ◽  
Large Sample Size ◽  
North East India ◽  
Presenting Symptoms ◽  
Cancer Management ◽  
North East ◽  
Kaplan Meier ◽  
Significant Difference

e16607 Background: Gallbladder cancer (GBC) is one of the three leading cancer among women of North and North-east India. The age standardized rate (ASR) for GBC in women of North and north-east India are 11.8/100,000 population and 17.1/100,000 population respectively It is one of the most fatal cancer, characterized by early spread, both local as well as distant. Radical resection is associated with the highest control rates. Presence of inter-aorto-caval lymph nodes (IAC) during preoperative workup is designated as metastatic disease in GBC and radical surgery is deferred. This study attempts to confirm the validity of such an approach. Methods: Between January 2017 and December 2018, 178 patients of GBC were registered at our hospital. Of these, 108 patients with radiologically resectable disease were evaluated preoperatively with endoscopic ultrasound (EUS) to look for IAC lymph nodes lying below the level of the renal vein. Patients with IAC involvement were taken up for chemotherapy while the others underwent upfront surgery. Results: Mean age at presentation was 51.1 (±10.9) years with a female predominance (N = 77, 71.2%). Presenting symptoms were either pain (N = 91, 84.2%) or jaundice (N = 42, 38.8%) in majority cases. Patients with jaundice presented earlier with mean of 53.27 days (Range2-240 days) while those with pain presented at a mean of 71.5 days (1-360 days) prior to diagnosis. Pathologically positive IAC cases (n = 12) of resectable GBC received systemic therapy upfront rather than immediate radical surgery. Rest of the patients underwent surgical resection followed by adjuvant treatment as indicated. Mean follow up was 179 days with a mortality of 62%(n = 67). No significant difference was seen in the stage distribution in IAC positive versus negative group. Median survival with Kaplan Meier method of IAC positive patients was 239 days versus 190 days in IAC negative patients. Conclusions: IAC lymph node may not necessarily portend poor prognosis. It needs to be validated in large sample size.

scholarly journals The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis

2020 ◽  
Author(s):  
Kai Zhou ◽  
Anqiang Wang ◽  
Sheng Ao ◽  
Jiahui Chen ◽  
Ke Ji ◽  
...  
Keyword(s):  
Propensity Score ◽  
Cox Regression ◽  
Radical Surgery ◽  
Survival Rates ◽  
Cancer Type ◽  
Radical Gastrectomy ◽  
Hepatoid Adenocarcinoma ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Propensity Matching

Abstract Background : To investigate whether there is a distinct difference in prognosis between hepatoid adenocarcinoma of the stomach ( HAS) and non-hepatoid adenocarcinoma of the stomach (non-HAS) and whether HAS can benefit from radical surgery. Methods : We retrospectively reviewed 722 patients with non-HAS and 75 patients with HAS who underwent radical gastrectomy between 3 November 2009 and 17 December 2018. Propensity score matching (PSM) analysis was used to eliminate the bias among the patients in our study. The relationships between gastric cancer type and overall survival (OS) were evaluated by the Kaplan-Meier method and Cox regression. Results : Our data demonstrate that there was no statistically significant difference in the OS between HAS and non-HAS {K-M, P=log rank (Mantel-Cox), (before PSM P=0.397); (1:1 PSM P=0.345); (1:2 PSM P=0.195)}. Moreover, there were no significant differences in the 1-, 2-, or 3-year survival rates between patients with non-HAS and patients with HAS (before propensity matching, after 1:1 propensity matching, and after 1:2 propensity matching). Conclusion : HAS was generally considered to be an aggressive gastric neoplasm, but its prognosis may not be as unsatisfactory as previously believed.

scholarly journals Skin color variation: A study on Eastern and North East India

2019 ◽  
Vol 10 (3) ◽  
pp. 13-16
Author(s):  
Sumit Maitra ◽  
Diptendu Chatterjee ◽  
Arup Ratan Bandyopadhyay
Keyword(s):  
Ethnic Groups ◽  
Skin Color ◽  
Skin Pigmentation ◽  
Color Space ◽  
Color Variation ◽  
Phenotypic Traits ◽  
North East India ◽  
North East ◽  
Wide Range ◽  
Significant Difference

Background: Skin pigmentation is one of the most variable phenotypic traits and most noticeable of human polymorphisms. Skin pigmentation in humans is largely determined by the quantity and distribution of the pigment melanin. The literature review on skin color variation revealed a few works on skin pigmentation variation has been conducted in India from Southern, Western and Northern part. Aims and Objectives: To best of the knowledge, the present discourse is the first attempt to understand skin color variation from Eastern and North Eastern part of India among three populations. Materials and Methods: The present study consisted of 312 participants from Chakma and Tripuri groups of Tripura, North East India, and participants from Bengalee Hindu caste population from West Bengal. Skin color was measured by Konica Minolta CR-10 spectrophotometer which measures and quantifies the colors with a 3D color space (CIELAB) color space created by 3 axes. All the skin color measurements from each participant were taken from unexposed (underarm) left and right to get a mean and exposed (forehead) to sunlight. Results: The distribution of skin color variation among the three populations demonstrated significant (p<0.05) difference in lightness for unexposed and exposed indicating lightness in unexposed area. Furthermore, the present study revealed significant difference (p<0.05) in skin color among the ethnic groups across the body location and all three attributes (lightness, redness and yellowness). Conclusion: Generally, skin color variation may be elucidated by two main factors: individual differences in lightness and yellowness and by and large due to ethnicity, where diversity in redness is due to primarily due to different body locations. Variation in lightness have more characteristic probability. The present study first time reports the wide range of quantitative skin color variation among the three ethnic groups from Eastern and North East India and highest yellowness (b*) among the population from North East India.

A randomized trial of chemoradiotherapy versus surgery alone in patients with resectable esophageal cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 4530-4530 ◽  
Author(s):  
H. Carstens ◽  
M. Albertsson ◽  
S. Friesland ◽  
G. Adell ◽  
G. Frykholm ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Oesophageal Cancer ◽  
Primary Tumour ◽  
Radical Resection ◽  
Phase Iii ◽  
Surgery Group ◽  
Significant Difference ◽  
Resectable Esophageal ◽  
Resectable Esophageal Cancer

4530 Background: The aim of this study was to compare survival in a randomized phase III trial of chemoradiotherapy (CHRT) versus surgery alone for localized resectable oesophageal cancer. Methods: Between 2000 and 2004, 91 patients with oesophageal cancer were enrolled in a Scandinavian multicenter study. Patients with resectable oesophageal squamous cell carcinoma (50%) or adenocarcinoma (50%) were randomized to chemoradiotherapy (CHRT) or surgery alone. Chemotherapy (CHT) was given in 3 cycles with cisplatin 100 mg/m2, day 1 and 5-fluorouracil 750 mg/m2/24 hours, infusion day 1–5, every three weeks. After one induction chemotherapy course, radiotherapy including the primary tumour and defined locoregional lymph nodes, was given concomitant with the following CHT cycles, to a total dose of 64 Gy, in 32 fractions. Surgery was performed according to Ivor Lewis and lymph nodes resected with standard two-field technique. Results: At a median follow-up of 51.8 month’s 65 deaths are noted. In the chemoradiation group 50% of the patients accomplished therapy according to protocol, 40% were treated with modifications of the protocol and radical resection was performed 76% of the patients. Median survival was 12.8 months for chemoradiation and 15.8 months for the surgery group. There was no significant difference in 1-year survival 56% and 55% for CHRT and surgery, respectively. By two years, survival curves diverge and 2-years survival was 37% (CI 95%: 23–51%) for the CHRT group and 25% (CI 95%: 12–39%) for the surgery group. At four years, survival was 29% for CHRT versus 23% for surgery (CI 95% CHRT: 16–43%, CI 95% Surgery: 10–36%). Both treatments were well tolerated and no treatment related deaths were recorded in any of the treatment arms. Most deaths were due to tumor disease (66%) in both groups. Conclusions: No statistically significant differences between the treatment arms were seen and survival results are equal to earlier reported. Both treatment arms were well tolerated. No significant financial relationships to disclose.

scholarly journals Comparative analysis of safety and effect of minimally invasive esophageal cancer radical resection and conventional thoracotomy for esophageal cancer

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Ke Du ◽  
Zhenxing Wang
Keyword(s):  
Esophageal Cancer ◽  
Blood Loss ◽  
Minimally Invasive ◽  
Lymph Nodes ◽  
Radical Surgery ◽  
Radical Resection ◽  
Control Group ◽  
Clinical Effects ◽  
Intraoperative Blood Loss ◽  
Experimental Group

【Abstract】Objective: To compare the clinical effects of minimally invasive esophageal cancer radical resection and traditional esophageal cancer radical resection.Methods: 200 cases of esophageal cancer radical resection were performed from July 2014 to July 2017 in our hospital.The cases were divided into experimental group and control group, 82 cases in the experimental group and 118 cases in the control group.The experimental group was treated with minimally invasive esophageal cancer radical surgery, and the control group was treated with conventional thoracotomy.Record the comparison between the two groups (1) surgical conditions, including the time of surgery, intraoperative blood loss, hospitalization time; (2) the number of lymph nodes cleaned; (3) the postoperative control group used conventional thoracotomy, including lung lesions, anastomotic fistula / narrow.RESULTS: The parameters of operation time, intraoperative blood loss, hospitalization time, and number of lymph nodes cleaned in the experimental group were lower than those in the control group, and the difference was statistically significant (p<0.05). In addition to pulmonary infection (p<0.05), There was no significant difference in the incidence of other complications between the experimental group and the control group (p>0.05).Conclusion: Minimally invasive esophageal cancer radical resection and conventional thoracotomy have good clinical effects in the treatment of esophageal cancer. Minimally invasive esophageal cancer radical surgery can effectively reduce intraoperative trauma and postoperative reaction, which is worthy of popularization and application.

scholarly journals Variation in spike initiation in some Piper longum germplasms of North East India

2019 ◽  
Vol 11 (3) ◽  
pp. 684-686
Author(s):  
Amrita Khound ◽  
D. Sharmah ◽  
P.C. Barua
Keyword(s):  
Significant Contribution ◽  
Adverse Reactions ◽  
Herbal Medicines ◽  
Herbal Remedies ◽  
Piper Longum ◽  
North East India ◽  
North East ◽  
Significant Difference ◽  
Check Variety ◽  
Spike Initiation

The risk of adverse reactions in herbal remedies is less and has become popular to be used traditionally for treating various diseases. The species associated with genus Piper are important medicinal plants used for preparation of herbal medicines. The present investigation was carried out in the Experimental farm, Department of Horticulture, Assam Agricultural University, Jorhat-13 during 2013-14 and 2014-15 to investigate the flowering variation of some Piper longum germplasms of North East  India. A total of 16 Piper longum germplasms including ‘Viswam’ as check variety were evaluated and experimental data revealed significant difference in spike initiation time among the germplasms with shortest spike initiation period (245.30 days) that recorded in germplasm PLJ-19 while the check var. recorded 287.40 days. Significant and shortest period for spike initiation to maturity was recorded in germplasm PLJ-19 (61.04days) followed by PLJ-01 (61.00days), PLJ-11 (61.38days) and check var. (70.03days).The number of flowering spike per plant ranges in between 58.53-113.73. The highest number of flowering spike per plant 113.73 was observed in germplasm PLJ-19 followed by PLJ-01 (109.40), PLJ-11 (104.11), PLJ-16 (100.33) and were found to be superior over check var.  (92.07). The present findings has a significant contribution in determination and identification of germplasm having shorter spike formation period with higher number of flowering spike as the variation in piperine content depends on both the characters also.

scholarly journals Chemical compositions of the essential oils of inflorescence and vegetative aerial parts of Elsholtzia blanda (Benth.) Benth. (Lamiales: Lamiaceae) from Meghalaya, North-East India

2017 ◽  
Vol 4 (7) ◽  
pp. 19-23
Author(s):  
Rumi Kotoky ◽  
Siddhartha Pratim Saikia ◽  
Bithika Chaliha ◽  
Subhan Chandra Nath
Keyword(s):  
Compositional Analysis ◽  
Chemical Compositions ◽  
North East India ◽  
Plant Parts ◽  
North East ◽  
Aerial Parts ◽  
Significant Difference ◽  
Linalool Oxide ◽  
First Time ◽  
Inflorescence Part

The compositional analysis of essential oil content in inflorescence and vegetative aerial parts of Elsholtzia blanda Benth. (Lamiales: Lamiaceae) growing wild in Meghalaya,North-East India were studied by GC and GC-MS. A total of 30 and 17 components representing 96.9%-98.3% and 92.6%-92.8% of the total oils from the inflorescence and vegetative aerial parts, respectively, were identified. Significant difference in composition of oils were observed between the two plant parts; 15 components detected in the oil of inflorescence were lacking in the oil of vegetative aerial parts, while two components present in the oil of vegetative aerial parts were absent in the inflorescence oil. Linalool was the major component in oils of both inflorescence (77.3%-80.2%) and vegetative aerial parts (57.9%-62.9%). Trans- linalool oxide (8.4%-9.9%), cis-linalool oxide (8.3%-9.3%) and 3,7-dimethyl-1,5-octadiene-3,7-diol (4.7%-5.1%) were however found in higher amount in the oil of vegetative aerial parts compared to inflorescence. For the first time the composition of oil in the inflorescence part has been reported in this communication while the oil from vegetative aerial parts containing linalool as the major component (44.9%) was although reported earlier but comparatively higher percentage of same was observed in vegetative aerial part (57.9%-62.9%) and inflorescence (77.3%-80.2%) in the present investigation with the plants from Meghalaya, India.

scholarly journals A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old

2021 ◽  
Vol 11 ◽  
Author(s):  
Qian Huang ◽  
Xiufeng Zheng ◽  
Yang Jiao ◽  
Yanna Lei ◽  
Xiaoying Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Late Onset ◽  
Radical Resection ◽  
Palliative Surgery ◽  
Clinicopathological Feature ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Differentiation Degree ◽  
Gastric Cancer Patients

PurposeThe aim of this retrospective study was to probe into clinicopathological features and prognosis of early-onset gastric cancer (EOGC) patients aged ≤ 45 years old.MethodsThis study selected 154 young gastric cancer patients aged ≤ 45 years old and 158 elderly gastric cancer patients aged &gt; 50 years old admitted to West China Hospital of Sichuan University in 2009-2019 as the research object. These patients were further divided into two groups according to whether tumor can be resected radically. The following parameters were analyzed: age, gender, helicobacter pylori (HP) infection status, Her-2 status, pathological type and stage, chemotherapy, tumor differentiation degree, overall survival (OS).ResultsMore than 3,000 patients with gastric carcinoma were screened, and 154 young gastric cancer patients aged ≤ 45 years old were identified as EOGC. Among them, the number of female patients in EOGC group was significantly higher than that of males, accounting for 63.6%. In addition, EOGC were associated with diffuse Laur´en type and poorly differentiated tumors. Interestingly, the Kaplan–Meier method showed that the OS of unresectable EOGC group was significantly lower than that of unresectable LOGC group (P = 0.0005) and chemotherapy containing paclitaxel tended to be more effective in the young people (P = 0.0511). Nevertheless, there was no significant difference in OS between young and elderly patients with gastric cancer in the radical resection group (P = 0.3881).ConclusionEOGC patients have a worse prognosis than late-onset gastric cancer (LOGC) patients with advanced unresectable gastric cancer. Palliative surgery or chemotherapy containing paclitaxel may improve the OS of unresectable young individuals with gastric cancer. Additional randomized controlled trials are required for guiding clinical practice.

Craniofacial anthropometry in newborns of Sikkimese origin

2014 ◽  
Vol 128 (6) ◽  
pp. 527-530 ◽  
Author(s):  
P Sinha ◽  
B K Tamang ◽  
S Chakraborty
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Racial Groups ◽  
Care Hospital ◽  
Anthropometric Parameters ◽  
North East India ◽  
North East ◽  
Significant Difference ◽  
Hereditary Factors ◽  
Term Newborns

AbstractBackground:Head and face dimensions vary according to race and geographical zone. Hereditary factors also greatly affect the size and shape of the head. There are important medical applications of craniofacial data specific to different racial and ethnic groups.Methods:Various cranial and facial anthropometric parameters were assessed in singleton, healthy, full-term newborns of Sikkimese origin in a tertiary care hospital in Sikkim, India. The data were then analysed to determine statistically significant differences between sexes.Results:Forty-five newborns were included in the study. Both male and female newborns were observed to be hyperbrachycephalic and hyperleptoprosopic. The only significant difference between the sexes was in commissural length, which was observed to be greater in male newborns.Conclusion:Craniofacial parameters in Sikkimese newborns vary in comparison with those of other newborns from around the world. Larger studies are needed in order to reveal sex-related variations. Similar studies on various racial groups in North-East India are needed to establish standards for populations with East Asian features.

scholarly journals The Role of Hyponatraemia Before Surgery in Patients With Radical Resected Pancreatic Cancer

2020 ◽  
Vol 14 ◽  
pp. 117955492093660
Author(s):  
Rossana Berardi ◽  
Silvia Rinaldi ◽  
Giulio Belfiori ◽  
Stefano Partelli ◽  
Stefano Crippa ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Cox Regression ◽  
Radical Surgery ◽  
Ductal Adenocarcinoma ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Kaplan Meier ◽  
Negative Prognostic Factor ◽  
Significant Difference

Objectives: Hyponatraemia represents a negative prognostic factor in patients with cancer. The aim of this study was to assess, for the first time, the role of hyponatraemia in patients undergoing radical surgery for pancreatic ductal adenocarcinoma. Methods: A total of 89 patients with stage I-III pancreatic ductal adenocarcinoma underwent radical surgery between November 2012 and October 2014. Relapse-free survival (RFS) and disease-specific survival (DSS) were estimated using Kaplan-Meier method. A Cox regression model was carried out for univariate and multivariate analyses. Fisher exact test was used to estimate correlation between variables. Results: In total, 12 patients (14%) presented with hyponatraemia at diagnosis. The median DSS was 20 months in patients with hyponatraemia and not reached in patients with eunatraemia ( P < .1073), while a statistical significant difference was observed in terms of median RFS (10 months vs 17 months, respectively; P = .0233). Considering clinical features (hyponatraemia, smoke and alcoholic habit, diabetes, pain, and jaundice), patients with 4 or more of these factors had a worse prognosis (mDSS: 30 months vs not reached; hazard ratio [HR]: 0.40, 95% confidence interval [CI] = 0.16-0.80; P = .0120). Conclusions: The presence of hyponatraemia and its prompt correction at the diagnosis time should be considered for the correct management of patients with pancreatic carcinoma.

scholarly journals Surgical Outcomes of Vaginal or Cervical Melanoma

2022 ◽  
Vol 8 ◽  
Author(s):  
Hui Tian ◽  
Xuan Wang ◽  
Bin Lian ◽  
Lu Si ◽  
Min Gao ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Proportional Hazards ◽  
Cox Regression ◽  
Radical Resection ◽  
Cox Proportional Hazards ◽  
Cox Regression Analysis ◽  
Resection Group ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Peking University

Objective: To evaluate the effectiveness of radical resection compared with non-radical resection for vaginal or cervical melanoma.Methods: We retrospectively analysed the clinical data of post-operative patients with primary lower genital tract melanoma hospitalised at Peking University Cancer Hospital between Jan 2014 and Dec 2020. The study endpoints were recurrence-free survival (RFS) and overall survival (OS). Kaplan–Meier method-plotted survival curves and univariate and multivariate Cox proportional hazards regression models were used to identify the factors associated with RFS and OS, and to calculate hazard ratios (HRs) and associated 95% confidence intervals (95% CIs).Results: A total of 80 patients were included. Thirty-one patients had received non-radical resection, and 49 patients had received radical resection. The median patient age was 55.5 (IQR 45.3–60.0) years. Sixty-two (77.5%) patients had vaginal melanoma. Sixty-four patients (80.0%) had received post-operative adjuvant therapy. The median follow-up time was 36.0 months (95% CI 10.1–62.1 months). Sixty-four patients developed recurrence, and 44 patients died. The median RFS (mRFS) was 6.0 months (95% CI 3.4–8.6 m), and the RFS for the radical resection group was longer than that for the non-radical resection group (9.5 vs. 5.3 m), with no significant difference (P &gt; 0.05). The median OS (mOS) was 25.9 months (95% CI 14.4–37.4 m). The mOS was 24.6 months (95% CI 10.3–38.9 m) and 25.9 months (95% CI 10.9–40.9 m) in the non-radical resection group and the radical resection group, respectively. Multivariate Cox regression analysis showed that surgical approach, infiltration depth of the tumour, lymph node metastasis, and post-operative adjuvant therapy were independent risk factors for RFS and that post-operative adjuvant therapy was an independent risk factor for OS.Conclusion: By performing multivariate analysis, which corrected for potential confounding factors, we identified surgical procedures that were associated with RFS, and we found that RFS and OS in patients with vaginal melanoma and cervical melanoma benefitted from post-operative adjuvant therapy.

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