Clinical implication of using up both fluoropyrimidine (FU) and paclitaxel (PTX) in patients with severe peritoneal metastases (SPM) of gastric cancer (GC).

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 221-221
Author(s):  
Hiroyuki Arai ◽  
Eisuke Inoue ◽  
Kensei Yamaguchi ◽  
Narikazu Boku ◽  
Hiroki Hara ◽  
...  
Keyword(s):  
Clinical Implication ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Best Supportive Care ◽  
Combination Strategy ◽  
Factors Affecting ◽  
The Difference ◽  
Post Hoc ◽  
The Impact ◽  
Selection Of

221 Background: JCOG1108/WJOG7312G trial showed favorable but not significantly better outcomes of 5-FU/ l-leucovorin ( l-LV) /PTX combination (FLTAX) compared to 5-FU/ l-LV (FL) in untreated patients with SPM of GC. However, a half of patients treated with FL could not sequentially use PTX which is a key drug for peritoneal metastasis. We conducted a post hoc analysis to investigate the clinical implication of using up both FU and PTX in either combination or sequential strategy for GC patients with SPM. Methods: Among 101 patients enrolled in the trial (FL: N = 51; FLTAX: N = 50), overall survival (OS) was compared between three subgroups: patients treated with FL followed by PTX (FL/PTX: N = 25), those treated with FL followed by best supportive care (BSC) (FL/BSC: N = 21), and those treated with FLTAX (per protocol population, N = 48). To identify the factors affecting the likelihood of using sequential PTX (LUSP), we compared baseline characteristics between the FL/PTX and FL/BSC subgroups. Each baseline covariate was tested for the impact on LUSP by logistic regression model. The difference of treatment efficacy between FL and FLTAX was assessed in subgroups stratified by the factors identified to affect LUSP. Results: Patients in the FL/PTX subgroup showed significantly better OS than those in the FL/BSC subgroup (median OS, 7.8 vs 2.0 months; hazard ratio [HR] 0.24, 95% confidence interval [CI] 0.12-0.48, p < 0.01) and equivalent OS compared to those in the FLTAX subgroup (median OS, 7.8 vs 8.0 months; HR 0.83, 95% CI 0.50-1.39, p = 0.49). Compared with patients in the FL/BSC subgroup, those in the FL/PTX subgroup had a trend for lower frequency of Glasgow prognostic score (GPS) 2 (40.0% vs 66.7%, p = 0.17) and unresectable type (76.0% vs 95.2%, p = 0.07). GPS 2 and unresectable type were identified as factors with a worse impact on LUSP compared to GPS 0 and recurrent type, with odds ratio (OR) of 0.29 (95% CI 0.05-1.78, p = 0.18) and that of 0.16 (95% CI 0.02-1.44, p = 0.10), respectively. Among all patients enrolled in the trial, 43 patients had both GPS2 and unresectable type (score 2), 45 had either (score 1), 11 had neither (score 0), and two lacked the data of GPS. Median OS in the patients with score 2, 1, and 0 was 4.7, 7.8, and 18.8 months, respectively (score 2 vs 0, HR 4.37, 95% CI 1.84-10.42; score 1 vs 0, HR = 2.80, 95% CI 1.19-6.64). Compared to FL, FLTAX showed better OS in patients with score 2 (HR = 0.60, 95% CI 0.32-1.13) and in those with score 1 (HR = 0.77, 95% CI 0.42-1.42), but worse OS in those with score 0 (HR = 4.74, 95% CI 0.49-45.85). Conclusions: Combination or sequential use of active two drugs, 5-FU and PTX, might contribute to better OS of GC patients with SPM. However, because selection of patients suitable to sequential use is difficult, the combination strategy FLTAX is a favorable treatment option.

scholarly journals The Factors of Deterioration of Natural Pastures From The View Point of Agricultural Employees in Al-Muthanna Governorate

2021 ◽  
Vol 923 (1) ◽  
pp. 012066
Author(s):  
Emad Fahad Nafeh Al-Bahli ◽  
Mahmoud Hadis Jassim Al-Jumaili
Keyword(s):  
Personal Characteristics ◽  
Research Area ◽  
Point Of View ◽  
Personal Factors ◽  
Factors Affecting ◽  
Work Location ◽  
Natural Factors ◽  
Significant Difference ◽  
The Impact ◽  
Selection Of

Abstract The research aimed to determine the impact studied factors represented by (people’s activities, government activities, natural factors) on the deterioration of natural pastures in the Governorate of Al-Muthanna the point of view of agricultural employees in the governorate. The research included all agricultural employees with a preparatory scientific qualification in agriculture and above in the governorate their number is (94) employees. A questionnaire was prepared to collect the data necessary to achieve the objectives of the research. It consisted of two parts. The first part included the factors related to the employees, which are (term of service, academic achievement, participation in extension activities, job position and work location). The second part included a measure to identify the agricultural employees’ the point of view of on the factors affecting the deterioration of natural pastures. It consists of (46) section spread over (3) field covered by the research. The results showed that government activities have the most impact on the deterioration of natural pastures, it was found a statistically significant difference in the respondents’ point of view about the influence of the studied factors according to their personal characteristics. The researchers concluded the necessity of agricultural expansion in pasture lands and industrial investments, as well as the importance of personal factors in assigning employees who can work in the development of natural pastures, and the researchers recommend activating government laws for the protection of natural pastures to prevent abuses (people’s activities, government activities) that contributed greatly to the deterioration of vegetation cover in the research area and taking into account the factors studied in the selection of workers in the development of natural pastures in the research area.

Factors Affecting the Selection of BIOX® as the Preferred Technology for the Treatment of a Refractory Gold Concentrate

2015 ◽  
Vol 1130 ◽  
pp. 191-196 ◽  
Author(s):  
Jan van Niekerk
Keyword(s):  
Operating Cost ◽  
Process Selection ◽  
Factors Affecting ◽  
Process Route ◽  
Refractory Gold ◽  
Project Risks ◽  
Fundamental Research ◽  
The Impact ◽  
Specific Project ◽  
Selection Of

The BIOX®process was developed in the late 1980’s for the treatment of refractory gold concentrates. The process has since developed into a commercially proven process with 12 successful installations of which 6 are currently still in operation. During this time development of the technology continued to improve the efficiency of the process, improve the reliability of the equipment used and to reduce the capital and operating cost for the implementation and operation of the process.This paper will look at some critical aspects in the selection of the BIOX as the preferred technology for the treatment of a refractory gold. Process selection will include technical criteria, for example the amenability of a concentrate to biooxidation and process design criteria, but will also include the overall project economic evaluation, a study of the project risks, the impact of the project and technology on the environment and local communities, operability of the process and implementation strategy.It is important that these aspects be taken into consideration in the design of any testwork program, be it fundamental research in the biooxidation field or in the development of a specific project. The impact of decisions taken during the execution of the program must also be tested continuously to gauge the impact on the overall process viability.The selection of biooxidation as the preferred process route for any project, be it gold, copper or any other mineral, will in most cases be based on the overall project economics compared to other processes, rather than technical considerations.

Stent retrievers with segmented design improve the efficacy of thrombectomy in tortuous vessels

2018 ◽  
Vol 11 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Naoki Kaneko ◽  
Yutaro Komuro ◽  
Hajime Yokota ◽  
Satoshi Tateshima
Keyword(s):  
Internal Carotid ◽  
Mechanical Thrombectomy ◽  
Vascular Anatomy ◽  
Success Rates ◽  
Link Type ◽  
Stent Retrievers ◽  
The Difference ◽  
Solitaire Fr ◽  
Post Hoc ◽  
The Impact

IntroductionTortuous vascular anatomy is one of the greatest challenges in mechanical thrombectomy. This study examines the impact of vascular tortuosity on the performance of stent retrievers and evaluates the efficacy of the newer generation stent retrievers with segmented design.Materials and methodsModels with mild, moderate, and severe tortuosity with an internal carotid artery (ICA) and a middle cerebral artery (MCA) were created. An elastic and cohesive clot was placed in the MCA lying from distal M1 and proximal M2. We assessed the revascularization rates of two commonly used stent retrievers (Trevo XP and Solitaire FR) and two newer stent retrievers with segmented design (Embotrap and Versi) in each vascular model.ResultsBoth the type of stent retriever and the severity of vessel tortuosity significantly affected the successful recanalization rate. Post-hoc tests showed that the rate of revascularization was significantly less in severe tortuosity than in mild or moderate tortuosity (P<0.001). The Versi resulted in higher success rates than the Solitaire (P<0.01) and the Trevo (P<0.05). The success rates of the Embotrap were higher than the Solitaire and Trevo stent retrievers, although the difference was not statistically significant.ConclusionsSevere tortuosity reduces the performance of mechanical thrombectomy. The segmented design in stent retrievers could improve the efficacy of mechanical thrombectomy in tortuous vessels.Trial registrationESCAPE NCT01778335;SWIFT PRIME >NCT01657461; REVASCAT >NCT01692379; All post-results.

Decision to choose fast food restaurants of the young people in HCMC, Vietnam

2020 ◽  
Author(s):  
Ha Nam Khanh Giao
Keyword(s):  
Young People ◽  
Fast Food ◽  
Ho Chi Minh City ◽  
Food Stores ◽  
Factors Affecting ◽  
Explanatory Factor Analysis ◽  
Fast Food Restaurants ◽  
Store Location ◽  
The Difference ◽  
The Impact

This study has four specific objectives: (1) Identifying the factors that affect the decision to choose fast food restaurants of the young people in Ho Chi Minh City, Vietnam (HCMC), (2) Measuring the impact level of factors affecting the decision to choose fast food restaurants of the young people in HCMC, (3) Proposing some managerial recommendations for those who are interested in the fast food business and (4) Analyzing the difference of the decision to choose fast food restaurants of the young people in Ho Chi Minh City, by surveying 225 young consumers living in HCMC. The SPSS 20 tool was used to analyze the reliability of the scale through the Cronbach's Alpha coefficient, EFA explanatory factor analysis, multiple linear regression analysis.The result of the model test shows four factors that positively affect the decision of choosing fast food restaurants of the young people in HCMC in the order of decreasing level: (1) Price, (2) Products, (3) Store location, and (4) Space. In addition, the results show that there is no difference in the decision to choose fast food restaurants of the young people in HCMC by gender but there are differences by occupation and income. From that, several managerial recommendations have been proposed for managers of fast-food stores to develop appropriate marketing strategies that impact on young people, enhancing their ability to attract shoppers.

Chinese farmer income’s fluctuant trajectory in the 1970s

2019 ◽  
Vol 11 (4) ◽  
pp. 719-722
Author(s):  
Yanping Zhao
Keyword(s):  
Academic Community ◽  
Content Type ◽  
Factors Affecting ◽  
Production Team ◽  
The Social ◽  
The Family ◽  
The Difference ◽  
The Impact ◽  
Textual Research

Purpose The purpose of this paper is to examine the farmers’ income and to analyze the factors affecting the farmers’ income as well as rural life during the People’s Commune period. Design/methodology/approach The study’s data are drawn from unique account books of production team and a great deal of rural archives from the aspects of commune, production brigade and production team during the People’s Commune period. Findings The fate of the people’s commune is closely related to the income of its members. This study tries to explore the answers to “what determines members’ income” and “what influences their income,” which include the impact of the materialization on farmers’ income, the gender structure of the household labor force, the life cycle of the family and the population and so on. The main reason for farmers’ income differentiation is the difference in the demographic structure of the farmers, while the social system and traditional culture strengthen the role of this factor. Originality/value The biggest feature of the study is that it deeply explored the unique account books of production team from a micro-view, and studied the issue of People’s Commune from the level of farmers using the methods of historical textual research and mathematical analysis. This study is a supplement of the research on the family level which has long been lacked in the academic community.

scholarly journals Selection of Optimal Path Control Algorithms for Probe Heads Used on Five-Axis Measuring Systems

2018 ◽  
Vol 8 (12) ◽  
pp. 2455 ◽  
Author(s):  
Adam Gąska ◽  
Piotr Gąska ◽  
Maciej Gruza ◽  
Jerzy Sładek
Keyword(s):  
Path Planning ◽  
Measurement Errors ◽  
Scientific Practice ◽  
Optimal Path ◽  
Measuring Systems ◽  
Factors Affecting ◽  
Path Control ◽  
Five Axis ◽  
The Impact ◽  
Selection Of

The utilization of rotational movements of a probing system during points measurementscontributes to the reduction of measurement duration and increases measurement repeatability.However, knowledge on such behavior and accuracy of probing systems is still unsatisfactory.Machines combined with articulating probing systems that have the ability of continuous indexationbecome redundant systems, which means that the same points can be measured using almost infinitemutual configurations of the machine and probe stylus orientations. Therefore, the proper selectionof inspection path planning method becomes one of the main factors affecting the accuracy of themeasurement. It is possible to assess the impact of this factor on the accuracy of the measurementby comparing the results of the measurements of gauge elements, which are done using differentpath controlling algorithms. After that, the best method for basic measuring tasks can be chosenin order to reduce measurement errors. Measurements of the multi-feature check gauge, using thedefault method for path planning and those chosen on the basis of described experiments, indicatesthat the improvement of accuracy may reach several microns. Results presented in this paper can bedirectly transferred to similar systems and measuring tasks, which are commonly met in industrialand scientific practice.

scholarly journals Mortality by marital status in the Republic of Serbia

2018 ◽  
pp. 597-606
Author(s):  
Ivan Marinkovic ◽  
Biljana Radivojevic
Keyword(s):  
Age Groups ◽  
Mortality Trends ◽  
Female Population ◽  
Men And Women ◽  
Male And Female ◽  
Factors Affecting ◽  
The Difference ◽  
The Republic ◽  
Population Mortality ◽  
The Impact

Mortality among married is lower than in those out of wedlock. Studies in European countries show that the difference in mortality between those who are married and those unmarried is increased regardless of sex. The main objective of the analysis in this paper is to show the impact of marriage on the mortality of the population, as well as the difference in the life expectancy of men and women in Serbia, by marriage status. Is there a protective effect of marriage? That is, can we confirm the hypothesis of higher importance of marriage status, when it comes to mortality of the men, and can we determine whether there are strong links between mortality and various modalities of marriage in the female population? Mortality trends for married and unmarried individuals were analyzed between the years 1981 and 2011, for both male and female population by five-year age groups. The scope of the analysis is the territory of Central Serbia and Vojvodina. This aspect of mortality is not sufficiently addressed in national research, which is why it is expected that the results of the conducted research can contribute to a deeper understanding of the factors affecting the mortality of the population in Serbia.

scholarly journals AN EMPIRICAL STUDY ON PERSONAL FACTORS AFFECTING EMOTIONAL INTELLIGENCE LEVELS OF EMPLOYEES IN THE U.S

2019 ◽  
Vol 7 (4) ◽  
pp. 1605-1620
Author(s):  
Sevim ÖZTİMURLENK
Keyword(s):  
New York ◽  
Emotional Intelligence ◽  
Service Sector ◽  
Personal Factors ◽  
Microsoft Excel ◽  
Factors Affecting ◽  
Pertinent Data ◽  
Post Hoc ◽  
The Impact ◽  
The U.S

This study explores the impact of some personal factors (i.e., gender, age, education, marital status) on employees’ emotional intelligence levels in service sector in the U.S. Using a questionnaire survey, pertinent data is gathered from a group of 98 employees who works in different companies and industries in New York and New Jersey. Employees’ EI is measured using Wong and Low Emotional Intelligence Scale (WLEIS). The data was analyzed using Microsoft Excel and SPSS. First, descriptive statistics were obtained. Then, t-tests ANOVA and Mann Whitney- U tests were conducted. Also, the differences obtained through ANOVA among the means are further compared through Tukey Post-hoc Tests. The results of the study show that education is a factor affecting emotional intelligence of employees positively in the U.S.

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