Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia

Abstract Background Hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by deficient activity of the tissue-nonspecific alkaline phosphatase entailing impaired turnover of phosphorus metabolites. Dietary mineral intake is suspected to influence clinical symptoms of HPP, but scientific evidence is missing. Methods Cross-sectional matched-pairs study collecting comprehensive data on nutrient intake in 20 HPP patients and 20 unaffected, age- and gender-matched controls. Dietary information and clinical symptoms were documented in detail over 7 consecutive days using structured diaries. Results Baseline data and type of energy-supplying nutrients were balanced between both groups. Median nutritional intake of phosphorus and calcium were significantly lower in HPP patients versus controls, which is partially attributable to lower energy consumption in HPP patients. Differences regarding phosphorus and calcium (Ca/P) ratio and uptake of magnesium, zinc, and vitamin B6 were not statistically significant. Both high (≥ 1375 mg/d) and low intakes (< 1100 mg/d) of phosphorus were significantly associated with an increased frequency of neuropsychiatric symptoms (P = 0.02). Similarly, very high and very low intake of calcium was significantly associated with musculoskeletal (P < 0.01), gastrointestinal (P = 0.02), and neuropsychiatric (P < 0.001) symptoms. An increased Ca/P ratio was associated with increased tiredness/fatigue (P < 0.01), whereas a decreased Ca/P was associated with gastrointestinal issues (P = 0.01). Conclusion Phosphorus and calcium intake seem reduced in HPP patients along with reduced total energy consumption. Particularly high as well as very low absolute or unbalanced phosphorus and calcium intake are associated with an increased frequency of clinical symptoms.

Download Full-text

Rubella Outbreak in Heballi Agasi Ward, Dharwad District, Karnataka, India, 2014–2015

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1014 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s380-s380

Author(s):

Sree Kalpana Mohankumar ◽

Vishweshwarayya Hiremath ◽

Rajashree Koppad

Keyword(s):

Attack Rate ◽

Clinical Symptoms ◽

Cross Sectional Study ◽

Routine Immunization ◽

Serum Samples ◽

Cross Sectional ◽

Epidemic Curve ◽

Surveillance Report ◽

And Gender ◽

Rubella Vaccination

Background: Countries that have good rubella surveillance, report ∼10,000–20,000 rubella cases annually. In India, not many cases of rubella are reported. The Hebballi Agasi ward of Dharwad district in Karnataka state, India, reported rubella cases on the last week of January 2015. Objective: We investigated the outbreak by time, place, person, and clinical symptoms. Methods: We performed a cross-sectional study. We defined a case as any resident of Heballi Agasi who had fever and rash, with or without lymphadenopathy, arthralgia, conjunctivitis, coryza, and cough, after December 15, 2014. We collected sociodemographic details and clinical symptoms of patients. We collected 5 serum samples and sent them to the National Measles Laboratory, Bangalore. We tested for measles and rubella antibodies. We drew an epidemic curve and a spot map. We computed mean age of cases, and we calculated attack rates by mean age and gender. We calculated proportions to describe clinical symptoms, and we interviewed stakeholders regarding rubella vaccination. We continued surveillance until March 2015. Results: The population of Heballi Agasi was 1,458. We identified 15 rubella cases (9 girls and 6 boys). The outbreak lasted between December 10, 2014, and February 21, 2015, with a peak on January 16, 2015. The overall attack rate was 1% (15 of 1,458). The mean age of the cases was 6 years (range, 1–23). The attack rate was high (7.7%) among those aged 1–6 years (11 of 143). The attack rate among those aged >6 years was 0.3% (4 of 1,315). In addition to fever and rash, 93% of cases (14 of 15) had coryza, 47% had cough (7 of 15), and 40% had conjunctivitis (6 of 15). Lymphadenopathy was present in only 1 case (1 of 15), and arthralgia was absent among all 15 cases. There was no death among the cases. All 5 sera were positive for rubella and negative for measles. Rubella vaccination was not given for any of the cases because no rubella vaccination is provided in the routine immunization program. Conclusions: There was a rubella outbreak in Heballi Agasi ward. Children aged 1–6 years were most affected. We recommend rubella vaccination in the routine immunization.Funding: NoneDisclosures: None

Download Full-text

Beverage consumption in Brazil: results from the first National Dietary Survey

Public Health Nutrition ◽

10.1017/s1368980014001657 ◽

2014 ◽

Vol 18 (7) ◽

pp. 1164-1172 ◽

Cited By ~ 21

Author(s):

Rosangela A Pereira ◽

Amanda M Souza ◽

Kiyah J Duffey ◽

Rosely Sichieri ◽

Barry M Popkin

Keyword(s):

Energy Consumption ◽

Total Energy ◽

Dietary Survey ◽

Cross Sectional Survey ◽

Total Energy Consumption ◽

Cross Sectional ◽

Beverage Consumption ◽

Public Health Challenge ◽

Nationally Representative ◽

Sugary Beverages

AbstractObjectiveTo provide an overview of beverage consumption patterns using the first nationally representative survey of dietary intake in Brazil.DesignBeverage consumption data were obtained by 1 d food records in an individual dietary survey.SettingNationwide cross-sectional survey, 2008–2009.SubjectsNationally representative sample of individuals aged ≥10 years (n 34 003).ResultsBeverages contributed 17·1 % of total energy consumption. Caloric coffee beverages provided the greatest level of energy overall (464 kJ (111 kcal)/d). Individuals aged 10–18 years (243 kJ (58 kcal)/d) and 19–39 years (230 kJ (55 kcal)/d) consumed a higher proportion of energy from sugar-sweetened soft drinks than individuals over this age (142 kJ (34 kcal)/d for those aged 40–59 years and 79 kJ (19 kcal)/d for those aged ≥60 years).ConclusionsOverall, the contribution of beverages, particularly sugary beverages, to total energy consumption in Brazil represents an important public health challenge and is comparable with those from other countries.

Download Full-text

Alexithymia and anxiety symptoms in Pakistani adolescents: a study of compounded directions

Journal of the Pakistan Medical Association ◽

10.47391/jpma.1247 ◽

2021 ◽

pp. 1-13

Author(s):

Sadia jafer ◽

Farzana Ashraf ◽

Amna Arif ◽

Admin

Keyword(s):

Psychological Health ◽

Clinical Symptoms ◽

Interactive Effect ◽

Age Groups ◽

Cross Sectional Study ◽

Anxiety Symptoms ◽

Cross Sectional ◽

Physical And Psychological Health ◽

And Gender ◽

Effect Of Age

Abstract Objectives: There is an empirical evidence that symptoms of internalizing disorders such as alexithymia and anxiety increase in adolescence and these symptoms varies across gender and age groups. The purpose of this study was to explore these differences in adolescents. Method: In this cross-sectional study conducted since November 2018 to March 2019, the sample of 185 adolescents selected through random sampling method from different schools. They were assessed on alexithymia and anxiety symptoms by administering Toronto Alexithymia Scale and Hamilton Anxiety Scale respectively. Multiple Analysis of Variance (MANOVA) was applied to determine the direct and interactive effect of age groups and gender on alexithymia and anxiety symptoms. Results: The results demonstrate that boys reported significantly (p<0.05) higher level of alexithymia symptoms partially (externally oriented) as compared to their counterparts. Further significant (p<0.05) interactive effect of age group and gender was also seen. Conclusion: The present study concluded that the presence of clinical symptoms in school going adolescents may hinder in the physical and psychological health of adolescents, which should be managed through suitable interventions. Keywords: Alexithymia symptoms, Anxiety symptoms, Continuous...

Download Full-text

Medical cannabis use in Thailand after its legalization: a respondent-driven sample survey

PeerJ ◽

10.7717/peerj.12809 ◽

2022 ◽

Vol 10 ◽

pp. e12809

Author(s):

Sawitri Assanangkornchai ◽

Kanittha Thaikla ◽

Muhammadfahmee Talek ◽

Darika Saingam

Keyword(s):

Scientific Evidence ◽

Neuropsychiatric Symptoms ◽

Cross Sectional Study ◽

Sample Survey ◽

First Year ◽

Medical Cannabis ◽

Cross Sectional ◽

Study Region ◽

For Profit ◽

Regulatory Frameworks

Background Many countries now allow the consumption of cannabis or cannabinoids for medical purposes with varying approaches concerning products allowed and the regulatory frameworks prevailing their endowment. On 18 February 2019 Thailand passed legislation allowing the use of cannabis for medical purposes. This study aimed to examine patterns and purposes for consumption of medical cannabis, and consumers’ perceptions and opinions towards benefits and harms of cannabis and related policies in 2019–2020. Methods A cross-sectional study using a respondent-driven sampling (RDS) method was conducted in four sites across Thailand. Participants were 485 adults aged 18 years and over, living in the study region, who had used cannabis for medical purposes within the past 12 months. Face-to-face interviews using a structured questionnaire were used to collect data on (1) demographic characteristics, (2) pattern of consumption, (3) source of information and perception of benefits and harms of medical cannabis, and (4) opinion towards cannabis policies. Data were analyzed using RDS Analyst and presented as percentage and mean with 95% confidence interval (CI). Results Most participants (84.7%, 95% CI [78.9–90.5]) used an oral form of crude oil extract while 9.2% (95% CI [4.1–14.2]) used the raw form. The most common uses were for treatment of cancers (23.3%, 95% CI [16.1–30.4]), neuropsychiatric symptoms (22.8%, 95% CI [17.5–28.0]), and musculoskeletal pains (21.6%, 95% CI [16.7–26.6]). Illegal sources such as underground traders (54.5%, 95% CI [40.8–68.3]), friends and relatives (12.2%, 95% CI [6.2–18.3]), not-for-profit provider groups (5.2%, 95% CI [0.5–10.9]), and clandestine growers or producers (2.9%, 95% CI [0.6–5.3]) were the main suppliers. Most (>80%) perceived cannabis could treat cancers, chronic pains, insomnia, Parkinson’s disease and generalized anxiety disorder. Less than half perceived that cannabis could cause adverse conditions e.g., palpitation, panic, memory impairment and schizophrenic-like psychosis. Most respondents agreed or strongly agreed with the policies regarding permission to use cannabis for medical purposes (95.1%, 95% CI [92.0–98.2]), for the legal sale of medical cannabis products (95.9%, 95% CI [93.7–98.2]), and for people to grow cannabis for medical use (94.2%, 95% CI [91.8–96.5]). However, only two-thirds agreed with policies concerning the sales of cannabis (65.3%, 95% CI [56.9–73.7]) and home-grown cannabis for recreational purposes (61.3%, 95% CI [52.7–69.9]). Conclusion Our study reports the experiences of consumers of medical cannabis in the first year after its legalization in Thailand. Consumers reported various patterns and indications of consumption that were not supported by scientific evidence, but had positive perception of the results of consumption. These findings highlight ongoing policy challenges for Thailand and can be a lesson to be learned for other countries in the region.

Download Full-text

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

10.53350/pjmhs211551635 ◽

2021 ◽

Vol 15 (5) ◽

pp. 1635-1640

Author(s):

Toomaj Shahverdi ◽

Mahdi Nikoo Hemmat ◽

Mohammad Islamy

Keyword(s):

Mortality Rate ◽

Clinical Outcomes ◽

Blood Count ◽

Complete Blood Count ◽

Clinical Symptoms ◽

Cross Sectional Study ◽

General Information ◽

Cross Sectional ◽

Laboratory Values ◽

And Gender

Introduction: At the end of 2019, a new coronavirus caused pneumonia in Wuhan, China. Several studies have described the clinical features and immune manifestations in COVID-19 patients with moderate to severe symptoms, while their clinical relevance is less clear. This study investigates the effects of clinical symptoms and laboratory values of COVID-19 patients' tests at the time of hospitalization on their clinical outcomes. Methodology: This descriptive cross-sectional study was performed on COVID-19 patients hospitalized in Arak hospitals from April 2020 to March 2020. Medical records of all the hospitalized patients were retrieved. Trained personnel extracted general information (age and gender) and clinical profiles (the complete blood count and other required tests). Findings: Analyzing the laboratory indices of the blood count and LDH and CPK levels revealed a positive relationship between the patients' serum CPK levels, and the mortality rate (P = 0.001) and length of hospitalization (P = 0.015). Conclusion: The patients' serum LDH levels and fever were also associated with the mortality rate, and the need for mechanical ventilation, respectively. We hope this information helps physicians treat COVID-19 patients. Keywords: COVID-19, clinical symptoms, laboratory tests

Download Full-text

Determinan Indeks Massa Tubuh Remaja Putri di Kota Bukit Tinggi, Tahun 2006

Kesmas National Public Health Journal ◽

10.21109/kesmas.v1i3.308 ◽

2006 ◽

Vol 1 (3) ◽

pp. 134

Author(s):

Rini Santy

Keyword(s):

Energy Consumption ◽

Light Level ◽

Eating Habit ◽

Total Energy Consumption ◽

Cross Sectional ◽

Systematic Random Sampling ◽

Energy Deficiency ◽

Chronic Energy Deficiency ◽

Study Population ◽

Variable Energy

Di Indonesia, pada 1999-2003, remaja putri yang mengalami Kekurangan Energi Kronis (KEK). akibat asupan energi yang kurang adalah 35 – 40% dan sekitar 50% remaja putri menderita status gizi kurang (IMT < 18,5 kg/m2). Tujuan penelitian adalah mengetahui gambaran epidemiologi. IMT remaja putri dan berbagai faktor yang berhubungan Rancangan studi yang digunakan adalah rancangan potong lintang ( cross sectional ). Populasi adalah remaja putriberusia 16-18 tahun yang tinggal di Buki Tinggi dan sampel adalah 156 siswi kelas III SLTA (SMA, MA, dan SMK) usia 16 – 18 tahun yang terpilih dari 11 sekolah yang diamati. Analisis data dilakukan secara multivariate dengan metoda logistic regression ganda. Hasil penelitian (1) Rata-rata IMT remja putri adalah 20,69 kg/m2 + 2,63. (2) Proporsi siswi dengan IMT<18,5 kg/m2 adalah 19,9% yang meliputi 14,1% kekurangan gizi ringan dan 5,8% kekurangan gizi berat.(3) Rata-rata asupan energi remaja putri adalah 1694 kalori dan. rata-rata kontribusi terhadap total energi protein (11,8%), lemak (26,7%) dan karbohidrat (58,7%). (4) Rata-rata asupan energi dibanding AKG meliputi total energi (77%), protein (93,6%). Variabel yang berhubungan secara bermakna dengan IMP pada remaja meliputi total energi, kebiasaan makan dan citra tubuh dengan IMT remaja putri dengan variabel utama adalah total energi.Kata Kunci : IMT, kekurangan energi kronik, remaja putriAbstractIn Indonesia, in period of 1999 – 2003, abot 35 – 40% women in productive age of 15 – 19 are at risk of Chronic Energy Deficiency (KEK) becouse of in-sufficient consumption of energy. This research is aimed at obtaining the description of nutritional status of girls in Bukittinggi and factors related to it. The re-search that was conductec in period of February tol March 2006 used the design of cross sectional. The study population is the girls studied are represented by the third-grade female students of senior high schools of 16 –18 who are categorized as a late teenager who is very close to pregnant period. The sample consist of 156 female student that was selected by systematic random sampling at 11 schools. The results show that the BMI of the girls is 20.69 kg/m2 ± 2.63 on average. The proportion of students having BMI<18.5 kg/m2 is 19.9% all of which is distributed to 14.1% of light level of malnutrition and 5.8% for heavy level of malnutrition. Intake per day is 1694 calorie on average with protein contributed to intake is 11,8%, fat 26,7% dan carbohydrat 58,7%. Intake energy compared with Recommended Dietary Allowence (RDA) are total energy consumption 77%, protein 93,6%, lemak 65,3% and carbohydrat 84,7%. There is a significant relation between energy consumption, eating habit, body image, by BMI. Variable energy consumption is the dominant variable influencing BMI.Keywords : BMI, chronic energy deficiency, teenagers

Download Full-text

Alexithymia and anxiety symptoms in Pakistani adolescents: a study of compounded directions

Journal of the Pakistan Medical Association ◽

10.47391/jpma.1077 ◽

2021 ◽

pp. 1-13

Author(s):

Sadia jafer ◽

Farzana Ashraf ◽

Amna Arif ◽

Admin

Keyword(s):

Psychological Health ◽

Clinical Symptoms ◽

Interactive Effect ◽

Age Groups ◽

Cross Sectional Study ◽

Anxiety Symptoms ◽

Cross Sectional ◽

Physical And Psychological Health ◽

And Gender ◽

Effect Of Age

Download Full-text

Vitamin B12 Deficiency Induces Imbalance in Melanocytes Homeostasis—A Cellular Basis of Hypocobalaminemia Pigmentary Manifestations

International Journal of Molecular Sciences ◽

10.3390/ijms19092845 ◽

2018 ◽

Vol 19 (9) ◽

pp. 2845 ◽

Cited By ~ 9

Author(s):

Zuzanna Rzepka ◽

Michalina Respondek ◽

Jakub Rok ◽

Artur Beberok ◽

Keith ó Proinsias ◽

...

Keyword(s):

Vitamin B12 ◽

Molecular Mechanisms ◽

Clinical Symptoms ◽

Scientific Evidence ◽

Neuropsychiatric Symptoms ◽

Skin Pigmentation ◽

Vitamin B12 Deficiency ◽

Image Cytometry ◽

B12 Deficiency

Vitamin B12 deficiency causes significant changes in cellular metabolism leading to various clinical symptoms, such as hematological, psychiatric, and neurological disorders. We hypothesize that skin pigmentation disorders may be a diagnostically important manifestation of vitamin B12 deficiency, however the cellular and molecular mechanisms underlying these effects remain unknown. The aim of this study was to examine the effect of vitamin B12 deficiency on melanocytes homeostasis. Hypocobalaminemia in vitro model was developed by treating epidermal melanocytes with synthesized vitamin B12 antagonist—hydroxycobalamin(c-lactam). The cells were examined using immunoenzymatic, spectrophotometric, and fluorimetric assays as well as image cytometry. Significant melanogenesis stimulation—the increase of relative melanin content and tyrosinase activity up to 131% and 135%, respectively—has been indicated. Cobalamin-deficient cells displayed the elevation (by 120%) in reactive oxygen species level. Moreover, the redox status imbalance was stated. The study provided a scientific evidence for melanocytes homeostasis disturbance under hypocobalaminemia, thus indicating a significant element of the hyperpigmentation mechanism due to vitamin B12 deficiency. Furthermore, the implication between pigmentary and hematological and/or neuropsychiatric symptoms in cobalamin-deficient patients may be an important issue.

Download Full-text

Identifying Suicide Typologies Among Trauma-Exposed Veterans

Crisis ◽

10.1027/0227-5910/a000637 ◽

2020 ◽

Vol 41 (4) ◽

pp. 288-295 ◽

Cited By ~ 1

Author(s):

Nadia Bounoua ◽

Jasmeet P. Hayes ◽

Naomi Sadeh

Keyword(s):

Latent Profile Analysis ◽

Suicide Attempts ◽

Clinical Symptoms ◽

Profile Analysis ◽

Risky Behaviors ◽

Self Report ◽

Cross Sectional ◽

Research Priority ◽

Self Harm ◽

And Behaviors

Abstract. Background: Suicide among veterans has increased in recent years, making the identification of those at greatest risk for self-injurious behavior a high research priority. Aims: We investigated whether affective impulsivity and risky behaviors distinguished typologies of self-injurious thoughts and behaviors in a sample of trauma-exposed veterans. Method: A total of 95 trauma-exposed veterans (ages 21–55; 87% men) completed self-report measures of self-injurious thoughts and behaviors, impulsivity, and clinical symptoms. Results: A latent profile analysis produced three classes that differed in suicidal ideation, suicide attempts and nonsuicidal self-injury (NSSI): A low class that reported little to no self-injurious thoughts or behaviors; a self-injurious thoughts (ST) class that endorsed high levels of ideation but no self-harm behaviors; and a self-injurious thoughts and behaviors (STaB) class that reported ideation, suicide attempts and NSSI. Membership in the STaB class was associated with greater affective impulsivity, disinhibition, and distress/arousal than the other two classes. Limitations: Limitations include an overrepresentation of males in our sample, the cross-sectional nature of the data, and reliance on self-report measures. Conclusion: Findings point to affective impulsivity and risky behaviors as important characteristics of veterans who engage in self-injurious behaviors.

Download Full-text

Personality's Correlates of Adult Development and Aging

European Psychologist ◽

10.1027//1016-9040.8.3.131 ◽

2003 ◽

Vol 8 (3) ◽

pp. 131-147 ◽

Cited By ~ 43

Author(s):

Gian Vittorio Caprara ◽

Mariagiovanna Caprara ◽

Patrizia Steca

Keyword(s):

Personality Traits ◽

Adult Development ◽

Self Efficacy ◽

Age Groups ◽

Well Being ◽

Efficacy Beliefs ◽

Cross Sectional ◽

Education And Health ◽

Development And Aging ◽

And Gender

Three cross-sectional studies examined stability and change in personality over the course of life by measuring the relations linking age to personality traits, self-efficacy beliefs, values, and well-being in large samples of Italian male and female participants. In each study, relations between personality and age were examined across several age groups ranging from young adulthood to old age. In each study, personality constructs were first examined in terms of mean group differences accrued by age and gender and then in terms of their correlations with age across gender and age groups. Furthermore, personality-age correlations were also calculated, controlling for the demographic effects accrued by marital status, education, and health. Findings strongly indicated that personality functioning does not necessarily decline in the later years of life, and that decline is more pronounced in males than it is in females across several personality dimensions ranging from personality traits, such as emotional stability, to self-efficacy beliefs, such as efficacy in dealing with negative affect. Findings are discussed in terms of their implications for personality theory and social policy.

Download Full-text