scholarly journals Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth

2019 ◽  
Vol 105 (3) ◽  
pp. e704-e714 ◽  
Author(s):  
Natalie J Nokoff ◽  
Sharon L Scarbro ◽  
Kerrie L Moreau ◽  
Philip Zeitler ◽  
Kristen J Nadeau ◽  
...  
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Lean Mass ◽  
Cross Sectional Study ◽  
Cardiometabolic Health ◽  
Pubertal Stage ◽  
Cross Sectional ◽  
Insulin Resistant ◽  
The Impact

Abstract Context As many as 1.8% of adolescents identify as transgender and many more seek care, yet the impact of gender-affirming hormone therapy (GAHT) on cardiometabolic health is unknown. Objective To determine insulin sensitivity and body composition among transgender females (TF) and males (TM) on estradiol or testosterone, compared with cisgender females (CF) and males (CM). Design Pilot, cross-sectional study conducted from 2016–2018. Setting Academic regional transgender referral center. Participants Transgender adolescents on either testosterone or estradiol for at least 3 months were recruited. Nineteen TM were matched to 19 CM and 42 CF on pubertal stage and body mass index (BMI). Eleven TF were matched to 23 CF and 13 TF to 24 CM on age and BMI. Main Outcome Measures 1/[fasting insulin] and body composition (dual-energy x-ray absorptiometry). Results Total body fat was lower in TM than CF mean ± SD: (29% ± 7% vs 33% ± 7%; P = 0.002) and higher than in CM (28% ± 7% vs 24% ± 9%; P = 0.047). TM had higher lean mass than CF (68% ± 7% vs 64% ± 7%, P = 0.002) and lower than CM (69% ± 7% vs 73% ± 8%; P = 0.029). Insulin sensitivity was not different between the groups. TF had lower body fat than CF (31% ± 7% vs 35% ± 8%; P = 0.033) and higher than CM (28% ± 6% vs 20% ± 10%; P = 0.001). TF had higher lean mass than CF (66% ± 6% vs 62% ± 7%; P = 0.032) and lower than CM (69% ± 5% vs 77% ± 9%; P = 0.001). TF were more insulin resistant than CM (0.078 ± 0.025 vs 0.142 ± 0.064 mL/μU; P = 0.011). Conclusions Transgender adolescents on GAHT have significant differences in body composition compared with cisgender controls, with a body composition intermediate between BMI-matched CMs and CFs. These changes in body composition may have consequences for the cardiometabolic health of transgender adolescents. ClinicalTrials.gov NCT02550431

scholarly journals Body composition and markers of cardiometabolic health in transgender youth compared to cisgender youth: a cross-sectional study

2019 ◽  
Author(s):  
Natalie J Nokoff ◽  
Sharon L Scarbro ◽  
Kerrie L Moreau ◽  
Philip Zeitler ◽  
Kristen J Nadeau ◽  
...  
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Hormone Therapy ◽  
Body Fat ◽  
Lean Mass ◽  
Cross Sectional Study ◽  
Cardiometabolic Health ◽  
Sectional Study ◽  
Cross Sectional ◽  
Transgender Youth

AbstractContextUp to 1.8% of adolescents identify as transgender and many more seek care, yet the impact of gender affirming hormone therapy (GAHT) on cardiometabolic health is unknown.ObjectiveTo determine insulin sensitivity and body composition among transgender females (TF) and males (TM) on estradiol or testosterone, compared to cisgender females (CF) and males (CM).DesignPilot, cross-sectional study conducted from 2016-2018.Setting. Academic regional transgender referral center.ParticipantsTransgender adolescents on either testosterone or estradiol for at least 3 months were recruited. Nineteen TM were matched to 19 CM and 42 CF on pubertal stage and body mass index (BMI). Eleven TF were matched to 23 CF and 13 TF to 24 CM on age and BMI.Main Outcome Measure(s)1/[fasting insulin] and body composition (dual-energy absorptiometry, DXA).ResultsTotal body fat was lower in TM than CF (29±7 vs. 33±7%, p=0.002) and higher than CM (28±7 vs. 24±9%, p=0.047). TM had higher lean mass than CF (68±7 vs. 64±7%, p=0.002) and lower than CM (69± vs. 73±8%, p=0.029). Insulin sensitivity was not different between the groups.TF had lower body fat than CF (31±7 vs. 35±8%, p=0.033) and higher than CM (28±6 vs. 20±10, p=0.001). TF had higher lean mass than CF (66±6 vs. 62±7%, p=0.032) and lower than CM (69±5 vs. 77±9%, p=0.001). TF were more insulin resistant than CM (0.078±0.025 vs. 0.142±0.064, p=0.011).ConclusionsTransgender adolescents on GAHT have significant differences in body composition compared to cisgender controls, with a body composition intermediate between BMI-matched cisgender males and females. These changes in body composition may have consequences for the cardiometabolic health of transgender adolescents.PrecisTransgender youth on gender affirming hormone therapy have differences in their percent fat and lean mass compared to cisgender (non-transgender) youth.

scholarly journals The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 310
Author(s):  
Kevin J. Scully ◽  
Laura T. Jay ◽  
Steven Freedman ◽  
Gregory S. Sawicki ◽  
Ahmet Uluer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Body Composition ◽  
Dietary Intake ◽  
Healthy Volunteers ◽  
Clinical Outcomes ◽  
Body Fat ◽  
Lean Mass ◽  
Cross Sectional ◽  
Adolescents And Adults

Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis (CF) than body mass index (BMI). Little is known about how diet quality and exercise may impact body composition in these patients. Dual X-ray absorptiometry (DXA) body composition, 24-h dietary recall, and physical activity were assessed in a cross-sectional analysis of 38 adolescents and adults with CF and 19 age-, race-, and gender-matched healthy volunteers. Compared with the healthy volunteers, participants with CF had a lower appendicular lean mass index (ALMI), despite no observed difference in BMI, and their diets consisted of higher glycemic index foods with a greater proportion of calories from fat and a lower proportion of calories from protein. In participants with CF, pulmonary function positively correlated with measures of lean mass, particularly ALMI, and negatively correlated with multiple measures of body fat after controlling for age, gender, and BMI. Higher physical activity levels were associated with greater ALMI and lower body fat. In conclusion, body composition measures, particularly ALMI, may better predict key clinical outcomes in individuals with CF than BMI. Future longitudinal studies analyzing the effect of dietary intake and exercise on body composition and CF-specific clinical outcomes are needed.

Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences

2021 ◽  
Author(s):  
Silvana Duran-Ortiz ◽  
Kathryn L. Corbin ◽  
Ishrat Jahan ◽  
Nicholas B. Whitticar ◽  
Sarah E Morris ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Body Fat ◽  
Isolated Islets ◽  
Wild Type ◽  
Cross Sectional ◽  
Islet Mass ◽  
The Impact

In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline and in adulthood impacts islet mass in general but more profoundly in male mice. GHR knockout (GHRKO) mice have enhanced insulin sensitivity and low circulating insulin. We show that the total cross-sectional area of isolated islets (estimated islet mass) was reduced by 72% in male but by only 29% in female GHRKO mice compared to wild type controls. Also, islets from GHRKO mice secreted ~50% less glucose-stimulated insulin compared to size-matched islets from wild type mice. We next used mice with a floxed Ghr gene to knock down the GHR in adult mice at six-months of age (6mGHRKO) and examined the impact on glucose and islet metabolism. By 12-months of age, female 6mGHRKO mice had increased body fat and reduced islet mass but had no change in glucose tolerance or insulin sensitivity. However, male 6mGHRKO mice had nearly twice as much body fat, substantially reduced islet mass, and enhanced insulin sensitivity, but no change in glucose tolerance. Despite large losses in islet mass, glucose-stimulated insulin secretion from isolated islets was not significantly different between male 6mGHRKO and controls while isolated islets from female 6mGHRKO mice showed increased glucose-stimulated insulin release. Our findings demonstrate the importance of GH to islet mass throughout life and that unique sex-specific adaptations to the loss of GH signaling allow mice to maintain normal glucose metabolism.

A cross-sectional study of the impact of school neighbourhood on children obesity and body composition

2020 ◽  
Author(s):  
Inês Paciência ◽  
João Cavaleiro Rufo ◽  
Francisca Mendes ◽  
Mariana Farraia ◽  
Pedro Cunha ◽  
...  
Keyword(s):  
Body Composition ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Children Obesity ◽  
The Impact

scholarly journals Body fatness or anthropometry for assessment of unhealthy weight status? Comparison between methods in South African children and adolescents

2012 ◽  
Vol 16 (11) ◽  
pp. 2005-2013 ◽  
Author(s):  
Eva Craig ◽  
John Reilly ◽  
Ruth Bland
Keyword(s):  
Body Composition ◽  
Children And Adolescents ◽  
Body Fat ◽  
Weight Status ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Sectional Study ◽  
Cross Sectional ◽  
Body Fatness ◽  
Unhealthy Weight

AbstractObjectiveA variety of methods are available for defining undernutrition (thinness/underweight/under-fat) and overnutrition (overweight/obesity/over-fat). The extent to which these definitions agree is unclear. The present cross-sectional study aimed to assess agreement between widely used methods of assessing nutritional status in children and adolescents, and to examine the benefit of body composition estimates.DesignThe main objective of the cross-sectional study was to assess underweight, overweight and obesity using four methods: (i) BMI-for-age using WHO (2007) reference data; (ii) BMI-for-age using Cole et al. and International Obesity Taskforce cut-offs; (iii) weight-for-age using the National Centre for Health Statistics/WHO growth reference 1977; and (iv) body fat percentage estimated by bio-impedance (body fat reference curves for children of McCarthy et al., 2006). Comparisons were made between methods using weighted kappa analyses.SettingRural South Africa.SubjectsIndividuals (n 1519) in three age groups (school grade 1, mean age 7 years; grade 5, mean age 11 years; grade 9, mean age 15 years).ResultsIn boys, prevalence of unhealthy weight status (both under- and overnutrition) was much higher at all ages with body fatness measures than with simple anthropometric proxies for body fatness; agreement between fatness and weight-based measures was fair or slight using Landis and Koch categories. In girls, prevalence of unhealthy weight status was also higher with body fatness than with proxies, although agreement between measures ranged from fair to substantial.ConclusionsMethods for defining under- and overnutrition should not be considered equivalent. Weight-based measures provide highly conservative estimates of unhealthy weight status, possibly more conservative in boys. Simple body composition measures may be more informative than anthropometry for nutritional surveillance of children and adolescents.

scholarly journals Pengetahuan, Status Hidrasi, Persen Lemak Tubuh, Kadar Hemoglobin, dan Kebugaran Atlet Senam

2019 ◽  
Vol 2 (2) ◽  
pp. 170
Author(s):  
Ayu Ghalda ◽  
Nazhif Gifari ◽  
Nadiyah Nadiyah
Keyword(s):  
Body Composition ◽  
Physical Fitness ◽  
Body Fat ◽  
Significant Relationship ◽  
Cross Sectional Study ◽  
Hemoglobin Level ◽  
The Body ◽  
Hydration Status ◽  
Cross Sectional ◽  
Spearman Correlation Test

AbstractPhysical fitness is the ability of a person body to do a day work without feeling significant fatigue, that the body has a reserve of energy to overcome the excessive workload. The purpose of this study was to determine the relationship between hydration knowledge, hydration status, body composition, hemoglobin level with physical fitness in gymnastics athletes. This study was design a cross sectional study at GOR Raden Inten East Jakarta. Independent variables were hydration knowledge, hydration status, body composition (percent of body fat) and hemoglobin level, while the dependent variable was physical fitness. The statistical test used in this study was the spearman correlation test, because the dependent variable in this study was abnormally distributed. The results of this study were that there was no significant relationship between hydration knowledge and physical fitness (r = 0.181; p > 0.05), there was no significant relationship between hydration status and physical fitness (r = -0,440; p = 0,052), there was no relationship significant between body composition (percent of body fat) and physical fitness (r = 0,351; p > 0.05), and there was a significant relationship between hemoglobin level and physical fitness (r = 0,600; p < 0.05). The conclusion in this study, there was a significant relationship between hemoglobin level and physical fitness.Kebugaran jasmani merupakan kemampuan tubuh seseorang untuk melakukan suatu pekerjaan sehari-hari tanpa merasakan kelelahan yang cukup berarti, sehingga tubuh itu sendiri memiliki cadangan energi untuk mengatasi beban kerja yang berlebih. Tujuanpenelitian ini untuk mengetahui hubungan pengetahuan hidrasi, status hidrasi, komposisi tubuh, kadar hemoglobin dengan kebugaran pada atlet senam. Penelitian ini adalah penelitian kuantitatif dengan desain penelitian cross sectional yang dilakukan di GOR Raden Inten Jakarta Timur. Variabel independen yaitu pengetahuan hidrasi, status hidrasi, komposisi tubuh (persen lemak tubuh)dan kadar hemoglobin, sedangkan variabel dependen yaitu kebugaran.  Uji statistik yang digunakan dalam penelitian ini menggunakan uji korelasi spearman, karena variabel dependen pada penelitan berdistribusi tidak normal. Hasil dari penelitian yaitu tidak terdapat hubungan yang signifikan antara pengetahuan hidrasi dan kebugaran (r=0,181; p>0,05), tidak terdapat hubungan yang signifikan antara status hidrasi dan kebugaran (r=-0,440; p>0,05), tidak terdapat hubungan yang signifikan antara komposisi tubuh dan kebugaran (r=0,351; p>0,05) dan terdapat hubungan yang signifikan antara kadar hemoglobin dan kebugaran (r=0,600; p<0,05). Kesimpulan dalam penelitian ini yaitu terdapat hubungan yang signifikan antara kadar hemoglobin dengan kebugaran atlet.

scholarly journals Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA

2011 ◽  
Vol 105 (12) ◽  
pp. 1750-1763 ◽  
Author(s):  
Gayathri Yepuri ◽  
Helena Marcelino ◽  
Yasaman Shahkhalili ◽  
Olivier Aprikian ◽  
Katherine Macé ◽  
...  
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Fat Mass ◽  
Lean Mass ◽  
Quadratic Model ◽  
High Fat ◽  
High Fat Diets ◽  
Catch Up ◽  
Fat Diets ◽  
The Impact

The present study investigates whether excessive fat accumulation and hyperinsulinaemia during catch-up growth on high-fat diets are altered by n-6 and n-3 PUFA derived from oils rich in either linoleic acid (LA), α-linolenic acid (ALA), arachidonic acid (AA) or DHA. It has been shown that, compared with food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed isoenergetically on diets enriched in LA or ALA, independently of the n-6:n-3 ratio, show improved insulin sensitivity, lower fat mass and higher lean mass, the magnitude of which is related to the proportion of total PUFA precursors (LA+ALA) consumed. These relationships are best fitted by quadratic regression models (r2>0·8, P < 0·001), with threshold values for an impact on body composition corresponding to PUFA precursors contributing 25–30 % of energy intake. Isoenergetic refeeding on high-fat diets enriched in AA or DHA also led to improved body composition, with increases in lean mass as predicted by the quadratic model for PUFA precursors, but decreases in fat mass, which are disproportionately greater than predicted values; insulin sensitivity, however, was not improved. These findings pertaining to the impact of dietary intake of PUFA precursors (LA and ALA) and their elongated–desaturated products (AA and DHA), on body composition and insulin sensitivity, provide important insights into the search for diets aimed at counteracting the pathophysiological consequences of catch-up growth. In particular, diets enriched in essential fatty acids (LA and/or ALA) markedly improve insulin sensitivity and composition of weight regained, independently of the n-6:n-3 fatty acid ratio.

The impact of body composition on vertebral fractures during aromatase inhibitors therapy: A cross-sectional study.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e12504-e12504
Author(s):  
Rebecca Pedersini ◽  
Sara Monteverdi ◽  
Filippo Maffezzoni ◽  
Antonella Turla ◽  
Lucia Vassalli ◽  
...  
Keyword(s):  
Body Composition ◽  
Aromatase Inhibitors ◽  
Vertebral Fractures ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Impact

scholarly journals POS0570 ASSOCIATION OF BODY FAT MASS AND ITS DISTRIBUTION WITH DISEASE ACTIVITY, PAIN AND DISABILITY IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 519.2-520
Author(s):  
O. Lamkhanat ◽  
H. Azzouzi ◽  
I. Linda
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Composition ◽  
Disease Activity ◽  
Body Fat ◽  
Fat Mass ◽  
Health Assessment ◽  
Cross Sectional Study ◽  
Body Fat Mass ◽  
Obese Patients ◽  
Cross Sectional

Background:Rheumatoid arthritis (RA) and body composition are closely related. Recent studies have found a significant association between fat mass and disease activity and disability in RA [1].Objectives:We aimed to study the association between body fat mass and its distribution with disease activity, disability, and pain in RA patients.Methods:This is a cross-sectional study of patients with RA diagnosis according to ACR-EULAR 2010 classification recruited from first January 2021. Those with prior cancer, hyperparathyroidism, hyperthyroidism, diabetes, chronic kidney disease, and cirrhosis were excluded. Body fat mass (BFM) and its distribution (gynoid (GFM), android (AFM), visceral (VFM), limbs (LFM), trunk (TFM)) were measured with dual-energy X-ray absorptiometry (Hologic, Horizon QDR®). Clinical data and laboratory tests of the same day of the DXA scan were analyzed. The associations between BFM and its distribution with disease activity score (DAS28CRP), pain visual analogue scale (VAS), and disability measured by health assessment questionnaire (HAQ) were explored. Obesity was defined as a body mass index (BMI) ≥ of 25kg/m2. Our statistical analysis was based on descriptive study, comparisons and linear regressions using SPSS 20.Results:It is about 69 RA patients. Their mean age was 49.86 ± 14.33 years, mean DAS28CRP was 2.56 ± 1.27, and mean disease duration was 14.84 ± 10.99 years. Sixty-two (89.9%) were women. The mean BMI was 26.46 ± 5.26 kg/m2, and 41 patients were obese (59.4%). Compared with non-obese patients, obese patients had a higher C-reactive protein (p = 0.03). DAS28CRP was higher in obese patients (2.77 ± 1.41 vs 2.25 ± 0.97) but did not reach significance (p = 0.07). We did not find any difference between the two groups regarding pain and disability. In univariate regression analysis, the LFM was positively associated with disease activity (p = 0.001; β = 0.38), pain (p = 0.001; β = 0.38) and disability (p = 0.007; β = 0.32). Adjusted on BMI, LDL cholesterol, triglyceride, cumulative dose of corticosteroid, disease and corticosteroid duration, menopause duration, dose and duration of methotrexate, we found a significant association between LFM, disability (p = 0.02; β = 0.51), disease activity (p = 0.02; β = 0.54) and pain (p = 0.009; β = 0.57). However, we had no association between disease activity, pain, and disability with BFM and the other components.Conclusion:Limbs fat mass was significantly associated with the activity, disability, and pain in RA patients.References:[1]Kyeong Min Son, Seong Hun Kang, Young Il Seo, Hyun Ah Kim. Association of body composition with disease activity and disability in rheumatoid arthritis. Korean J Intern Med. 2021 Jan;36(1):214-222.Disclosure of Interests:None declared

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