scholarly journals Effect of a nanocomposite containing ostrich eggshell on calvarium healing in the rabbit: a pathologic study

2020 ◽  
Vol 70 (4) ◽  
pp. 1757
Author(s):  
H ALEMI ◽  
A. ASGHARI ◽  
G. ABEDI ◽  
A. AKBARZADEH ◽  
P. MORTAZAVI
Keyword(s):  
Filling Defect ◽  
Control Group ◽  
Skull Defects ◽  
Post Surgery ◽  
Significant Difference ◽  
Tissue Specimens ◽  
Hematoxylin Eosin ◽  
Absorb Material ◽  
Determine Effect ◽  
Ostrich Eggshell

The aim of the current study was to determine effect of a nanocomposite containing ostrich eggshell (NCOE) on the calvarium healing in the rabbit. Fresh ostrich eggshell was ground (300-500 μm), treated in phosphate-containing solutions and sterilized by gamma irradiation. Fifteen New Zealand white adult male rabbits were used. Four full-thickness skull defects were created in the calvarium. The first defect kept unfilled (control). The second defect was filled with autograft bone. The third defect was filled using NCOE. The fourth defect was filled with mixture of the autograft+NCOE bone. At 30, 60 and 90 days after surgery animals were euthanized and tissue specimens were collected and stained with hematoxylin eosin and trichrome staining method. Microsections were examined toassess the extent and intensity of inflammation, calvarium formation status and foreign body reaction. According to the results, filling defect significantly increased in NCOE-treated rabbits compared to the control group at 30 and 60 days post-surgery (P<0.05). There a statistically significant difference between experimental groups compared to the control group at 30 and 60 days post-surgery (P<0.05) while no statistically significant differences were observed among autograft, NCOE, autograft+NCOE (P>0.05). Also, absorb material significantly decreased in NCOE and autograft+NCOE groups compared to the control group at 60 days post-surgery (P<0.05). The filling defect significantly increased in autograft, NCOE and NCOE+autograft groups compared to the control group at 90 days post-surgery (P<0.05). There was no significant difference on inflammation and absorb material among the groups at 90 days post-surgery (P>0.05). These results suggested NCOE+autograft has improved the rate of calvarium healing in rabbits.

scholarly journals PENGARUH GELATIN IKAN PATIN (PANGASIUS DJAMBAL) TERHADAP JUMLAH FIBROBLAS PADA LUKA PASCA PENCABUTAN GIGI TIKUS PUTIH (RATTUS NORVEGICUS)

2019 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Fredy Mardiyantoro ◽  
Fidya Fidya ◽  
Dena Savira Andriani
Keyword(s):  
Rattus Norvegicus ◽  
Tooth Extraction ◽  
Control Group ◽  
Fish Gelatin ◽  
Tukey Test ◽  
White Rats ◽  
Significant Difference ◽  
Post Hoc ◽  
Hematoxylin Eosin ◽  
Test Result

Background: Gelatin has been used as a hemostatic agent to stop bleeding and it can be absorbed by human body within 6 hours. The patin fish (Pangasius djambal) gelatin has a high amount of amino acid, especially glutamine which has an important role in increasing the proliferation of fibroblast in wounds. The purpose of this study was to determine the effect of patin fish gelatin to the number of fibroblast in wound after tooth extraction.Method: Rat’s tooth extraction is done on the lower left incisive tooth. Thirty white rats were divided into two groups randomly with 3 time series. Control group was the rats without given of patin fish gelatin and treatment group was the rats given 1cc of patin fish gelatin with pipette. Socket taken for histologically processed by Hematoxylin Eosin staining.Result: It showed there were significant differences in the number of fibroblasts between groups. The Post Hoc Tukey test result showed there was a significant difference between the control group and the treatment group.Conclusion: Patin fish gelatin has effect increasing the number of fibroblast inwound after white rat’s (Rattus norvegicus) tooth extraction

scholarly journals The effects of intra-articular tranexamic acid given intraoperatively and intravenous tranexamic acid given preoperatively on post surgical bleeding and transfusion rate post total knee arthroplasty

2017 ◽  
Vol 25 (4) ◽  
pp. 234-9 ◽  
Author(s):  
Aryo N. Triyudanto ◽  
Andri M.T. Lubis
Keyword(s):  
Blood Transfusion ◽  
Tranexamic Acid ◽  
Postoperative Bleeding ◽  
Control Group ◽  
Transfusion Rate ◽  
Intraoperative Bleeding ◽  
Post Surgery ◽  
Drain Removal ◽  
Significant Difference ◽  
Total Knee

Background: Despite the advances in the design and fixation of implants in total knee replacement (TKR). the amount of postoperative bleeding is still an important issue that has not been resolved. This study aimed to measure the effectiveness of various tranexamic acid administration. Methods: This was a randomized controlled trial study, held from August 2014 to February 2016 at Cipto Mangunkusumo Hospital, Jakarta. Twenty two patients having TKR were divided into three groups: the control group, the tranexamic acid intra-articular-intraoperative group, and the intravenous preoperative group. Intraoperative bleeding, haemoglobin (Hb) level on preoperative to five-day-post-surgery, total drain production, total blood tranfusion needed and the drain removal timing were recorded and compared. Numerical data were analyzed by using parametric and non-parametric test, depended on the normality of the data. Results: The amount of blood transfusion needed in both the intra-articular group (200±SD 100 mL) and the intravenous group (238±SD 53 mL) were significantly different compared to those in the control group (1,016±SD 308.2 mL) (p=0.001). Meanwhile, there was no significant difference between the amount of blood transfusion needed in the intra-articular group and the intravenous group. Total drain production in the intra-articular group (328±SD 193 mL) and intravenous group (391±SD 185 mL) was significantly different compared to the control group (652±SD 150 mL) (p=0.003). No significant difference between the levels of both preoperative and postoperative haemoglobin, the amount of intraoperative bleeding, and the duration of drain usage. Conclusion: Intravenous and intra-articular tranexamic acid effectively decreased transfusion volume and drain production in patients undergoing TKR.

scholarly journals Effects of Intra-vitreal Injection of Bevacizumab as an Adjunct during Phacoemulsification in Diabetic Maculopathy

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Ali Afzal Bodla ◽  
Syeda Minahil Kazmi ◽  
Noor Tariq ◽  
Ayema Moazzam ◽  
Muhammad Muneeb Aman
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Proliferative Diabetic Retinopathy ◽  
Macular Thickness ◽  
Control Group ◽  
Key Words Diabetes Mellitus ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Post Surgery ◽  
Significant Difference

Purpose:  To study the effects of Intra-vitreal injection of Bevacizumab as an adjunct during phacoemulsification in patients with diabetic retinopathy. Study Design:  Quasi experimental study. Methods:  Hundred diabetic patients who were scheduled to undergo phacoemulsification were included in the study. They were equally divided into two groups; Bevacizumab and control group. Complete ocular examination and macular thickness and volume were determined using an OPTOVUE-OCT machine. The patients in the Bevacizumab group were given intra-vitreal injection of 1.25 mg/0.05ml of Bevacizumab at the time of Phacoemulsification. A written ethical approval was obtained and the study was conducted according to principles of declaration of Helsinki. Results:  The bevacizumab group manifested low value of CMT one month post-surgery as compared to the control group (262.2 ± 32.2 and 288.5 ± 54.1, respectively) with P = 0.01. The Total Macular volume, and Best-corrected visual acuity in the two groups showed no significant difference one month after surgery. Amongst the patients who developed postsurgical macular edema, four patients did not possess a positive history for diabetic retinopathy and 3 of them had Non Proliferative Diabetic Retinopathy. We found no significant relationship between the post-surgical macula edema with the presence of mild Non Proliferative Diabetic Retinopathy. (Fisher's test, P = 0.321). Conclusion:  The ocular anti-VEGF therapy substantially reduces macular edema secondary to post-surgical inflammation in diabetic patients. It effectively reduces the central macular thickness although the results are not found to be statistically significant when compared with the control group. Key Words:  Diabetes mellitus; diabetic macular edema; diabetic retinopathy: Bevacizumab.

scholarly journals Acute and sub-acute changes in dynamic postural control following hip arthroscopy and post-operative rehabilitation.”

2021 ◽  
Author(s):  
Matthew D Freke ◽  
Matthew King ◽  
Kay M Crossley ◽  
Kevin J Sims ◽  
Adam Semciw
Keyword(s):  
Postural Control ◽  
Hip Arthroscopy ◽  
Balance Control ◽  
Dynamic Balance ◽  
Hip Pain ◽  
Control Group ◽  
Healthy Controls ◽  
Pain Group ◽  
Post Surgery ◽  
Significant Difference

Abstract Context: Hip pain is associated with impairments in postural control and balance. The Star Excursion Balance Test (SEBT) is a reliable and valid method to measure dynamic postural control. Objective: Examine changes to dynamic postural control following hip arthroscopy and subsequent rehabilitation from pre-surgery to three and six months post arthroscopy. Setting: Sixty-seven individuals (47 men) scheduled for hip arthroscopy to address chondrolabral pathology were matched with sixty-seven healthy controls. The hip pain group underwent post-operative rehabilitation including SEBT training. Main outcome measures: SEBT reach normalized to limb length was collected pre-surgery and at three and six months post surgery, and compared with healthy matched controls. Repeated measure analysis of variance (ANOVA) evaluated whether SEBT reach differed between the three time points and t-tests were used to evaluate between-limb and between-group differences. Results: Pre-surgical SEBT reach was significantly less than the control group in all directions (p&lt;0.001). At three months post surgery, SEBT reach significantly increased in the posterior-lateral (PL) (p&lt;0.001), anterior-lateral (AL) (p&lt;0.001) and posterior-medial (PM) (p=0.006) directions from pre-surgery. At six months post surgery, all directions of reach had significantly increased (p&lt;0.001) from baseline. Compared to the control group, AL (−2.5 %, p=0.038), anterior medial (AM) (−2.9%, p=0.019) and posterior-medial (PM) (−5.2%, p= 0.002) reach remained significantly less at six months post surgery. No significant difference existed between the control and surgical groups for reach in the PL (−3.6%, p=0.061) direction. Conclusions: Pre-surgical dynamic balance control within a hip pain group was significantly poorer than matched controls as measured by the SEBT. At three months post hip arthroscopy, there were significant improvements in dynamic balance in the PM, PL and AL SEBT directions. By six months post surgery, all directions of SEBT reach had significantly improved but only PL reach improved to the level of healthy controls.

scholarly journals The Role of Chewing Gum on Post-operative Bowel Recovery after Gynecological Laparoscopic Surgery: A Short Report and Updated Review

2021 ◽  
Vol 9 (B) ◽  
pp. 1123-1127
Author(s):  
Nicko Pisceski Kusika ◽  
Imelda E. B. Hutagaol ◽  
Muhammad Yusuf ◽  
Suyanto Suyanto ◽  
Shinta Puja Tilusari
Keyword(s):  
Laparoscopic Surgery ◽  
Literature Review ◽  
Oral Feeding ◽  
Chewing Gum ◽  
Control Group ◽  
Short Report ◽  
Post Surgery ◽  
Significant Difference ◽  
And Control

BACKGROUND: Adverse post-operative complication of gynecological laparoscopic surgery, post-operative ileus, could be reduced by mimicking early post-operative oral feeding; however, the role of chewing gum is still lack evidence. AIM: This study was conducted to assess chewing gum’s role in post-operative bowel recovery after gynecological laparoscopic surgery. METHODS: This prospective clinical trial recruited 60 participants who had undergone gynecological laparoscopic surgery under general anesthesia. The study was conducted at Arifin Achmad Hospital, Riau Province, Indonesia, from January to April 2021. The patients were equally divided into two groups: Intervention (n = 30) and control (n = 30). They were asked to chew sugar-free gum every 2 h after the surgery (i.e. 5 times within 10 h post-surgery). Time of the first flatus and the first bowel sounds were recorded (i.e. 5 times of assessment within 10 h post-surgery). In addition, a literature review was conducted to add evidence of the role of chewing gum on postoperative bowel recovery after gynecological laparoscopic surgery. RESULTS: Patients from both groups had a close age range (23–44-year-old versus 21–42-year-old). Our data suggested a significant difference in the time of the first flatus between the treatment and control group (15.95 h vs. 45.05 h), p < 0.001. The length of stay in the hospital among those from the treatment group was also significantly shorter compared to controls (15.50 h vs. 45.50 h), p < 0.001. The literature review of four updated randomized clinical trials suggests chewing gum in the early onset of first flatus and bowel movement. CONCLUSION: Chewing gum following gynecological laparoscopic surgery could accelerate gastrointestinal recovery.

scholarly journals ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM

1970 ◽  
Vol 17 (2) ◽  
Author(s):  
Abu Surur ◽  
Suwandi Sugandi ◽  
Zulhardi Haroen ◽  
Bambang S Noegroho ◽  
Tjahdjojati Tjahjodjati ◽  
...  
Keyword(s):  
Vaginal Epithelium ◽  
Control Group ◽  
Epithelial Layer ◽  
Estrogen Replacement ◽  
Bilateral Ovariectomy ◽  
Significant Difference ◽  
Insignificant Difference ◽  
The Mean ◽  
Estrogen Effect ◽  
Hematoxylin Eosin

Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A pair T-test was use for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in wistar’s vagina. The mean thickness of epithelial layer in vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared to control group (p>0,05), while the first group showed insignificant difference compared to the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect.

scholarly journals Comparing the Endoscopic Sub Ureteral Injection of Lyophilized/Micronized Decellular Prepuce with Urodex: Histological Findings

2021 ◽  
Vol 7 (3) ◽  
Keyword(s):  
Normal Tissue ◽  
Sem Analysis ◽  
Bulking Agent ◽  
Histological Evaluation ◽  
Control Group ◽  
Post Surgery ◽  
Immunohistochemistry Staining ◽  
Significant Difference ◽  
Acellular Tissue

Objectives: In the present study, a new engineered bulking agent called lyophilized micronized prepuce was examined as a natural scaffold to compare its safety and efficacy with the Urodex®. Methods: For an in vivo study, 12 rabbits were divided into two groups. In the first group (n = 6), 0.2 cc of lyophilized and micronized prepuce, and in the second group, 0.2 cc of Urodex® was injected into the seromuscular wall of the bladder. The biopsy was provided from all animals for histological evaluation in 3 and 6 months’ post-surgery and for each timeline 12 animals were assigned. The biopsies were stained with H&E and trichrome Masson. IHC staining was also performed with anti-LCA+, anti-CD34+, and anti-CD68+ antibodies. Resluts: Microscopic examination of acellular prepuce compared with normal tissue demonstrated the success of this process, and ECM and collagen fibers were preserved with no evidence of cellular remnants in the acellular tissue, Immunohistochemistry staining with CD68 and LCA revealed a higher inflammation grade in Urodex as compared with Prepuce. However, no significant difference was detected in CD34 staining between Prepuce and Urodex experimental groups SEM analysis detected the micronized particle size varying between 2-5 µm. MTT assay revealed that cell proliferation was similar in the presence of control group and acellular prepuce. Conclusion: The results of this study disclosed that lyophilized and micronized prepuce could be an operative alternative to Urodex® as a natural and non-synthetic bulking agent in the treatment of children with vesicoureteral reflux (VUR).

scholarly journals Pengaruh Penggunaan Modul Berbasis Research pada Pembelajaran Think Pair Share dan Group Investigation terhadap Pemahaman Konsep dan Kemampuan Metakognisi Peserta Didik Kelas X SMA Negeri 1 Boyolali Tahun Ajaran 2013/2014

2015 ◽  
Vol 8 (1) ◽  
pp. 60
Author(s):  
ARIEF RIDHO WICAKSONO ◽  
Sri Widoretno ◽  
Nurmiyati Nurmiyati
Keyword(s):  
Sampling Method ◽  
Choice Test ◽  
Control Group ◽  
Control Group Design ◽  
10Th Grade ◽  
Significant Difference ◽  
Research Population ◽  
Academic Year ◽  
Cluster Random Sampling ◽  
Determine Effect

<p class="5abstrak">The purpose of the research to determine effect of the use of Module-Based Research on Learning Model  of Think Pair Share and Group Investigation to Understanding of Concept and Metacognition Ability of 10th Grade Students at SMA Negeri 1 Boyolali 2013/2014 Academic Year. This research was quasi experiment research which use Pretest-postest Nonequivalent control group design. The research population was all students of 10th Grade at SMA Negeri 1 Boyolali 2013/2014 Academic Year. The sample is taken by using Cluster Random Sampling method, in order to obtain 4 class  experimental and 1 control class with the same capabilities. Experimental class is a class with treatment of different learning, namely TPS + module-based research, GI + module-based research, TPS, GI, and one class as a control. Data was collected using a multiple-choice test, test description, and observation sheets. Hypothesis testing using Anacova test. The research concluded that there are significant differences to understanding concept of  students as a result of the use Think Pair Share and Group Investigation with module-based research. Results for metacognition abilities showed no significant difference from the treatment that used, namely TPS + module-based research, GI + module-based research, TPS, GI towards metacognitive abilities of of 10th Grade Students at SMA Negeri 1 Boyolali 2013/2014 Academic Year.</p>

scholarly journals VBAC or not VBAC? Improvement of performance and outcome indexes with the promotion of care safety

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
G Nasi ◽  
S Parrocchia ◽  
A M Mastromatteo ◽  
A Triggiani ◽  
B A Miraglia ◽  
...  
Keyword(s):  
Quality Management System ◽  
Post Partum ◽  
Good Clinical Practice ◽  
Structured Interview ◽  
Control Group ◽  
Continuous Training ◽  
Post Surgery ◽  
Performance Indexes ◽  
Significant Difference ◽  
And Performance

Abstract Background In a multidisciplinary approach to Quality Management System and humanization of care, we aimed at evaluating the characteristics that influence the request of women to carry out Vaginal Birth after Cesarean (VBAC). Methods Skills have been improved, with the use of tests on dummies and case by case assessments. For the psychological-motivational study we have adopted: Informed consent, Semi-structured interview and Big Five Questionnaire. The women were recruited by both Gemelli and Cristo Re Hospital: the women following the counseling decided to undergo a second Caesarean Section (CS) (41, control group) and women who decided to complete a VBAC (22, experimental group). Results The analysis of the data shows that the women of the VBAC group are in the average between 31-35 years (57%), 80% has an education = or &gt; at the 3rd level and the choice of the VBAC was conditioned by the partner (64%). The women of the control group are in average &gt; 35 years (51%), 60% have a higher average education and the influence on the choice is oriented by the gynecologist/obstetrician (64%). From the personality test a statistically significant difference emerges between the dimensions Energy and Mental Opening. Past experience influences the choice of the next birth: women who are inclined to a second CS considered the previous CS as a positive event (66%) while only 36% in the VBAC group; 64% of this was the recovery of the painful post-surgery and a certain type of difficulty in the care of the child, in breastfeeding, of having suffered from post-partum mood alterations, which is why they chose to undertake a Trial of Labor After Cesarean. Conclusions The deeper knowledge of women as well as the preparation and safety of the same operators has shown that it is possible to perform a greater number of VBACs, with the sharing, participation and satisfaction of women and the entire team, leading to an improvement in outcomes and performance indexes. Key messages The promotion of care safety also improves the performance indexes through continuous training to the operators and the study of psychological aspects that lead to the choice to carry out a VBAC. Good Clinical Practice shown that it is possible to perform a greater number of VBACs, with the sharing, participation and satisfaction of women and the entire team.

scholarly journals The effect of lead acetate administration to the uterine malondialdehyde level and endometrial thickness in albino rats (Rattus novergicus)

2018 ◽  
Vol 27 (3) ◽  
pp. 150-4 ◽  
Author(s):  
Novita S.E. Diantini ◽  
Setyawati Soeharto ◽  
I W.A. Wiyasa
Keyword(s):  
Lead Acetate ◽  
Endometrial Thickness ◽  
Control Group ◽  
Albino Rats ◽  
Treatment Groups ◽  
Significant Difference ◽  
Female Wistar Rats ◽  
High Level ◽  
The Brain ◽  
Hematoxylin Eosin

Background: Indonesian seawater has been found to contain a high level of lead acetate and tends to become toxic. The previous study suggested lead acetate exposure could be harmful to many organs including the brain, liver, heart, as well as the reproductive system. This study aimed to analyze the effect of lead acetate on both the uterine level of malondialdehyde (MDA) level and endometrial thickness in female Wistar rats (Rattus norvegicus).Methods: Twenty-four rats were divided into 4 groups: 1 control group, and 3 treatment groups that were given lead acetate at 30, 100, and 300 ppm p.o./day for 30 days, consecutively. Rats were sacrificed; the uterus was isolated and processed for both MDA level measurements (using TBARS and a spectrophotometer) and histopathology using hematoxylin-eosin (HE) staining.Results: There was no significant difference in mean MDA level between the control and lead acetate administration groups. There was a reduction in endometrial thickness from 352.6±81.88 µm in the control group to 323.5±90.67 µm; 313.6±40.30 µm; 303.4±62.75 µm in 30, 100, and 300 ppm, respectively. Consequently, spacious uterus was observed reflects the endometrial damage, including the decrease in the size of the epithelium, columnar, stroma, and lumen in the whole part of the uterus and these differences in uterine thickening was considered statistically significant (p=0.005).Conclusion: Lead acetate could reduce the thickness of the endometrium but had no effect on the level of MDA in the uterus.

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