scholarly journals Obesity and Bone

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1111
Author(s):  
Joseph Proietto

Obesity and osteoporosis are both common conditions with high rates of morbidity and mortality. There is a relationship between obesity and bone. There are multiple factors that influence the risk of fracture, including the quality of bone, the risk of falls, and the padding around the bone. These multiple factors partly explain the finding that obesity protects against fractures in some sites while increasing the risk in other parts of the body. While it is well known that increased weight builds bone, there are several mechanisms related to the obese state that make the bone more fragile. These include the increased production of bone marrow fat cells at the expense of bone-forming osteoblasts, an increase in inflammatory cytokines leading to the activation of bone-resorbing osteoclasts, mutations in the FTO gene, and obesity-induced increased osteoblast senescence. Surprisingly, the relationship between bone and obesity is not unidirectional; there is now evidence that osteocytes are able to regulate body weight by acting as weighing machines.

2021 ◽  
Vol 22 (24) ◽  
pp. 13662
Author(s):  
Giuseppe Rinonapoli ◽  
Valerio Pace ◽  
Carmelinda Ruggiero ◽  
Paolo Ceccarini ◽  
Michele Bisaccia ◽  
...  

There is a large literature on the relationship between obesity and bone. What we can conclude from this review is that the increase in body weight causes an increase in BMD, both for a mechanical effect and for the greater amount of estrogens present in the adipose tissue. Nevertheless, despite an apparent strengthening of the bone witnessed by the increased BMD, the risk of fracture is higher. The greater risk of fracture in the obese subject is due to various factors, which are carefully analyzed by the Authors. These factors can be divided into metabolic factors and increased risk of falls. Fractures have an atypical distribution in the obese, with a lower incidence of typical osteoporotic fractures, such as those of hip, spine and wrist, and an increase in fractures of the ankle, upper leg, and humerus. In children, the distribution is different, but it is not the same in obese and normal-weight children. Specifically, the fractures of the lower limb are much more frequent in obese children. Sarcopenic obesity plays an important role. The authors also review the available literature regarding the effects of high-fat diet, weight loss and bariatric surgery.


2014 ◽  
Vol 5 ◽  
Author(s):  
Torbjörn Hjort ◽  
Alexandru Panican

Due to increased market orientation and deregulation, welfare services in Sweden have taken on the form of market-based services. The body of research on deregulation and privatization is quite substantial regarding the implications of this kind of development. However, studies of the actual process of how choices are made are less common. This article discusses the implications of greater freedom of choice for Swedish citizens in diverse socioeconomic situations, focusing on factors that limit opportunities for choice. Deregulation and the increasing number of alternatives affect the relationship between the citizen and the welfare state in several ways. The Swedish school system is used here as an example of an empirical field. The analytical focus of the article consists of two different kinds of restrictions on choice: structure-based and agency-based. One conclusion is that both affluent and underprivileged citizens have limited choices. Another conclusion is that social citizenship, when freedom of choice is stimulated, can reproduce and even increase social and ethnic segregation. An additional potential consequence is that, when we consider social rights in their tangible form, the development of greater freedom of choice is focused increasingly on the consumer’s range of choices and less on the quality of the service offered.


2021 ◽  
Vol 5 (2) ◽  
pp. 8
Author(s):  
Riris Andriati ◽  
Fenita Purnama Sari Indah ◽  
Aisyah Aisyah

Compliance with hemodialysis therapy is one of the important things to note, if the patient is not compliant, it can cause a buildup of harmful substances in the body and if left unchecked, it can lead to death. The purpose of this study was to determine the relationship between adherence to undergo hemodialysis therapy with the quality of life of patients with chronic renal failure in the Hemodialysis Unit of the Jakarta Hajj Hospital. This research method is a quantitative study using primary data (questionnaires) and using cross-sectional research. Data collected by using questionnaires. The number of samples were 54 people who were in the hajodialysis unit at the Jakarta Hajj Hospital for the past three months. The results of the study of 54 respondents who have moderate compliance there are 11 people (20.4%), and good compliance a number of 43 people (79.%), in general patients obedient. While from the aspect of quality of life, there were 6 respondents (11.1%) who experienced less quality of life, 35 people had a moderate quality of life (75.%) and 13 people (24.1%) had a good quality of life, in general the quality of life of patients was moderate. After analyzing the relationship between adherence to undergo hemodialysis with quality of life using the Chi Square test p value = 0.468˃0.05, meaning that Ho is accepted, so it can be concluded that there is no relationship between adherence to hemodialysis with the quality of life of patients at Jakarta Hajj Hospital .ABSTRAKKepatuhan menjalani terapi hemodialisa merupakan salah satu hal yang penting untuk diperhatikan, jika pasien tidak patuh dapat menyebabkan terjadinya penumpukan zat-zat berbahaya dalam tubuh dan apabila hal tersebut dibiarkan maka dapat mengakibatkan kematian. Tujuan penelitian untuk mengetahui hubungan antara kepatuhan menjalani terapi hemodialisa dengan kualitas hidup pasien gagal ginjal kronik di Unit Hemodialisa RS Haji Jakarta. Metode penelitian ini merupakan penelitian kuantitatif dengan menggunakan data primer (kuisioner) dan memakai metode penelitian cross-sectional. Data yang dikumpulkan dengan cara menggunakan kuisioner. Jumlah sampel  sebanyak 54 orang yang berada di unit hemodialisa Rumah Sakit haji Jakarta selama tiga bulan terakhir. Hasil penelitian dari 54 responden yang memiliki kepatuhan sedang terdapat 11 orang (20.4 %), dan kepatuhan baik sejumlah 43 orang (79.6 %), secara umum pasien patuh. Sementara dari aspek kualitas hidup diperoleh  responden  yang  mengalami  kualitas  hidup  kurang sejumlah 6 orang (11.1%), kualitas hidup sedang sejumlah 35 orang (75.%)  dan  kualitas  hidup  baik  13 orang  (24.1%), secara umum kualitas hidup pasien sedang. Setelah dilakukan analisa hubungan antara kepatuhan menjalani hemodialisa dengan kualitas hidup dengan menggunakan uji Chi Square diperoleh p value = 0.468˃0.05,  artinya Ho diterima, sehingga dapat disimpulkan tidak ada hubungan antara kepatuhan menjalani hemodialisa dengan kualitas hidup pasien di Rumah Sakit Haji Jakarta.


2016 ◽  
Vol 07 (02) ◽  
pp. 232-237 ◽  
Author(s):  
Abdul Qayyum Rana ◽  
Mohamad Saleh

ABSTRACT Objective: To determine the relationship between resting tremor (RT) and action tremor (AT) in Parkinson’s disease (PD) patients. Methods: A retrospective study of RT and AT severity was conducted in 100 PD patients. The severity rating for each type of tremor in the upper extremities was assessed. The disparity in tremor severity between extremities for each tremor type was compared to that of the other two to identify commonalities in the laterality of the tremor manifestation. Results: Overall, RT is predictive of AT on the same side, but not the opposing side of the body. Patients with less intense resting right upper limb (RRU) tremor and moderately intense RRU tremor were significantly more likely to have an action right upper limb (ARU) tremor (−1.53, P = 0.020; −1.88, P = 0.005, respectively). Similarly, patients with less intense resting left upper limb (RLU) tremor and moderately intense RLU tremors were significantly more likely to have an action left upper limb (ALU) tremor (−3.49, P = 0.000; −1.86, P = 0.017, respectively). In addition, RRU and ALU tremors were associated with an increase in RLU and ARU tremors, respectively. Conclusion: Tremors are common findings in PD patients, and often impair quality of life. By identifying and classifying the relationship between resting and ATs in PD patients, our study sheds light onto the importance of better understanding and future management of this debilitating symptomology.


2019 ◽  
Vol 1 (2) ◽  
pp. 48-52
Author(s):  
Selamat Ginting ◽  
Adi Arianto

Health is a prosperous state of the body, soul, and social which is very possible for every individual to live productively in a social and economic way. Tests of research are to identify the relationship between the quality of health services to the level of satisfaction of BPJS Mandiri in Public Health Center Deli Tua Kab Deli Serdang. The research method uses an analytical survey type with a sample of 95 people. The results of the study are that there is a significant relationship between Tangible, reliability, responsiveness, assurance, empathy for the satisfaction of BPJS Mandiri in Public Health Center Deli Tua Kab Deli Serdang wit p-value(0.00). The conclusion in this study is that the most dominant factors affecting patient satisfaction are direct evidence of this indicated by the highest Exp (B) of 6,374


2015 ◽  
Vol 8 (7) ◽  
pp. 110 ◽  
Author(s):  
Somaye Ansari Moghadam ◽  
Zohre Abdollahi ◽  
Sirous Risbaf Fakour ◽  
Alireza Ansari Moghaddam ◽  
Farin Kiany ◽  
...  

<p><strong>BACKGROUND:</strong> Periodontal diseases, such as periodontitis, are considered the main cause of tooth loss in the elderly.The present study is aimed to determine the relationship between periodontal condition and quality of life. Quality of life consists of a range of people’s objective needs related to the self-perception of well-being.</p><p><strong>METHODS:</strong> This study was done from January 2014 to June 2015 in a healthcare clinic in Zahedan, southeast Iran. Using the random sampling method, the researchers enrolled 700 individuals over 35 years of age. The participants initially completed a demographic questionnaire consisting of data, such as age, sex, educational level, and smoking habit. Then, the periodontal chart was completed. Moreover, patients, based on the number of their natural teeth, were divided into two groups (≥10 teeth in both maxillary and mandible arches and &lt;10 teeth in at least one arch). The body mass index (BMI) was also measured.To assess the participants’ general health, the WHO’s quality of life questionnaire (WHOQOL-BREF) was used.</p><p><strong>RESULTS: </strong>Of the 700 enrolled individuals, 53.3% were womenand 47.7% were men. Moreover, most of the participants (63.71%) had BMI of less than 25 and 68% did not smoke.We found that as the people’s periodontal status deteriorated, their quality of life also declined and the total mean score in all four health domains decreased (P&lt;0.001)<strong>.</strong>Moreover, people with more than 10 teeth in both arches scored higher with respect to life quality than those with less than 10 teeth in at least one arch (P&lt;0.001).</p><p><strong>CONCLUSION: </strong>This studyindicates a decrease in the general quality of life in patients with periodontal disease.The authors suggest performing studies with larger sample sizes andcohort studies for more reliable results.</p>


1984 ◽  
Vol 62 (3) ◽  
pp. 381-385 ◽  
Author(s):  
W. Bruce McGillivray

Much of the variance in feeding rates of nestlings by adult House Sparrows (Passer domesticus) at Calgary, Alberta appears to be due to individual variation in the quality of the parents. Males contribute less to nestling feeding than do males at other localities. The body size and sexual size dimorphism of House Sparrows has been shown to increase with increasing latitude in North America. Hence, sparrows at Calgary are larger than average and there is a suggestion that the relative contribution by the sexes is related to male size and concomitant energetic limitations. The relationship between weight and body size is strong in the fall for both male and female House Sparrows but is poor during the breeding season. Adult females, but not males, increase their nestling feeding rate in inclement weather.


2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Li-Ming Chen ◽  
Chun-Hui Bao ◽  
Yu Wu ◽  
Shi-Hua Liang ◽  
Di Wang ◽  
...  

AbstractInflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a higher incidence of depression than the general population. Depression also adversely affects the quality of life and disease prognosis of patients with IBD. The tryptophan-kynurenine metabolic pathway degrades more than 90% of tryptophan (TRP) throughout the body, with indoleamine 2,3-dioxygenase (IDO), the key metabolic enzyme, being activated in the inflammatory environment. A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression. In this review, the relationship between depression in IBD and the tryptophan-kynurenine metabolic pathway is overviewed in the light of recent publications.


2021 ◽  
Vol 8 ◽  
Author(s):  
Pan Liu ◽  
Yun Li ◽  
Lina Ma

Frailty is an age-related clinical syndrome that may increase the risk of falls, disability, hospitalization, and death in older adults. Delaying the progression of frailty helps improve the quality of life in older adults. Caloric restriction (CR) may extend lifespan and reduce the risk of age-related diseases. However, few studies have explored the relationship between CR and frailty. In this review, we focused on the impact of CR on frailty and aimed to identify potential associated mechanisms. Although CR may help prevent frailty, further studies are required to determine the underlying mechanisms and specific CR regimens suitable for use in humans.


2020 ◽  
pp. 115-132
Author(s):  
Patrícia Vieira BONFIM ◽  
Luciana Esmeralda OSTETTO

With the body, the individual suspects the world, affects and is affected by it, builds relationships, signifies and expresses existence. What do the bodies of babies and adults say about each other? Based mainly on Wallonian Psychology and Lebretonian Anthropology, this article presents partial results of a doctoral research that aims to analyze narratives about/with the body woven in the interactions between teachers and babies. The data, resulting from the observation of a group of babies with their teachers, were generated through written and photographic records, focusing on different moments of the routine, later appreciated and discussed in meetings with the teachers. For the analysis presented here, relational movements composed by the gestures produced between babies and teachers were observed in the environment outside the reference room. It was preliminarily noted that the quality of the relationship established between them was fundamental to activate the discovery of the body, in the experimentation of space, textures, shapes and flavors.


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