scholarly journals Patient delay impact on breast cancer survival at Khartoum Referral Hospital: a retrospective study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 862
Author(s):  
Amanda Elgoraish ◽  
Ahmed Alnory
Keyword(s):  
Breast Cancer ◽  
Demographic Data ◽  
Patient Delay ◽  
Diagnosis And Treatment ◽  
P Value ◽  
Fisher Exact Test ◽  
Advanced Stage ◽  
Breast Cancer Patients ◽  
Survival Times ◽  
Cross Sectional

Background: Breast cancer can be invasive and advanced at diagnosis causing enormous suffering and premature death. Delay to stage diagnosis and treatment is related to survival evaluation and several factors determine delay. The aim of the study was to examine predictor covariates associated with breast cancer delay and its impact on patient prognosis and survival. Methods: This retrospective cross-sectional hospital-based study was carried out at Khartoum Oncology Hospital. Participants were 411 breast cancer patients diagnosed and treated during the period 2016. Patients’ pathological and socio-demographic data were extracted from their medical files and delay data from telephone questionnaire survey and survival times calculated from follow-up. Fisher exact test, Cox and Logistic regression models were used to examine relationships between demographic, clinical and delay variables and survival outcome. Results: The mean age of the study subjects was 50.07 years old and the majority were ≥45 years. Cancer delay analysis showed that there were different reasons for different types of delay but the majority of participants (86.2%) claimed fear of the disease and treatment and lack of information were real drivers of delay. The study confirmed the majority of participants expressed  long delay estimated at 28.3 weeks and patient delay had a significant association with the advanced stage (P-value<0.05). The hazard ratio was four times for risk of dying from cancer for long delay compared to the short one. Conclusion: The results of the study suggest delays at diagnosis and treatment are more common steps leading to advanced stage at diagnosis and poor survival. Early detection of the disease provides tremendous opportunities for early diagnosis, effective treatment and high chances of survival.

scholarly journals Memory and Spatial Cognition in Breast Cancer Patients Undergoing Adjuvant Endocrine Therapy

Breast Care ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 240-246 ◽  
Author(s):  
Ute Berndt ◽  
Bernd Leplow ◽  
Robby Schoenfeld ◽  
Tilmann Lantzsch ◽  
Regina Grosse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spatial Cognition ◽  
Verbal Memory ◽  
Multiple Testing ◽  
Local Therapy ◽  
Protective Role ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Switch Group

Introduction: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. Methods: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI (‘SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21). Duration of the 2 endocrine monotherapy arms prior to the assessment ranged from 1 to 3 years. The ‘SWITCH group' received 2-3 years TAM followed by at least 1 year and at most 3 years of AI. Memory and spatial cognition were investigated as planned comparisons. Investigations of processing speed, attention, executive function, visuoconstruction and self-perception of memory were exploratory. Results: With regard to general memory, AI patients performed significantly worse than the LT group (p = 0.013). Significant differences in verbal memory did not remain significant after p-value correction for multiple testing. We found no significant differences concerning spatial cognition between the groups. Conclusion: AI treatment alone significantly impairs general memory compared to the LT group.

scholarly journals Fatigue dan status nutrisi pada pasien dengan kanker payudara yang menjalani kemoterapi

2020 ◽  
Vol 13 (4) ◽  
pp. 278-283
Author(s):  
Sapti Ayubbana ◽  
Sari Narulita
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Nursing Intervention ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy

Fatigue and nutritional status in patients with breast cancer undergoing chemotherapyBackground: Breast cancer is one type of cancer and is one of the leading causes of death in the world. Cancer patients who receive chemotherapy are at risk of impaired nutritional status due to the disease and its treatment. Chemotherapy treatment can have side effects on the gastrointestinal system such as nausea, vomiting, stomatitis, anorexia, changes in taste. These side effects can cause the patient's nutritional intake to decrease. Cancer and its treatment can cause fatigue complaints.Purpose: to identify the relationship between fatigue and nutritional status in patients with breast cancer patients undergoing chemotherapyMethods: The design of this study was quantitative using a cross sectional approach. The population in this study were patients with breast cancer undergoing chemotherapy. This research was conducted at Dr.H. Abdul Moeloek Hospital of Lampung Province with 42 respondents.Results: Spearman correlation test results found that nutritional status variables have a significant relationship with fatigue (p value = 0.031) with moderate correlation strength (r = 0.471).Conclusion: The nursing intervention on the side effects of chemotherapy treatment which has a positive effect on nutritional conditions in an effort to overcome nutritional disorders and complaints of fatigue in cancer patients.Keywords: Breast Cancer; Chemotherapy; Fatigue; Nutritional StatusPendahuluan: Kanker payudara merupakan salah satu jenis kanker dan menjadi salah satu penyebab kematian di dunia. Pasien kanker yang menerima kemoterapi memiliki resiko gangguan status nutrisi akibat penyakit dan pengobatannya. Pengobatan kemoterapi dapat memberikan efek samping terhadap sistem ganstrointestinal seperti mual, muntah, stomatitis, anoreksia, perubahan rasa. Efek samping tersebut dapat menyebabkan asupan nutrisi pasien dapat mengalami penurunan. Kanker dan pengobatannya dapat menyebabkan keluhan fatigue.Tujuan: Mengetahui adanya hubungan antara status nutrisi terhadap fatigue pada pasien kanker payudara yang menjalani kemoterapi.Metode: Desain penelitian ini adalah kuantitatif dengan menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah pasien dengan kanker payudara yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Dr.H. Abdul Moeloek Provinsi Lampung dengan 42 responden.Hasil: Pada uji korelasi spearman didapatkan bahwa variabel status nutrisi mempunyai hubungan yang bermakna dengan fatigue ( p value = 0,031) dengan kekuatan korelasi sedang (r = 0,471).Simpulan: Kesimpulan diperlukan intervensi keperawatan terhadap efek samping pengobatan kemoterapi yang berdapak terhadap kondisi nutrisi dalam upaya mengatasigangguan nutrisi dan keluhan fatigue pada pasien kanker 

scholarly journals Hubungan Dukungan Keluarga dengan Self Esteem pada Pasien Kanker Payudara di Poliklinik Bedah Onkologi RSUP Sanglah Denpasar

2020 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Ni luh Putu Mahayani ◽  
Ni Komang Sukraandini ◽  
Ni Wayan Suniyadewi
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Surgical Oncology ◽  
Self Esteem ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

AbstractBreast cancer sufferers have a tendency to experience a decrease of self esteem that make  patients shall showing symptoms such as blaming themself for what they experienced. One way to increase self esteem in cancer patients is by increasing family participation through family support. The aim of this study is to determine the relationship between family support and self esteem in breast cancer patients. This study was using cross sectional design. The study was taken place at the Surgical Oncology Polyclinic, found samples of 188 respondents which was selected with a purposive sampling technique.The results showed that the majority of respondents were in the category of moderate self-esteem were 98 respondents (52.1%) and the category of moderate family support were 96 respondents (51.1%). The Rank Spearmen test results shows p value 0,000 (p <ɑ), means there is a relationship between self-esteem and family support in breast cancer patients with r value of 0.566 (positive relationship). It is expected that the family will always support the patient in every process of treatment, whether in the form of physical, psychological or financial support that could increase the patient's self esteem

scholarly journals LDL-c as a predictor of hormonal status and determining factor for therapy of breast cancer patients

2021 ◽  
Vol 2 (2) ◽  
pp. 023-031
Author(s):  
Reynard Budy Setiawan ◽  
Desak Gede Agung Suprabawati ◽  
Jusak Nugraha
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Density Lipoprotein ◽  
P Value ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Characteristic Analysis ◽  
Chi Square ◽  
Cross Sectional

Background: Immunohistochemical testing is important in determining clinical diagnosis and therapy, and is useful as a prognostic and predictive factor, but it is not easy to do and is not always available. Breast cancer patient with higher low-density-lipoprotein cholesterol [LDL-c]. level tends to have larger tumor size, higher grade, higher proliferation rate, positive Human Epidermal growth factor Receptor-2 (HER2-neu) and occasionally come at late stage. High LDL-c receptors are found on the surface of breast cancer cells, where cancer cells will take up cholesterol in serum, and a metabolite of 27-hydroxycholesterol cholesterol will affect Estrogen Receptor-α. Methods: Analytical observational study by cross sectional method, during July 2020 – November 2020, at Oncology Clinic Dr. Soetomo Hospital Surabaya with a total sample size of 42. The data obtained were analyzed using the SPSS version 23.0 program, regression test and Chi-Square were performed for characteristic analysis and Chi-Square Fischer’s Exact Test were performed for correlation test between lipid profiles with hormonal status. Results: The mean value of LDL-c was 117.88 ± 33.89 mg/dL. In the analysis of the correlation between LDL-c and hormonal status, it was found that the majority of patients who had positive hormonal status had LDL-c levels of ≤160 mg/dL with p value = 0.049. ROC analysis shown LDL-c cut-off point of 132 mg/dL, p value = 0.034 (OR 5.031, 95% CI 1.159-21.848), sensitivity 46.7% and specificity 83.35%. Conclusion: There is a statistically significant relationship between LDL-c levels and hormonal status with the cut-off point of 132 mg/dL. The increase in LDL-c in serum increases the tendency of negative hormonal status, therefore LDL-c levels can be considerate in determining the therapy for breast cancer patients.

scholarly journals ROLE OF MALONDIALDEHYDE (MDA) IN PATIENTS WITH BREAST CANCER DISEASES

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Eti Yerizel ◽  
Niki Astria ◽  
Daan Khambri
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Gene Mutations ◽  
Observational Research ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
The Many ◽  
Many Sources ◽  
And Control

Background: Breast cancer is one of the most common cancers as well as one of the leading causes of cancer mortality in women worldwide. Cancer risk potentially continues to increase because of the many sources of exposure to carcinogenic chemical compounds. Carcinogenic compounds can contribute to free radical formation which might further interact and damage biomolecules such as lipids. Lipid peroxidation will increase malondialdehyde (MDA) levels, triggering gene mutations that leads to cancer.  Objective: The purpose of this research was to measure and compare MDA levels between breast cancer patients and control.Methods: This research was observational research using a cross-sectional comparative design of 30 breast cancer patients and 30 healthy controls. The place of this research is in Ropanasuri specialized surgery hospital and biochemical laboratory,  Faculty of Medicine, Andalas University, Padang. This research was conducted from August to September 2019. The MDA was measured using a spectrophotometer and an independent T-test was done.Results: The result of this research showed the mean MDA level of breast cancer patients was 3.98 ± 0.35 nmol/ml, higher than controls was 3.04 ± 0.36 nmol/ml with p-value = 0.001.Conclusion: There were significant differences in MDA levels among breast cancer patients and control in Ropanasuri specialized surgery hospital, Padang. 

scholarly journals HUBUNGAN DUKUNGAN KELUARGA DENGAN KEJADIAN DEPRESI PADA PASIEN KANKER PAYUDARA DI RUMAH SAKIT UMUM DAERAH RADEN MATTAHER JAMBI

2019 ◽  
Vol 8 (2) ◽  
pp. 194
Author(s):  
Desti Herlianda Siregar ◽  
Nurfitriani Nurfitriani
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Single Cells ◽  
Demographic Data ◽  
Sampling Technique ◽  
Bivariate Analysis ◽  
Fisher Exact Test ◽  
Breast Cancer Patients ◽  
Family Supports

Cancer is a group of diseases caused by single cells that grow abnormally and uncontrollably.Cancer which is the number two cause of death in the world in 2012 was breast cancer (12.90%) after lung cancer (19.70%).In Indonesia, the incidence of breast cancer is highest in the province of Yogyakarta at 40 per 100.000 populations.Jambi province ranks 13th highest out of 34 provinces, with cancer incidence of 1.5 per 1000 population.From 2014 to 2017 there were 1,287 breast cancer patients and had received treatment. Raden Mattaher hospital Jambi is one of the places that served breast cancer treatment,in January to April 2018; there were 39 cases of breast cancer in poly surgery. This study aimed to determine the correlation between family supports with the incidence of depression in breast cancer patients at Raden Mattaher hospital Jambi. This is an analytic descriptive research with population were 39 breast cancer women, it used total sampling technique. This study was conducted at Raden Mattaher hospital Jambi toward 34 breast cancer patients. While 5 patients were respondents in the initial survey. The instruments used a demographic data questionnaire, family support, the incidence of depression; it used univariate and bivariate analysis (fisher exact test). The findings indicated that there is no significant correlation between family supports with the incidence of depression in breast cancer patients with p score were p=0.769. It is concluded that the correlation of good family support did not effect in patients to depression. It is suggested to the next research can study about the correlation of family support with the incidence of depression in breast cancer patients with different method such as qualitative.

Estrogen receptor-positive, progesterone receptor-negative tumors: Pathology and outcome correlations from a single-center cohort.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 160-160
Author(s):  
Oana Cristina Danciu ◽  
Jigisha P. Thakkar ◽  
Divyesh Mehta
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Recurrence Rate ◽  
Demographic Data ◽  
Outcome Data ◽  
High Recurrence Rate ◽  
P Value ◽  
Breast Cancer Patients ◽  
Pathology Data

160 Background: Estrogen receptor (ER) + progesterone receptor (PR) - tumors are a distinct subset of breast cancers characterized by aggressive behavior and tamoxifen resistance in spite of being ER+. We sought to describe the characteristics of the patients treated for this type of breast cancer at a large, urban, academic center, compare them with ER+PR+ patients and evaluate the outcomes achieved with the current modern treatments and establish the predictors of worse outcomes. Methods: All patients with the diagnosis of breast cancer who underwent a biopsy at our center between January 1st, 2005 and December 31st 2010 were included into a database. We compared ER+/PR- with ER+/PR+ patients. Demographic data, comorbidities, obstetric data, pathology data, type of treatment and outcome data were collected retrospectively through extensive electronic medical records review. The study was approved by the local IRB. Standard statistical methods were used and a p value <0.05 was considered significant. Results: We found 101 ER+/PR- and 150 ER+/PR+ breast cancer patients. Baseline characteristics, pathology data, treatment and outcomes are shown in the table. Within the ER+/PR- group the degree of Ki67 expression was directly associated with recurrence rate (p 0.0039). Conclusions: ER+/PR- breast cancer is an aggressive type with high recurrence rate and mortality, that affects mainly postmenopausal women. This subtype is associated more frequently with p53 and Ki67 overexpression, and the later levels appear useful in predicting recurrence in this subtype of breast cancer. Novel treament paradigms guided by molecular studies are currently being implemented. [Table: see text]

scholarly journals Neutrofil Darah Tepi pada Pasien Kanker Payudara Stadium Lanjut Sebelum dan Sesudah Dilakukan Tindakan

2019 ◽  
Vol 11 (1) ◽  
pp. 62
Author(s):  
Rizky Asri ◽  
Victor Pontoh ◽  
Marselus Merung
Keyword(s):  
Breast Cancer ◽  
Peripheral Blood ◽  
Advanced Stage ◽  
Blood Neutrophil ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Peripheral Blood Neutrophil ◽  
Stadium Iv ◽  
Significant Difference ◽  
Before And After

Abstract: Worldwide, there were around 2.1 million breast cancer cases diagnosed in 2018. There was nearly 1 of 4 cancer cases among women with an incidence of 38,1 per 100.000 and mortality of 14,1 per 100.000. This study was aimed to determine whether there was a change in response score of systemic inflammation by using peripheral blood neutrophil level in female patients with advanced stage of breast cancer before and after treatment. This was an interventional analytical study with a cross sectional design, conducted at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that there were 43 patients in the period of May 2018 to August 2018. The youngest age was 34 years and the oldest age was 70 years with a mean of 52.16 years (SD±10.002). The most frequent stage was III B (58.1%), followed by IIIC (25.6%), IIIA (11.6%), and IV (4.7%). Before treatment, the highest level of neutrophil was 55%, the lowest level was 12%, with a mean of 27.84% (SD±10.005). After treatment, the highest level of neutrophil was 45%, the lowest level was 11%, with a mean of 22.7% (SD±6.635). The paired-t test showed a very significant difference in peripheral blood neutrophil level between before and after treatment (P<0.001). Conclusion: There was a significant decrease of peripheral blood neutrophil level in breast cancer patients after treatment.Keywords: plasma neutrophil, advanced stage of breast cancerAbstrak: Di seluruh dunia, terdapat sekitar 2,1 juta kasus kanker payudara wanita yang didiagnosis pada tahun 2018, serta terhitung hampir 1 dari 4 kasus kanker di kalangan wanita dengan insidensi 38,1 per 100.000 dan kematian sebanyak 14,1 per 100.000. Penelitian ini bertujuan untuk untuk menilai adanya perubahan skor respons peradangan sistemik dengan menggunakan kadar neutrofil darah tepi pada pasien kanker payudara stadium lanjut sebelum dan setelah terapi. Jenis penelitian ialah intervensional analitik dengan desain potong lintang, yang dilakukan di RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian mendapatkan 43 pasien sejak Mei 2018 s/d Agustus 2018. Usia termuda 34 tahun dan usia tertua 70 tahun dengan rerata usia 52,16 tahun (SD±10,002). Stadium terbanyak ialah stadium IIIB (58,1%), diikuti stadium IIIC (25,6%), stadium IIIA (11,6%), dan stadium IV (4,7%). Sebelum dilakukan tindakan didapatkan kadar neutrofil tertinggi 55%, kadar terendah 12%, dan rerata 27,84% (SD±10,005). Setelah dilakukan tindakan didapatkan kadar neutrofil tertinggi 45%, terendah 11%, dan rerata 22,7% (SD±6,635). Hasil uji t berpasangan mendapatkan perbedaan yang sangat bermakna dari kadar neutrofil sebelum dan sesudah terapi (P<0,001). Simpulan: Terdapat penurunan bermakna dari kadar neutrofil darah tepi pada pasien kanker payudara setelah dilakukan tindakan.Kata kunci: neutrofil darah tepi, kanker payudara stadium lanjut

scholarly journals Hubungan Usia Dengan Estrogen Receptor Pada Penderita Kanker Payudara di RSUD Dr. Pirngadi Medan Tahun 2018

2020 ◽  
Vol 6 (1) ◽  
pp. 1-4
Author(s):  
Jumikha Tamara Sahmaulyana Sidauruk
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Cancer Patients ◽  
Test Method ◽  
Bivariate Analysis ◽  
P Value ◽  
Breast Cancer Patients ◽  
Research Subjects ◽  
Cross Sectional

Background: Breast cancer is a malignancy in breast tissue that can be originated from ductal epithelium and lobules. It is the main cause of death from cancer suffered by women in the world. Age and hormonal are important risk factors for breast cancer where the longer a person is exposed to estrogen, the higher is the risk for breast cancer. The estrogen receptor is one of the main prognostic and predictive factors examined in breast cancer and can be determinant for hormonal therapy. Objectives: This study aimed to discover the relation between age and estrogen receptor in breast cancer patients of RSUD Dr.Pirngadi Medan in 2018. Methods: This research was an analytical study with a cross-sectional design. The research sample was 96 breast cancer patients by medical records of RSUD Dr.Pirngadi Medan in 2018 collected by a consecutive sampling method. Analysis of the data in this study was done by univariate to describe the characteristics of research subjects, while bivariate analysis used the chi-square test method to analyze the relationship between age and estrogen receptor. Results: The patients with breast cancer in RSUD Dr.Pirngadi Medan 2018 was mostly >40 years old (79.2%), with negative estrogen receptor hormonal status (53%), status was married (99%), and the highest level of education was high school (54.2%). The results of the study showed that there was a relationship between age and estrogen receptor in breast cancer patients with p-value =0.007 (p value<0,05). Conclusion: There was a significant relationship between age and estrogen receptors and estrogen receptors in breast cancer patients in RSUD Dr.Pirngadi Medan 2018.

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