scholarly journals Memory and Spatial Cognition in Breast Cancer Patients Undergoing Adjuvant Endocrine Therapy

Breast Care ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 240-246 ◽  
Author(s):  
Ute Berndt ◽  
Bernd Leplow ◽  
Robby Schoenfeld ◽  
Tilmann Lantzsch ◽  
Regina Grosse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spatial Cognition ◽  
Verbal Memory ◽  
Multiple Testing ◽  
Local Therapy ◽  
Protective Role ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Switch Group

Introduction: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. Methods: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI (‘SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21). Duration of the 2 endocrine monotherapy arms prior to the assessment ranged from 1 to 3 years. The ‘SWITCH group' received 2-3 years TAM followed by at least 1 year and at most 3 years of AI. Memory and spatial cognition were investigated as planned comparisons. Investigations of processing speed, attention, executive function, visuoconstruction and self-perception of memory were exploratory. Results: With regard to general memory, AI patients performed significantly worse than the LT group (p = 0.013). Significant differences in verbal memory did not remain significant after p-value correction for multiple testing. We found no significant differences concerning spatial cognition between the groups. Conclusion: AI treatment alone significantly impairs general memory compared to the LT group.

scholarly journals Fatigue dan status nutrisi pada pasien dengan kanker payudara yang menjalani kemoterapi

2020 ◽  
Vol 13 (4) ◽  
pp. 278-283
Author(s):  
Sapti Ayubbana ◽  
Sari Narulita
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Nursing Intervention ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy

Fatigue and nutritional status in patients with breast cancer undergoing chemotherapyBackground: Breast cancer is one type of cancer and is one of the leading causes of death in the world. Cancer patients who receive chemotherapy are at risk of impaired nutritional status due to the disease and its treatment. Chemotherapy treatment can have side effects on the gastrointestinal system such as nausea, vomiting, stomatitis, anorexia, changes in taste. These side effects can cause the patient's nutritional intake to decrease. Cancer and its treatment can cause fatigue complaints.Purpose: to identify the relationship between fatigue and nutritional status in patients with breast cancer patients undergoing chemotherapyMethods: The design of this study was quantitative using a cross sectional approach. The population in this study were patients with breast cancer undergoing chemotherapy. This research was conducted at Dr.H. Abdul Moeloek Hospital of Lampung Province with 42 respondents.Results: Spearman correlation test results found that nutritional status variables have a significant relationship with fatigue (p value = 0.031) with moderate correlation strength (r = 0.471).Conclusion: The nursing intervention on the side effects of chemotherapy treatment which has a positive effect on nutritional conditions in an effort to overcome nutritional disorders and complaints of fatigue in cancer patients.Keywords: Breast Cancer; Chemotherapy; Fatigue; Nutritional StatusPendahuluan: Kanker payudara merupakan salah satu jenis kanker dan menjadi salah satu penyebab kematian di dunia. Pasien kanker yang menerima kemoterapi memiliki resiko gangguan status nutrisi akibat penyakit dan pengobatannya. Pengobatan kemoterapi dapat memberikan efek samping terhadap sistem ganstrointestinal seperti mual, muntah, stomatitis, anoreksia, perubahan rasa. Efek samping tersebut dapat menyebabkan asupan nutrisi pasien dapat mengalami penurunan. Kanker dan pengobatannya dapat menyebabkan keluhan fatigue.Tujuan: Mengetahui adanya hubungan antara status nutrisi terhadap fatigue pada pasien kanker payudara yang menjalani kemoterapi.Metode: Desain penelitian ini adalah kuantitatif dengan menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah pasien dengan kanker payudara yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Dr.H. Abdul Moeloek Provinsi Lampung dengan 42 responden.Hasil: Pada uji korelasi spearman didapatkan bahwa variabel status nutrisi mempunyai hubungan yang bermakna dengan fatigue ( p value = 0,031) dengan kekuatan korelasi sedang (r = 0,471).Simpulan: Kesimpulan diperlukan intervensi keperawatan terhadap efek samping pengobatan kemoterapi yang berdapak terhadap kondisi nutrisi dalam upaya mengatasigangguan nutrisi dan keluhan fatigue pada pasien kanker 

scholarly journals Breast Cancer Treatment and Cognitive Function: The Current State of Evidence, Underlying Mechanisms and Potential Treatments

2009 ◽  
Vol 5 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Andrea Vodermaier
Keyword(s):  
Breast Cancer ◽  
Cognitive Function ◽  
Cancer Patients ◽  
Verbal Memory ◽  
Menopausal Status ◽  
Future Research ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Confounding Variables ◽  
Wide Range

Within the last decade, several studies have investigated whether adjuvant treatment of breast cancer affects cognitive function. A number of prospective studies have demonstrated inconsistent results regarding whether chemotherapy affects cognitive function. Approximately half of the studies demonstrated subtle cognitive decline in a wide range of domains among some breast cancer patients following chemotherapy, and half did not. Concomitant changes in brain structure and function have been identified in neuroimaging and neurophysiologic studies. Estrogenic therapy has been specifically associated with deterioration in verbal memory and processing speed. However, evidence is mostly based on smaller studies with cross-sectional data. Breast cancer patients who underwent both chemotherapy and estrogenic therapy showed the most deterioration and the most persistant decline in cognitive function. Since cognitive impairment is subtle, if evident at all, discrepant findings are due to hormonal, physiological, psychological or temporal confounding variables and differences in study design. Neuropsychological training has been demonstrated to improve cognitive dysfunction experienced by breast cancer patients after chemotherapy. Future research may examine the unique impact of endocrine therapy on cognitive function with prospective, controlled trials, as well as the role of further confounding variables (e.g., menopausal status, cytokine deregulation, cortisol and concurrent medication).

scholarly journals Hubungan Dukungan Keluarga dengan Self Esteem pada Pasien Kanker Payudara di Poliklinik Bedah Onkologi RSUP Sanglah Denpasar

2020 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Ni luh Putu Mahayani ◽  
Ni Komang Sukraandini ◽  
Ni Wayan Suniyadewi
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Surgical Oncology ◽  
Self Esteem ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

AbstractBreast cancer sufferers have a tendency to experience a decrease of self esteem that make  patients shall showing symptoms such as blaming themself for what they experienced. One way to increase self esteem in cancer patients is by increasing family participation through family support. The aim of this study is to determine the relationship between family support and self esteem in breast cancer patients. This study was using cross sectional design. The study was taken place at the Surgical Oncology Polyclinic, found samples of 188 respondents which was selected with a purposive sampling technique.The results showed that the majority of respondents were in the category of moderate self-esteem were 98 respondents (52.1%) and the category of moderate family support were 96 respondents (51.1%). The Rank Spearmen test results shows p value 0,000 (p <ɑ), means there is a relationship between self-esteem and family support in breast cancer patients with r value of 0.566 (positive relationship). It is expected that the family will always support the patient in every process of treatment, whether in the form of physical, psychological or financial support that could increase the patient's self esteem

scholarly journals LDL-c as a predictor of hormonal status and determining factor for therapy of breast cancer patients

2021 ◽  
Vol 2 (2) ◽  
pp. 023-031
Author(s):  
Reynard Budy Setiawan ◽  
Desak Gede Agung Suprabawati ◽  
Jusak Nugraha
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Density Lipoprotein ◽  
P Value ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Characteristic Analysis ◽  
Chi Square ◽  
Cross Sectional

Background: Immunohistochemical testing is important in determining clinical diagnosis and therapy, and is useful as a prognostic and predictive factor, but it is not easy to do and is not always available. Breast cancer patient with higher low-density-lipoprotein cholesterol [LDL-c]. level tends to have larger tumor size, higher grade, higher proliferation rate, positive Human Epidermal growth factor Receptor-2 (HER2-neu) and occasionally come at late stage. High LDL-c receptors are found on the surface of breast cancer cells, where cancer cells will take up cholesterol in serum, and a metabolite of 27-hydroxycholesterol cholesterol will affect Estrogen Receptor-α. Methods: Analytical observational study by cross sectional method, during July 2020 – November 2020, at Oncology Clinic Dr. Soetomo Hospital Surabaya with a total sample size of 42. The data obtained were analyzed using the SPSS version 23.0 program, regression test and Chi-Square were performed for characteristic analysis and Chi-Square Fischer’s Exact Test were performed for correlation test between lipid profiles with hormonal status. Results: The mean value of LDL-c was 117.88 ± 33.89 mg/dL. In the analysis of the correlation between LDL-c and hormonal status, it was found that the majority of patients who had positive hormonal status had LDL-c levels of ≤160 mg/dL with p value = 0.049. ROC analysis shown LDL-c cut-off point of 132 mg/dL, p value = 0.034 (OR 5.031, 95% CI 1.159-21.848), sensitivity 46.7% and specificity 83.35%. Conclusion: There is a statistically significant relationship between LDL-c levels and hormonal status with the cut-off point of 132 mg/dL. The increase in LDL-c in serum increases the tendency of negative hormonal status, therefore LDL-c levels can be considerate in determining the therapy for breast cancer patients.

scholarly journals ROLE OF MALONDIALDEHYDE (MDA) IN PATIENTS WITH BREAST CANCER DISEASES

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Eti Yerizel ◽  
Niki Astria ◽  
Daan Khambri
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Gene Mutations ◽  
Observational Research ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
The Many ◽  
Many Sources ◽  
And Control

Background: Breast cancer is one of the most common cancers as well as one of the leading causes of cancer mortality in women worldwide. Cancer risk potentially continues to increase because of the many sources of exposure to carcinogenic chemical compounds. Carcinogenic compounds can contribute to free radical formation which might further interact and damage biomolecules such as lipids. Lipid peroxidation will increase malondialdehyde (MDA) levels, triggering gene mutations that leads to cancer.  Objective: The purpose of this research was to measure and compare MDA levels between breast cancer patients and control.Methods: This research was observational research using a cross-sectional comparative design of 30 breast cancer patients and 30 healthy controls. The place of this research is in Ropanasuri specialized surgery hospital and biochemical laboratory,  Faculty of Medicine, Andalas University, Padang. This research was conducted from August to September 2019. The MDA was measured using a spectrophotometer and an independent T-test was done.Results: The result of this research showed the mean MDA level of breast cancer patients was 3.98 ± 0.35 nmol/ml, higher than controls was 3.04 ± 0.36 nmol/ml with p-value = 0.001.Conclusion: There were significant differences in MDA levels among breast cancer patients and control in Ropanasuri specialized surgery hospital, Padang. 

scholarly journals Hubungan Usia Dengan Estrogen Receptor Pada Penderita Kanker Payudara di RSUD Dr. Pirngadi Medan Tahun 2018

2020 ◽  
Vol 6 (1) ◽  
pp. 1-4
Author(s):  
Jumikha Tamara Sahmaulyana Sidauruk
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Cancer Patients ◽  
Test Method ◽  
Bivariate Analysis ◽  
P Value ◽  
Breast Cancer Patients ◽  
Research Subjects ◽  
Cross Sectional

Background: Breast cancer is a malignancy in breast tissue that can be originated from ductal epithelium and lobules. It is the main cause of death from cancer suffered by women in the world. Age and hormonal are important risk factors for breast cancer where the longer a person is exposed to estrogen, the higher is the risk for breast cancer. The estrogen receptor is one of the main prognostic and predictive factors examined in breast cancer and can be determinant for hormonal therapy. Objectives: This study aimed to discover the relation between age and estrogen receptor in breast cancer patients of RSUD Dr.Pirngadi Medan in 2018. Methods: This research was an analytical study with a cross-sectional design. The research sample was 96 breast cancer patients by medical records of RSUD Dr.Pirngadi Medan in 2018 collected by a consecutive sampling method. Analysis of the data in this study was done by univariate to describe the characteristics of research subjects, while bivariate analysis used the chi-square test method to analyze the relationship between age and estrogen receptor. Results: The patients with breast cancer in RSUD Dr.Pirngadi Medan 2018 was mostly >40 years old (79.2%), with negative estrogen receptor hormonal status (53%), status was married (99%), and the highest level of education was high school (54.2%). The results of the study showed that there was a relationship between age and estrogen receptor in breast cancer patients with p-value =0.007 (p value<0,05). Conclusion: There was a significant relationship between age and estrogen receptors and estrogen receptors in breast cancer patients in RSUD Dr.Pirngadi Medan 2018.

scholarly journals Family Support and Quality of Life in Breast Cancer Patients

2020 ◽  
Vol 4 (3) ◽  
pp. 78-83
Author(s):  
Noorhidayah Noorhidayah ◽  
Hesti Prawita Widiastuti ◽  
Umi Kalsum
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Family Support ◽  
Cancer Patients ◽  
Total Sample ◽  
P Value ◽  
Life Questionnaire ◽  
Breast Cancer Patients ◽  
Cross Sectional

Introduction: In these days, one of the terrifying cancers for women throughout the world is breast cancer. The treatment of cancer should be holistic. Patients need family support to create a good quality of life. The purpose of this study was to determine the relationship between family support and quality of life in breast cancer patients at the Chemotherapy Unit of Abdul Wahab Sjahranie Hospital Samarinda. Methods: Quantitative research with analytical study and cross-sectional design. Sampling was done with a total sample of 76 respondents. The instruments used in this research were family support standards and the Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for quality of life. The data were analyzed using the Chi-Square test. Results: The p-value was 0.003, OR = 4.090, indicating that there was a relationship between family support and quality of life in breast cancer patients. Conclusion: There is a relationship between family support and quality of life in breast cancer patients. It is expected that the hospital can proceed in providing health education and motivation to breast cancer patients and their families related to the importance of family support for the quality of life of breast cancer patients. Keywords: family support; breast cancer; quality of life

scholarly journals Patient delay impact on breast cancer survival at Khartoum Referral Hospital: a retrospective study

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 862
Author(s):  
Amanda Elgoraish ◽  
Ahmed Alnory
Keyword(s):  
Breast Cancer ◽  
Demographic Data ◽  
Patient Delay ◽  
Diagnosis And Treatment ◽  
P Value ◽  
Fisher Exact Test ◽  
Advanced Stage ◽  
Breast Cancer Patients ◽  
Survival Times ◽  
Cross Sectional

Background: Breast cancer can be invasive and advanced at diagnosis causing enormous suffering and premature death. Delay to stage diagnosis and treatment is related to survival evaluation and several factors determine delay. The aim of the study was to examine predictor covariates associated with breast cancer delay and its impact on patient prognosis and survival. Methods: This retrospective cross-sectional hospital-based study was carried out at Khartoum Oncology Hospital. Participants were 411 breast cancer patients diagnosed and treated during the period 2016. Patients’ pathological and socio-demographic data were extracted from their medical files and delay data from telephone questionnaire survey and survival times calculated from follow-up. Fisher exact test, Cox and Logistic regression models were used to examine relationships between demographic, clinical and delay variables and survival outcome. Results: The mean age of the study subjects was 50.07 years old and the majority were ≥45 years. Cancer delay analysis showed that there were different reasons for different types of delay but the majority of participants (86.2%) claimed fear of the disease and treatment and lack of information were real drivers of delay. The study confirmed the majority of participants expressed  long delay estimated at 28.3 weeks and patient delay had a significant association with the advanced stage (P-value<0.05). The hazard ratio was four times for risk of dying from cancer for long delay compared to the short one. Conclusion: The results of the study suggest delays at diagnosis and treatment are more common steps leading to advanced stage at diagnosis and poor survival. Early detection of the disease provides tremendous opportunities for early diagnosis, effective treatment and high chances of survival.

scholarly journals High Prevalence of Mitochondrial tRNA A3243G Mutation in Invasive Breast Cancer

2021 ◽  
Vol 6 (2) ◽  
pp. 133-139
Author(s):  
Mohammed A. Alhomidi ◽  
Qurratullain Hasan
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Invasive Breast Cancer ◽  
Cellular Proliferation ◽  
Clinicopathological Parameters ◽  
P Value ◽  
Breast Cancer Patients ◽  
Mitochondrial Trna ◽  
Cross Sectional ◽  
A3243g Mutation

Background & Aim: Mitochondria play vital roles in various cellular activities, such as energy production, maintaining the redox balance of the cell, the regulation of cellular proliferation and differentiation, and programmed cell death. Mitochondrial tRNA mutations are associated with many pathological conditions and numerous diseases have been associated with them. Therefore, the objectives of this study were to evaluate the presence and the frequency of mutations in the selected tRNAs in breast cancer patients and to correlate these mutations with the clinicopathological characters. Materials & Methods: The is a cross sectional study, where seventy seven breast tumors and adjacent non-tumorous (normal) tissue samples were analyzed by PCR- RFLP, and direct DNA sequencing. In this study three mt-tRNAs wre selected, two of them are the most important disease associated mt-tRNAs i.e tRNALue (UUR), tRNALys and one of the least pathogenic associated tRNA which is tRNAarg. Statistical analysis was used to determine the relationship between the detected mutations and the clinicopathologhical characters. Results: The tRNAleu (UUR) A3243G mutation occurring at the highly conserved location was detected in 4 samples (5.2%) of both breast cancer and adjacent non-tumorous tissue except one detected only in tumor tissue. Another A8343G mutation was detected in tRNAlys. There was no significant association between these mutations and clinicopathological parameters (P. value > 0.05). Conclusion: The detection of high frequent A3243G mutations in patients with invasive breast cancer suggests role of this mutation in the carcinogenesis. This mutation affects complex I, reduces translation of its core subunits, which can contribute to the impairment of oxidative phosphorylation and increase ROS production, leading to cancer progression.

scholarly journals HUBUNGAN PENGETAHUAN DENGAN PERILAKU SADARI (PERIKSA PAYUDARA SENDIRI ) SEBAGAI TINDAKAN DETEKSI DINI KANKER PAYUDARA PADA SISWI KELAS X DI SMA NEGERI 3 KOTA PADANGSIDIMPUAN

2021 ◽  
Vol 6 (1) ◽  
pp. 8-13
Author(s):  
Nurhanifah Siregar
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Fast Food ◽  
Univariate Analysis ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Keywords Bse ◽  
Cross Sectional Design ◽  
Self Examination

ABSTRACT       Breast cancer is a type of malignant tumor that is still the number one killer. Indonesia at first breast cancer attacks women aged over 30 years, but now the age of breast cancer patients becomes young or teenagers. Breast cancer can be found as early as BSE. If you don't do BSE breast cancer will be detected at an advanced stage and ultimately cause death. Early detection can reduce mortality by 25-30%. Breast self-examination is very important to be recommended for the community or adolescents because almost 86% of lumps in the breast are found by patients themselves.This type of research is an analytical survey with cross sectional design, a sample of 45 people. The measuring instrument is a questionnaire with 22 questions developed by researchers. This study aims to determine the relationship between independent and dependent variables. The analysis used is univariate analysis to see the description of the characteristics of respondents and bivariate tests using Chisquare.The results showed that there was no relationship between knowledge and conscious behavior (P-value = 0.487, where P-value was 5 0.05). It was emphasized with the results of the study, there were 34 students with only 1 knowledgeable behavior. With that, good student knowledge will not necessarily understand good BSE behavior. It could be less knowledgeable but understand good BSE behavior.Based on the results of this study, suggestions for students to care more about their health, more often to check their own breasts after each menstrual period - 7 to 10 days from the first day of menstruation, reduce the habits of fast food patterns because it will accelerate the trigger of breast cancer.  Keywords: BSE Behavior, Early Detection of Breast Cancer

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