scholarly journals Cardiotoxic effect of bleomycin with a single administration in the experiment

2021 ◽  
Vol 11 (10) ◽  
pp. 242-251
Author(s):  
E. Bestanchuk ◽  
A. Gozhenko ◽  
O. Kashchenko ◽  
T. Narbutova ◽  
O. Berezovskyi ◽  
...  
Keyword(s):  
Single Injection ◽  
Statistical Processing ◽  
Myocardial Damage ◽  
Single Administration ◽  
Cardiotoxic Effect ◽  
Correlation And Regression Analysis ◽  
National Medical ◽  
Medical University ◽  
And Control ◽  
Experimental Group

The aim of the study was to evaluate the effect of a single injection of bleomycin on the heart Material and methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. The experimental model of the cardiotoxic effect of the bleomycin was performed using the medication "Bleocin" manufactured by Nippon Kayaku Co., Ltd. (Japan). According to the task, the study was performed on 10 mature rats of both sexes of the Wistar line with a body weight of 237 ± 20 g. Rats were housed in standard vivarium conditions of Odessa National Medical University. Animals were divided into 2 groups: experimental group (n = 5) and control (n = 5). Bleomycin animals of the experimental group were obtained intraperitoneally at a dose of 0.5 IU / kg once. Withdrawal of animals from the experiment was performed on the 5th day of the experiment, followed by morphological and morphometric examination. Statistical processing of the obtained data was performed by methods of variance, correlation and regression analysis using Statistica 14.0 software (TIBCO, USA) Results. Single administration os bleomycin causes changes in macroscopic parameters (myocardial weight, visual changes) are minimal. The main changes at the microscopic level are represented by contractural degeneration with segmental and / or partial-lateral lysis, ie there is not total but partial myocardial damage. Conclusion. A single injection of bleomycin can cause inflammatory-dystrophic changes of the myocardium.

scholarly journals Cumulative cardiotoxic effect of bleomycin in experiment

2021 ◽  
Vol 11 (6) ◽  
pp. 301-308
Author(s):  
A. Gozhenko ◽  
O. Bestanchuk ◽  
O. Kaschenko ◽  
T. Narbutova
Keyword(s):  
Toxic Effect ◽  
Tissue Concentration ◽  
Repeated Administration ◽  
Vascular Pathology ◽  
Experimental Conditions ◽  
Cardiotoxic Effect ◽  
National Medical ◽  
The Right ◽  
And Control ◽  
Experimental Group

The aim of the study was to evaluate the cumulative toxic effect of bleomycin under experimental conditions Material and Methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. The experimental model of the cardiotoxic effect of the bleomycin was performed using the medication "Bleocin" manufactured by Nippon Kayaku Co., Ltd. (Japan). According to the task, the study was performed on 10 mature rats of both sexes of the Wistar line with a body weight of 237 ± 20 g. Rats were housed in standard vivarium conditions of Odessa National Medical University. Animals were divided into 2 groups: experimental group (n = 5) and control (n = 5). Bleomycin animals of the experimental group were obtained intraperitoneally at a dose of 0.5 IU / kg on 1st and 8th days. Withdrawal of animals from the experiment was performed on the 5th, 14th and 28th day of the experiment, followed by morphological and morphometric examination. The material after weighing and morphometry was fixed with a neutral 10% formalin solution and poured into paraffin. Histological sections were stained with hematoxylin-eosin, MSB, Van Gizon. Performed light microscopy. After two weeks there was a decrease in myocardial weight by 7-10% from baseline, there were pronounced dystrophic changes in the myocardium. Repeated administration of bleomycin has a cumulative cardiotoxic effect leading to irreversible changes in the myocardium and endothelial dysfunction clinically manifested by heart attack, vascular pathology at significant cumulative doses of bleomycin. Morphofunctional changes of the right ventricle are prominent and considered to be pathognomic for bleomycin toxicity. Conclusions: 1. Bleomycin has a cumulative toxic effect on the myocardium of mammals 2. The severity of the cardiotoxic effect of bleomycin is proportional to the tissue concentration of the drug, which is proportional to the duration of exposure

scholarly journals The more we know, the more we forget…

2021 ◽  
pp. 101-107
Author(s):  
L. M. Sokurenko ◽  
Yu. B. Chaikovsky ◽  
O. E. Majewskyi ◽  
L. M. Yaremenko ◽  
N. V. Bidenko ◽  
...  
Keyword(s):  
Oral Cavity ◽  
General Result ◽  
Methodological Approach ◽  
Control Measures ◽  
Practical Skills ◽  
Professional Activities ◽  
National Medical ◽  
Direct Knowledge ◽  
Medical University ◽  
And Control

Summary. Students of dentistry faculties need a special methodological approach aimed at the acquisition of practical skills, but the study of fundamental disciplines is different from the dental-oriented ones. The aim of the study – to assess presumed deficits in the histology, cytology, and embryology knowledge of dentistry students at O. Bohomolets National Medical University, to identify the problems associated with it, and to address them. Materials and Methods. Testing of students of different courses of O. Bohomolets National Medical University using the standard licensed examination tests ‘‘Step 1 Dentistry’’. Results and Discussion. Students of the dentistry faculty have shown the level of students’ knowledge at 4th and 5th years – 33.5 %. The general result of the ‘‘Step 1 Dentistry’’ license exam in the same students is 66.6 % (2019) and 62.2 % (2018), respectively. The percentage of this result of the test higher when checked professional direct knowledge. We found that it was determined the prevalence of correct answers in the block on the topic "Oral Cavity" at the test on histology, cytology and embryology of  O. Bohomolets NMU Dentistry Faculty different courses students. Conclusions. In accordance with the obtained results and the analysis of the problems, it is recommended to make adjustments to the curricula and control measures with a focus on the competencies that will be applied in professional activities.

scholarly journals Influence of latent iron deficiency on cognitive abilities in students

2022 ◽  
Vol 12 (1) ◽  
pp. 117-124
Author(s):  
Ali Dani Sheikh ◽  
V. Babienko ◽  
E. Kobolev
Keyword(s):  
Iron Deficiency ◽  
Cognitive Abilities ◽  
Statistical Processing ◽  
Deficiency Anemia ◽  
National Medical ◽  
General Weakness ◽  
Latent Iron Deficiency ◽  
Medical University ◽  
The Impact ◽  
Screening Survey

The aim of the study is to assess the impact of latent iron deficiency on students' cognitive abilities. Material and methods. The study was conducted during 2018-2021 at the Department of Hygiene and Medical Ecology of Odessa National Medical University. A survey of 188 medical students aged 18-20 was conducted using a screening survey. Estimation of the qualitative content of iron compounds in the diet was performed by a calculation method using the USDA / FDA database. Persons with probable iron deficiency were examined for hemoglobin, erythrocytes, hematocrit (general clinical blood test) and serum ferritin. Additionally, the cognitive abilities of people with latent iron deficiency were assessed using MoSA, TMT, GPB, Schulte tables and TAS-20. As a control, 30 students aged 18-20 years who showed no signs of latent or overt iron deficiency were interviewed. Statistical processing was performed by methods of variance and correlation anamnesis using the software Statistica 13.0 (TIBCO, USA). Results. When evaluating diets, probable iron deficiency was identified in 69 (36.7%) students surveyed. A significant number of students reported signs of iron deficiency, namely general weakness (27 or 14.4%), increased fatigue (30 cases or 15.9%), pale skin and mucous membranes (6 or 3.2%), drowsiness (8 or 4.3%), dry mouth (11 or 5.9%), brittle hair (4 or 2.1%), bleeding gums (3 or 1.6%). In isolated cases, hyposmia, dysgeusia and dysphagia have occurred. Probable iron deficiency was found at the previous stage of the study in 29 (15.4%) patients, they subsequently underwent verifying laboratory tests. In the analysis of the obtained data, the diagnosis of mild iron deficiency anemia was confirmed in 2 (6.9%) girls. Latent iron deficiency was identified in 16 (55.2%) students, among whom girls predominated (10 people or 62.5%). Subsequent studies have shown that a significant number of students with latent iron deficiency showed moderate signs of decreased cognition. Conclusions: 1. The frequency of latent iron deficiency in the surveyed contingent was 8.5%, with an absolute predominance of girls (62.5%). 2. Latent iron deficiency in student youth can be manifested by cognitive impairment, and therefore affect academic performance. 3. The most pronounced correlation was found for ferritin content and severity of alexithymia (r = -0.61).

scholarly journals Package of menthol measures for thirst relief: a randomized clinical study

2019 ◽  
Vol 72 (3) ◽  
pp. 600-608 ◽  
Author(s):  
Viviane Moreira Serato ◽  
Lígia Fahl Fonseca ◽  
Marcela Maria Birolim ◽  
Edilaine Giovanini Rossetto ◽  
Lílian Denise Mai ◽  
...  
Keyword(s):  
Clinical Study ◽  
Oral Cavity ◽  
Recovery Room ◽  
Control Group ◽  
Single Administration ◽  
Randomized Clinical Study ◽  
Intervention Point ◽  
The Difference ◽  
And Control ◽  
Experimental Group

ABSTRACT Objective: To evaluate the effectiveness of the menthol package (lip hydration and ice popsicles) compared to a package of non-menthol measures (lip hydration and ice popsicles) as a way to relieve thirst in patients in the Anesthetic Recovery Room. Method: Randomized and parallel trial study, with 120 patients randomized patients in an experimental group - menthol measurements (n=59) and control group - measures without menthol (n = 61). Results: There was a significant (p<0.05) decrease in intensity, hydration, dryness and taste in the oral cavity between the three moments of assessment/intervention in the two groups. The difference was significant in the experimental group for thirst intensity at the second assessment/intervention point (p<0.05) after a single administration of the menthol package. Conclusion: There was a reduction in thirst intensity in both groups. Patients who received menthol packages showed a significant decrease in intensity after a single evaluation/intervention time. NCT: 02869139.

scholarly journals Optimization of methodology of education, self- education and level knowledge control of pharmacists-interns for «Krok 3. Pharmacy»

2019 ◽  
pp. 54-64
Author(s):  
Ya. O. Hrynkiv ◽  
I. Yu. Revyatskyy ◽  
O. M. Zaliska
Keyword(s):  
Pharmaceutical Analysis ◽  
Information Technologies ◽  
Statistical Processing ◽  
Educational Process ◽  
Test Results ◽  
National Medical ◽  
Pharmaceutical Technology ◽  
Anonymous Questionnaire ◽  
Drug Technology ◽  
Medical University

Since 2017 exam «Krok 3. Pharmacy» (pilot in 2017–2018) has been included to the system of licensed integrated exams for pharmacists-interns specialty «General Pharmacy». Which introduced some adjustments to the educational process at the postgraduate stage of education. The task was to review the existing methods of education, self-education and level knowledge control of pharmacists-interns to «Krok 3. Pharmacy» at the Department of organization and economics of pharmacy, drug technology and pharmacoeconomics FPE of Danylo Halytskyy Lviv National Medical University and determined possible directions for their optimization. The objects of the research were the processes of education, self-education and level knowledge control of pharmacists-interns for the exam «Krok 3. Pharmacy»; the results of conducted pre-tests pharmacists-interns for 2017–2019; the results of anonymous survey of students pharmacy faculty and pharmacists-interns on possible areas of optimization of the above processes. It was used methods of statistical processing of the results of an anonymous questionnaire the Google form and the results of pre-tests to «Krok 3. Pharmacy» for pharmacists-interns 2017–2019 learning years. It was found that a significant majority of pharmacists-interns begin preparation for «Krok 3. Pharmacy» 1–3 months before the date of exam. Questions on clinical pharmacy and pharmaceutical technology are easier, pharmaceutical analysis of drugs and special training are the most difficult. It was confirmed that, there is no a direct relationship between the complexity of studying questions and the pre-test results of subjects. 57% of respondents consider that pre-testing should be conducted only online; 25% – only on paper; 18% – by two methods: on paper and online. It was determined promising areas for further optimization preparation of the pharmacists-interns were determined on the basis of the obtained results: education period; formation of blocks of test tasks for the «MISA» system and paper by the quantity of questions and by subjects; use computer information technologies for self-education for «Krok 3. Pharmacy».

scholarly journals The analysis of influence factors on the quality of the organizing process of preparing for the exam «Krok. Pharmacy»

2020 ◽  
pp. 60-68
Author(s):  
Ya. O. Hrynkiv ◽  
I. Yu. Revyatskyy ◽  
O. M. Zaliska ◽  
D. V. Kaminskyy
Keyword(s):  
Influence Factors ◽  
Statistical Processing ◽  
Pharmaceutical Chemistry ◽  
Average Score ◽  
Positive Direction ◽  
Factors Affecting ◽  
National Medical ◽  
Intern Training ◽  
Level Of Knowledge ◽  
Medical University

Based on the results of the Licensed Integrated Exam (LIЕ), the level of knowledge of students and interns of higher educational institutions of medical direction is determined, a decision is made on the possibility of their further study and work, and a rating of medical universities is formed. Purpose: to determine, structure, analyze and evaluate factors affecting the process of preparing students and interns in the pharmaceutical field for LIE «Krok 2. Pharmacy» and «Krok 3. Pharmacy» (K2F and K3F); based on the data obtained, study the possibilities of optimizing the implementation of this process. Objects: results (general and by discipline) of the K2F licensed exam of 2016‒2019, the pilot (2017) and licensed (2019) K3F exam at the Danylo Halytskyy Lviv National Medical University. Methods: statistical processing of the results of LIE. Factors that affect the success of student/intern training are structured in three groups: individual (personalized), group (group training) and external. There is no interdependence between the results of LII K2F and the average score for training in the diploma supplement. It is established that there is a connection between the success of preparation for LIE K2F and belonging to the group. This leads to the assumption that the success of training may be partly influenced by the personality and method of teaching, the level of knowledge and demands on pairs of specific teachers, as well as the environment of a particular student (the influence of classmates). The analysis of deviations of the indicator of an estimation of a level of knowledge of students on separate educational disciplines has shown, approximately on 80%, a homogeneous tendency. The largest intervals of deviation of this indicator were observed for pharmaceutical chemistry and pharmacognosy, slightly smaller ‒ drug technology; the smallest ‒ for the organization of the economics of pharmacy, management and marketing in pharmacy, clinical pharmacy. According to the results of the analysis of the indicator of assessment of the level of knowledge it was established that its distribution both in the negative and in the positive direction in the main group was uniform (is at one level), but in others ‒ negative prevails 1.5 times. The value of the deviation of the indicator of assessment of the level of knowledge had a natural relation to the medial indicator.

The Effect of Applying POSSE (Predict- Organize-Search-Summarize-Evaluate) on the Students’ Reading Comprehension

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Eka Rejeki Maha ◽  
Berlin Sibarani
Keyword(s):  
Reading Comprehension ◽  
Experimental Design ◽  
Null Hypothesis ◽  
Alternative Hypothesis ◽  
Choice Test ◽  
Control Group ◽  
Multiple Choice Test ◽  
Level Of Significance ◽  
And Control ◽  
Experimental Group

This study was aimed at finding out The Effect of Applying POSSE (Predict-Organize-Search-Summarize-Evaluate) Strategy on the Students’ Reading Comprehension. This study used the experimental design. The population of this study was the students of SMA Negeri 2 Medan. There were sixty students taken as the sample of the research. This study was conducted with two randomized groups namely experimental and control group. The experimental group was taught by applying POSSE strategy while control group was taught without applying POSSE strategy. The instrument of collecting the data was multiple choice test which consists of 40 items. To obtain the reliability of the test, the researcher used Kuder-Richardson (KR-21). The calculation shows the reliability was 0.81(high). The data were analyzed by using t-test. The calculation shows that t-observed (4.76) is higher than t-table (2.00) at the level of significance (α) 0.05 with the degree of freedom (df) 58. Therefore, the null hypothesis (Ho) is rejected and alternative hypothesis (Ha) is accepted. It means that there was a significant effect of applying POSSE strategy on the students’ reading comprehension. Keywords: POSSE Strategy, Reading Comprehension.

The Effect of Applying Learning Together Method on the Students’ Reading Comprehension

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Haryato Siregar ◽  
Elia Masa Ginting
Keyword(s):  
Reading Comprehension ◽  
Alternative Hypothesis ◽  
Choice Test ◽  
Control Group ◽  
Teaching Reading ◽  
Multiple Choice Test ◽  
Level Of Significance ◽  
And Control ◽  
Experimental Group ◽  
Learning Together

This study was aimed at finding out the effect of applying Learning Together Method on the students’ reading comprehension. This study used the experimental design. The population of this study was the students of SMP Negeri 1 Muara. There were sixty students of eighth class as the sample of the research. This study was conducted with two randomized groups namely experimental and control group. The experimental group was taught by applying Learning Together Method while control group was taught without applying Learning Together Method. The instrument of collecting the data was multiple choice test which consists of 20 items. To obtain the reliability of the test, the researcher used Kuder-Richardson (KR-21) formula. The calculation shows the reliability was 0.82(high). The data were analyzed by using t-test. The calculation shows that t-observed (4.9) is higher than t-table (2.00) at the level of significance (α) 0.05 with the degree of freedom (df) 58. Therefore, the null hypothesis (Ho) is rejected and alternative hypothesis (Ha) is accepted. It means that teaching reading comprehension by applying Learning Together Method significantly affect reading comprehension. Keywords: Learning Together Method, Reading Comprehension

THE EFFECT OF APPLYING ANIMAL CARTOON PICTURES ON STUDENTS’ ACHIEVEMENT IN WRITING NARRATIVE TEXT

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Hasanul Arifin Zul And Masitowarni Siregar
Keyword(s):  
T Test ◽  
Narrative Text ◽  
Control Group ◽  
First Year ◽  
Writing Achievement ◽  
Control Groups ◽  
Post Test ◽  
Written Test ◽  
And Control ◽  
Experimental Group

This thesis is focused on the investigation of the effect of applying animal cartoon pictures on students’ achievement in writing narrative text. This study aims to find whether applying animal cartoon pictures significantly affect the students’ writing achievement or not. The data in this study were obtained by administering a written test. The population was the 2015/2016 first year (grade XI) of SMA Swasta Nusantara Lubuk Pakam and 66 students were taken as the sample by using random sampling. The sample was divided into two groups, experimental and control groups. The experimental group was taught by applying animal cartoon pictures while the control group without animal cartoon pictures (x = lecturing). The data were taken the scores from the pre-test and post-test to both experimental and control groups. These data were analyzed by using t-test. The result of computing the t-test obviously showed that t-observed is higher than t-table (5.21 >1,67) with the degree of freedom 64 (df =N-2) at the level significance 0,05 one tail test. It showed that the application of animal cartoon pictures significantly affected the students of SMA Swasta Nusantara Lubuk Pakam achievement in writing narrative text.

THE EFFECT OF PEER REVIEW STRATEGY ON THE STUDENTS’ ACHIEVEMENT IN WRITING DESCRIPTIVE PARAGRAPH

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Sri Agus Murniasih And I Wayan Dirgeyasa
Keyword(s):  
Peer Review ◽  
Experimental Research ◽  
Research Method ◽  
Alternative Hypothesis ◽  
Control Group ◽  
Post Test ◽  
Class Viii ◽  
And Control ◽  
Essay Test ◽  
Experimental Group

This study was conducted to know the effect of applying Peer Review Strategy on the students’ achievement in writing descriptive paragraph. It was conducted by using experimental research method. This research design was conducted pre-test, post test in experimental and control group. The population of this research was the eight (VIII) grade students of SMP IT IQRA’ Medan. The sample of this research was taken by lottery technique. They were in class VIII-1 by experimental group and the class VIII-2 by control group. The experimental group was taught by using Peer Review Strategy while the control group was given no treatment. The instrument used to collect the data was writing essay test. The data were analyzed by using t-test formula. The result showed that the value of t-observed was higher than the value of t-table. (3,55 > 2,05 (a = 0.05)) with the degree of freedom (df) = 28. It means that there was a significant effect of applying Peer Review Strategy on the students’ achievement in writing descriptive paragraph. So, the alternative hypothesis (Ha) was accepted.

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