scholarly journals Somatic status of adolescent girls with gynecological disorders born with low and excessive weight

2022 ◽  
Vol 12 (1) ◽  
pp. 34-42
Author(s):  
I. Tuchkina ◽  
N. Pylypenko ◽  
M. Tuchkina ◽  
O. Piontkovska ◽  
N. Romanova ◽  
...  
Keyword(s):  
Body Weight ◽  
Adolescent Girls ◽  
Large Body ◽  
Statistical Processing ◽  
Population Based ◽  
Excess Body Weight ◽  
Gynecological Disorders ◽  
Prophylactic Measures ◽  
Increased Risk ◽  
Starting Point

In modern conditions, health problems (somatic, reproductive, mental) of adolescent girls occupy a special place in the health care system, as a reserve in reducing maternal and infant mortality, maintaining the fertility of the expectant mother. The aim. To study the frequency and character of extragenital diseases of adolescent girls with gynecological pathology, born with low and excessive body weight. Materials and methods. The project design is a population-based prospective cohort study. To achieve the goal and the implementation of the tasks, a prospective examination of girls and adolescent girls born with deficiency or excess body weight was carried out. The sample size was 77 people. Additionally, statistical processing was carried out using the Excell software. Results. Thus, the study of somatic health indicates its deterioration in the groups of girls born with polar values ​​of body weight. In groups 1 and 3, infectious diseases were identified, which can serve as a starting point in the development of reproductive system disorders. In girls of group 1, mumps prevailed (20.0%), which could cause damage to the follicular apparatus, while in group 3, girls were more likely to have influenza (25.8%), the virus of which has a damaging effect not only on the structure of the ovaries, but also on endometrium. Conclusions. Comparative analysis of the structure of somatic morbidity made it possible to identify the most significant pathology characteristic of each of the groups. Girls born with a large body weight have an increased risk of endocrine pathology. In girls born with low body weight, somatic diseases associated with manifestations of diseases of the musculoskeletal system prevail. This dictates the need to single out girls born with polar values ​​of body weight in the risk group for the development of somatic pathology and requires complex therapeutic and prophylactic measures.

Multiple Myeloma and Infections: A Population-Based Study Based On 9,610 Multiple Myeloma Patients

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 945-945
Author(s):  
Cecilie Blimark ◽  
Ulf-Henrik Mellqvist ◽  
Ola Landgren ◽  
Magnus Björkholm ◽  
Malin L Hultcrantz ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Normal Population ◽  
Large Population ◽  
Population Based ◽  
First Year ◽  
Population Based Study ◽  
Prophylactic Measures ◽  
Increased Risk

Abstract Abstract 945 Background Infections are a major cause of morbidity and mortality in patients with multiple myeloma (MM). No large population-based evaluation has been made to assess the risk of infections in MM patients compared to the normal population. Therefore, we performed a large study, using population-based data from Sweden, to estimate the risk of bacterial and viral infections among 9,610 MM patients compared to 37,718 matched controls. Methods We gathered information on all MM patients reported to the nationwide Swedish Cancer Registry from 1988 to 2004, with follow-up to 2007. For each MM patient, four population-based controls (matched by age, sex, and county of residence) were identified randomly from the Swedish population database. Information on occurrence and date of infections was obtained from the centralized Swedish Patient registry that captures information on individual patient-based discharge diagnosis from inpatient (with very high coverage) and outpatient care (since 2000). Cox proportional hazard models were used to estimate the overall, one- and five-year risk of infections. In addition, the effect of gender, age and calendar period of diagnosis was evaluated. Hazard ratios (HRs) and confidence intervals (CIs) were calculated for the occurrence of different infections. Results Overall, MM patients had a 6-fold (HR= 5.9; 95% CI=5.7-6.1) risk of developing any infection compared to matched controls (Figure). The increased risk of developing a bacterial infection was 6-fold (HR=5.9; 95%; CI=5.6-6.1), and for viral infections 9-fold (HR=9.0; 95% CI=8.0-10.1), compared to controls. More specifically, MM patients had an increased risk (p<0.05) of the following bacterial infections: cellulitis (HR=2.6; 95% CI =2.2-3.1), osteomyelitis (HR=3.0; 95% CI 2.0–4.4), endocarditis (HR=4.4; 95% CI 2.9–6.6), meningitis (HR=14.5; 95% CI 9.1–23.0), pneumonia (HR=6.2; 95% CI 5.9–6.5), pyelonephritis (HR=2.5; 95% CI 2.1–3.0), and septicaemia (HR=13.7; 95% CI 12.5–14.9) and for the viral infections influenza (HR=5.4; 95% CI 4.4–6.7) and herpes zoster (HR=12.8; 95% CI 10.5–15.5). The risk of infections was highest during the first year after diagnosis; the risk of bacterial infections was 11-fold (95% CI 10.7–12.9) and the risk of viral infections was 18-fold (95% CI 13.5–24.4) higher compared to controls during the first year after diagnosis. MM patients diagnosed in the more recent calendar periods had significantly higher risk of infections, reflected in a 1.6-fold (95% CI=1.5-1.7) and 2-fold (95% CI=1.9-2.1) increased risk in patients diagnosed during 1994–1999 and 2000–2004, compared to patients diagnosed 1986–1993. Females had a significantly lower risk of infections compared to males (p<0.001). Increasing age was significantly associated with a higher risk of infections (p<0.001). Discussion In this large population-based study including over 9,000 MM patients and 35,000 matched controls, we found that bacterial and viral infections represent a major threat to myeloma patients. We found the risk of specific infections like pneumonia, and septicemia to be over ten times higher in patients than in controls during the first year after MM diagnosis. Importantly, the risk of infections increased in more recent years. The effect on infectious complications due to novel drugs in the treatment of MM needs to be established and trials on prophylactic measures are required. Disclosures: Mellqvist: Janssen, Celgene: Honoraria.

scholarly journals Особливості клінічних проявів ураження тканин пародонта у підлітків на тлі аліментарно-конституціонального ожиріння

2017 ◽  
Author(s):  
O. I. Lebid ◽  
K. M. Duda
Keyword(s):  
Body Weight ◽  
Statistical Processing ◽  
Pathological Process ◽  
The State ◽  
Index Score ◽  
The Body ◽  
Control Group ◽  
Excess Body Weight ◽  
Clinical Indicators ◽  
Periodontal Tissues

The article presents the results of clinical examination of periodontal tissues in adolescents against the background of alimentary-constitutional obesity.The aim of the study – to investigate the features of the course of diseases of the periodontal tissue according to clinical indices in persons with alimentary-constitutional obesity.Materials and Methods. As a result of the survey, 95 adolescents aged 16–18 years old were included to study the features of the course of infl ammatory diseases of periodontal tissues in adolescents with alimentary-constitutional obesity 76 adolescents and 19 adolescents with harmonious physical development. To clarify the diagnosis, «excessive body weight» was determined by weight and height of the patient, and measured the circumference of the waist and hips. In the future, the body mass index (BMI) was calculated as the ratio of body weight in kg to square of growth in m2. Diagnosis of excess body weight was confi rmed with BMI less than 30kg/m2. The evaluation of the condition of periodontal tissues was carried out according to subjective and objective criteria (clinical parameters, index score). For the verifi cation of the pathological process in the periodontium, the classifi cation of M. F. Danilevskyi (1994) was used. The state of periodontal tissues was described using a traditional index score. Statistical processing of the results was carried out using commonly used methods of variation statistics with a help of personal computer using a statistical software package «Statistica 8.0» («Statsoft», USA). The probability level was estimated at 95 % (p<0.05) using Student’s t criterion.Conclusions. Consequently, the clinical indicators of the state of periodontal tissues in the context of alimentaryconstitutional obesity (Fedorov-Volodkin’s index, Green-Vermillion index, Sillness-Loe index, CPITN index) signifi cantly deteriorate compared with the corresponding indicators in the control group of adolescents without AKO, indicating the effect of alimentary-constitutional obesity on the clinical course, the severity and severity of theinfl ammatory process and the feasibility of timely and effective pharmacotherapy.

scholarly journals Excess Body Weight, Snack Limits and Dental Caries in Brazilian Preschoolers: A Population-Based Study

2019 ◽  
Vol 19 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Gabriela Macedo Fraiz ◽  
Sandra Patrícia Crispim ◽  
Gisele Ristow Montes ◽  
Giovana Solheid Gil ◽  
Francine Sumie Morikava ◽  
...  
Keyword(s):  
Body Weight ◽  
Dental Caries ◽  
Population Based ◽  
Excess Body Weight ◽  
Population Based Study

scholarly journals Body Mass Index and Risk of Gastric Cancer in Asian Adults: A Meta-Epidemiological Meta-Analysis of Population-Based Cohort Studies

2020 ◽  
Vol 52 (2) ◽  
pp. 369-373 ◽  
Author(s):  
Jong-Myon Bae
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Body Weight ◽  
Cohort Studies ◽  
Body Mass ◽  
Meta Analysis ◽  
Population Based ◽  
Overweight And Obesity ◽  
Excess Body Weight ◽  
Inverse Association

PurposeA previous meta-analysis (MA) published in 2009 reported that excess body weight was associated with an increased risk of gastric cancer in non-Asians, but not in Asians. The aim was to conduct a meta-epidemiological MA (MEMA) to evaluate association between excess body weight and the risk of gastric cancer in Asian adults with using the proposed classification of weight by body mass index (BMI) in Asian adults.Materials and MethodsThe selection criteria were population-based prospective cohort studies that measured BMI of cohort participants and evaluated a risk of gastric cancer. Overweight group (OW) and obesity group (OB) were defined as 23.0-24.9 and ≥ 25.0, respectively. A group only showing results for BMI over 23.0 was defined as overweight and obesity group (OWB). Random effect model was applied if I<sup>2</sup> value was over 50%.ResultsAfter four new studies were added through citation discovery tools, seven cohort studies with 21 datasets were selected finally for MEMA. The I<sup>2</sup> value of OW, OB, and OWB were 76.1%, 83.5%, and 97.1%, respectively. Only OWB in men had a I<sup>2</sup> value below 50% (22.5%) and showed a statistical significance with inverse association (summary relative risk, 0.79; 95% confidence interval, 0.77 to 0.81).ConclusionThis MEMA supported the hypothesis that OW might be a protective factor in gastric cancer risk in Asian adults. It will be necessary to conduct additional cohort studies with lengthening follow-up periods and re-analyzing the effect of overweight and obesity classified by the Asian criteria.

Excess body weight association with various cancer: A United States population-based study 2021.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e18558-e18558
Author(s):  
Akram Alkrekshi ◽  
Raul Arroyo Suarez ◽  
Ahmad Nader Kassem
Keyword(s):  
United States ◽  
Body Weight ◽  
Strong Association ◽  
The United States ◽  
Population Based ◽  
Normal Weight ◽  
P Value ◽  
Excess Body Weight ◽  
Multiple Cancer ◽  
Multiple Myelomas

e18558 Background: Excess body weight (EW) is a rising healthcare issue affecting over two-thirds of the United States (US) population, and it is a risk factor for various cancer. Methods: We used Explorys, IBM, a US database that includes ̃ 73 million patients. We evaluated non-gastrointestinal cancers prevalence based on age (18-64 and ≥ 65 years; for female cancers 18-49 and ≥ 50 years), race; Caucasians (C) and African-Americans (AA), and weight; normal weight (N) with BMI 18.5- 24.9 kg/m2 and EW for BMI ≥ 25 kg/m2. Compared to NW, the odds ratio (OR) and 95% confidence interval (CI) for multiple cancer rates in the EW group were calculated. p-value of <0.001 was considered significant (S) and > 0.001 as non-significant (NS). Results: A population of 26.9 million was included. C 85.6%, AA 14.4%. See table. Conclusions: A strong association between EW and urological cancers (prostate, bladder, renal), non-Hodgkin's lymphoma, multiple myelomas (MM), breast cancer, endometrial cancer, ovarian cancer in C 18-64 yrs but not in C ≥ 65 yrs with the exception for kidney cancer. A similar finding in AA 18-64 yrs for cancers of prostate, renal, breast, uterus, and MM compared to AA ≥ 65 yrs. EW is possibly more oncogenic earlier in life, especially in C.[Table: see text]

Excess Body Weight during Childhood and Adolescence Is Associated with the Risk of Multiple Sclerosis: A Meta-Analysis

2016 ◽  
Vol 47 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Zhen Liu ◽  
Ting-Ting Zhang ◽  
Jie Yu ◽  
Ying-Li Liu ◽  
Su-Fen Qi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Weight ◽  
Observational Studies ◽  
Overweight And Obesity ◽  
Excess Body Weight ◽  
Female Group ◽  
Childhood And Adolescence ◽  
Case Control Studies ◽  
Male Group ◽  
Increased Risk

Background and Aim: Several epidemiological studies have reported the association between obesity and multiple sclerosis (MS). Methods: A literature search of the observational studies, published as original articles in English before December 2015, was performed using electronic databases. Results: Five observational studies were included, of which 3 were case-control studies and 2 were cohort studies. The pooled relative risk (RR) for overweight and obesity during childhood and adolescence compared with normal weight (body mass index = 18.5-24.9 kg/m2) was 1.44 (95% CI 1.22-1.70) and 2.01 (95% CI 1.63-2.48), respectively. In subgroup analyses, we found that excess body weight during childhood and adolescence increased the risk of MS in the female group (overweight: pooled RR = 1.62, 95% CI 1.35-1.94; obesity: pooled RR = 2.25, 95% CI 1.77-2.85), but not in the male group (overweight: pooled RR = 1.19, 95% CI 0.91-1.55; obesity: pooled RR = 1.22, 95% CI 0.79-1.90). Conclusions: Excess body weight during childhood and adolescence was associated with an increased risk of MS; severe obesity demonstrated a stronger risk. A statistically significant association was found in the female group, but not in the male group.

scholarly journals Patterns of Infectious Morbidity in Patients with Waldenström’s Macroglobulinaemia/Lymphoplasmacytic Lymphoma: A Population-Based Study

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3350-3350
Author(s):  
Sigrun Helga Lund ◽  
Malin Hultcrantz ◽  
Lynn Goldin ◽  
Ola Landgren ◽  
Magnus Björkholm ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Viral Infections ◽  
Large Population ◽  
Population Based ◽  
Calendar Period ◽  
Lymphoplasmacytic Lymphoma ◽  
Population Based Study ◽  
Infectious Morbidity ◽  
Prophylactic Measures ◽  
Increased Risk

Abstract Background Infections are a major cause of morbidity and mortality in patients with hematologic malignancies. However, largely due to the rarity of Waldenström’s macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL), the literature on infectious morbidity is limited. Using population-based data from Sweden, we estimated the risk of bacterial and viral infections among 2,608 LPL/WM patients compared to 10,433 matched controls. Patients and Methods We identified all WM/LPL patients diagnosed 1980-2005 in the nationwide Swedish Cancer and Patient Registries, as well as a national network database including all major hematology/oncology centers; duplicate records were removed. Follow-up time was up to 2006. For each WM/LPL patient, four population-based controls (matched by age, sex, and county of residence) were identified randomly from the Swedish population database. Information on type of infection and date of infection was obtained from the Patient Registry which captures information on all individual patient-based discharge diagnosis from inpatient (since 1964) and outpatient care (since 2000). Through linkage to the nationwide Cause of Death Registry, we identified dates of death for WM/LPL patients and controls. Cox proportional hazard models were used to estimate the overall risk of infections. Models were adjusted for sex, age, and calendar period. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for individual infections. Results Overall, WM/LPL patients had a 3.4-fold (95% CI=3.1-3.6) elevated risk of developing any infection than controls (Figure). Compared to controls, the risk of developing bacterial and viral infections was 3.2-fold (95%; CI=2.9-3.5) and 6.0-fold (95% CI=4.9-7.3) higher, respectively. More specifically, WM/LPL patients had an increased risk (p<0.05) of the following types of bacterial infections: septicaemia (HR=9.3; 95% CI 3.7-23.5), endocarditis (HR=5.0; 95% CI 2.5-10.0), pneumonia (HR=3.8; 95% CI 3.4-4.2), meningitis (HR=3.4; 95% CI 1.1-10.3), cellulitis (HR=2.6; 95% CI 2.0-3.4), osteomyelitis (HR=1.9; 95% CI 1.01-3.6), and pyelonephritis (HR=1.6; 95% CI 1.2-2.4). Regarding viral infections, WM/LPL patients had an increased risk of herpes zoster (HR=9.2; 95% CI 6.7-12.6) and influenza (HR=2.3; 95% CI 1.5-3.5). The risk of infections was highest during the first year after diagnosis. Interestingly, WM/LPL patients diagnosed in the more recent calendar periods had significantly higher risk of infections (Figure). Compared to WM/LPL patients diagnosed in 1980-1989, patients diagnosed in 1990-1999 and 2000-2004 had a 1.5-fold (95% CI=1.3-1.6) and 1.8-fold (95% CI=1.6-2.1) increased risk of any infection, respectively. The same patterns were observed when bacterial infections were analyzed separately. In analysis focusing on viral infections; there was only a significant increased risk during the most recent calendar period (p=0.027). Females had a significantly lower risk of infections compared to males (p<0.001). Increasing age was significantly associated with a higher risk of infections (p<0.001). Discussion In this large population-based study including over 2,600 WM/LPL patients and 10,000 matched controls, we found that bacterial and viral infections represent a major threat to WM/LPL patients. This was particularly true during the first years following diagnosis. Importantly, the risk of infections increased in more recent years. The effects on infectious complications due to novel drugs in the treatment of WM/LPL need to be better defined and trials on prophylactic measures are needed. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Excess Body Weight and Long-Term Incidence of Lung and Colon Cancer in Men; Follow-Up Study of 43 Years

2021 ◽  
Vol 18 (19) ◽  
pp. 10418
Author(s):  
Yftach Gepner ◽  
Shahar Lev-ari ◽  
Uri Goldbourt
Keyword(s):  
Lung Cancer ◽  
Colon Cancer ◽  
Body Weight ◽  
Cancer Risk ◽  
Cox Proportional Hazards ◽  
Excess Body Weight ◽  
Follow Up Study ◽  
Increased Risk

Most evidence for an association between excess body weight and cancer risk has been derived from studies of relatively short duration with little reference to the effect on tumor site. This study was designed to evaluate the association between categories of body mass index (BMI: <20, 20–25, 25–30, and >30 kg/m2) and the incidence of colon and lung cancer over 43 years of follow-up (1963–2006), in 10,043 men from the Israeli Ischemic Heart Disease (IIHD) prospective cohort (mean age at baseline 49.3 years, mean BMI 25.7 kg/m2). Data from the Israel National Cancer Registry was linked with the IIHD, and the Cox proportional hazards regression model was applied to analyze the relative risks for lung and colon cancer across BMI categories at baseline. Three hundred cases of lung cancer (2.9%) and 328 cases of colon cancer (3.3%) were diagnosed in the total population. Applying a multivariate model adjusted for age, smoking intensity, and total cholesterol, higher BMI category was associated with an increased risk of colon cancer [HR = 1.22 (95% CI 1.02–1.45)], and with a decreased risk for lung cancer [HR = 0.66 (95% CI 0.56–0.77)]. In this long-term follow-up study over four decades, we observed a consistent dose-response pattern between BMI and increased risk for colon cancer, but decreased risk for lung cancer. Specific associations between excess body weight and cancer risk may suggest different patterns of body fat and cancer incidence at a given site.

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