J0203-2-1 Transvascular drug delivery to target tissue by the use of photomechanical waves

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System

Current Drug Delivery ◽

10.2174/1567201817666200717090623 ◽

2020 ◽

Vol 17 (10) ◽

pp. 911-924

Author(s):

Rohitas Deshmukh

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Targeted Drug Delivery ◽

Targeted Delivery ◽

Therapeutic Agent ◽

Therapeutic Agents ◽

Delivery Systems ◽

Target Tissue ◽

Polymer Carriers

Colon cancer is one of the most prevalent diseases, and traditional chemotherapy has not been proven beneficial in its treatment. It ranks second in terms of mortality due to all cancers for all ages. Lack of selectivity and poor biodistribution are the biggest challenges in developing potential therapeutic agents for the treatment of colon cancer. Nanoparticles hold enormous prospects as an effective drug delivery system. The delivery systems employing the use of polymers, such as chitosan and pectin as carrier molecules, ensure the maximum absorption of the drug, reduce unwanted side effects and also offer protection to the therapeutic agent from quick clearance or degradation, thus allowing an increased amount of the drug to reach the target tissue or cells. In this systematic review of published literature, the author aimed to assess the role of chitosan and pectin as polymer-carriers in colon targeted delivery of drugs in colon cancer therapy. This review summarizes the various studies employing the use of chitosan and pectin in colon targeted drug delivery systems.

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Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

New Journal of Chemistry ◽

10.1039/d0nj00939c ◽

2020 ◽

Vol 44 (20) ◽

pp. 8232-8240 ◽

Cited By ~ 1

Author(s):

Hasan Keshavarz ◽

Alireza Khavandi ◽

Somaye Alamolhoda ◽

M. Reza Naimi-Jamal

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Protein Corona ◽

Target Tissue ◽

Burst Effect

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

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Formulation and Characterization of Cefixime Phytosomes for Oral Drug Delivery

Asian Journal of Pharmaceutical Research and Development ◽

10.22270/ajprd.v7i5.559 ◽

1970 ◽

Vol 7 (5) ◽

pp. 65-73

Author(s):

Saloni Jain ◽

Rahul Ancheriya ◽

S Srivastva ◽

Shankar Lal Soni ◽

Mukesh Sharma

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Biological Activities ◽

Herbal Medicines ◽

Memory Loss ◽

Oral Drug ◽

Target Tissue ◽

Drug Bioavailability ◽

Age Related ◽

Health Promoting

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Over the last century, phyto-chemical science and phyto-pharmacological science established numerous plant compounds with various biological activities and health promoting benefits such as anti-mutagenicity, anti-carcinogenicity and anti-oxidative activity, for age-related diseases namely memory loss, osteoporosis, diabetic wounds, immune and liver disorders, etc. Herbal medicines have been known since eons for their safety, efficacy, folk acceptability and fewer side effects.

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Ophthalmic Drug Delivery Systems (Review)

Drug development & registration ◽

10.33380/2305-2066-2021-10-1-57-66 ◽

2021 ◽

Vol 10 (1) ◽

pp. 57-66

Author(s):

E. O. Bakhrushina ◽

M. N. Anurova ◽

N. B. Demina ◽

I. V. Lapik ◽

A. R. Turaeva ◽

...

Keyword(s):

Drug Delivery ◽

Drug Administration ◽

Dosage Forms ◽

Delivery Systems ◽

Eye Drops ◽

Target Tissue ◽

Advantages And Disadvantages ◽

Wide Range ◽

Ophthalmic Delivery ◽

Ophthalmic Diseases

Introduction. Effective delivery of ophthalmic drugs is challenging. The eye has a number of protective systems and physiological barriers, which is why ophthalmic dosage forms have a low bioavailability, usually not exceeding 5 %. Topical drug administration is relatively easy to use and is most commonly prescribed by physicians for the treatment of ophthalmic diseases, especially the anterior segment of the eye. However, when using traditional delivery systems, a number of problems arise: patients' violation of the drug administration technique, and, as a consequence, a decrease in treatment compliance, restriction of drug delivery to the target eye tissues due to low epithelial permeability and rapid clearance after drug administration. Maintaining a constant therapeutic drug level is another challenge that traditional delivery systems often fail to cope with.Text. The article discusses the types of ophthalmic delivery systems. Traditional ones are represented by such dosage forms as eye drops, ointments, gels. Modern ophthalmic dosage forms are represented by: eye films, contact lenses and eye implants. The characteristics, advantages and disadvantages of each type of delivery systems and their promising directions of development, as well as modern developments in this area are given.Conclusion. Currently, most of the scientific research on the development of ophthalmic delivery systems is devoted to obtaining dosage forms capable of maintaining a constant concentration of the drug in the target tissue, providing the transport of active ingredients to them. This is achieved by using modern advances in nanotechnology and polymer chemistry. Receive liquid and soft dosage forms with micro-, nano- and micro-nano-carriers. Polymeric delivery systems such as films, lenses and implants are being actively developed and studied. The development of modern technological approaches opens up new possibilities for the treatment of a wide range of ophthalmic diseases by reducing the side effects often induced by the intrinsic toxicity of molecules, reducing the frequency of the administered dose and maintaining the pharmacological profile of the drug. Thus, the use of modern ophthalmic delivery systems can significantly limit the use of invasive treatments.

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Hyperthermia, bladder pressure, and intravesical drug delivery.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.6_suppl.469 ◽

2021 ◽

Vol 39 (6_suppl) ◽

pp. 469-469

Author(s):

Dominic C. Grimberg ◽

Scott P. Campbell ◽

Wiguins Etienne ◽

Ping Fan ◽

Paolo F. Maccarini ◽

...

Keyword(s):

Drug Delivery ◽

Linear Regression ◽

Drug Concentration ◽

Dwell Time ◽

Bladder Wall ◽

Foley Catheter ◽

Bladder Pressure ◽

Bathing Solution ◽

Target Tissue ◽

Bladder Temperature

469 Background: Little is known about the pharmacokinetics of intravesical chemotherapies. Various parameters can be altered including temperature, dwell time, drug concentration, and bladder pressure. Here, we hypothesize that increasing bladder pressure during instillation will improve drug delivery. Methods: An ex-vivo porcine model was developed to evaluate determinants of drug penetration into the bladder wall. Porcine bladders were suspended in isotonic saline at 37°C with a three-way Foley catheter in the bladder. Temperature probes were positioned in the extravesical bathing solution, bladder lumen, and sutured to the detrusor to ensure maintenance of desired temperatures. 2g gemcitabine in 100mL normal saline was heated to 43°C and circulated through the bladder using the Combat Bladder Recirculation System. Bladder pressures were monitored throughout each trial. After 60 minutes of dwell time, rapid dissection was performed to obtain full-thickness bladder samples from the bladder dome, posterior wall, trigone, and left and right lateral walls. Tissue was homogenized and liquid chromatography with tandem mass spectrometry (LC/MS/MS) was performed to measure gemcitabine concentration within the bladder wall. Linear regression and Pearson correlation were performed to determine the association between mean bladder pressure during instillation and drug concentration within the bladder wall. Multiple linear regression was conducted to control for bladder location and thickness. Results: Gemcitabine concentration within the bladder wall was measured 25 times across five trials. Mean gemcitabine concentration within bladder wall was 3.68 mg/g (sd 1.35). Pressure ranged from 149.8 mmHg to 277.7 mmHg (mean 194.8, sd 22.0). On univariate analysis, higher pressure was associated with increased gemcitabine concentration within the bladder wall (correlation = 0.49, p = 0.013). This result persisted after adjusting for bladder location (ß = 0.49, p = 0.006) and thickness (ß = 0.70, p = 0.03). Unstandardized regression coefficient in each of the models was 0.099 (mmHg x g)/mg, demonstrating that for each pressure increase of 10mmHg there was an associated increase in gemcitabine concentration of approximately 1 mg/g (Table). Conclusions: Data suggest that bladder pressure dramatically improves the extent of gemcitabine penetration into the bladder wall. Future research is needed to evaluate the therapeutic effect of increased gemcitabine delivery to target tissue in patients with bladder cancer. [Table: see text]

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Multi-physics study of acoustofluidic delivery agents' clustering behavior

Physics in Medicine and Biology ◽

10.1088/1361-6560/ac4666 ◽

2021 ◽

Author(s):

Hussain AlSadiq ◽

Karnaker Reddy Tupally ◽

Robert Vogel ◽

Harendra S Parekh ◽

Martin Veidt

Keyword(s):

Drug Delivery ◽

Brownian Motion ◽

Drug Delivery Systems ◽

Cluster Formation ◽

Radiation Force ◽

Delivery Systems ◽

Electrostatic Repulsion ◽

Clear Understanding ◽

Target Tissue ◽

Zeta Potentials

Abstract Acoustofluidicly manipulated microbubbles (MBs) and echogenic liposomes (ELIPs) have been suggested as drug delivery systems for the ‘on demand’ release of drug in target tissue. This requires a clear understanding of their behaviour during ultrasonication and after ultrasonication stops. The main focus of this study is to investigate the behaviour of MBs and ELIPs clusters after ultrasonication stops and the underlaying cause of cluster diffusion considering electrostatic repulsion, steric repulsion and Brownian motion. It also examines the capability of existing models used to predict MBs’ attraction velocity due to secondary radiation force, on predicting ELIPs’ attraction velocity. Tunable resistive pulse sensing (TRPS) and phase analysis light scattering (PALS) techniques were used to measure zeta potentials of the agents and the size distributions were measured using TRPS. The zeta potentials were found to be -2.43 mV and -0.62 mV for Definity™ MBs, and -3.62 mV and -2.35 mV for ELIPs using TRPS and PALS, respectively. Both agents were shown to have significant cluster formation at pressures as low as 6 kPa. Clusters of both agents were shown to diffuse as sonication stops at a rate that approximately equals the sum of the diffusion coefficients of the agents forming them. The de-clustering behaviours are due to Brownian motion as no sign of electrostatic repulsion was observed and particles movements were observed to be faster for smaller diameters. These findings are important to design and optimise effective drug delivery systems using acoustofluidically manipulated MBs and ELIPs.

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Temoporfin-in-Cyclodextrin-in-Liposome—A New Approach for Anticancer Drug Delivery: The Optimization of Composition

Nanomaterials ◽

10.3390/nano8100847 ◽

2018 ◽

Vol 8 (10) ◽

pp. 847 ◽

Cited By ~ 17

Author(s):

Ilya Yakavets ◽

Henri-Pierre Lassalle ◽

Dietrich Scheglmann ◽

Arno Wiehe ◽

Vladimir Zorin ◽

...

Keyword(s):

Drug Delivery ◽

Surface Charge ◽

Tumor Tissue ◽

Target Tissue ◽

Tumor Spheroid ◽

New Approach ◽

Anticancer Drug Delivery ◽

Hybrid Delivery ◽

Optimization Of Composition ◽

Almost All

The main goal of this study was to use hybrid delivery system for effective transportation of temoporfin (meta-tetrakis(3-hydroxyphenyl)chlorin, mTHPC) to target tissue. We suggested to couple two independent delivery systems (liposomes and inclusion complexes) to achieve drug-in-cyclodextrin-in-liposome (DCL) nanoconstructs. We further optimized the composition of DCLs, aiming to alter in a more favorable way a distribution of temoporfin in tumor tissue. We have prepared DCLs with different compositions varying the concentration of mTHPC and the type of β-cyclodextrin (β-CD) derivatives (Hydroxypropyl-, Methyl- and Trimethyl-β-CD). DCLs were prepared by thin-hydration technique and mTHPC/β-CD complexes were added at hydration step. The size was about 135 nm with the surface charge of (−38 mV). We have demonstrated that DCLs are stable and almost all mTHPC is bound to β-CDs in the inner aqueous liposome core. Among all tested DCLs, trimethyl-β-CD-based DCL demonstrated a homogenous accumulation of mTHPC across tumor spheroid volume, thus supposing optimal mTHPC distribution.

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Radioiodination of cyclin dependent kinase inhibitor Olomoucine loaded Fe@Au nanoparticle and evaluation of the therapeutic efficacy on cancerous cells

Radiochimica Acta ◽

10.1515/ract-2016-2629 ◽

2017 ◽

Vol 105 (3) ◽

Author(s):

Gokhan Takan ◽

Ozge Kozgus Guldu ◽

Emin Ilker Medine

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Au Nanoparticles ◽

Kinase Inhibitor ◽

Au Nanoparticle ◽

Target Tissue ◽

Cyclin Dependent Kinase Inhibitor ◽

Magnetic Drug Delivery ◽

Cancerous Cells

AbstractMagnetic nanoparticles have promising biomedical applications such as drug delivery, novel therapeutics and diagnostic imaging. Magnetic drug delivery combination works on the delivery of magnetic nanoparticles loaded with drug to the target tissue by means of an external magnetic field. Gold coated iron oxide (Fe@Au) nanoparticles can provide useful surface chemistry and biological reactivity. Covalent conjugation to the Fe@Au nanoparticles through cleavable linkages can be used to deliver drugs to tumor cells, then the drug can be released by an external. In this paper, purine based cyclin dependent kinases (CDKs) inhibitor Olomoucine (Olo) [2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine] was loaded on gold coated iron oxide (Fe@Au) nanoparticles and radiolabeled with

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Role of Novel Drug Delivery Systems in Bioavailability Enhancement: At A Glance

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v6i1.8884 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Mehta Abhinav ◽

Jain Neha ◽

Grobler Anne ◽

Vandana Bharti

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Systemic Circulation ◽

Delivery Systems ◽

New Drugs ◽

Target Tissue ◽

Drug Bioavailability ◽

Bioavailability Enhancement ◽

Advantages And Disadvantages ◽

Novel Drug

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Most of the new drugs used today have poor bioavailability and are required to be administered at higher doses because only a small fraction of the administered dose is absorbed in the systemic circulation and able to reach the target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

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