scholarly journals Crown Ether Schiff bases and their Complexes: Recent Advances (A Review )

2018 ◽  
Vol 34 (4) ◽  
pp. 1701-1718 ◽  
Author(s):  
KHALID MAHER ◽  
SHIREEN MOHAMMED
Keyword(s):  
Crown Ether ◽  
Schiff Bases ◽  
Review Paper ◽  
Literature Survey ◽  
Present Review ◽  
Chelating Activity ◽  
Recent Advances

In latterly years, an interest in the synthesis of crown ether Schiff bases and their Complexes has been increased, due to the significance and broadly the uses of these compounds in various fields. In the present review paper outline extensive recent advances literature survey on the crown ether including azomethine gathering and their complexes with the tough and easy granter atoms, has been reconsidered. Assertiveness has been done on element complexation with crown ether holding Schiff bases to enable the researchers to procure valuable information of the chelating activity of crown ether containing azomethine gathering and their enforcement.

Synthetic Strategies, Chemical Reactivities and Biological Activities of 3-Thioxo-1,2,4-Triazin-5-Ones and Their Derivatives

2019 ◽  
Vol 16 (4) ◽  
pp. 308-322
Author(s):  
Mohammad S.T. Makki ◽  
Reda M. Abdel-Rahman ◽  
Abdulrahman S. Alharbi
Keyword(s):  
Biological Activities ◽  
Biological Evaluation ◽  
Literature Survey ◽  
Recent Advances ◽  
Nucleophilic Reagents ◽  
Anti Hiv ◽  
Biological Field

In recent years, a very interest in the synthesis of functionalized 3-thioxo-1,2,4-triazin-5- ones and their derivatives as vital probes has been increased, due to the important, applications of the medicinal, pharmacological, and biological field as a drug, semi drug, and bioactive systems. The present work review outlines extensive recent advances literature survey on the synthesis of sulfurbearing 1,2,4-triazin-5-one derivatives has been reconsidered. Also, the behavior of these family towards electrophilic and nucleophilic reagents in different media and conditions reported. The biological evaluation of the most synthesized systems included anticancer, anti-HIV, antimicrobial as well as their enzymatic effects (cellobiase produced by fungi) have been reported. The reactivity of these systems depends on the polarity of solvent, temperature, molarity as well as a type of tautomeric present.

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

2020 ◽  
Vol 16 (4) ◽  
pp. 454-486 ◽  
Author(s):  
Smita Verma ◽  
Vishnuvardh Ravichandiran ◽  
Nihar Ranjan ◽  
Swaran J.S. Flora
Keyword(s):  
Heterocyclic Compounds ◽  
Wide Spectrum ◽  
Dna Recognition ◽  
Present Review ◽  
Pharmacological Activities ◽  
Structural Motifs ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Nitrogen-containing heterocycles are one of the most common structural motifs in approximately 80% of the marketed drugs. Of these, benzimidazoles analogues are known to elicit a wide spectrum of pharmaceutical activities such as anticancer, antibacterial, antiparasitic, antiviral, antifungal as well as chemosensor effect. Based on the benzimidazole core fused heterocyclic compounds, crescent-shaped bisbenzimidazoles were developed which provided an early breakthrough in the sequence-specific DNA recognition. Over the years, a number of functional variations in the bisbenzimidazole core have led to the emergence of their unique properties and established them as versatile ligands against several classes of pathogens. The present review provides an overview of diverse pharmacological activities of the bisbenzimidazole analogues in the past decade with a brief account of its development through the years.

Therapeutic properties of organotin complexes with reference to their structural and environmental features

2017 ◽  
Vol 37 (2) ◽  
pp. 51-70 ◽  
Author(s):  
Muhammad Iqbal ◽  
Saqib Ali ◽  
Ali Haider ◽  
Nasir Khalid
Keyword(s):  
Mode Of Action ◽  
Therapeutic Potential ◽  
Biological Systems ◽  
Structural Features ◽  
Present Review ◽  
Environmental Features ◽  
Recent Advances ◽  
Target Sites ◽  
Therapeutic Properties ◽  
Modes Of Interaction

AbstractOrganotin complexes are being extensively studied and screened for their therapeutic potential. Although many recent advances and achievements in this field have been made, the exact mode of action of these complexes is yet to be unveiled. In the present review, an attempt has been made to correlate the therapeutic properties of organotin complexes with their structural features and the environment in which these interact with biological systems. The mechanism, various modes of interaction with biological systems, and physiological target sites of organotin complexes have been highlighted as well.

scholarly journals What Did We Learn about VADs in 2015?

2016 ◽  
Author(s):  
Maya Guglin
Keyword(s):  
Full Text ◽  
Mechanical Circulatory Support ◽  
Review Paper ◽  
Present Review ◽  
Circulatory Support

The field of mechanical circulatory support is rapidly evolving and new data are published at a rate that can be overwhelming. Last year, we published a review paper entitled “What Did We Learn about VADs in 2014?” That paper was well received – the full text was downloaded over 350 times by the readers around the globe. Encouraged by this, we wrote the present review, where, like before, we summarized some of the publications from 2015 that we think are particularly important.

scholarly journals Brain Concussion: New Classifications and Current Physiopathological Knowledge of the Disease

2017 ◽  
Vol 38 (04) ◽  
pp. 284-291
Author(s):  
Daniel Damiani ◽  
Durval Damiani
Keyword(s):  
Review Paper ◽  
Present Review ◽  
Emergency Rooms ◽  
Late Sequelae ◽  
Brain Concussion ◽  
Cerebral Concussion ◽  
High Prevalence ◽  
The World ◽  
New Evidence

AbstractThe present review paper aims to update the definition and classification of cerebral concussion, highlighting its pathophysiological mechanisms. The high prevalence of cerebral concussion in emergency rooms around the world makes it necessary to know its proper management to avoid its late sequelae, which traditionally compromise cognitive aspects of behavior. New evidence on potential neuroprotective treatments is being investigated.

scholarly journals Remote Methods for Conducting Tobacco-Focused Clinical Trials

2020 ◽  
Vol 22 (12) ◽  
pp. 2134-2140 ◽  
Author(s):  
Jennifer Dahne ◽  
Rachel L Tomko ◽  
Erin A McClure ◽  
Jihad S Obeid ◽  
Matthew J Carpenter
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Mobile Health ◽  
Digital Technologies ◽  
Present Review ◽  
Promising Alternative ◽  
Representative Study ◽  
Recent Advances ◽  
Adherence Monitoring ◽  
Key Aspects

Abstract Most tobacco-focused clinical trials are based on locally conducted studies that face significant challenges to implementation and successful execution. These challenges include the need for large, diverse, yet still representative study samples. This often means a protracted, costly, and inefficient recruitment process. Multisite clinical trials can overcome some of these hurdles but incur their own unique challenges. With recent advances in mobile health and digital technologies, there is now a promising alternative: Remote Trials. These trials are led and coordinated by a local investigative team, but are based remotely, within a given community, state, or even nation. The remote approach affords many of the benefits of multisite trials (more efficient recruitment of larger study samples) without the same barriers (cost, multisite management, and regulatory hurdles). The Coronavirus Disease 2019 (COVID-19) global health pandemic has resulted in rapid requirements to shift ongoing clinical trials to remote delivery and assessment platforms, making methods for the conduct of remote trials even more timely. The purpose of the present review is to provide an overview of available methods for the conduct of remote tobacco-focused clinical trials as well as illustrative examples of how these methods have been implemented across recently completed and ongoing tobacco studies. We focus on key aspects of the clinical trial pipeline including remote: (1) study recruitment and screening, (2) informed consent, (3) assessment, (4) biomarker collection, and (5) medication adherence monitoring. Implications With recent advances in mobile health and digital technologies, remote trials now offer a promising alternative to traditional in-person clinical trials. Remote trials afford expedient recruitment of large, demographically representative study samples, without undo burden to a research team. The present review provides an overview of available methods for the conduct of remote tobacco-focused clinical trials across key aspects of the clinical trial pipeline.

scholarly journals Synthesis and Study the Chelating Activity of some Polymers Containing Heterocyclic Rings, The Derivatives from 1,2,4- trizol Levofloxacin acid

2018 ◽  
Vol 34 (4) ◽  
pp. 2031-2042 ◽  
Author(s):  
Tahseen Saddam Fandi Al-Mathkuri ◽  
Hamid Mohammed Saleh Al-Jubori ◽  
Ali Taha Saleh
Keyword(s):  
Schiff Bases ◽  
Treatment Time ◽  
Phenol Formaldehyde ◽  
Thermal Studies ◽  
Structural Features ◽  
Batch Method ◽  
Synthetic Compounds ◽  
Chelating Activity ◽  
Effect Of Treatment ◽  
Chelating Polymers

The compound 6-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij] quinolin-7-one (M1) synthesize from the reaction of thiocarbohydrazide with levofloxacin acid by using ethanol as a solvent, phenolic Schiff bases (Z)-9-fluoro-6-(4-((4-hydroxybenzylidene) amino)-5-mercapto4H1,2,4-triazol-3-yl)-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij] quinolin-7-one (M2), (Z)-6-(4-((2,4-dihydroxybenzylidene) amino)-5-mercapto-4H-1,2,4-triazol-3-yl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij]quinolin-7-one (M3) and (Z)-6-(4-((5-chloro-2-hydroxybenzylidene) amino)-5-mercapto-4H-1,2,4-triazol-3-yl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H- [1,4] oxazino[2,3,4-ij] quinolin-7-one (M4) were prepared from the reaction of trizol derivative of [M1] compound with the appropriate phenolic aldehydes by using ethanol as a solvent. The synthetic Schiff bases used to prepare numbers of phenolic polymers [M5-M7] from the reaction of Schiff bases [M2-M4] with phenol formaldehyde. The analytical efficiency of the synthetic chelating polymers studied by the batch method with different transition metals ions (Cd2+, Fe3+, Cu2+), in terms of the effect of treatment time and the pH on the loading capacity of the polymers, controlling the other factors such as temperature, ions concentration and quantity of polymers. The result shows that the capacity of the polymer increased with increasing of the pH and treating time. The synthetic compounds were characterized by various instrumental techniques like FTIR, 1H-NMR, DTG and TGA studies.These spectral and thermal studies provide very valuable information about the structural features.

scholarly journals Recent Advances in the Chemistry of Metal Carbamates

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3603
Author(s):  
Giulio Bresciani ◽  
Lorenzo Biancalana ◽  
Guido Pampaloni ◽  
Fabio Marchetti
Keyword(s):  
Carbon Dioxide ◽  
Periodic Table ◽  
Large Family ◽  
Present Review ◽  
Metal Species ◽  
Recent Advances

Following a related review dating back to 2003, the present review discusses in detail the various synthetic, structural and reactivity aspects of metal species containing one or more carbamato ligands, representing a large family of compounds across all the periodic table. A preliminary overview is provided on the reactivity of carbon dioxide with amines, and emphasis is given to recent findings concerning applications in various fields.

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