scholarly journals The prevalence, preventive measures and economic impact of pandemic COVID-19 in India: the initial phase

2020 ◽  
Vol 64 (1) ◽  
pp. 43-62
Author(s):  
Arindam Ganguly ◽  
Ujjal Konar ◽  
Animesh Kundu ◽  
Subhadeep Ghosh ◽  
Ishita Chatterjee ◽  
...  
Keyword(s):  
Preventive Measures ◽  
Clinical Symptoms ◽  
The Novel ◽  
High Population Density ◽  
Fatal Disease ◽  
Second Stage ◽  
The World ◽  
Community Transmission ◽  
Novel Coronavirus ◽  
Democratic Country

The novel coronavirus (SARS-CoV-2) is posing a serious threat to the mankind with its massive infection rate and potentially fatality. A total of 212 countries have been infected within the 112 days of first report causing 2 314 621 confirmed cases and 157 847 deaths worldwide. India, the country which is already battling with poverty, malnutrition and high population density is also at the second stage of coronavirus transmission. The situation is worsening and the attention has focused on the prevalence and preventive measures to be taken to protect 1.35 billion people of the largest democratic country of the world. In this review, a study has been designed to evaluate the prevalence, transmission, clinical symptoms, and preventive measures to control the community transmission of this fatal disease. The initial impact of coronavirus disease (COVID-19) outbreak on Indian economy has also been dealt with. This study reviews and summarizes the main points of the epidemic in India until the end of April 2020.

Total Joint Arthroplasty during Coronavirus Disease-2019 COVID-19 Pandemic

2020 ◽  
Author(s):  
Seyed Mohammad Javad Mortazavi ◽  
Seyed Hadi Kalantar ◽  
Alireza Moharrami ◽  
Mohammad Zarei ◽  
Nima Hoseini Zare
Keyword(s):  
Physical Examination ◽  
Total Joint Arthroplasty ◽  
Clinical Symptoms ◽  
Joint Arthroplasty ◽  
The Novel ◽  
History Taking ◽  
The World ◽  
Total Knee ◽  
Novel Coronavirus ◽  
Careful Physical Examination

Background: Since the outbreak of the novel coronavirus disease-2019 (COVID-19) pandemics many orthopedic elective surgeries have been postponed all over the world. There are several guidelines for resuming elective surgeries during this crisis. In our center (Imam Khomeini hospital, Tehran, Iran), we resumed total joint arthroplasty (TJAs) surgeries using preoperative history taking and physical examination. Here, we report our experience. Methods: From February 2020 to August 2020, we included 165 patients who underwent TJA [70 total hip arthroplasty (THA) and 95 total knee arthroplasty (TKA)] in Imam Khomeini hospital, a referral center for COVID-19. We followed each patient from the day of hospitalization to two weeks after discharge by telephone for clinical symptoms of COVID-19. Results: Only one patient became infected with COVID-19 a week after discharge from the hospital, and other patients did not show any sign or symptoms within two weeks after the discharge. Conclusion: We recommend resuming the elective surgeries using a careful physical examination and medical history for all patients, and in suspicious cases, referring to a specialized COVID-19 clinic for further investigation.

scholarly journals Psychological Effects of the Coronavirus Disease 2019 Pandemic

2020 ◽  
Vol 95 (6) ◽  
pp. 360-363
Author(s):  
Minyoung Sim
Keyword(s):  
Psychological Distress ◽  
Social Interactions ◽  
Preventive Measures ◽  
Psychological Effects ◽  
Economic Losses ◽  
The Novel ◽  
Loss Of Autonomy ◽  
The World ◽  
Secondary Stressors ◽  
Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) pandemic has spread across the world, reducing social interactions and causing substantial psychological distress and economic losses. This review summarizes the psychological effects of the COVID-19 pandemic in terms of uncertainty, the loss of autonomy associated with preventive measures, and secondary stressors such as potential future economic losses.

scholarly journals Development of an Android application for viewing Covid-19 containment zones and monitoring violators who are trespassing into it using Firebase and Geofencing

2020 ◽  
Author(s):  
Ranajoy Mallik ◽  
Amlan Protim Hazarika ◽  
Sudarshana Ghosh ◽  
Dilip Sing ◽  
Rajib Bandyopadhyay
Keyword(s):  
Social Awareness ◽  
World Health ◽  
The Novel ◽  
Android Application ◽  
The People ◽  
The World ◽  
Community Transmission ◽  
Precautionary Measures ◽  
Novel Coronavirus ◽  
Health Organization

Abstract The World Health Organization has declared the outbreak of the novel coronavirus, COVID-19 as pandemic across the world. With its alarming surge of affected cases throughout the world, lockdown and awareness (social distancing, use of masks etc) among people are found to be the only means for restricting the community transmission. In a densely populated country like India, it is very difficult to prevent the community transmission even during lockdown without social awareness and precautionary measures taken by the people. Recently, several containment zones had been identified throughout the country and divided into red, orange and green zones, respectively. The red zones indicate the infection hotspots, orange zones denote some infection and green zones indicate an area with no infection.This paper mainly focuses on development of an Android application which can inform people of the COVID-19 containment zones and prevent trespassing into these zones. This Android application updates the locations of the areas in a Google map which are identified to be the containment zones. The application also notifies the users if they have entered a containment zone and uploads the user’s IMEI number to the online database. With this IMEI number, the police can keep an eye on the people who are frequently violating the lockdown rules. To achieve all these functionalities, many tools and APIs from Google like Firebase and Geofence are used in this app. Therefore, this application can be used as a tool for creating further social awareness about the arising need of precautionary measures to be taken by the people of India.

scholarly journals A PRE - EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAM ON KNOWLEDGE REGARDING DOMICILIARY CARE IN POST COVID -19 PATIENTS AMONG PRIMARY CAREGIVER AT SELECTED AREA OF NAINITAL

2021 ◽  
Vol 9 (10) ◽  
pp. 225-226
Author(s):  
Chanchal Chaukrayat ◽  
G. Ramalakshmi ◽  
Renjith Thomas
Keyword(s):  
Experimental Study ◽  
Immune System ◽  
High Risk ◽  
Preventive Measures ◽  
Face Mask ◽  
The Novel ◽  
Teaching Program ◽  
Medical Practitioners ◽  
The World ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China in December 2019. The disease has since spread worldwide, leading to an ongoing pandemic.After COVID-19 infection, most people form adequate antibodies which prevents them from contracting the virus again. Nonetheless, its an unknown territory for the medical practitioners across the world, as to how long can that immunity stand. Cases where patients had the novel coronavirus again, have been reported too. More in this way, for individuals who are at a high risk of reinfection are either old or dont take enough preventive measures to additionally protect their immune system which makes post-COVID care important for them. While the standard laws of staying safe suggest everyone to cover their face with a face mask, wash hands regularly and practice social distancing.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

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