scholarly journals Hibiscus rosa-sinensis L. (red Hibiscus) Tea, Can It Be Used as A Home-Remedy to Control Diabetes and Hypercholesterolemia?

2021 ◽  
Vol 10 (1) ◽  
pp. 59-65
Author(s):  
Subhashinie Sanadheera ◽  
Deepanjana Subasinghe ◽  
Melissa Nethmi Solangaarachchi ◽  
Manju Suraweera ◽  
Noshara Yushanthi Suraweera ◽  
...  
Keyword(s):  
Heart Diseases ◽  
Scientific Data ◽  
Journal Articles ◽  
Medical Databases ◽  
Hibiscus Rosa Sinensis ◽  
Common Variety ◽  
Effective Doses ◽  
The Common ◽  
Anti Inflammatory ◽  
Antidiabetic Effects

According to traditional medicine, Hibiscus is used to treat hypertension, heart diseases and many other ailments. Commercially available Hibiscus tea is prepared with H. sabdariffa and is expensive. H. rosasinensis is the common variety which is abundant in tropical home-gardens, however the scientific data are lacking on the effects. The present review focuses on the available scientific data on the effects of H. rosasinensis on controlling diabetes and hypercholesterolemia. The endeavour was to identify whether H. rosasinensis flower petals as a ‘tea’ is effective for diabetic and hypercholesterolemic patients. Medical databases such as MEDLINE, BMC, BMJ, research gate, Mendelay literature search database, Google scholar and the general engine Google were searched from November 2018 to April 2019. Search was carried out using keywords such as “Hibiscus rosasinensis”, “antidiabetic effects”, “antihyperlipidemic effects”, “toxic effects”, “anti-inflammatory effects”, “phytochemicals in Hibiscus” etc. Data were critically analyzed to assess whether the effective doses of the research studies on a par with the doses present in H. rosasinensis teas. We found thirty-nine journal articles fulfilled the criteria. The data were categorized and extracted on uses of H. rosasinensis, anti-diabetic effects, anti-inflammatory effects, anti-hypercholesterolemic effects and its phytochemicals. The review revealed that the dose of H. rosasinensis petals present in a home-made Hibiscus tea is theoretically sufficient to elicit anti-hyperglycemic and anti-hyperlipidemic effects. Home-made Hibiscus tea is effective in controlling diabetes and hypercholesterolemia without causing acute toxicity.

Causality Then and Now

1993 ◽  
Vol 10 (2) ◽  
pp. 165-177
Author(s):  
Karen Harding
Keyword(s):  
Quantum Theory ◽  
Common Sense ◽  
Mechanical Model ◽  
Physical World ◽  
Scientific Data ◽  
The World ◽  
The Common ◽  
The Universe ◽  
The Way

Ate appearances deceiving? Do objects behave the way they do becauseGod wills it? Ate objects impetmanent and do they only exist becausethey ate continuously created by God? According to a1 Ghazlli, theanswers to all of these questions ate yes. Objects that appear to bepermanent are not. Those relationships commonly tefemed to as causalare a result of God’s habits rather than because one event inevitably leadsto another. God creates everything in the universe continuously; if Heceased to create it, it would no longer exist.These ideas seem oddly naive and unscientific to people living in thetwentieth century. They seem at odds with the common conception of thephysical world. Common sense says that the universe is made of tealobjects that persist in time. Furthermore, the behavior of these objects isreasonable, logical, and predictable. The belief that the univetse is understandablevia logic and reason harkens back to Newton’s mechanical viewof the universe and has provided one of the basic underpinnings ofscience for centuries. Although most people believe that the world is accutatelydescribed by this sort of mechanical model, the appropriatenessof such a model has been called into question by recent scientificadvances, and in particular, by quantum theory. This theory implies thatthe physical world is actually very different from what a mechanicalmodel would predit.Quantum theory seeks to explain the nature of physical entities andthe way that they interact. It atose in the early part of the twentieth centuryin response to new scientific data that could not be incorporated successfullyinto the ptevailing mechanical view of the universe. Due largely ...

Pharmacological effects of secondary bile acid microparticles in diabetic murine model

2020 ◽  
Vol 16 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Bozica Kovacevic ◽  
Corina Mihaela Ionescu ◽  
Giuseppe Luna ◽  
...  
Keyword(s):  
Bile Acid ◽  
Blood Glucose ◽  
Bile Acids ◽  
Lithocholic Acid ◽  
Diabetes Treatment ◽  
Secondary Bile Acid ◽  
Glucose Levels ◽  
Anti Inflammatory ◽  
Antidiabetic Effects

Aim: Examine bile acids effects in Type 2 diabetes. Background: In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti-inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid chenodeoxycholic acid were decreased, in plasma. Objective: Hence, this study aimed to examine applications of novel UDCA nanoparticles in diabetes. Methods: Diabetic balb/c adult mice were divided into three equal groups and gavaged daily with either empty microcapsules, free UDCA, or microencapsulated UDCA over two weeks. Their blood, tissues, urine, and faeces were collected for blood glucose, inflammation, and bile acid analyses. UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Results: UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Conclusion: Bile acids modulated the bile profile without affecting blood glucose levels.

A Review of Selected Adult Congenital Heart Diseases Encountered in Daily Practice

2020 ◽  
Vol 16 ◽  
Author(s):  
Farhan Bajwa ◽  
Syed M Jafri ◽  
Karthik Ananthasubramaniam
Keyword(s):  
Surgical Procedures ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Daily Practice ◽  
Congenital Heart Diseases ◽  
Congenital Diseases ◽  
Adult Congenital ◽  
The Common ◽  
Adult Congenital Heart Diseases

: The advancement in corrective surgical procedures and anaesthesia technology has resulted in the increase survival of patients with Congenital Heart Diseases (CHD). Most of the surviving CHD patients have successfully reached adulthood and those surviving adults now outnumber the infants born with the CHD. Unfortunately, the surviving adults with CHD do not get proper care due to either inconsistent follow up or not getting care from a specialist in the field of CHD. It is imperative for general practicing clinicians to be aware of the congenital diseases as well as the current clinical recommendations. This manuscript reviews some of the common congenital diseases seen in adults such as cardiac shunts, left heat obstructive lesions and aortopathies.

scholarly journals PHYTONCIDES IN THE COMPOSITION OF COMMON BIRD CHERRY

2021 ◽  
Vol 447 (3) ◽  
pp. 70-75
Author(s):  
P.N. Naguman ◽  
A.A. Zhorabek ◽  
A.S. Amanzholova ◽  
I.V. Kulakov ◽  
A.N. Rakhimbaeva
Keyword(s):  
Plant Protection ◽  
Folk Medicine ◽  
Antimicrobial Properties ◽  
Biologically Active ◽  
Natural Immunity ◽  
Prussic Acid ◽  
Destructive Effect ◽  
Inflammatory Processes ◽  
The Common ◽  
Anti Inflammatory

Everyone knows that forest air is very good for health, and one of the most important reasons for this is the presence of phytoncides in it, which kill or suppress pathogens and have a healing effect. Also, phytoncides are one of the factors of the natural immunity of plants (plants sterilize themselves with the products of their vital activity). Their large number is allocated by plants. One of them is the common bird cherry. Cherry-a representative of the genus of plums of the Rosaceae family. The view includes low trees and shrubs. Cheremukha-forest orderly. Its flowers and leaves are rich in phytoncides, thanks to which they exude an alluring aroma. However, when they break down, they release prussic acid, which is dangerous for all living things. This gave them the opportunity to attract and destroy pests. Phytoncides are volatile biologically active substances formed by plants that kill or inhibit the growth and development of bacteria, microscopic fungi, and protozoa. In addition to all of the above, bird cherry has exceptional properties. The strong, somewhat intoxicating scent of flowers and leaves cleanses the air of germs. Antimicrobial properties of phytoncides have led to a large number of studies on their use in medicine, veterinary medicine, plant protection, storage of fruit and vegetable products, in the food industry and other areas of practice. Almost all parts of the plant have bactericidal, fungicidal and insecticidal properties. In folk medicine, bird cherry has long been used as an astringent, fixing, anti-inflammatory and anti-scurvy agent. Bird cherry produces the most powerful phytoncides containing prussic acid. Protozoa die under the influence of bird cherry phytoncides in 5 minutes. On the basis of numerous studies, the time of death of protozoa after noncontact exposure to phytoncidal plants has been established. Especially a lot of phytoncides are released by young leaves in spring and summer, in autumn phytoncides are released much less. The presence of tannins and essential oil in the fruit has an anti-inflammatory effect, which is used to treat inflammatory processes in the gastrointestinal tract and dysentery. The infusion of cherry fruits has a destructive effect on microorganisms. Preparations of the fruits of the common cherry have an antiseptic effect. They are used in dental practice in the treatment of inflammatory processes of the oral mucosa, paradontosis, toothache and hypovitaminosis.

scholarly journals PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1845 ◽  
Author(s):  
Giovanna Giacalone ◽  
Nicolas Tsapis ◽  
Ludivine Mousnier ◽  
Hélène Chacun ◽  
Elias Fattal
Keyword(s):  
Polymeric Nanoparticles ◽  
Heart Diseases ◽  
The United States ◽  
Drug Uptake ◽  
Dependent Manner ◽  
Raw264.7 Macrophages ◽  
Efficient Delivery ◽  
Anti Inflammatory ◽  
Atherosclerosis Treatment ◽  
Inflammatory Effect

Among cardiovascular diseases, atherosclerosis remains the first cause of death in the United States of America and Europe, as it leads to myocardial infarction or stroke. The high prevalence of heart diseases is due to the difficulty in diagnosing atherosclerosis, since it can develop for decades before symptoms occur, and to the complexity of the treatment since targets are also important components of the host defenses. The antidiabetics thiazolidinediones, among which is rosiglitazone (RSG), have demonstrated anti-atherosclerotic effect in animal models, and are therefore promising candidates for the improvement of atherosclerosis management. Nevertheless, their administration is hindered by the insurgence of severe side effects. To overcome this limitation, rosiglitazone has been encapsulated into polymeric nanoparticles, which permit efficient delivery to its nuclear target, and selective delivery to the site of action, allowing the reduction of unwanted effects. In the present work, we describe nanoparticle formulation using polylactic acid (PLA) coupled to polyethylene glycol (PEG), their characterization, and their behavior on RAW264.7 macrophages, an important target in atherosclerosis treatment. RSG nanocarriers showed no toxicity on cells at all concentrations tested, an anti-inflammatory effect in a dose-dependent manner, up to 5 times more efficient than the free molecule, and an increased RSG uptake which is consistent with the effect shown. These biodegradable nanoparticles represent a valid tool to be further investigated for the treatment of atherosclerosis.

Health benefits of avicularin in the medicine against cancerous disorders and other complications: Biological importance, therapeutic benefit and analytical aspects of the medicine

2021 ◽  
Vol 17 ◽  
Author(s):  
Kanika Patel ◽  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Scientific Data ◽  
Lespedeza Cuneata ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Biological Importance ◽  
Anti Cancer ◽  
Scientific Data Analysis ◽  
Different Types ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals have been used in medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different types of human disorders including cancerous disorders. Flavonoids have been well known in medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza cuneata. Avicularin has been well known in medicine for its anti-cancer properties. Methods: In the present work, scientific data of avicularin have been collected from different databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin. The present review summarized the health beneficial properties of avicularin in medicine through data analysis of various scientific research works. Further analytical progress in medicine for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the present work. Results: Scientific data analysis of different literature work revealed the biological importance of flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory, anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid arthritis has been also established with its underlying molecular mechanisms in the scientific work. Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity in the medicine. Conclusion: The present work signified the biological importance of avicularin in medicine through its medicinal uses, pharmacological activities and analytical aspects in the biological system.

Depression and dementia: A conspiracy ?

2011 ◽  
Vol 26 (S2) ◽  
pp. 2211-2211
Author(s):  
C. Hanon
Keyword(s):  
Differential Diagnosis ◽  
Cognitive Functioning ◽  
Elderly Population ◽  
The Elderly ◽  
Scientific Data ◽  
The Other ◽  
Comorbid Depression ◽  
Adequate Treatment ◽  
Treatment Of Depression ◽  
The Common

Depression and dementia are two very common clinical entities in the elderly population. Differential diagnosis of these disorders may pose difficulties. On the other hand, when they are comorbid, depression and dementia may affect the outcome of each other. When adequate treatment for depression is provided, patients with dementia may experience a significant improvement in cognitive functioning. Therefore, the possibility of comorbid depression and dementia should always be taken into account in the elderly population. This presentation will address the common clinical obstacles encountered while managing these disorders. Using the latest scientific data, the adequate treatment of depression and dementia will be discussed.

scholarly journals The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 280
Author(s):  
Chandrakala Aluganti Narasimhulu ◽  
Dinender K Singla
Keyword(s):  
Cardiovascular Diseases ◽  
Growth Factor ◽  
Bone Morphogenetic Protein ◽  
Bone Fracture ◽  
Heart Diseases ◽  
Calcium Deposition ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein ◽  
Anti Inflammatory ◽  
Inflammatory Growth

Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 stimulates the target cells by binding to specific membrane-bound receptor BMPR 2 and transduces signals through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. To date, rhBMP-7 has been used clinically to induce the differentiation of mesenchymal stem cells bordering the bone fracture site into chondrocytes, osteoclasts, the formation of new bone via calcium deposition and to stimulate the repair of bone fracture. However, its use in cardiovascular diseases, such as atherosclerosis, myocardial infarction, and diabetic cardiomyopathy is currently being explored. More importantly, these cardiovascular diseases are associated with inflammation and infiltrated monocytes where BMP-7 has been demonstrated to be a key player in the differentiation of pro-inflammatory monocytes, or M1 macrophages, into anti-inflammatory M2 macrophages, which reduces developed cardiac dysfunction. Therefore, this review focuses on the molecular mechanisms of BMP-7 treatment in cardiovascular disease and its role as an anti-fibrotic, anti-apoptotic and anti-inflammatory growth factor, which emphasizes its potential therapeutic significance in heart diseases.

Professional Advice and the Utilization of Non-Steroidal Anti-Inflammatory Drugs at Community Pharmacies in the United Arab Emirates

2003 ◽  
Vol 21 (4) ◽  
pp. 377-388
Author(s):  
M. Y. Hasan ◽  
M. Das ◽  
A. Bener
Keyword(s):  
Side Effects ◽  
United Arab Emirates ◽  
Disease Duration ◽  
Community Pharmacies ◽  
Self Medication ◽  
Professional Advice ◽  
Duration Of Disease ◽  
Inflammatory Drugs ◽  
The Common ◽  
Anti Inflammatory

The present study examined the pattern of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in relation to the source of advice. Ten community pharmacies in the United Arab Emirates were randomly selected and patients visiting these sites were interviewed using a standard questionnaire. The interview covered “source of advice,” “name of medicine,” “type of disease,” “duration of disease,” and “knowledge of adverse effects and drug interactions.” After a month the patients were contacted. On average 22.7% of prescriptions contained NSAIDs and 17.5% of visits were for these drugs. Advice from physicians was given to 33.3%, from pharmacists 32.5%, from friends 18.8%, and 15.4% depended on themselves. Other medicines were taken by 14.5% and 12% suffered from gastrointestinal upsets. Paracetamol followed by ibuprofen and diclofenac were the most frequently utilized agents. Headache, fever, and musculoskeletal pain were the common complaints. A month later, 50.7% of the patients continued taking their medications. This study revealed an association between the source of advice and knowledge of side effects. It is argued that, although self-care is important, professional advice in its support is essential since unsupervised self-medication exposes the patient to harmful consequences.

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