Lettuce: a promising leafy vegetable with functional properties

2017 ◽  
Vol 2 (2) ◽  
pp. 178 ◽  
Author(s):  
K. R. Anilakumar ◽  
S. N. Harsha ◽  
Mallesha . ◽  
R. K. Sharma
Keyword(s):  
Lactuca Sativa ◽  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Sesquiterpene Lactones ◽  
Bioactive Compound ◽  
Well Being ◽  
Biological Properties ◽  
The Body ◽  
Leafy Vegetable ◽  
Correct Operation

<em><span lang="EN-US">Lactuca sativa</span></em><span lang="EN-US"> (lettuce) belongs to Asteraceae family important leafy vegetable known for its medicinal properties. The lettuce is a food that should not lack in our meals, we should keep in mind that its low fat and carbohydrate contents and its high contents of water, it provides caloric power of only 13 Kcal /100gm are very appropriate for weight loss diets. It is rich in minerals, especially potassium that is very necessary to maintain appropriate levels of liquids in the body, together with calcium and phosphorus makes it especially for the correct well being of the bones. It contains selenium, an antioxidant that has a medicinal property in prevention of certain type of cancers, colon, prostrate and lungs. It contains many necessary amino acids for the formation of the proteins, alanine, and necessary for the construction of muscular and nervous tissues, glycine for the correct operation of immunological system. The most of therapeutic properties of this plant is due to sesquiterpene lactones- lactucin, lactucopicrin the most bioactive compound of <em>Lactuca sativa</em>. This review mainly focuses on the pharmacological action of the Lettuce and active constituents for the wide spectrum biological properties, such as anti-oxidant, anti-inflammatory, anti-microbial, analgesic, neuroprotective and sedative properties etc. Since Lettuce has medicinal therapeutic potential its usage in dietary supplementation can be exploited. Lettuce has also acquired a folk reputation. More clinical studies are needed to further asses the efficiency and safety in therapeutic application</span>

Integrating Focusing and Differentiation: A Therapeutic Path for Couples in Intimate Relationships

2018 ◽  
Vol 3 ◽  
Author(s):  
Evi Zohar
Keyword(s):  
Couples Therapy ◽  
Therapeutic Potential ◽  
Well Being ◽  
Point Of View ◽  
The Body ◽  
Self Awareness ◽  
Emotional Healing ◽  
Felt Sense ◽  
Inner World

Continuing the workshop I've given in the WPC Paris (2017), this article elaborates my discussion of the way I interlace Focusing with Differentiation Based Couples Therapy (Megged, 2017) under the systemic view, in order to facilitate processes of change and healing in working with intimate couples. This article presents the theory and rationale of integrating Differentiation (Bowen, 1978; Schnarch, 2009; Megged, 2017) and Focusing (Gendlin, 1981) approaches, and its therapeutic potential in couple's therapy. It is written from the point of view of a practicing professional in order to illustrate the experiential nature and dynamics of the suggested therapeutic path. Differentiation is a key to mutuality. It offers a solution to the central struggle of any long term intimate relationship: balancing two basic life forces - the drive for individuality and the drive for togetherness (Schnarch, 2009). Focusing is a body-oriented process of self-awareness and emotional healing, in which one learns to pay attention to the body and the ‘Felt Sense’, in order to unfold the implicit, keep it in motion at the precise pace it needs for carrying the next step forward (Gendlin, 1996). Combining Focusing and Differentiation perspectives can cultivate the kind of relationship where a conflict can be constructively and successfully held in the inner world of each partner, while taking into consideration the others' well-being. This creates the possibility for two people to build a mutual emotional field, open to changes, permeable and resilient.

scholarly journals ABC membrane transporters and their multifunctional nature

2018 ◽  
Vol 72 ◽  
pp. 606-622
Author(s):  
Magdalena Smolik ◽  
Joanna Suraj ◽  
Anna Kurpinska ◽  
Maria Walczak
Keyword(s):  
Abc Transporters ◽  
Therapeutic Potential ◽  
Wide Spectrum ◽  
The Body ◽  
Hyperinsulinemic Hypoglycemia ◽  
Regulatory Systems ◽  
Johnson Syndrome ◽  
Popular Knowledge ◽  
Disease Entities ◽  
Cellular Immune

ABC transporters are the largest family of transport proteins, which mediate the active translocation of a wide spectrum of molecules through the cell membrane, using energy from hydrolysis of ATP. They can act as importers (in Procaryota exclusively) or exporters (in both Procaryota and Eucaryota) of specified substrates. Despite a quite conservative structure model, ABC transporters are diverse in terms of functions performed in the body. These proteins are important elements of the blood-organ barriers, they maintain lipid homeostasis, participate in cellular immune response but also are involved in the development of multidrug resistance as well as affect the biology of tumour cells. Additionally, they play the role of ion channels or regulators of their activity. The activity of ABC transporters is also correlated with the occurrence of certain disease entities, such as cystic fibrosis, Dubin-Johnson syndrome, Tangier disease, persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and neoplasia. Due to their therapeutic potential, ABC transporters are becoming increasingly popular. Knowledge of the mechanisms of action of ABC transporters and their regulatory systems will provide the basis for the development of personalized medicine, which may be significant especially in the context of cancer treatment.

scholarly journals Review on Phytochemicals and Pharmacological Studies of Allium cepa (Onion)

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
Battagani Deepthi ◽  
Jada Naga Lakshmi
Keyword(s):  
Therapeutic Agent ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Herbal Medicines ◽  
Mutagenic Effect ◽  
Biological Properties ◽  
Hepatoprotective Activity ◽  
The Body ◽  
Economic Implications ◽  
Intestinal Gas

In present days, herbal medicines have gained importance with both medical and economic implications. Throughout the world raised concerns of quality, safety and efficacy. Onion has been valued as a food, medicinal plant since ancient times and widely cultivated. And known as “Queen of the kitchen”. Due to its flavor, aroma, unique taste, medicinal properties of its compound. And acts as food which provides a good amount of nutrients, immunity to the body, helps in treating high cholesterol, diabetes, joint disorders, digestive ailments, loss of appetite, gallbladder diseases, angina pectoris, high blood pressure, atherosclerosis, sore throat, asthma, bronchitis, cough, intestinal gas and intestinal worms as therapeutic agent. Different biological properties, such as, antioxidants, antiinflammatory, anti-cholesterol, antihypertensive, anti-cancer, anti-arthritic, anti-bacterial, bronchodilator, expectorant, antispasmodic, antiseptic, carminative, anti-coagulant, fibrinolytic, anti-helminthic, anti-platelet, hepatoprotective activity, anti-diabetic, anti-viral, cardiovascular protective, anti-microbial, neuro protective, anti-genotoxic and anti-mutagenic effect, anti-pyretic, analgesic, and various other biological activities. Wide spectrum of biological activities of onion makes it as a potential medicinal and therapeutic agent

Current trends on repurposing and pharmacological enhancement of andrographolide

2020 ◽  
Vol 27 ◽  
Author(s):  
Xuan Ren ◽  
Wenzhou Xu ◽  
Jiao Sun ◽  
Biao Dong ◽  
Hussein Awala ◽  
...  
Keyword(s):  
Drug Targets ◽  
Water Solubility ◽  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Drug Marketing ◽  
Disease States ◽  
Recent Developments ◽  
New Treatment ◽  
Underlying Mechanisms

: Andrographolide, the main bioactive component separated from Andrographis paniculata in 1951, have been scrutinized with modern drug discovery approach for anti-inflammatory properties since 1984. Identifying new uses for existing drugs can be facilitated by evidence linking them to known or yet undiscovered drug targets and human disease states to develop new therapeutic indications. Afterwards, a wide spectrum of biological properties of andrographolide such as anti-cancer, antibacterial, antiviral, hepatoprotective, antioxidant, anti-malarial, anti-atherosclerosis were also reported. However, poor water solubility and instability limit its clinical application. it becomes crucial to enhance its pharmacological function and find new treatment for more diseases. Therefore, this article reviews the major recent developments in andrographolide, including repurposing application in different diseases and underlying mechanisms, particularly focusing on pharmacological enhancement of andrographolide such as derivatives, chemical modifications with potent biological activity and drug delivery. The repurposing and pharmacological enhancement of andrographolide would not only have exciting therapeutic potential to different diseases to facilitate drug marketing, but also decrease the burden on health economies worldwide.

Therapeutic Potential of Young Green Barley Leaves in Prevention and Treatment of Chronic Diseases: An Overview

2015 ◽  
Vol 43 (07) ◽  
pp. 1311-1329 ◽  
Author(s):  
Lamia Lahouar ◽  
Safia El-Bok ◽  
Lotfi Achour
Keyword(s):  
Chronic Diseases ◽  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Essential Amino Acids ◽  
The Body ◽  
Barley Plant ◽  
Hordeum Vulgare L ◽  
Beneficial Effects ◽  
Prevention And Treatment ◽  
Barley Leaves

Medicinal plants have played a major role as a functional food and pharmacological source of active substances. Barley grass (BG) is young green barley leaves. It is the young grass of the common barley plant Hordeum vulgare L. of the family Poeaceae (Graminae). It is a type of green grasses, and the only vegetation on the earth that can supply sole nutritional support from birth to old age. It contains a wide spectrum of vitamins, minerals, as well as eight essential amino acids that we must get from our diets. BG possesses several pharmacological activities as anticancer activity, anti-oxidant activity and anti-inflammatory activity. It has been argued that BG helps blood flow, digestion and general detoxification of the body. The major pharmacologic interest of BG is its use in the treatment of chronic diseases. The beneficial effects observed in chronic disease may be related to bioactive compounds contained in BG such as superoxide dismutase (SOD) and bioflavonoids (lutonarin and saponarin). Thus, this paper is focused on the various studies that emphasize the therapeutic potential of BG in the prevention and treatment of chronic diseases.

scholarly journals The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Ali Jangjou ◽  
Amir Hossein Meisami ◽  
Kazem Jamali ◽  
Mohammad Hadi Niakan ◽  
Milad Abbasi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Drug Carrier ◽  
Well Being ◽  
The Body ◽  
Biologically Active ◽  
Medicinal Uses ◽  
Medication Delivery ◽  
Effective Care ◽  
Wide Range ◽  
Area Of Concern

AbstractMicrobubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the microbubble is surrounded by a membrane that may consist of biocompatible biopolymers, polymers, surfactants, proteins, lipids, or a combination thereof. One of the most effective implementation techniques for tiny bubbles is to apply them as a drug carrier that has the potential to activate ultrasound (US); this allows the drug to be released by US. Microbubbles are often designed to preserve and secure medicines or substances before they have reached a certain area of concern and, finally, US is used to disintegrate microbubbles, triggering site-specific leakage/release of biologically active drugs. They have excellent therapeutic potential in a wide range of common diseases. In this article, we discussed microbubbles and their advantageous medicinal uses in the treatment of certain prevalent disorders, including Parkinson's disease, Alzheimer's disease, cardiovascular disease, diabetic condition, renal defects, and finally, their use in the treatment of various forms of cancer as well as their incorporation with nanoparticles. Using microbubble technology as a novel carrier, the ability to prevent and eradicate prevalent diseases has strengthened the promise of effective care to improve patient well-being and life expectancy.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors

2019 ◽  
Vol 25 (26) ◽  
pp. 2892-2905 ◽  
Author(s):  
Sumit Jamwal ◽  
Ashish Mittal ◽  
Puneet Kumar ◽  
Dana M. Alhayani ◽  
Amal Al-Aboudi
Keyword(s):  
Nervous System ◽  
Therapeutic Potential ◽  
The Body ◽  
Membrane Receptors ◽  
Physiological Importance ◽  
Physiological Processes ◽  
Central Nervous Systems ◽  
Energy Consuming ◽  
Metabolic Dysfunctions ◽  
G Protein Coupled

Adenosine is a naturally occurring nucleoside and an essential component of the energy production and utilization systems of the body. Adenosine is formed by the degradation of adenosine-triphosphate (ATP) during energy-consuming processes. Adenosine regulates numerous physiological processes through activation of four subtypes of G-protein coupled membrane receptors viz. A1, A2A, A2B and A3. Its physiological importance depends on the affinity of these receptors and the extracellular concentrations reached. ATP acts as a neurotransmitter in both peripheral and central nervous systems. In the peripheral nervous system, ATP is involved in chemical transmission in sensory and autonomic ganglia, whereas in central nervous system, ATP, released from synaptic terminals, induces fast excitatory postsynaptic currents. ATP provides the energetics for all muscle movements, heart beats, nerve signals and chemical reactions inside the body. Adenosine has been traditionally considered an inhibitor of neuronal activity and a regulator of cerebral blood flow. Since adenosine is neuroprotective against excitotoxic and metabolic dysfunctions observed in neurological and ocular diseases, the search for adenosinerelated drugs regulating adenosine transporters and receptors can be important for advancement of therapeutic strategies against these diseases. This review will summarize the therapeutic potential and recent SAR and pharmacology of adenosine and its receptor agonists and antagonists.

Tamarix articulata (T. articulata) - An Important Halophytic Medicinal Plant with Potential Pharmacological Properties

2019 ◽  
Vol 20 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Abdullah M. Alnuqaydan ◽  
Bilal Rah
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
In Vivo Model ◽  
Drug Candidate ◽  
Phytochemical Analysis ◽  
Pharmacological Properties

Background:Tamarix Articulata (T. articulata), commonly known as Tamarisk or Athal in Arabic region, belongs to the Tamaricaece species. It is an important halophytic medicinal plant and a good source of polyphenolic phytochemical(s). In traditional medicines, T. articulata extract is commonly used, either singly or in combination with other plant extracts against different ailments since ancient times.Methods:Electronic database survey via Pubmed, Google Scholar, Researchgate, Scopus and Science Direct were used to review the scientific inputs until October 2018, by searching appropriate keywords. Literature related to pharmacological activities of T. articulata, Tamarix species, phytochemical analysis of T. articulata, biological activities of T. articulata extracts. All of these terms were used to search the scientific literature associated with T. articulata; the dosage of extract, route of administration, extract type, and in-vitro and in-vivo model.Results:Numerous reports revealed that T. articulata contains a wide spectrum of phytochemical(s), which enables it to have a wide window of biological properties. Owing to the presence of high content of phytochemical compounds like polyphenolics and flavonoids, T. articulata is a potential source of antioxidant, anti-inflammatory and antiproliferative properties. In view of these pharmacological properties, T. articulata could be a potential drug candidate to treat various clinical conditions including cancer in the near future.Conclusion:In this review, the spectrum of phytochemical(s) has been summarized for their pharmacological properties and the mechanisms of action, and the possible potential therapeutic applications of this plant against various diseases discussed.

Therapeutic Potential of Citronella Essential Oil: A Review

2019 ◽  
Vol 16 (4) ◽  
pp. 330-339 ◽  
Author(s):  
Ruchi Sharma ◽  
Rekha Rao ◽  
Sunil Kumar ◽  
Sheefali Mahant ◽  
Sarita Khatkar
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Environmental Protection Agency ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Toxic Encephalopathy ◽  
Practical Applications ◽  
Insect Repellents ◽  
Citronella Oil ◽  
Medicinal Value

Mosquito-borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alternatives/adjuvants in pharmaceuticals, biomedical, cosmetic, food, veterinary and agriculture applications. These oils have also gained popularity and interest for prevention and treatment of various disorders. However, several reports on adverse effects including skin eruption, contact artricaria or toxic encephalopathy in children are available for synthetic repellent in the literature. Thus, natural insect repellents like essential oils have been explored recently as an alternative. One such essential oil studied widely, is citronella oil, extracted mainly from Cymbopogon nardus. This essential oil has exhibited good efficacy against mosquitoes. It is a mixture of components including citronellal, citronellol, geraniol as major constituents contributing to various activities (antimicrobial, anthelmintic, antioxidant, anticonvulsant antitrypanosomal and wound healing), besides mosquito repellent action. Citronella essential oil is registered in US EPA (Environmental protection agency) as insect repellent due to its high efficacy, low toxicity and customer satisfaction. However, poor stability in the presence of air and high temperature limits its practical applications. Since specific knowledge on properties and chemical composition of oil is fundamental for its effective application, the present review compiles and discusses biological properties of citronella oil. It also sheds light on various formulations and applications of this essential oil.

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