scholarly journals Scientific substantiation of the concentration of excipients for the manufacture of eye drops Angiolin

2021 ◽  
Vol 14 (1) ◽  
pp. 52-55
Author(s):  
L. I. Kucherenko ◽  
I. A. Mazur ◽  
R. R. Akopian ◽  
O. O. Portna ◽  
H. I. Tkachenko
Keyword(s):  
Sodium Chloride ◽  
Dosage Form ◽  
Pharmaceutical Chemistry ◽  
Eye Drops ◽  
Technological Parameters ◽  
Three Solutions ◽  
High Molecular Weight Complex ◽  
Scientific Substantiation ◽  
Medical University

Throughout human history, cataracts have been one of the leading causes of blindness. For this disease, we studied the market of drugs of domestic and foreign production. The object of our study was the subgroup S10X Other ophthalmic drugs. Employees of the Department of Pharmaceutical Chemistry of Zaporizhzhia State Medical University (ZSMU) together with specialists of the NGO “Pharmatron” was synthesized a new compound, which was named Angiolin. A rational dosage form in the form of eye drops was proposed for the new drug. Since the drops continue to be the most common and widely used in practice dosage form. We have previously selected the optimal content of the active substance in eye drops. As is known from the technological parameters, eye drops must be isotonic, ie in their composition should be added excipients. The aim of our work is to select the concentration of excipients for the manufacture of eye drops Angiolin. Materials and methods. During the work at the Department of Pharmaceutical Chemistry of ZSMU, three solutions of eye drops Angiolin with different composition were prepared, and later the theoretical osmolarity was calculated. Results. Accurate theoretical calculation of the osmolarity of solutions containing substances with high molecular weight, complex total extracts, and highly concentrated solutions is impossible. Since the excipient was used methylcellulose, it was better to perform such a calculation experimentally, through the determination of osmolality. On the basis of the conducted researches, for correction of osmolarity, we were chosen – sodium chloride. Sodium chloride was selected at a concentration of 7.0 g/l, which creates an osmolality of the drug equal to 234.3 mosmol/kg. The estimated value at the same concentration of sodium chloride was 239.56 mosmol/l. The value of osmolarity of eye drops was calculated from it makes 302,18 mosmol/l that was confirmed the correctness of the chosen concentration of sodium chloride as a part of eye drops. Conclusions. Based on the above, we selected the concentration of excipients for the manufacture of eye drops Angiolin.

scholarly journals VALIDATION OF THE SPECTROFOTOMETRIC METHOD FOR THE DETERMINATION OF QUANTITATIVE COMPOSITION OF S-2,6-DIAGENOXIC ACID OF 3-METHYL-1,2,4-TRIAZOLYL- 5-THIOACETATE

2018 ◽  
Vol 11 (9) ◽  
pp. 91
Author(s):  
Kucherenko Lyudmila Ivanovna ◽  
Idnenko Oleksandr Sergeevich ◽  
Khromylova Olga Vladimirovna
Keyword(s):  
The State ◽  
Pharmaceutical Chemistry ◽  
State Enterprise ◽  
Ultraviolet Region ◽  
Quantitative Composition ◽  
National Academy Of Sciences ◽  
Accurate Analysis ◽  
Absorption Spectrophotometry ◽  
Medical University

Objective: The aim of the work was to determine the validation characteristics for the designed procedure for quantitation of the (S)-2,6- diaminohexanoic acid substance, 3-methyl-1,2,4-triazolyl-5-thioacetate, by absorption spectrophotometry in the ultraviolet region.Methods: For study purposes, the substance (S)-2,6-diaminohexanoic acid of 3-methyl-1,2,4-triazolyl-5-thioacetate and a standard sample (SS) obtained from the State Enterprise “Chemical Reagents Plant” of the Scientific-Technological Complex “Institute of Single Crystals” of the National Academy of Sciences of Ukraine, was used. In the course of our work, we used chemical, physical, physicochemical (absorption spectrophotometry in the ultraviolet region), and statistical methods of analysis. The study was carried out at the Laboratory for Standardization and Technology of Medicines at the Department of Pharmaceutical Chemistry at the Zaporizhia State Medical University (Ukraine).Results: In previous studies, we have developed a technique for spectrophotometric determination of the quantitative composition of (S)-2,6- diaminohexanoic acid of 3-methyl-1,2,4-triazolyl-5-thioacetate. The results of the conducted studies showed that the absorption curve in the UV region of the substance solution has a maximum absorption, namely: λ = 238 nm. The results of the quantitation of the substance (S)-2,6-diaminohexanoic acid of 3-methyl-1,2,4-triazolyl-5-thioacetate prove that our technique is accurate and reproducible and meets the current requirements. In order for the developed methodology to ensure consistent and accurate analysis results, its validation was carried out. According to the requirements of the State Pharmacopoeia of Ukraine (DFU) (2 editions), the developed method for the quantitation of the substance was checked for such validation characteristics as specificity, linearity, range of use, accuracy, correctness, and robustness.Conclusion: As a result of the work, it was proved that the developed method of the quantitation of the substance (S)-2,6-diaminohexanoic acid of 3-methyl-1,2,4-triazolyl-5-thioacetate by spectrophotometric method is valid.

scholarly journals DEVELOPMENT OF A METHOD TO DETERMINE RELATED IMPURITIES IN BROMIDE 1-(β-PHENYLETHYL)-4-AMINO-1,2,4-TRIAZOLE TABLETS

2020 ◽  
pp. 40-42
Author(s):  
Natalia Derevianko ◽  
Dmytro Skoryna
Keyword(s):  
High Performance ◽  
Antioxidant Properties ◽  
Modern Method ◽  
Test Solution ◽  
Pharmaceutical Chemistry ◽  
Related Impurities ◽  
Study Results ◽  
Scientific Production Association ◽  
Medical University

Aim: to develop a modern method to determine related impurities in bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole tablets by high performance liquid chromatography (HPLC). Methods: The development of a method to determine related impurities in bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole tablets involved an already developed method for the determination of 4-amino-1,2,4-triazole impurities in tablets by HPLC. The test solution and the comparison solution were prepared and chromatographed alternately according to the developed methods. At least three chromatograms were obtained for each solution for the purpose of the reliability of the study results. Results: Scientists of the Scientific-Production Association "Farmatron" jointly with the staff of the Pharmaceutical Chemistry Department of Zaporizhzhia State Medical University under the leadership of Professor Mazur I. A. obtained a new original compound – bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole (conditional name "Hypertril"), which exhibits antihypertensive, anti-ischemic and antioxidant properties. It is known that the quality of medicines largely depends on the degree of their purity. Therefore, in accordance with the regulatory documentation and quality control methods of medicines, it is mandatory to carry out tests for impurities. According to the results, the content of impurities of 4-amino-1,2,4-triazole in the tested tablets of bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole is in the range from 0.049 % to 0.195 % which meets the requirements of regulatory documentation. No peaks of unidentified impurities were detected on the chromatograms of the test solution. Conclusion: Therefore, a modern method to determine the related impurity of 4-amino-1,2,4-triazole in tablets of bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole has been developed. The methodology is reproducible, accurate and meets the requirements of regulatory documentation.

Substantiation of the parameters of the process of plasma-mechanical milling of titanium alloys and alloyed steels

2020 ◽  
Vol 14 (4) ◽  
pp. 7520-7527
Author(s):  
Anton Ryazantsev ◽  
V.P. Nechaev ◽  
O.V. Bondar
Keyword(s):  
Mechanical Milling ◽  
Plasma Heating ◽  
High Strength ◽  
Milling Process ◽  
Technological Parameters ◽  
Construction Time ◽  
Heating Source ◽  
Thermal Calculations ◽  
Scientific Substantiation

The article is devoted to the development and scientific substantiation of the method of processing high-strength materials using surface plasma heating. A method for determining the parameters of the plasma-mechanical milling process has been formed, which includes: thermal calculations of the plasma arc power; thermal field characteristics in the part material; determination of residual stresses and hardness of the surface layer of the part. The choice of technological parameters of a plasma heating source is grounded. Criteria are formulated to which the source of plasma heating must correspond. Calculations are performed to determine the dependence of the performance of the milling process on titanium alloy Ti-6Al-4V with the achievement of a certain microstructure of the part being cut off under the influence of plasma heating. A new scheme of plasma-mechanical milling is proposed, which provides for arc scanning in a magnetic field in the direction of the minute vector filing cutters and additional cyclical movement across the plasma torch feed vector with an amplitude of approximately equal to width milling. The proposed method of plasma heating a cut off layer allows lowering costs of processing time, and solve the problem of shortening ships' construction time.

High-performance thin-layer chromatographic determination of rosiglitazone in its dosage form

2002 ◽  
Vol 15 (3) ◽  
pp. 192-195 ◽  
Author(s):  
Ramesh Sane ◽  
Mary Francis ◽  
Atul Moghe ◽  
Sachin Khedkar ◽  
Ajit Anerao
Keyword(s):  
Thin Layer ◽  
High Performance ◽  
Dosage Form ◽  
Chromatographic Determination

Relationship between satisfaction with learning outcomes and mental health among medical and engineering students

2020 ◽  
pp. 70-78
Author(s):  
O. Bukhanovskaya ◽  
N. Demcheva
Keyword(s):  
Mental Health ◽  
Academic Performance ◽  
Mental Disorders ◽  
University Students ◽  
Learning Outcomes ◽  
Engineering Students ◽  
Clinical Forms ◽  
Complete Survey ◽  
Medical University

Method of calculating the index of crisis of gratification has been developed on the basis of the complete survey of 995 students of medical university and 804 students of engineering university, determination of clinical and social parameters and factors related to the process of education in the specialized university. It included: a scale for the assessment of the degree of intellectual intensity, academic performance, stress situations related to the peculiarities of education. Reliable differences in values between groups of healthy students, students with preclinical and clinical forms of mental disorders are revealed as a result of calculation of the index of gratification. The authors conclude that satisfaction with the results of education has a significant impact on the mental health of university students.

Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

2012 ◽  
Vol 4 (4) ◽  
pp. 1563-1568
Author(s):  
Sagar Suman Panda ◽  
Ravi Kumar B V V ◽  
D Patanaik
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Dosage Form ◽  
Dosage Forms ◽  
Alendronate Sodium ◽  
Colored Complex ◽  
Pharmaceutical Dosage Forms ◽  
Recovery Study ◽  
Assay Conditions

A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recovery study were found to be in the range of 99.37%-100.46%. The R.S.D. values for intraday and inter-day precision were found to be 0.48 and 0.62, respectively. The optimized assay conditions were applied successfully for determination of ALS in pharmaceutical dosage forms. No interference was observed from the excipients present in the dosage form. The method is statistically validated as per the ICH requirements.  

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