Plant-derived medicines for neuropathies: a comprehensive review of clinical evidence

2019 ◽  
Vol 30 (6) ◽  
pp. 671-684 ◽  
Author(s):  
Farnaz Ebrahimi ◽  
Mohammad Hosein Farzaei ◽  
Roodabeh Bahramsoltani ◽  
Mojtaba Heydari ◽  
Kiana Naderinia ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Viral Infections ◽  
Cannabis Sativa ◽  
Linseed Oil ◽  
Curcuma Longa ◽  
Herbal Medicines ◽  
Cochrane Library ◽  
Congenital Diseases ◽  
Beneficial Effects ◽  
Long Time

AbstractNeuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies. The aim of the present study is to review the current clinical data on the beneficial effects of medicinal plants in neuropathy. Electronic databases including PubMed, Scopus, and Cochrane Library were searched with the keywords ‘neuropathy’ in the title/abstract and ‘plant’ or ‘extract’ or ‘herb’ in the whole text from inception until August 2017. From a total of 3679 papers, 22 studies were finally included. Medicinal plants were evaluated clinically in several types of neuropathy, including diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, and HIV-associated neuropathy. Some studies reported the improvement in pain, nerve function, nerve conduction velocity, and quality of life.Cannabis sativa(hemp),Linum usitatissimum(linseed oil), capsaicin, and a polyherbal Japanese formulation called Goshajinkigan had the most evidence regarding their clinical efficacy. Other investigated herbal medicines in neuropathy, such asMatricaria chamomilla(chamomile),Curcuma longa(turmeric), andCitrullus colocynthis(colocynth), had only one clinical trial. Thus, future studies are necessary to confirm the safety and efficacy of such natural medicines as a complementary or alternative treatment for neuropathy.

Antiviral and Immunity-modulating Natural Herbs in the Prevention of COVID-19

2021 ◽  
pp. 81-94
Author(s):  
Sonali S Gadge
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Antiviral Drug ◽  
Herbal Medicines ◽  
Echinacea Purpurea ◽  
Black Pepper ◽  
Tinospora Cordifolia ◽  
Ocimum Sanctum

The COVID-19 has spread all over the world and there is no single drug or medicine for the prevention and the treatment of this deadly disease. One can get prevention from this disease by boosting the immune system. Persons with weak immune system e.g. children, elder patients or patients with preexisting diseases affect rapidly due to coronavirus. This novel coronavirus attacks mainly on the person immunity. For the centuries the herbal medicinal plants have many beneficial effects against deadly viruses. Herbal medicines provide a rich resource for new antiviral drug development. These natural agents interact with the life cycle of virus such as virus entry, replication, assembly and release. In this review, the importance, immunomodulator, antiviral and pharmacological activities of some medicinal plants, namely, Allium Sativum, Zingiber Officinalis, Cinnamomum zeylanicum, Curcuma longa, Ocimum sanctum, Glycyrrhiza glabra, Ginseng, Black pepper, Emblica officinalis, Withania somnifera, Tinospora cordifolia, Echinacea purpurea, Azadirachta indica, Piper betel, Eugenia caryophyllata, Cinchona calisaya, Nigella sativa, Cuminum cyminum are highlighted. These medicinal plants have many phytoconstituents like alkaloids, glycosides, terpenoids, flavonoids, lactones, polysaccharides, volatile oils, tannins, resins, etc which are helpful for boosting immunity and will help in the prevention and in the management of COVID-19. Several types of research attempted to use herbal medicines against COVID-19.

scholarly journals Study of the genus Curcuma in Indonesia used as traditional herbal medicines

2019 ◽  
Vol 20 (5) ◽  
Author(s):  
DYAH SUBOSITI ◽  
SLAMET WAHYONO
Keyword(s):  
Medicinal Plants ◽  
Ethnic Groups ◽  
Local Knowledge ◽  
Relative Frequency ◽  
Sampling Method ◽  
Curcuma Longa ◽  
Economic Value ◽  
Herbal Medicines ◽  
Traditional Healers ◽  
Use Value

Abstract. Subositi D, Wahyono S. 2019. Study of the genus Curcuma in Indonesia used as traditional herbal medicines. Biodiversitas 20: 1356-1361. Research into local knowledge is very important in providing a database of medicinal plants and as a basis for further research. The genus Curcuma (Zingiberaceae) has been used as medicines and other purposes, so it has a high economic value.  The aim of this study was to record the use of the species of the genus Curcuma as traditional herbal medicines in Indonesia. The study was a part of a project called RISTOJA (Research on Medicinal Plants and Traditional Herbal Medicines), which collected data from 415 ethnic groups in Indonesia from 2012 to 2017. A purposive sampling method was used to select 2,354 respondents (traditional healers) for interviews, 1,042 of whom used Curcuma as herbal medicines. It was found that eight species of the genus were used to treat 73 different ailments. Curcuma longa was found to have the highest relative frequency of citation (0.274) and use value (0.563), and members of the genus Curcuma were found to be extensively used to treat a wide variety of ailments in Indonesia.

scholarly journals Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sibhghatulla Shaikh ◽  
Khurshid Ahmad ◽  
Syed Sayeed Ahmad ◽  
Eun Ju Lee ◽  
Jeong Ho Lim ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Herbal Medicines ◽  
Therapeutic Management ◽  
Bioactive Constituents ◽  
Active Components ◽  
Beneficial Effects ◽  
Therapeutic Benefits ◽  
Division Process ◽  
Autophagic Degradation ◽  
Cytoplasmic Content

Autophagy is an essential cellular process that involves the transport of cytoplasmic content in double-membraned vesicles to lysosomes for degradation. Neurons do not undergo cytokinesis, and thus, the cell division process cannot reduce levels of unnecessary proteins. The primary cause of neurodegenerative disorders (NDs) is the abnormal deposition of proteins inside neuronal cells, and this could be averted by autophagic degradation. Thus, autophagy is an important consideration when considering means of developing treatments for NDs. Various pharmacological studies have reported that the active components in herbal medicines exhibit therapeutic benefits in NDs, for example, by inhibiting cholinesterase activity and modulating amyloid beta levels, and α-synuclein metabolism. A variety of bioactive constituents from medicinal plants are viewed as promising autophagy controllers and are revealed to recover the NDs by targeting the autophagic pathway. In the present review, we discuss the role of autophagy in the therapeutic management of several NDs. The molecular process responsible for autophagy and its importance in various NDs and the beneficial effects of medicinal plants in NDs by targeting autophagy are also discussed.

scholarly journals Optimasi Metode 1H-NMR Profiling pada Rimpang Kunyit (Curcuma domestica)

2019 ◽  
Vol 5 (2) ◽  
pp. 106-113
Author(s):  
Caroline Dwiseptianti ◽  
Febri Adi Susanto ◽  
Yekti Asih Purwestri ◽  
Tri Rini Nuringtyas
Keyword(s):  
Medicinal Plants ◽  
1H Nmr ◽  
Curcuma Longa ◽  
Herbal Medicines ◽  
Optimization Method ◽  
Raw Material ◽  
Active Components ◽  
Analytical Technique ◽  
Natural Medicine

The use of medicinal plants is increasing due to the lack of side effects caused and the number of bioactive compounds that cannot be represented by synthetic chemical synthesis compounds. However, the management and use of natural medicines for the main handling of diseases are often hampered by the quality of the ingredients which are low and unstable. The standardized quality control system of OAI (Indonesian Natural Medicine) is the main key to improve clinical assurance and safety of the use of herbal medicines in Indonesia. One of the medicinal plants known to the public is Curcuma longa L. (turmeric). The main active components contained in turmeric are curcumin, demetoksikurkumin, bis-demetoksikurkumin, and ar-turmeron. Information about the quality of turmeric is needed in its use as a raw material for drugs so we need an analytical technique that is able to identify the diversity of metabolite profiles of active compounds. In this research, an optimization method is used to improve efficiency in the extraction of turmeric rhizome metabolites so that the best solvent concentration is known for the analysis of fingerprinting secondary metabolites with 1H-NMR 500 MHz spectroscopy in turmeric rhizomes. The results were analyzed with MNOVA software and chemical shift obtained compared with the reference. From the results obtained a concentration of methanol-d4 (CD3OD) 100% able to extract curcumin better than other solvents. The solvent is able to extract saccharide (sugar) compounds in the form of sucrose, amino acids and fatty acids in the form of methionine, glutamine, acetate, and glycero phospho choline.

scholarly journals Review of Antiviral Medicinal Plants used in Taraba State Nigeria: A Possible Source for COVID-19 Drug Discovery

2020 ◽  
Vol 1 (2) ◽  
pp. 1-23
Author(s):  
Cletus Anes Ukwubile ◽  
Troy Silvia Malgwi ◽  
Alexander Ezekiel Angyu ◽  
Otalu Otalu ◽  
Mathias Simon Bingari
Keyword(s):  
Medicinal Plants ◽  
Allium Sativum ◽  
Viral Infections ◽  
Curcuma Longa ◽  
Antiviral Agents ◽  
Zingiber Officinale ◽  
Human Influenza Virus ◽  
Infectious Bronchitis ◽  
The Usa ◽  
Ocimum Tenuiflorum

Purpose: Coronavirus also known as COVID-19 is a viral infection that has been tagged as the greatest pandemic since the existence of humans by the WHO, resulting in the deaths of thousands of people globally; with the USA one of the highest. The full biology of the virus is yet to be known. This study reviews sixteen natural antiviral plants used in Taraba State to manage viral infections locally. Subjects and Methods: Sixteen medicinal plants popularly used as antiviral agents in Taraba State, Nigeria were surveyed based on a field-trip experience with herbal medicine practitioners in the three zones of the state. Plants that were in both zones were counted as the same. The plants that are majorly used for various viral infections are Allium sativum, Zingiber officinale, Camellia sinensis, Hibiscus sabdariffa, Cirus lemon, Azardirachta indica, Ocimum tenuiflorum, Curcuma longa, Haematostaphis barteri, Olea europaea, Melastomastrum capitatum, Astragalus canadensis, Carissa edulis, Spondias venulosa, Vitellaria paradoxa, and Euphorbia hirta. Results: Of the sixteen plants, ten have been reported to have antiviral properties against at least one of these viruses avian or bird flu, human influenza virus, infectious bronchitis virus (a type of coronavirus), herpes virus, hepatitis C virus and HIV. Conclusion: The study revealed that further research on these antiviral plants used traditionally might pave the way for the discovery of potent antiviral drugs against COVID-19.

scholarly journals Can antimalarial, antiviral and anti-respiratory infections Cameroonian medicinal plants be used as one of the potential ways to cure COVID-19? Pharmacological and ethnomedicinal proof

2020 ◽  
pp. 61-85
Author(s):  
Tsobou Roger ◽  
Hamawa Yougouda ◽  
Fawa Guidawa ◽  
Tatsimo Ndendoung Simplice Joël ◽  
Avana Tientcheu Marie-Louise ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Curcuma Longa ◽  
Research Work ◽  
Zingiber Officinale ◽  
Traditional Healers ◽  
Global Public Health ◽  
Tract Infections

COVID-19 is a severe acute respiratory syndrome-related corona-virus SARS-CoV-2, that constitutes a pandemic threat to global public health. Unfortunately, there are no specific available therapies. This research work presents the findings of an investigation on traditional Cameroonian remedies of respiratory tract infections, malaria and viral infections, and also recipes that could serve as a baseline for the prevention, alleviate symptoms, treatment and perhaps may help for the anti-COVID-19 drugs discovery. Data on the medicinal plants were collected from traditional healers, Cameroonian medicinal plants books, the internet, and in addition to our personal experience as researchers and herbalists. Details of 85 plant species used to manage these three mentioned diseases in Cameroon and their pharmacological properties are recorded. Due to their ethnomedicinal uses and pharmacological activities, twenty-eight (28) plant species and 13 recipes are suggested for COVID-19 prevention, alleviate symptoms, treatment and baseline for anti-COVID-19 drug discovery. Amongst the proposed plants we have the following, Curcuma longa, Azadirachta indica, Zingiber officinale, Allium sativum and Ocimum gratissimum which were reported to possess certain inhibition properties against COVID-19 protease.

The Role of Traditional Chinese Herbal Medicines and Bioactive Ingredients on Ion Channels: A Brief Review and Prospect

2019 ◽  
Vol 18 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Yian Huang ◽  
Shumei Ma ◽  
Yan Wang ◽  
Renjie Yan ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Bioactive Compounds ◽  
Cannabis Sativa ◽  
Salvia Miltiorrhiza ◽  
Curcuma Longa ◽  
Herbal Medicines ◽  
Scientific Basis ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Regulatory Effects

Traditional Chinese Medicines (TCMs), particularly the Chinese herbal medicines, are valuable sources of medicines and have been used for centuries. The term “TCMs” both represents to the single drug agent like Salvia miltiorrhiza, Ligusticum chuanxiong and Angelica sinensis, and those herbal formulas like Jingshu Keli, Wenxin Keli and Danzhen powder. In recent years, the researches of TCMs developed rapidly to understand the scientific basis of these herbs. In this review, we collect the studies of TCM and their containing bioactive compounds, and attempt to provide an overview for their regulatory effects on different ion channels including Ca2+, K+, Na+, Cl- channels and TRP, P2X receptors. The following conditions are used to limit the range of our review. (i) Only the herbal materials are included in this review and the animal- and mineral-original TCMs are excluded. (ii) The major discussions in this review focus on single TCM agent and the herbal formulas are only discussed for a little. (iii) Those most famous herbal medicines like Capsicum annuum (pepper), Curcuma longa (ginger) and Cannabis sativa (marijuana) are excluded. (iv) Only those TCM herbs with more than 5 research papers confirming their effects on ion channels are discussed in this review. Our review discusses recently available scientific evidences for TCMs and related bioactive compounds that have been reported with the modulatory effects on different ion channels, and thus provides a new ethnopharmacological approach to understand the usage of TCMs.

Herbal Drugs as Immune Booster against Viral Infections

2021 ◽  
Vol 17 ◽  
Author(s):  
Gyanendra Mohapatra ◽  
Biswa Mohan Sahoo ◽  
Bimalendu Chowdhury ◽  
J. Sruti ◽  
Rabi Narayan Rana ◽  
...  
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Viral Infections ◽  
Curcuma Longa ◽  
Herbal Medicines ◽  
Passive Immunization ◽  
Ocimum Sanctum ◽  
Herbal Drugs ◽  
Herbal Plants ◽  
Immune Booster

: The immune system involves both active and passive immunization. The antibodies are devloped against the antigens during active immunization and are permanently stored. But, in case of passive immunization, the antibodies are exposed to the same antigens in every person who are already infected. In order to enhance the immune systems i.e. innate and adaptive immune responses, herbal plants are used as immune booster. Some of the herbal plants have been proved clinically to enhance the immunity that include Morniga oleifera (Drumstick), Azadirachta indica (Neem), Ocimum sanctum (Tulsi), Withania somnifera (Aswagandha), Zingiber officinale (Ginger), Allium sativum (Garlic), Curcuma longa (Turmeric), Emblica officinalis (Amla) etc. Compared to synthetic drugs, the herbal drugs have fewer or less side effects and stimulate the immune system to defend against various foreign pathogens. Even though, herbal medicines are usually considered as safe and effective therapy, but it is clinically proved that if a drug is effective, it would have some side effects. But, sometimes the antioxidant property of herbal medicines is helpful to reduce the toxicities produced by any toxic substances or any drugs. This review aims to encourage the study of various herbal constituents and their role in the treatment of different types of viral infections.

scholarly journals Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

Planta Medica ◽  
2021 ◽  
Author(s):  
Silvia Borrás ◽  
Isabel Martínez-Solís ◽  
José Luis Ríos
Keyword(s):  
Clinical Trials ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Mechanisms Of Action ◽  
Cochrane Library ◽  
Psychological Interventions ◽  
Clinical Tests ◽  
Search Terms ◽  
The Cochrane Library

AbstractSleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, and “clinical trial”, combined with the search terms “herbs” and “medicinal plants”, in addition to individual herbal medicines by both their common and scientific names. This updated review, which focuses mainly on clinical trials, includes research on 23 medicinal plants and their combinations. Essential oils and their associations have also been reviewed. The efficacy of medicinal plants depends on treatment duration, types of study subjects, administration route, and treatment method. More clinical trials with an adequate, standardized design are necessary, as are more preclinical studies to continue studying the mechanisms of action. As a result of our work, we can conclude that the 3 plants with the most potential are valerian, passionflower, and ashwagandha, with the combination of valerian with hops and passionflower giving the best results in the clinical tests.

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

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