Stretchable Bioelectrodes

2010 ◽  
Vol 1271 ◽  
Author(s):  
Pinghung Wei ◽  
B. Ziaie

AbstractIn this paper, we present a stretchable electrode array for studying cell behavior subjected to mechanical strain. The electrode array consists of four gold nail-head pins (250μm tip diameter and 1.75mm spacing) or tungsten microwires (25.4μm in diameter) inserted into a polydimethylsiloxane (PDMS) platform (25.4×25.4mm2). Fusible indium alloy (liquid at room temperature) filled microchannels were used to connect the electrodes to the outside, thus providing the required stretchability. The electrodes were able to withstand strains of up to 40%. Repeated strain tests of several hundred cycles did not reveal any failure, illustrating the robustness of the platform. Mice cardiomyocytes and chick neurons were successfully cultured onto the platform.

2020 ◽  
Vol 11 (1) ◽  
pp. 49-56
Author(s):  
T.A. Nguyen ◽  
D. Echtermeyer ◽  
A. Barthel ◽  
G. Urban ◽  
U. Pliquett

AbstractDesigning proper frontend electronics is critical in the development of highly sophisticated electrode systems. Multielectrode arrays for measuring electrical signals or impedance require multichannel readout systems. Even more challenging is the differential or ratiometric configuration with simultaneous assessment of measurement and reference channels. In this work, an eight-channel frontend was developed for contacting a 2×8 electrode array (8 measurement and 8 reference electrodes) with a large common electrode to the impedance gain-phase analyzer Solartron 1260 (S-1260). Using the three independent and truly parallel monitor channels of the S-1260, impedance of trapped cells and reference material was measured at the same time, thereby considerably increasing the performance of the device. The frontend electronics buffers the generator output and applies a potentiostatic signal to the common electrode of the chip. The applied voltage is monitored using the current monitor of the S-1260 via voltage/current conversion. The frontend monitors the current through the electrodes and converts it to a voltage fed into the voltage monitors of the S-1260. For assessment of the 8 electrode pairs featured by the chip, a relay-based multiplexer was implemented. Extensive characterization and calibration of the frontend were carried out in a frequency range between 100 Hz and 1 MHz. Investigating the influence of the multiplexer and the frontend electronics, direct measurement with and without frontend was compared. Although differences were evident, they have been negligible below one per cent. The significance of measurement using the complex S-1260-frontend-electrode was tested using Kohlrausch's law. The impedance of an electrolytic dilution series was measured and compared to the theoretical values. The coincidence of measured values and theoretical prediction serves as an indicator for electrode sensitivity to cell behavior. Monitoring of cell behavior on the microelectrode surface will be shown as an example.


2017 ◽  
Vol 139 (2) ◽  
Author(s):  
Steven A. Klein ◽  
Aleksandar Aleksov ◽  
Vijay Subramanian ◽  
Pramod Malatkar ◽  
Ravi Mahajan

Stretchable electronics have been a subject of increased research over the past decade (Lacour, S., et al., 2006, “Mechanisms of Reversible Stretchability of Thin Metal Films on Elastomeric Substrates,” Appl. Phys. Lett., 88(20), p. 204103; Lacour, S., et al., 2004, “Design and Performance of Thin Metal Film Interconnects for Skin-Like Electronic Circuits,” IEEE Electron Device Lett., 25(4), pp. 179–181; and Maghribi, M., et al., 2005, “Stretchable Micro-Electrode Array,” International IEEE-EMBS Conference on Microtechnologies in Medicine and Biology, pp. 80–83.). Although stretchable electronic devices are a relatively new area for the semiconductor/electronics industries, recent market research indicates that the market could be worth more than $900 million by 2023 (PR Newswire, 2015, “Stretchable Electronics Market Worth $911.37 Million by 2023,” PR Newswire, Albuquerque, NM.). This paper investigates mechanical testing methods designed to test the stretching capabilities of potential products across the electronics industry to help quantify and understand the mechanical integrity, response, and the reliability of these devices. Typically, the devices consist of stiff modules connected by stretchable traces (Loher, T., et al., 2006, “Stretchable Electronic Systems,” Electronics Packaging Technology Conference (EPTC '06), pp. 271–276.). They require electrical and mechanical connectivity between the modules to function. In some cases, these devices will be subject to biaxial and/or cyclic mechanical strain, especially for wearable applications. The ability to replicate these mechanical strains and understand their effect on the function of the devices is critical to meet performance, process, and reliability requirements. In this paper, methods for simulating biaxial and out-of-plane strains similar to what may occur in a wearable device on the human body are proposed. Electrical and/or optical monitoring (among other methods) can be used to determine cycles to failure depending on expected failure modes. Failure modes can include trace damage in stretchable regions, trace damage in functional component regions, or bulk stretchable material damage, among others. Three different methods of applying mechanical strain are described, including a stretchable air bladder method, membrane test method, and lateral expansion method.


2003 ◽  
Vol 795 ◽  
Author(s):  
Paul R. Besser ◽  
Qing-Ting Jiang

ABSTRACTThe mechanical stresses in Cu interconnect lines arise from thermal expansion (CTE) differences, and the magnitude of the stress can be calculated based on the measured strain. In the current work, the strain (and stress) state of narrow Cu lines fabricated in oxide and porous organic spin-on dielectrics (low K) has been determined with X-Ray diffraction (XRD) during annealing. The room temperature stress along the length (X) and width (Y) of the lines are not dramatically different while the Z component is somewhat smaller with the spin-on ILD. These small perturbations in the magnitude of the Cu stress do not reflect the dramatic differences in the CTE. More insight into the materials system is obtained by studying the strain-temperature behavior, which illustrates the effect of the ILD clearly. The X strain is similar in magnitude and variation with temperature for both ILDs, supporting strain being imposed by the substrate. However, the Z strain is compressive at RT and linearly increases with temperature for Cu in low K, reflecting the lack of constraint by the ILD and the higher CTE of the ILD.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sujie Kang ◽  
Bo-Yeon Lee ◽  
Sin-Hyung Lee ◽  
Sin-Doo Lee

Abstract A microarray of conducting polymer electrodes with high resolution and high pattern-fidelity is developed on a stretchable substrate through the directed wetting localization (DWL) by the differential hydrophobicity. The large difference in the surface energy between the wetting and dewetting regions serves as the major determinant of the pattern resolution and the pattern-fidelity, yielding the full surface coverage in the stretchable electrode array (SEA) with 30 μm in width. The electrical characteristics of the SEA are well preserved under different types of elastic deformations. All-solution-processed polymer light-emitting diodes (except for the cathode) based on our patterned stretchable electrodes show no appreciable degradation of the performance under stretching. The DWL provides a simple and effective way of building up diverse stretchable electrical and optoelectronic devices in advanced wearable and bio-integrated electronics.


2020 ◽  
Vol 9 (9) ◽  
pp. 2776 ◽  
Author(s):  
Nadja Rohr ◽  
Katja Fricke ◽  
Claudia Bergemann ◽  
J Barbara Nebe ◽  
Jens Fischer

Plasma-polymerized allylamine (PPAAm) coatings of titanium enhance the cell behavior of osteoblasts. The purpose of the present study was to evaluate a PPAAm nanolayer on zirconia after a storage period of 5 years. Zirconia specimens were directly coated with PPAAm (ZA0) or stored in aseptic packages at room temperature for 5 years (ZA5). Uncoated zirconia specimens (Zmt) and the micro-structured endosseous surface of a zirconia implant (Z14) served as controls. The elemental compositions of the PPAAm coatings were characterized and the viability, spreading and gene expression of human osteoblastic cells (MG-63) were assessed. The presence of amino groups in the PPAAm layer was significantly decreased after 5 years due to oxidation processes. Cell viability after 24 h was significantly higher on uncoated specimens (Zmt) than on all other surfaces. Cell spreading after 20 min was significantly higher for Zmt = ZA0 > ZA5 > Z14, while, after 24 h, spreading also varied significantly between Zmt > ZA0 > ZA5 > Z14. The expression of the mRNA differentiation markers collagen I and osteocalcin was upregulated on untreated surfaces Z14 and Zmt when compared to the PPAAm specimens. Due to the high biocompatibility of zirconia itself, a PPAAm coating may not additionally improve cell behavior.


MRS Advances ◽  
2017 ◽  
Vol 2 (50) ◽  
pp. 2865-2873 ◽  
Author(s):  
J. M. Durán-Olvera ◽  
R. Orozco-Cruz ◽  
R. Galván-Martínez ◽  
C.A. León ◽  
A. Contreras

ABSTRACTThis work shows the electrochemical study of nickel (Ni) and TiC/Ni composite immersed in synthetic seawater. In order to characterize the corrosion process, polarization curves (PC) were carried out. All electrochemical measures were made under static conditions, room temperature, atmospheric pressure and 24 hours exposure time. An electrochemical cell with a typical three-electrode array was used. Effect of TiC as reinforcement into the Ni matrix was evaluated. According PC results, it is possible to point out that the corrosion rate (CR) of the TiC/Ni composite was higher than Ni corrosion rate. The obtained results indicate that the corrosion process of both materials is of mixed type, that is to say a process of transfer of load influenced by a mechanism of mass transfer. Observations through scanning electron microscopy (SEM) revealed that mechanism of corrosion was cells of differential aeration (difference of concentration of oxygen). The corrosion morphology was localized type (pits and crevice).


2013 ◽  
Vol 87 ◽  
pp. 17-20 ◽  
Author(s):  
Niko Münzenrieder ◽  
Christoph Zysset ◽  
Luisa Petti ◽  
Thomas Kinkeldei ◽  
Giovanni A. Salvatore ◽  
...  

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